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| 1 | Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer显示文摘The q24 band of chromosome 8(8q24)is frequently amplified in human cancers including breast cancer,and several SNPs(single nucleotide polymorphisms)at 8q24,including rs13281615,have been identified for their association with cancer risks.These SNPs are in a'gene desert'region,and their functions in cancer development remain to be illustrated,although several of the SNPs appear to influence the genes in the'desert'in a long-range manner,including the v-myc avian myelocytomatosis viral oncogene homolog(MYC)and the nonprotein coding plasmacytoma variant translocation 1(PVT1),both of which have been implicated in human cancers.In the current study,we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer.In addition to confirming the association of the GG genotype of rs13281615 with breast cancer risk,we found that germline GG genotype was significantly associated with estrogen receptor(ER)positivity,higher tumor grade and higher proliferation index.We also found frequent somatic mutations(22/121 or 18.2%)of this SNP in breast cancer.Interestingly,the majority of the mutations(17/22 or 77%)involved a G/A change,resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers.Furthermore,PVT1 expression was increased in cancers,and the increase was associated with the GG genotype of rs13281615.These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression,and that during oncogenesis,'protective'mutations could occur. | Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong | 2014 | Journal of Genetics and Genomics2014，41，4： | 12 |
| 2 | MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling显示文摘发信号的 BMP 怎么集成到并且使动摇人的 pluripotent 干细胞(hPSCs ) 的 pluripotency 电路开始区别进单个细菌层是一个长期的难题。这里,我们报导肌肉片断 homeobox 2 (MSX2 ) , msh 家庭的一个 homeobox 抄写因素, BMP 发信号的直接目标基因和 hPSC 到 mesendoderm 的区别的一个主人调停人。MSX2 的强制表示足够废除 pluripotency 并且导致 hPSCs 的指导 mesendoderm 区别,当 MSX2 弄空损害 mesendoderm 正式就职时。MSX2 是在 hPSCs 的 BMP 小径的直接目标基因,并且能被 Wnt 信号 synergistically 在 mesendoderm 正式就职期间经由 LEF1 激活。而且, MSX2 使动摇通过到 SOX2 倡导者和 SOX2 抄写的压抑的直接绑定的 pluripotency 电路,当 MSX2 通过节的倡导者的直接绑定和激活由 SOX2 的同时的抑制和节的表示的正式就职控制 mesendoderm 系承诺时。有趣地, SOX2 能支持 MSX2 蛋白质的降级,建议在在干细胞命运的控制的二个指定系的因素之间的相互的对抗。一起,我们的调查结果揭示使动摇的关键新机制在 hPSCs 的 pluripotency 和指导系承诺。 | Qingqing Wu Leisheng Zhang Pei Su Xiaohua Lei Xin Liu Hongtao Wang Lisha Lu Yang Bai Tao Xiong Dong Li Zhengmao Zhu Enkui Duan Erlie Jiang Sizhou Feng Mingzhe Hang Yuanfu Xu Fei Wang Jiaxi Zhou | 2015 | Cell Research2015，25，12： | 8 |
| 3 | Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment显示文摘有强壮的增长和 angiogenesis 能力的 Glioma 是在中央神经系统的最普通、恶意的主要肿瘤。垂体肿瘤转变基因(PTTG ) 在垂体肿瘤被发现,并且在房间增长,房间周期,房间 apoptosis,和 angiogenesis 起重要作用。然而,在 glioma 的 PTTG 的角色仍然不完全地被调查。这里,我们探索了在 PTTG 和 glioma 等级,以及微容器的密度(MVD ) 之间的关联。另外, siRNA 包括 U87MG, U251,和 SHG44 在 glioma 房间线习惯于沉默 PTTG 表示。房间增长, apoptosis,侵略,和 angiogenesis 在 vitro 并且在 vivo 被学习。我们的结果证明那 PTTG 表情在 glioma 是显著地起来调整的,并且与 glioma 等级和 MVD 有积极关联。PTTG 的 Silencing 禁止了 glioma 房间增长,迁居 / 侵略,和 angiogenesis,导致了房间 apoptosis,压制了房间侵略,并且逮捕了在 G0/G1 舞台的房间周期。PTTG 的 Silencing 能也在 vivo 禁止肿瘤生长,侵略,和 angiogenesis。我们的数据显示 PTTG 可能是为 glioma 处理的一个潜在的目标。 | Lishan Cui Songbai Xu Zhengmao Song Gang Zhao Xiaoqian Liu Yuwen Song | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 6 |
| 4 | Genomic landscapes of Chinese sporadic autism spectrum disordersrevealed by whole-genome sequencing显示文摘Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical and genetic heterogeneity.In this study,we identified all classes of genomic variants from whole-genome sequencing (WGS) dataset of 32 Chinese trios with ASD,including de novo mutations,inherited variants,copy number variants (CNVs) and genomic structural variants.A higher mutation rate (Poisson test,P<2.2×10^(-16)) in exonic (1.37×10^(-8)) and 3'-UTR regions (1.42×10^(-8)) was revealed in comparison with that of whole genome (1.05×10^(-8)).Using an integrated model,we identified 87 potentially risk genes (P<0.01) from 4832 genes harboring various rare deleterious variants,including CHD8 and NRXN2,implying that the disorders may be in favor to multiple-hit.In particular,frequent rare inherited mutations of several microcephaly-associated genes (ASPM,WDR62,and ZNF335)were found in ASD.In chromosomal structure analyses,we found four de novo CNVs and one de novo chromosomal rearrangement event,including a de novo duplication of UBE3A-containing region at 15q11.2-q13.1,which causes Angelman syndrome and microcephaly,and a disrupted TNR due to de novo chromosomal translocation t (1;5) (q25.1;q33.2).Taken together,our results suggest that abnormalities of centrosomal function and chromatin remodeling of the microcephaly-associated genes may be implicated in pathogenesis of ASD.Adoption of WGS as a new yet efficient technique to illustrate the full genetic spectrum in complex disorders,such as ASD,could provide novel insights into pathogenesis,diagnosis and treatment. | Jinyu Wu Ping Yu Xin Jin Xiu Xu Jinchen Li Zhongshan Li Mingbang Wang Tao Wang Xueli Wu Yi Jiang Wanshi Cai Junpu Mei Qingjie Min Qiong Xu Bingrui Zhou Hui Guo Ping Wang Wenhao Zhou Zhengmao Hu Yingrui Li Tao Cai Yi Wang Kun Xia Yong-Hui Jiang Zhong Sheng Sun | 2018 | Journal of Genetics and Genomics2018，45，10： | 3 |
| 5 | Modulation response performances of a Fabry-Perot semiconductor laser subjected to light injection from another Fabry-Perot semiconductor laser显示文摘The modulation response characteristics of a Fabry-Perot semiconductor laser(slave FP-LD) subjected to light injection from another Fabry-Perot semiconductor laser(master FP-LD) have been investigated theoretically.The results show that the modulation response performances of the slave FP-LD depend on the light injection strength,the central mode frequency detuning Δf and the mode spacing difference Δλ between the slave FP-LD and the master FP-LD.With the increase of the light injection strength from the master FP-LD,the 3 dB modulation bandwidth of the slave FP-LD will be enhanced;however,if the injection strength is increased to certain degree,the front side of the relaxation oscillation peak will be reduced to below 3 dB,which results in the rapid decrease of the 3 dB modulation bandwidth.With the increase of Δf,for a relatively small injection strength level,the 3 dB modulation bandwidth will behave a monotonous enlargement until the slave FP-LD operates in a period-one state(P1).For a relatively strong optical injection level,the slave FP-LD has a broad injection-locked frequency detuning area.Within the injection-locked area,with the increase of frequency detuning Δf,the 3dB modulation bandwidth increases at first and then decreases after experiencing a maximum value.For given light injection strength and frequency detuning,the 3 dB modulation bandwidth of the slave FP-LD has two maximums and behaves a symmetrical distribution with the change of Δλ.By choosing reasonable parameters,the 3 dB modulation bandwidth can be significantly improved.For the parameter values selected in this paper,the 3 dB modulation bandwidth can increase 5.5 times compared with the case of free running. | XIA GuangQiong WU ZhengMao YANG Qi LIN XiaoDong | 2009 | Chinese Science Bulletin2009，54，20： | 3 |
| 6 | Nanoporous membrane device for ultra high heat flux thermal management显示文摘High power density electronics are severely limited by current thermal management solutions which are unable to dissipate the necessary heat flux while maintaining safe junction temperatures for reliable operation.We designed,fabricated,and experimentally characterized a microfluidic device for ultra-high heat flux dissipation using evaporation from a nanoporous silicon membrane.With~100 nm diameter pores,the membrane can generate high capillary pressure even with low surface tension fluids such as pentane and R245fa.The suspended ultra-thin membrane structure facilitates efficient liquid transport with minimal viscous pressure losses.We fabricated the membrane in silicon using interference lithography and reactive ion etching and then bonded it to a high permeability silicon microchannel array to create a biporous wick which achieves high capillary pressure with enhanced permeability.The back side consisted of a thin film platinum heater and resistive temperature sensors to emulate the heat dissipation in transistors and measure the temperature,respectively.We experimentally characterized the devices in pure vaporambient conditions in an environmental chamber.Accordingly,we demonstrated heat fluxes of 665±74 W/cm^(2) using pentane over an area of 0.172mm×10mm with a temperature rise of 28.5±1.8 K from the heated substrate to ambient vapor.This heat flux,which is normalized by the evaporation area,is the highest reported to date in the pure evaporation regime,that is,without nucleate boiling.The experimental results are in good agreement with a high fidelity model which captures heat conduction in the suspended membrane structure as well as non-equilibrium and sub-continuum effects at the liquid–vapor interface.This work suggests that evaporative membrane-based approaches can be promising towards realizing an efficient,high flux thermal management strategy over large areas for high-performance electronics. | Daniel F.Hanks Zhengmao Lu Jay Sircar Todd R.Salamon Dion S.Antao Kevin R.Bagnall Banafsheh Barabadi Evelyn N.Wang | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 7 | Establishment of a highly efficient hematopoietic differentiation model from human embryonic stem cells for functional screening显示文摘Human embryonic stem cells(hESCs)have been successfully differentiated into hematopoietic progenitor cells with colony formation capacity and further into various kinds of blood cells including erythrocytes,megakaryocytes,neutrophils,nature killer cells and T lymphocytes[1 7].Nevertheless,the differentiation efficiency is extremely low. | PANG SuLei WU QingQing TIAN Sha SU Pei BAI Yang GAO Jie YANG YiQing LIU Xin ZHU ZhengMao XU YuanFu ZHOU JiaXi | 2013 | Science China(Life Sciences)2013，56，12： | 3 |
| 8 | Zinc finger factor ZNF121 is a MYC-interacting protein functionally affecting MYC and cell proliferation in epithelial cells显示文摘MYC is a potent oncoprotein that modulates multiple cellular processes including proliferation,apoptosis, differentiation, stemness, senescence, and migration. Functioning primarily as a transcriptional factor, MYC interacts with a large number of proteins, and identification and characterization of MYC-interacting proteins are important for understanding how MYC functions. In this study, we used different systems to demonstrate that a novel zinc finger transcription factor, ZNF121, physically interacted with MYC, and the interaction involved their N-terminal regions. Overexpression of ZNF121 increased, while its knockdown decreased, the expression of MYC in multiple epithelial cell lines, and MYC had similar effects on ZNF121 expression. An expression correlation was also detectable in a panel of epithelial cell lines and a cohort of human breast cancer tissues. Functionally, knockdown of ZNF121 in several breast epithelial cell lines attenuated the expressions of MYC and its target genes(e.g., EGR1,CDC2, and nucleolin) and slowed cell proliferation, accompanied by cell cycle arrest in the G1 phase and expression alteration of cell cycle regulators(cyclin D1, p14 and p21). Analysis of publically available databases showed that ZNF121 expression is up-regulated in human breast cancer, and the up-regulation significantly associates with worse patient survival in the luminal A subtype of breast cancer. These findings establish ZNF121 as a MYC-interacting protein with functional effects on MYC and cell proliferation. | Ang Luoa Xuan Zhanga Liya Fua Zhengmao Zhua Jin-Tang Dong | 2016 | Journal of Genetics and Genomics2016，43，12： | 2 |
| 9 | Construction of eukaryotic expression vector carrying human TSLC1 gene and its expression in HepG2 cells显示文摘Objective:To construct the eukaryotic expression vector for human TSLC1 gene,and to express TSLC1 in HepG2 cells for investigating its effect on HepG2 cell growth.Methods:Full length of TSLC1 cDNA was amplified from RNA of normal human liver by RT-PCR,and cloned into pCI-neo expression vector.The recombinant plasmid pCI-TSLC1 was identified with restriction enzyme and sequenced,and then was stably transfected into HepG2 cells with lipofectamine 2000. The positive clones were examined by western-blotting and immunofluorescence,cell growth was analyzed with MTT assay. Results:The eukaryotic expression vector pCI-TSLC1 was successfully constructed and the stable cell line highly expressing TSLC1 protein was obtained.The growth of TSLC1-transfected cells was significantly suppressed in vitro.Conclusion:The HepG2 stable cell line could highly express TSLC1 protein,which provided a basis for further exploring the roles of TSLC1 in hepatocellular carcinoma. | Li Qin Yongjun Tian Zhengmao Zhang Youhua Hao Dongliang Yang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 2 |
| 10 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 11 | Re- habihty Analysis - Based Numerical Calculation of Metal Structure of Bridge Crane 显示文摘 | Meng Wenjun Yang Zhengmao Qi Xiaolong | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 12 | 查看详情显示文摘 | Liang Xiaojie Ye Zhengmao Chang Jun | | 0，，02： | 1 |
| 13 | Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis显示文摘Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders that cause severe social,communication,and behavioral problems.Recent studies show that the variants of a histone methyltransferase gene KMT5B cause neurodevelopmental disorders(NDDs),including ASD,and the knockout of Kmt5b in mice is embryonic lethal.However,the detailed genotype-phenotype correlations and functional effects of KMT5B in neurodevelopment are unclear.By targeted sequencing of a large Chinese ASD cohort,analyzing published genome-wide sequencing data,and mining literature,we curated 39 KMT5B variants identified from NDD individuals.A genotype-phenotype correlation analysis for 10 individuals with KMT5B pathogenic variants reveals common symptoms,including ASD,intellectual disability,languages problem,and macrocephaly.In vitro knockdown of the expression of Kmt5b in cultured mouse primary cortical neurons leads to a decrease in neuronal dendritic complexity and an increase in dendritic spine density,which can be rescued by expression of human KMT5B but not that of pathogenic de novo missense mutants.In vivo knockdown of the Kmt5b expression in the mouse embryonic cerebral cortex by in utero electroporation results in decreased proliferation and accelerated migration of neural progenitor cells.Our findings reveal essential roles of histone methyltransferase KMT5B in neuronal development,prenatal neurogenesis,and neuronal migration. | Guodong Chen Lin Han Senwei Tan Xiangbin Jia Huidan Wu Yingting Quan Qiumeng Zhang Bin Yu Zhengmao Hu Kun Xia Hui Guo | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 14 | TSPAN1 functions as an oncogene in gastric cancer and is downregulated by miR-573显示文摘 | Zhengmao Lu Tianhang Luo Mingming Nie Tao Pang Xin Zhang Xiaojun Shen Liye Ma Jianwei Bi Guo Wei Guoen Fang Xuchao Xue | 2015 | FEBS Letters2015，，： | 1 |
| 15 | Antidiabetic effects of Artemisia sphaerocephala Krasch gum, a novel food additive in China, on streptozotoein-induced type 2 diabetic rats显示文摘 | XING Xiaohui ZHANG Zhengmao HU Xinzhong | 2009 | Journal of Et hnopharmaeology2009，125，3： | 1 |
| 16 | Synthesis of oetenyl succinic derivative of mechanically activated indica rice starch显示文摘 | Zhang Zhengmao Zhao Siming Xiong Shanbai | 2010 | Starch2010，62，2： | 1 |
| 17 | Optimization of Extraction Process of Olive Leaves by RSM and Evaluation of Antioxidant Capacity Measurements to the Mixtures显示文摘 | Zhengmao Cao Fanxi Meng Guanghua Zhao | 2013 | Journal of Food Science and Engineering2013，3，10： | 1 |
| 18 | Synthesis of octenyl succinic derivative of mechanically activated Indica rice starch显示文摘 | ZHANG Zhengmao ZHAO Siming XIONG Shanbai | | 0，，02： | 1 |
| 19 | A Mixed-integer SDP Solution to Distributionally Robust Unit Commitment with Second Order Moment Constraints显示文摘A power system unit commitment(UC)problem considering uncertainties of renewable energy sources is investigated in this paper,through a distributionally robust optimization approach.We assume that the first and second order moments of stochastic parameters can be inferred from historical data,and then employed to model the set of probability distributions.The resulting problem is a two-stage distributionally robust unit commitment with second order moment constraints,and it can be recast as a mixed-integer semidefinite programming(MI-SDP)with finite constraints.The solution algorithm of the problem comprises solving a series of relaxed MI-SDPs and a subroutine of feasibility checking and vertex generation.Based on the verification of strong duality of the semidefinite programming(SDP)problems,we propose a cutting plane algorithm for solving the MI-SDPs;we also introduce an SDP relaxation for the feasibility checking problem,which is an intractable biconvex optimization.Experimental results on the IEEE 6-bus system are presented,showing that without any tuning of parameters,the real-time operation cost of distributionally robust UC method outperforms those of deterministic UC and two-stage robust UC methods in general,and our method also enjoys higher reliability of dispatch operation. | Xiaodong Zheng Haoyong Chen Yan Xu Zhengmao Li Zhenjia Lin Zipeng Liang | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 1 |
| 20 | Integrated construction technology for natural gas gravity drive and underground gas storage显示文摘Based on the mechanisms of gravity displacement,miscibility,viscosity reduction,and imbibition in natural gas flooding,an integrated reservoir construction technology of oil displacement and underground gas storage(UGS)is proposed.This paper systemically describes the technical connotation,site selection principle and optimization process of operation parameters of the gas storage,and advantages of this technology.By making full use of the gravity displacement,miscibility,viscosity reduction,and imbibition features of natural gas flooding,the natural gas can be injected into oil reservoir to enhance oil recovery and build strategic gas storage at the same time,realizing the win-win situation of oil production and natural gas peak shaving.Compared with the gas reservoir storage,the integrated construction technology of gas storage has two profit models:increasing crude oil production and gas storage transfer fee,so it has better economic benefit.At the same time,in this kind of gas storage,gas is injected at high pressure in the initial stage of its construction,gas is injected and produced in small volume in the initial operation stage,and then in large volume in the middle and late operation stage.In this way,the gas storage wouldn’t have drastic changes in stress periodically,overcoming the shortcomings of large stress variations of gas reservoir storage during injection-production cycle due to large gas injection and production volume.The keys of this technology are site selection and evaluation of oil reservoir,and optimization of gravity displacement,displacement pressure,and gas storage operation parameters,etc.The pilot test shows that the technology has achieved initial success,which is a new idea for the rapid development of UGS construction in China. | JIANG Tongwen WANG Zhengmao WANG Jinfang | 2021 | Petroleum Exploration and Development2021，48，5： | 1 |
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