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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy显示文摘AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased evaluation.RESULTS: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE. | Falk R Miese Hans-Jrg Wittsack Gerald Kircheis Arne Holstein Christian Mathys Ulrich Mdder Mathias Cohnen | 2009 | World Journal of Gastroenterology2009，15，41： | 2 |
| 3 | Irradiation Induces a Biphasic Expression of Pro-Inflammatory Cytokines in the Lung显示文摘 | Claudia E. Rübe MD Falk Wilfert Jan Palm Jochem K?nig Susanne Burdak-Rothkamm Li Liu Andreas Schuck Normann Willich Christian Rübe | 2004 | Strahlentherapie und Onkologie2004，，7： | 2 |
| 4 | Robotic surgery of the pancreas显示文摘Pancreatic surgery is one of the most challenging and complex fields in general surgery.While minimally invasive surgery has become the standard of care for many intra-abdominal pathologies the overwhelming majority of pancreatic surgery is performed in an open fashion.This is attributed to the retroperitoneal location of the pancreas,its intimate relationship to major vasculature and the complexity of reconstruction in the case of pancreatoduodenectomy.Herein,we describe the application of robotic technology to minimally invasive pancreatic surgery.The unique capabilities of the robotic platform have made the minimally invasive approach feasible and safe with equivalent if not better outcomes(e.g.,decreased length of stay,less surgical site infections)to conventional open surgery.However,it is unclear whether the robotic approach is truly superior to traditional laparoscopy;this is a key point given the substantial costs associated with procuring and maintaining robotic capabilities. | Daniel Joyce Gareth Morris-Stiff Gavin A Falk Kevin El-Hayek Sricharan Chalikonda R Matthew Walsh | 2014 | World Journal of Gastroenterology2014，20，40： | 2 |
| 5 | A comparison of 13C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of glucose显示文摘 | Mason G F Falk Petersen K de Graaf R A | 2003 | Brain Res Protoc2003，10，3： | 1 |
| 6 | The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation显示文摘 | CLAUDIA E R DANIELA U FALK W | | 0，，05： | 1 |
| 7 | Combined Interpretation of Fracture Zones In Crystalline Rock Using Single hole,Crosshole Tomography and Directional Borehole-radar Data显示文摘 | Sandberg E V Olsson O L Falk Lars R | 1991 | The Log Analyst1991，32，： | 1 |
| 8 | Retinalon-bipolar cells contain a nitric oxide-sensitive guanylate cyclase显示文摘 | Shiells R Falk G | 1992 | Neuroreport1992，3，10： | 1 |
| 9 | The systemic amyloidoses 显示文摘 | Falk R H Comenzo R L Skinner M | 1997 | N Engl J Med1997，337，13： | 1 |
| 10 | 2012 Revised international chapel hill consensus conference nomenclature of vasculitides 显示文摘 | Jennette JC Falk R J Bacon PA | 2013 | Arthritis Rheum2013，65，1： | 1 |
| 11 | Nomenclature of systemic vasculitis : proposal of international consensus conference显示文摘 | Jennette JC Falk R J Andrassyk | 1994 | Arthritis Rheum1994，37，： | 1 |
| 12 | Definition of Organ Involvement and Treatment Response in Immunoglobulin Light Chain Amyloidosis(AL): a Consensus Opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004显示文摘 | Gertz M A Comenzo R Falk R H | 2005 | Am J Hematol2005，79，4： | 1 |
| 13 | Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis(AL):a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis显示文摘 | Gertz MA Comenzo R Falk RH | 2005 | Am J Hematol2005，79，： | 1 |
| 14 | 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitldes 显示文摘 | Jennette JC Falk R J Bacon PA | 2013 | Arthritis Rheum2013，65，1： | 1 |
| 15 | Clinical value of a new Doppler index in cardiac amyloidosis显示文摘 | Reisinger J Falk R H | 1997 | J Am Coll Cardiol1997，29，2： | 1 |
| 16 | Haze trend over the United States, 1980-1995 显示文摘 | Schichtel B A Husar R B Falke R S | 2001 | Atmospheric Environment2001，35，： | 1 |
| 17 | The Leipzig experience with robotic valve surgery显示文摘 | Autschbach R Onnasch JF Falk V | 2000 | J Card Surg2000，15，1： | 1 |
| 18 | 2012 revised internation- al chapel hill consensus conference nomenclature of vasculiti- des显示文摘 | Jennette JC Falk R J Bacon PA | 2013 | Arthritis Rheum2013，65，1： | 1 |
| 19 | Nomenclature of systemic vasculitides: Proposal of an international consensus conference 显示文摘 | Jennette JC Falk R J Andrassy K | 1994 | Arthritis Rheum1994，37，2： | 1 |
| 20 | Error estimate for the approximation of a class of varitional inequalities显示文摘 | Falk R | 1974 | Mathematics of Computation1974，28，： | 1 |
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