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| 1 | Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet显示文摘AIM: To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn’s disease (CD) in patients who have achieved remission,who are a high-risk group for relapse.METHODS: A prospective,single center,2-year clinical trial was conducted.Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease.The primary endpoint was clinical relapse defi ned as the appearance of active symptoms of CD.Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse.A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.RESULTS: SVD was continued by 16 patients (compliance 73%).Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%)in the omnivorous group.Remission rate with SVD was 100% at 1 year and 92% at 2 years.SVD showed signif icant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003,log rank test).The concentration of C-reactive protein was normal at the f inal visit in more than half of the patients in remission who were taking an SVD,who maintained remission during the study (9/15;60%),who terminated follow-up (8/12;67%),and who completed 2 years follow-up (7/10;70%).There was no untoward effect of SVD.CONCLUSION: SVD was highly effective in preventing relapse in CD. | Mitsuro Chiba Toru Abe Hidehiko Tsuda Takeshi Sugawara Satoko Tsuda Haruhiko Tozawa Katsuhiko Fujiwara Hideo Imai | 2010 | World Journal of Gastroenterology2010，16，20： | 17 |
| 2 | Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes显示文摘Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Several therapeutic approaches for ameliorating each of these abnormalities have been attempted, including various antidiabetic agents or new compounds targeting lipid metabolism. | Toru Hiyoshi Mutsunori Fujiwara Zemin Yao | 2019 | The Journal of Biomedical Research2019，33，1： | 5 |
| 3 | Comparison between sitagliptin and nateglinide on postprandial lipid levels: The STANDARD study显示文摘AIM: To assess the effects of sitagliptin and nateglinide on lipid metabolism. METHODS: In a parallel group comparative open trial, patients with type 2 diabetes mellitus under treatment at the Japanese Red Cross Medical Center were randomly assigned to receive either sitagliptin (50 mg once daily) or nateglinide (90 mg three times daily before meals). Eligible patients met the following criteria: age ≥ 20 years; hemoglobin A 1c (HbA 1c ) > 6.5% despite diet and exercise; HbA 1c between 6.5% and 8.0%; fasting glucose < 7.77 mmol/L; diet and exercise therapy for more than 3 mo; and ability to read and understand the information for written informed consent. Exclusion criteria were contraindications to sitagliptin, contraindications to nateglinide, pregnancy or possible pregnancy, and severe liver/renal failure. Patients who were considered to be unsuitable by the attending physician for other reasons were also excluded. Blood samples were collected at one and three hours after intake of a test meal. The primary outcome measure was the area under the curve (AUC) of apolipoprotein (Apo) B48 at three hours postprandially. RESULTS: Twenty patients were randomly assigned to the sitagliptin group and sixteen patients were randomized to the nateglinide group. All 36 patients took the medication as directed by the physician in both groups, and they all were analyzed. Apart from antidiabetic drugs, there was no difference between the two groups with respect to the frequency of combined use of lipid-lowering, antihypertensive, and/or antiplatelet drugs. The doses of these medications were maintained during 12 wk of treatment. Detailed dietary advice, together with adequate exercise therapy, was given to the patients so that other factors apart from the two test drugs were similar in the two groups. There were no significant differences of the baseline characteristics between the two groups, except for body mass index (the sitagliptin group: 25.14 ± 3.05 kg/m 2 ; the nateglinide group: 21.39 ± 2.24 kg/m 2 ). Fasting levels of HbA 1c , glycated albumin, 1.5-anhydroglucitol, and blood glucose, as well as the blood glucose levels at one and three hours postprandially, improved in both groups after 12 wk of treatment, and there were no significant differences between the two groups. However, the glucagon level at one hour postprandially (P = 0.040) and the diastolic blood pressure (P<0.01) only showed a significant decrease in the sitagliptin group. In the nateglinide group, there was no significant change in the AUC of Apo B48, the glucagon level at one hour postprandially, the fasting triglyceride level, or the diastolic blood pressure. Body weight was unchanged in both groups. However, the AUC of Apo B48 at three hours postprandially showed a significant decrease in the sitagliptin group from 2.48 ± 0.11 at baseline to 1.94 ± 0.78 g/L per hour after 12 wk (P=0.019). The fasting triglyceride level also decreased significantly in the sitagliptin group (P = 0.035). With regard to lipid-related markers other than Apo B48 and fasting triglycerides, no significant changes were observed with respect to Apo A1, Apo B, or Apo C3 in either group. No adverse events occurred in either group. CONCLUSION: Sitagliptin significantly improves some lipid parameters while having a comparable effect on blood glucose to nateglinide. A large-scale prospective study of sitagliptin therapy is warranted. | Yuichi Kojima Hideyoshi Kaga Shinu Hayashi Toru Kitazawa Yuko Iimura Makoto Ohno Michiyasu Yoshitsugu Mutsunori Fujiwara Toru Hiyoshi | 2013 | World Journal of Diabetes2013，4，1： | 5 |
| 4 | Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks显示文摘 | Yu Kataoka Toru Mukohara Hideo Tomioka Yohei Funakoshi Naomi Kiyota Yutaka Fujiwara Masakazu Yashiro Kosei Hirakawa Midori Hirai Hironobu Minami | 2012 | Investigational New Drugs2012，，： | 2 |
| 5 | Phase I/II study of S-1 plus cisplatin combined with peptide vaccinesfor human vascular endothelial growth factor receptor 1 and 2 in patients withadvanced gastric cancer显示文摘 | Toru Masuzawa Yoshiyuki Fujiwara Kaoru Okada Ayumu Nakamura Shuji Takiguchi Kiyokazu Nakajima Hiroshi Miyata Makoto Yamasaki Yukinori Kurokawa Ryuji Osawa Kazuyoshi Takeda Koji Yoshida Takuya Tsunoda Yusuke Nakamura Masaki Mori Yuichiro Doki | 2012 | International Journal of Oncology2012，，4： | 2 |
| 6 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 7 | Design of 'Tatara Bridge' 显示文摘 | YABUNO Masashi FUJIWARA Toru SUMI Kazuo | 2003 | IHI Engineering Review2003，36，2： | 1 |
| 8 | Cadmium transport and tolerance in rice: perspectives for reducing grain cadmium accumulation显示文摘 | Shimpei Uraguchi Toru Fujiwara | 2012 | Rice2012，，1： | 1 |
| 9 | Linkage map of random amplified Polymorphic DNAs(RAPDs)inthesilkworm,Bomyx mori显示文摘 | Andorran Promboon Toru Shimada Haruhiko Fujiwara and Mas ahiko Kobayashi | 1995 | GenetiealResearch (Cambridge)1995，，： | 1 |
| 10 | Improvement of seed yields under boron-limiting conditions through over expression of BOR1, a boron transporter for xylem loading, in Arabidopsis thaliana显示文摘 | Kyoko Miwa Junpei Takano Toru Fujiwara | 2006 | The Plant Journal2006，46，： | 1 |
| 11 | Rice breaks ground for cadmium-free cereals显示文摘 | Shimpei Uraguchi Toru Fujiwara | 2013 | Current Opinion in Plant Biology2013，，3： | 1 |
| 12 | Tissue-specific and temporal regulation of a β-conglycinin gene: roles of the RY repeat and other cis-acting elements显示文摘 | Toru Fujiwara Roger N. Beachy | 1994 | Plant Molecular Biology1994，，2： | 1 |
| 13 | Tissue-specific and temporal regulation of a β-conglycinin gene: roles of the RY repeat and other cis-acting elements显示文摘 | Toru Fujiwara Roger N. Beachy | 1994 | Plant Molecular Biology1994，，2： | 1 |
| 14 | Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells显示文摘 | Yuko Sato Guo-Gang Feng Lei Huang Jun-Hua Fan Chang Li Jun An Koji Tsunekawa Shuji Kurokawa Yoshihiro Fujiwara Toru Komatsu Fumio Kondo Naohisa Ishikawa | 2010 | Clinical and Experimental Nephrology2010，，3： | 1 |
| 15 | A protocol for rapid DNA extraction fromArabidopsis thaliana for PCR analysis显示文摘 | Ichiro Kasajima Yoko Ide Naoko Ohkama-Ohtsu Hiroaki Hayashi Tadakatsu Yoneyama Toru Fujiwara | 2004 | Plant Molecular Biology Reporter2004，，1： | 1 |
| 16 | Role of O-acetyl-l-serine in the coordinated regulation of the expression of a soybean seed storage-protein gene by sulfur and nitrogen nutrition显示文摘 | Hoyeun Kim Masami Yokota Hirai Hiroaki Hayashi Mitsuo Chino Satoshi Naito Toru Fujiwara | 1999 | Planta1999，，3： | 1 |
| 17 | In-situ observations of melt growth behavior of polycrystalline silicon显示文摘 | Kozo Fujiwara Yoshikazu Obinata Toru Ujihara Noritaka Usami Gen Sazaki Kazuo Nakajima | 2003 | Journal of Crystal Growth2003，，： | 1 |
| 18 | PIN FORMED 2 Modulates the Transport of Arsenite in Arabidopsis thaliana显示文摘Arsenic contamination is a major environmental issue,as it may lead to serious health hazard.The reduced trivalent formof inorganic arsenic,arsenite,is in generalmore toxic to plants comparedwith the fully oxidized pentavalent arsenate.Theuptakeof arsenite inplants hasbeenshown tobemediatedthrough a large subfamily of plant aquaglyceroporins,nodulin 26-like intrinsic proteins(NIPs).However,the efflux mechanisms,as well as themechanismof arsenite-induced root growth inhibition,remain poorly understood.Usingmolecular physiology,synchrotron imaging,and root transport assay approaches,we show that the cellular transport of trivalent arsenicals inArabidopsis thalianais stronglymodulatedbyPINFORMED2(PIN2)auxin efflux transporter.Root transport assay using radioactive arsenite,X-ray fluorescence imaging(XFI)coupled with X-ray absorption spectroscopy(XAS),and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots comparedwith the wild-type.At the cellular level,arsenite specifically targets intracellular sorting of PIN2 and thereby alters the cellular auxin homeostasis.Consistently,loss of PIN2 function results in arsenite hypersensitivity in roots.XFI coupled with XAS further revealed that loss of PIN2 function results in specific accumulation of arsenical species,but not the other metals such as iron,zinc,or calcium in the root tip.Collectively,these results suggest that PIN2 likely functions as an arsenite efflux transporter for the distribution of arsenical species in planta. | Mohammad Arif Ashraf Kana Umetsu Olena Ponomarenko Michiko Saito Mohammad Aslam Olga Antipova Natalia Dolgova Cheyenne D.Kiani Susan Nehzati Keitaro Tanoi Katsuyuki Minegishi Kotaro Nagatsu Takehiro Kamiya Toru Fujiwara Christian Luschnig Karen Tanino Ingrid Pickering Graham N.George Abidur Rahman | 2020 | Plant Communications2020，1，3： | 0 |
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