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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 3 | Introduction to a system for distributed databases (SDD-1)显示文摘 | Rothnie Jr J B Bernstein P A Fox S | 1980 | ACM Transactions on Database Systems (TODS)1980，5，1： | 1 |
| 4 | Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study显示文摘 | Mathieu K B Ai H Fox P S | 2014 | J Appl Clin Med Phys2014，15，2： | 1 |
| 5 | TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts显示文摘 | Wong B Fox S | 1998 | J Exp Med1998，188，5： | 1 |
| 6 | Feeding infants and toddlersstudy:What foods are infants and toddlers eating? 显示文摘 | Fox MK Pac S Devaney B | 2004 | J AmDiet Assoc2004，104，11： | 1 |
| 7 | TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts显示文摘 | Fuller K Wong B Fox S | 1998 | J Exp Med1998，188，5： | 1 |
| 8 | On the modeling of actuator dynamics and the computation of prescribed trajectory显示文摘 | FOX B JENNINGS L S ZOMAYA A Y | 2002 | Computers and Structures2002，80，7： | 1 |
| 9 | Nonlinear electrical properties of lead-lanthanum-titanate thin fill deposited by multi-ion-beam reactive sputtering 显示文摘 | Fox G R Krupanidhi S B | 1993 | J Appl Phys1993，74，： | 1 |
| 10 | Trends in Biotechnology,显示文摘 | Fox D B Moody T S | 2001 | 19:292001，19，： | 1 |
| 11 | On the modeling of actuator dynamics and the computation of prescribed trajectories显示文摘 | FOX B JENNINGS L S ZOMAYA A Y | | 0，，7： | 1 |
| 12 | Relationship of endothe- lial cell proliferation to tumor vascularity in human breast cancer 显示文摘 | Fox S B Garter K C Bicknell R | 1993 | Cancer Res1993，53，18： | 1 |
| 13 | Association of tumour necrosis factor alpha and its receptors with thymidine phospho- rylase expression in invasive breast carcinoma显示文摘 | Leek R D Landers R Fox S B | 1998 | Br J Cancer1998，77，12： | 1 |
| 14 | Quantification of reg- ulatory T ceils enables the identification of high-risk breast cancer patients and those at risk of late relapse 显示文摘 | Bates G J Fox S B Han C | 2006 | J Clin Oncol2006，24，34： | 1 |
| 15 | Upregulation of basic fibroblast growth factor in breast carcinoma and itsrelationship to vascular density, oestrogen receptor and survival显示文摘 | Smith K Fox S B Whitehouse R | 1999 | Ann Oncol1999，10，： | 1 |
| 16 | Quantification and localization of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection显示文摘 | Ward S M Fox B C Brown P J | 2007 | J Heptol2007，47，： | 1 |
| 17 | Reactions of the diiron enzyme stearoyl-acyl carrier protein desaturase显示文摘 | Fox B G Lyle K S Rogge C E | 2004 | Acc Chem Res2004，37，7： | 1 |
| 18 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 19 | Increased striatal pre- proenkephalin B expression is associated with dyskinesia in Parkinson' s disease 显示文摘 | Henry B Duty S Fox SH | 2003 | Exp Neurol2003，183，2： | 1 |
| 20 | Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study 显示文摘 | MEIGS J B LARSON M G FOX C S | 2007 | Diabetes Care2007，30，10： | 1 |
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