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| 1 | Friction and wear behaviors of MoS2-multi-walled-carbonnanotube hybrid reinforced polyurethane composite coating显示文摘MoS2-multi-walled-carbon-nanotube(MWCNT)hybrids containing two-dimensional MoS2 and one-dimensional MWCNTs were synthesized through a one-step hydrothermal reaction.X-ray-diffraction and transmission-electron-microscopy results demonstrated that MoS2 nanosheets were successfully synthesized,and uniformly anchored on the MWCNTs’surfaces.Furthermore,the effects of the Mo S2-MWCNT hybrids on the tribological performances of polyurethane composite coatings were investigated using a UMT-2MT tribo-tester.Friction and wear test results revealed that the friction coefficient and wear rate of a 3 wt%Mo S2-MWCNT-1 filled polyurethane composite coating were reduced by 25.6% and 65.5%,respectively.The outstanding tribological performance of the MoS2-MWCNT-1 reinforced polyurethane composite coating was attributed to the excellent load-carrying capacity of the MWCNTs and good lubricant ability of MoS2.The surface morphologies of the worn surfaces and counterpart ball surfaces were investigated to reveal the wear mechanisms. | Zhaozhu ZHANG Mingming YANG Junya YUAN Fang GUO Xuehu MEN | 2019 | Friction2019，7，4： | 7 |
| 2 | Characterization of the most abundant Lactobacillus species in chicken gastrointestinal tract and potential use as probiotics for genetic engineering显示文摘在不同的胃肠的道的 Lactobacilli 种类的计数和散开(官方补给) broilers 的区域被量的即时 polymerasechain 反应,和六 L 的 probiotic 特征调查。从 broiler 的官方补给的道孤立的 reuteri 种类也被调查为遗传工程获得潜在的目标。Lactobacilli 在盲肠在庄稼和最低庄稼有最高的差异。与更低的官方补给的道相比,更多的 Lactobacilli 在上面的官方补给的道被发现。乳杆菌 reuteri, L。johnsonii, L。acidophilus, L。crispatus, L。salivarius,和 L。aviarius 在整个鸡的官方补给的道是占优势的乳杆菌种类和礼品。乳杆菌 reuteri 是最丰富的乳杆菌种类。乳杆菌 reuteri XC1 有将是为遗传工程的一个潜在、理想的目标的好 probiotic 特征。 | Lei Wang Mingjian Fang Yanping Hu Yuxin Yang Mingming Yang Yulin Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 4 |
| 3 | Modeling and analysis of cantilever beam with active-passive hybrid piezoelectric network显示文摘The active-passive hybrid piezoelectric network (APPN) is investigated to reduce the vibration of cantilever beam. Hamilton's principle with the Rayleigh-Ritz method is used to derive the equations of motion of the beam with the APPN. Only one piezoelectric actuator is bonded on the cantilever beam, so in the segment of the beam where the piezoelectric actuator is attached, the neutral axis is not the geometric center of the beam. This change on the neutral axis is considered in the process of deriving equations. Selecting RL circuit as passive shunt circuit, open-loop analysis is performed to gain insight into the passive damping features. Velocity feedback control is then employed to analyze the characteristics of the closed-loop system. Numerical results show that the APPN has a significant effect on vibration suppression, especially at narrow frequency bands. On this basis, variable RL circuit is proposed and analyzed for broadband vibration attenuation. Numerical simulations illustrate that this scheme is effective and feasible. | LI MingMing FANG Bo CAO DengQing HUANG WenHu | 2013 | Science China(Technological Sciences)2013，56，9： | 4 |
| 4 | Switch type PANI/ZnO core-shell microwire heterojunction for UV photodetection显示文摘In this study,single crystal ZnO microwires(MW)with size of~5.4 mm×30μm are prepared through a chemical vapor deposition technique at high temperature(1200℃).Subsequently,p-type conducting polyaniline(PANI)polymers with different conductivities are densely coated on part of the ZnO MW to construct organic/inorganic core-shell heterojunction photodetectors.The hetero-diodes reach an extremely high rectifcation ratio(I_(+3V)/I_(-3V))of 749230,and a maximum rejection ratio(I_(350nm)/I_(dark))of 3556(at-3 V),indicating great potential as rectifed switches.All the heterojunction devices exhibit strong response to ultraviolet(UV)radiation with high response speed.Moreover,the obvious photovoltaic behavior can also be obtained,allowing the device to operate as an independent and stable unit without externally supplied power.Under 0 V bias voltage,the self-powered photodetector shows a maximum responsivity of 0.56 mA W~(-1)and a rapid response speed of 0.11 ms/1.45 ms(rise time/decay time).Finally,a fnite difference time domain(FDTD)simulation is performed to further demonstrate the interaction mechanism between the incident light feld and the hexagonal cavity,which strongly supports the enhancement of the light absorption in whispering-gallery-mode resonator. | Yihan Chen Longxing Su Mingming Jiang Xiaosheng Fang | 2022 | Journal of Materials Science & Technology2022，，10： | 3 |
| 5 | Fabrication of PTFE/Nomex fabric/phenolic composites using a layer-by-layer self-assembly method for tribology field application显示文摘Fabric composites are widely applied as self-lubricating liner for radial spherical plain bearings owing to their excellent mechanical and tribological properties.Nevertheless,the poor interfacial strength between fibers and the resin matrix limits the performance of composites utilized as tribomaterials.To overcome this drawback,a mild layer-by-layer(LbL)self-assembly method was successfully used to construct hybrid fabric composites in the present work.In addition,this investigation addressed the effect of self-assembly cycles on the friction and wear behaviors of hybrid fabric composites under dry sliding condition.The results demonstrate that fabric composites with three or more self-assembly cycles have significantly enhanced surface activities and anti-wear performances.The results obtained in this work can provide guidance in the preparation of self-lubricating liner composites and highlight how the LbL self-assembly techniques could influence the properties of hybrid fabric composites. | Mingming YANG Zhaozhu ZHANG Junya YUAN Liangfei WU Xin ZHAO Fang GUO Xuehu MEN Weimin LIU | 2020 | Friction2020，8，2： | 3 |
| 6 | Myocardin-related transcription factor A cooperates with brahmarelated gene 1 to activate P-selectin transcription显示文摘Expression of P-selectin in injured or activated endothelia cells serves as a permissive step towards leukocyte recruitment and perpetuation of inflammation in the pathogenesis of atherosclerosis.P-selectin can be induced by pro-inflammatory stimuli via the transcription factor NF-κB,but the epigenetic mechanisms remain incompletely understood.Previously we reported that myocardin-related transcription factor A(MRTF-A)mediates the transactivation of a slew of adhesion molecules by oxidized low-density lipoprotein(oxLDL),likely through a crosstalk with brahma-related gene 1(BRGl),a chromatin remodeling protein.Here,we show that MRTF-A was both sufficient and necessary for the transactivation of P-selectin gene in endothelial cells treated with TNF-α.Depletion of MRTF-A using small interfering RNA(siRNA)abrogated the binding of BRGl on the P-selectin promoter.Overexpression of BRG1 up-regulated the activity of P-selectin promoter activity while BRGl knockdown attenuated P-selectin expression.Finally,BRGl silencing suppressed the accumulation of acetylated histone H3 and methylated histone H3K4,and altered the binding of NF-κB on the P-selectin promoter.Therefore,our data demonstrate an essential role for MRTF-A and BRGl in P-selectin transactivation in endothelial cells. | Mingzi Song Mingming Fang Liming Yu Yong Xu | 2016 | The Journal of Biomedical Research2016，30，1： | 2 |
| 7 | Class Ⅱ transactivator(CIITA)mediates transcriptional repression of pdk4 gene by interacting with hypermethylated in cancer 1(HIC1)显示文摘Increased accumulation and/or impaired utilization of fatty acid in extra-adipose tissues are implicated in the pathogenesis of insulin resistance and type 2 diabetes. Pyruvate dehydrogenase kinase 4(Pdk4) is a key enzyme involved in fatty oxidation and energy expenditure, and its expression can be repressed by pro-inflammatory stimuli.Previously, we have shown that class II transactivator(CIITA) mediates the adverse effect of interferon gamma(IFN-y) in skeletal muscle cells by cooperating with hypermethylated in cancer 1(HIC1) to repress silent informa?tion regulator 1(SIRT1) transcription. Building upon this finding, we report here that CIITA interacted with HIC1 via the GTP-binding domain(GBD) while HIC1 interacted with CIITA via the BTB/POZ domain. The GBD domain was required for CIITA to repress SIRT1 transcription probably acting as a bridge for CIITA to bind to HIC1 and consequently to bind to the SIRT1 promoter. IFN-y stimulation, CIITA over-expression, or HIC1 overexpression repressed Pdk4 promoter activity while silencing either CIITA or HIC1 normalized Pdk4 expression in the presence of IFN-y. An increase in SIRT1 expression or activity partially rescued Pdk4 expression in the pre?sence of CIITA, but SIRT1 inhibition abrogated Pdk4 normalization even in the absence of CIITA. Taken together,our data have identified a HIC1-CIITA-SIRT1 axis that regulates Pdk4 transcription in response to IFN-y stimula?tion. | Mingming Fang Ping Li Xiaoyan Wu Yong Xu | 2015 | The Journal of Biomedical Research2015，29，4： | 2 |
| 8 | Rapid estimation of soil heavy metal nickel content based on optimized screening of near-infrared spectral bands显示文摘In near-infrared spectroscopy,the traditional feature band extraction method has certain limitations.Therefore,a band extraction method named the three-step extraction method was proposed.This method combines characteristic absorption bands and correlation coefficients to select characteristic bands corresponding to various spectral forms and then uses stepwise regression to eliminate meaningless variables.Partial least squares regression(PLSR)and extreme learning machine(ELM)models were used to verify the effect of the band extraction method.Results show that the differential transformation of the spectrum can effectively improve the correlation between the spectrum and nickel(Ni)content.Most correlation coefficients were above 0.7 and approximately 20%higher than those of other transformation methods.The model effect established by the feature variable selection method based on comprehensive spectral transformation is only slightly affected by the spectral transformation form.Infive types of spectral transformation,the RPD values of the proposed method were all within the same level.The RPD values of the PLSR model were concentrated between 1.6 and 1.8,and those of the ELM model were between 2.5 and2.9,indicating that this method is beneficial for extracting more complete spectral features.The combination of the three-step extraction method and ELM algorithm can effectively retain important bands associated with the Ni content of the soil.The model based on the spectral band selected by the three-step extraction method has better prediction ability than the other models.The ELM model of the first-order differential transformation has the best prediction accuracy(RP^2=0.923,RPD=3.634).The research results provide some technical support for monitoring heavy metal content spectrum in local soils. | Qian Lu Shijie Wang Xiaoyong Bai Fang Liu Shiqi Tian Mingming Wang Jinfeng Wang | 2020 | Acta Geochimica2020，39，1： | 2 |
| 9 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 10 | Biological function of Presenilin and its role in AD pathogenesis显示文摘Presenilins(PSs)are the catalytic core of γ-secretase complex.However,the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive.Here we review the general biology and mechanism of γ-secretase and focus on the catalytic components–presenilins and their biological functions and contributions to the AD pathogenesis.The functions of presenilins are divided into γ-secretase dependent and γ-secretase independent ones.The γ-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch;the γ-secretase independent functions of presenilins include stabilizing β-catenin in Wnt signaling pathway,regulating calcium homeostasis and their interaction with synaptic transmission. | Shuting Zhang Mingming Zhang Fang Cai Weihong Song | 2013 | Translational Neurodegeneration2013，2，1： | 1 |
| 11 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 12 | Airborne Wide Band Coherent Radar for Ice Thickness Measurement显示文摘 | LIU Xiaojun ZHAO Bo ZHAO Mingming LU Cewu FANG Guangyou | 2008 | Chinese Journal of Electronics2008，17，4： | 1 |
| 13 | Preparation and application of the sol - gel-derived acrylate/silicone co-polymer coatings for headspace solid-phase microextraction of 2-chloroethyl ethyl sulfide in soil显示文摘 | LIU Mingming ZENG Zhaorui FANG Huaifang | 2005 | J Chromatogr: A2005，1076，： | 1 |
| 14 | Sonochemical synthesisofironcolloids显示文摘 | Mingming Fang Taeghwan Hyeon | 1996 | American Chemistry Society1996，118，11： | 1 |
| 15 | Sonochemical synthesis of nanostructured catalysts 显示文摘 | Suslick S Hyeon T Fang Mingming | 1995 | Materials Science and Engineerings1995，204，： | 1 |
| 16 | Preparation and Application of the Sol-Gel-Derived Acrylate/Silicone Co-Polymer Coatings for Headspace Solid-Phase Microextraction of 2-Chloroethyl Ethyl Sulfide in Soil显示文摘 | Liu Mingming Zeng Zhaorui Fang Huaifang | 2005 | J of Chromatogr A2005，1076，12： | 1 |
| 17 | 本校近期发表IF≥4.0的SCI论文摘要(英文)——RFXB and its splice variant RFXBSV mediate the antagonism between IFN gamma and TGF beta on COLIA2 transcription in vascular smooth muscle cells显示文摘 | Fang Mingming Kong Xiaocen Li Ping Fang Fei Wu Xiaoyan Bai Hui Qi Xiaohong Chen Qi Xu Yong | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 1 |
| 18 | MKL1 mediates TNF-α induced pro-inflammatory transcription by bridging the crosstalk between BRG1 and WDR5显示文摘Tumor necrosis factor alpha(TNF-a) is a cytokine that can potently stimulate the synthesis of a range of proinflammatory mediators in macrophages. The underlying epigenetic mechanism, however, is underexplored. Here we report that the transcriptional modulator megakaryocytic leukemia 1(MKL1) is associated with a histone H3 K4 methyltransferase activity. Re-ChIP assay suggests that MKL1 interacts with and recruits WDR5, a component of the COMPASS complex responsible for H3 K4 methylation, to the promoter regions of pro-inflammatory genes in macrophages treated with TNF-α. WDR5 enhances the ability of MKL1 to stimulate the promoter activities of proinflammatory genes. In contrast, silencing of WDR5 attenuates TNF-a induced production of pro-inflammatory mediators and erases the H3 K4 methylation from the gene promoters. Of interest, the chromatin remodeling protein BRG1 also plays an essential role in maintaining H3 K4 methylation on MKL1 target promoters by interacting with WDR5. MKL1 knockdown disrupts the interaction between BRG1 and WDR5. Together, our data illustrate a role for MKL1 in moderating the crosstalk between BRG1 and WDR5 to activate TNF-a induced pro-inflammatory transcription in macrophages. | Wenping Xu Quanyi Zhao Min Wu Mingming Fang Yong Xu | 2019 | The Journal of Biomedical Research2019，33，3： | 1 |
| 19 | Particle dispersion and circulation patterns in a 3D spouted bed with or without draft tube显示文摘 | LUO Kun YANG Shiliang FANG Mingming | 2013 | Industrial & Engineer- ing Chemistry Research2013，52，28： | 1 |
| 20 | 显示文摘 | Suslick Kenneth S Fang Mingming | 1996 | J Am Chem Soc1996，118，11： | 1 |
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