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| 1 | Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stern cell generation显示文摘 | Xiaoyuan Wei Yueting Chen Yongyu Xu YangZhan Ru Zhang Min Wang Qiuhong Hua Haifeng Gu Fajun Nan Xin Xie | 2014 | Journal of Molecular Cell Biology2014，8，5： | 13 |
| 2 | Dynamic Perception of Jasmonates by the F-Box Protein C0l1显示文摘 | Jianbin Yan Ruifeng Yao Li Chen Suhua Lit Min Gut Fajun Nan Daoxin Xie | 2018 | Molecular Plant2018，11，10： | 7 |
| 3 | The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer显示文摘Objective:The novel compound GCJ-490A has been discovered as a pan-histone deacetylase(HDAC)inhibitor that exerts potent inhibitory activity against HDAC1,HDAC3,and HDAC6.Because of the important roles of HDACs in lung cancer development and the high distribution of GCJ-490A in lung tissue,we explored the anti-tumor potency of GCJ-490A against non-small cell lung cancer(NSCLC)in vitro and in vivo in this study.Methods:The in vitro effects of GCJ-490A alone or combined with the EGFR inhibitor gefitinib against NSCLC were measured with proliferation,apoptosis,and colony formation assays.NSCLC xenograft models were used to investigate the efficacy of GCJ-490A combined with gefitinib for the treatment of NSCLC in vivo.Western blot assays,luciferase reporter assays,chromatin immunoprecipitation assays,quantitative real time-PCR,immunohistochemistry,and transcription factor activity assays were used to elucidate possible mechanisms.Results:GCJ-490A effectively inhibited NSCLC cell proliferation and induced apoptosis in vitro and in vivo.Interestingly,inhibition of HDAC1 and HDAC6 by GCJ-490A increased histone acetylation at the IKKαpromoter and enhanced IKKαtranscription,thus decreasing c-Met.Moreover,this c-Met downregulation was found to be essential for the synergistic anti-tumor activity of GCJ-490A and gefitinib.Conclusions:These findings highlight the promising potential of HDAC inhibitors in NSCLC treatment and provide a rational basis for the application of HDAC inhibitors in combination with EGFR inhibitors in clinical trials. | Ting He Yinglei Gao Yanfen Fang Yangming Zhang Shuwei Zhang Fajun Nan Jian Ding Yi Chen | 2022 | Cancer Biology & Medicine2022，19，8： | 3 |
| 4 | Development of superconducting microcalorimeters for the HUBS mission显示文摘Hot Universe Baryon Surveyor(HUBS)is a proposed space‐borne observatory for X‐ray astronomy.The primary scientific objectives of the mission are to fill a void in probing the ecosystem of galaxies and thus to advance our understanding of galaxy formation and evolution,which is of fundamental importance in cosmology.More specifically,HUBS aims at directly detecting soft X‐ray emission from diffuse gas of temperature exceeding 106 K,which is theoretically postulated to permeate the large structures in the cosmic web and also fill the extended halo of galaxies.However,although some indirect evidence exists,the presence of such hot gas has yet to be well established observationally,due to the lack of effective tools to probe it.In this paper,we describe the design of HUBS,focusing on its scientific payload,which employs superconducting technologies in the detector system,and particularly on progress in the development of superconducting microcalorimeters. | Sifan Wang Guole Wang Naihui Chen Yanling Chen Wei Cui Jiao Ding Fajun Li Yajie Liang Qian Wang Yeru Wang | 2022 | Superconductivity2022，，4： | 2 |
| 5 | Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia显示文摘Hepatic cholesterol accumulation is an important contributor to hypercholesterolemia,which results in atherosclerosis and cardiovascular disease(CVD).ATP-citrate lyase(ACLY)is a key lipogenic enzyme that converts cytosolic citrate derived from tricarboxylic acid cycle(TCA cycle)to acetyl-CoA in the cytoplasm.Therefore,ACLY represents a link between mitochondria oxidative phosphorylation and cytosolic de novo lipogenesis.In this study,we developed the small molecule 326E with an enedioic acid structural moiety as a novel ACLY inhibitor,and its CoA-conjugated form 326E-CoA inhibited ACLY activity with an IC_(50)=5.31±1.2μmol/L in vitro.326E treatment reduced de novo lipogenesis,and increased cholesterol efflux in vitro and in vivo.326E was rapidly absorbed after oral administration,exhibited a higher blood exposure than that of the approved ACLY inhibitor bempedoic acid(BA)used for hypercholesterolemia.Chronic 326E treatment in hamsters and rhesus monkeys resulted in remarkable improvement of hyperlipidemia.Once daily oral administration of 326E for 24 weeks prevented the occurrence of atherosclerosis in ApoE^(-/-)mice to a greater extent than that of BA treatment.Taken together,our data suggest that inhibition of ACLY by 326E represents a promising strategy for the treatment of hypercholesterolemia. | Zhifu Xie Mei Zhang Qian Song Long Cheng Xinwen Zhang Gaolei Song Xinyu Sun Min Gu Chendong Zhou Yangming Zhang Kexin Zhu Jianpeng Yin Xiaoyan Chen Jingya Li Fajun Nan | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
| 6 | Effect of GR24 Stereoisomers on Plant Development in Arabidopsis显示文摘 | Suhua Li Linhai Chen Yuwen Li Ruifeng Yao Fei Wang Mai Yang Min Gu Fajun Nan Daoxin Xie Jianbin Yan | 2016 | Molecular Plant2016，9，10： | 1 |
| 7 | Decrease in catalase activity of Folsomia candida fed a Bt rice diet显示文摘 | Yiyang Yuan Xin Ke Fajun Chen | 2011 | Environmental Pollution2011，，159： | 1 |
| 8 | Protecting-Group-Free One-Step Palladium-Catalyzed Coupling on C25 of Cucurbitacin B Expands Chemical Diversity with Improved Cytotoxicity against A549 Cells显示文摘The natural product cucurbitacin B has been widely studied because of its multiple biological activities,especially its potent antitumor effects.However,modifications of cucurbitacin B are mainly focused on the C2 and C16 site,studies on the C25 acetoxy group are still limited.We successfully developed a palladium-catalyzed allylic coupling of cucurbitacin B with boronic acids,providing a one-step approach to expand the chemical diversity of the C25 position.Our method was protecting-group-free,showing a good functional group tolerance and a wide substrate scope under mild reaction conditions.A library of 29 derivatives was prepared,compounds 2q and 2u showed higher cytotoxicity against A549 cells than cucurbitacin B,compounds 2n and 2o maintained potency,and the introduced hydroxyl and amino groups could be further derived. | Ning Zhuo Jie Ma Lei Cao Linhai Chen Fajun Nan | 2022 | Chinese Journal of Chemistry2022，40，14： | 0 |
| 9 | The exploration and utilization of functional substances in edible insects: a review显示文摘Edible insects as food have been considered as a core future protein source. Not only are edible insects abundant in nutrient value, but also have numbers of functional substances, which could provide a multiple valuable benefits for humans. This review examines and summarizes the functional substances in edible insects and their special effects for people, as well as the use and prospects for these functional substances. There are many functional substances in edible insects, such as antimicrobial peptides, interferon, sex attractant hormones, cordycepin, active polysaccharides, microelement, chitin/chitosan, steroidal material, vitamin, lecithin, etc., which could provide multiple benefits for human beings. These special functional substances could help people enhance immunity, inhibit tumor, regulate intestinal function, relieve fatigue, anti oxidation, protect against colds, improve sleeping, promote the growth and development, as well as reducing blood sugar and blood pressure, among others. According to these valuable efficacies, the functional substances extracted from edible insects can be exploited mainly in three ways: edible insects are used to discover new medicines or health care products for people;and edible insects are applied in chemical, agricultural, food technology, pollutant treatment and textile sectors;as well as being consumed as animal feedstuff for livestock and other animals, which indirectly meet the different requirements for humans. Currently, edible insects have generated global interest to be developed as different forms of products and has promoted more research and development. However, pupae and larvae are still the main consumption ways in the market, which is unacceptable to most people. It is expected that the edible insect industry would be prosperous and sustainable by integrating the power of beneficial policies and regulations, huge consumer demand and proper strategies of promotion and production. | Lei Qian Pan Deng Fajun Chen Ye Cao Hongwu Sun Huaijian Liao | 2022 | Food Production, Processing and Nutrition2022，4，1： | 0 |
| 10 | Study on the Crustal Velocity Model of Xinjiang and Its Subareas显示文摘In this paper,we firstly analyze the '3,400 travel time table 'used for a long time in Xinjiang Seismological Network to obtain the velocity structure models in accord with the table by fitting. Then we fit the velocity of all seismic phases recorded in Xinjiang region in January 2009 ~ December 2013. Simulation analysis is done on the reliability and stability of the velocities,and a concept is proposed for building subarea crustal velocity models according to partitioning of seismic cluster regions. The crustal velocity model suitable for the Yutian area is fitted with the data of all phases of seismic events within a radius of 1°around the 2014 Yutian M_S7.3 earthquake since January 2009,and the model is applied to the relocation of the Yutian M_S7.3 earthquake and determination of focal depths of the earthquake sequence. | Chen Xiangjun Shangguan Wenming Song Xiuqing Wang Jun Liu Shuangqing Miao Fajun Zhu Yuanqing | 2014 | Earthquake Research in China2014，28，4： | 0 |
| 11 | Study on the Precise Location of the Xinjiang Yutian M_S7.3 Earthquake显示文摘The seismic waveform of the Yutian MS7.3 earthquake,Xinjiang on February 12,2014 was recorded clearly and completely by the Digital Seismic Networks of Xinjiang,Qinghai,Tibet,and Xinjiang Hotan array,so the method of joint location by regional seismic network and seismic array can be used to accurately determine the earthquake source location.The following technologies were used in the process of location:(1) We selected seismic stations equally located around the epicenter of the MS7.3 earthquake with an average interval of about 15 degrees in the initial location.(2) The recording waveforms of Yutian seismic station were rotated to the radial and tangential directions to precisely obtain the arrival time of S-waves to determine the epicentral distance.(3) The velocity model was used in the determination of location of the epicenter,based on the historical records of earthquakes in the area within a radius of 1.0° from the source as the center,and the velocity model is obtained after re-fitting and calibration.(4) Based on the waveform records of the Hotan seismic array,the method of waveform beaming was used to determine the azimuths and perform the correction of the epicenter location with these azimuths.(5) The deterministic method was used to measure the source depth.Finally,it is concluded that the Yutian MS7.3 main shock hypocenter location is 36.197°N,82.467°E,focal depth 12 km and original time 17:19:48.2 p.m.February 12,2014. | Zhan Xiaoyan Song Xiuqing Chen Xiangjun Wang Jun Miao Fajun Liu Shuangqing Zhu Yuanqing | 2015 | Earthquake Research in China2015，29，1： | 0 |
| 12 | Focal Depth Determination of the 2014 Yutian M_S7.3 Earthquake Sequence,Xinjiang显示文摘An M_S7.3 earthquake occurred on February 12,2014 in Yutian County,Xinjiang Uygur Autonomous Region,which was followed by a series of aftershocks. This paper calculates the depth of the M_S7.3 earthquake sequence by using the deterministic approach with the seismic phase data from the catalog database of the China Earthquake Networks Center,combined with original seismic wave records from the Digital Seismic Network Center of the Earthquake Administration of Xinjiang Uygur Autonomous Region. | Song Xiuqing Miao Fajun Liu Shuangqing Chen Xiangjun Wang Jun Zhu Yuanqing | 2014 | Earthquake Research in China2014，28，4： | 0 |
| 13 | 迟缓爱德华氏菌六型分泌系统效应物EvpP通过调控钙离子浓度及Jnk活性抑制NLRP3炎症小体激活并影响细菌感染显示文摘文章简介研究发现海洋鱼类病原菌迟缓爱德华氏菌(Edwardsiela tarda)能通过其三型分泌系统(T3SS)在小鼠巨噬细胞内激活NLRC4和NLRP3两种炎症小体,而其六型分泌系统(T6SS)却能够抑制NLRP3炎症小体的激活。 | Hao Chen Dahai Yang Fajun Han Jinchao Tan Lingzhi Zhang Jingfan Xiao Yuanxing Zhang 刘琴 | 2018 | 科学新闻2018，0，4： | 0 |
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