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| 1 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 2 | Chromosome-Level Reference Genome and Population Genomic Analysis Provide Insights into the Evolution and Improvement of Domesticated Mulberry (Morns alba)显示文摘Mulberry(Morns spp.)is the sole plant consumed by the domesticated silkworm.However,the genome of domesticated mulberry has not yet been sequenced,and the ploidy level of this species remains unclear.Here,we report a high-quality,chromosome-level domesticated mulberry(Morus alba)genome.Analysis of genomic data and karyotype analyses confirmed that M.alba is a diploid with 28 chromosomes(2/7=2x=28).Population genomic analysis based on resequencing of 134 mulberry accessions classified domesticated mulberry into three geographical groups,namely,Taihu Basin of southeastern China(Hu mulberry),northern and southwestern China,and Japan.Hu mulberry had the lowest nucleotide diversity among these accessions and demonstrated obvious signatures of selection associated with environmental adaptation.Further phylogenetic analysis supports a previous proposal that multiple domesticated mulberry accessions previously classified as different species actually belong to one species.This study expands our understanding of genome evolution of the genus Morus and population structure of domesticated mulberry,which would facilitate mulberry breeding and improvement. | Feng Jiao Rongsong Luo Xuelei Dai Hui Liu Gang Yu Shuhua Han Xin Lu Chao Su Qi Chen Qinxia Song Caiting Meng Fanghong Li Hongmei Sun Rui Zhang Tian Hui Yonghua Qian Aichun Zhao Yu Jiang | 2020 | Molecular Plant2020，13，7： | 10 |
| 3 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 4 | Meiofauna Distribution in Intertidal Sandy Beaches Along China Shoreline(18?–40?N)显示文摘In this study,the distribution pattern of meiofauna from nine sandy beaches at six latitudinal gradients along Chinese coast between 18 and 40?N was studied on their meiofauna abundance to examine the effect of latitudinal gradients.In general,meiofauna abundance was lower in four subtropical beaches in Xiamen(24?N) and Zhoushan(29?N) than that in other beaches.Meiofauna abundance differed little between tropical and temperate beaches.The taxonomic structure of meiofauna showed a dominance of nematode in colder area.The relative composition of turbellarians and polychaetes increased in warmer area.In addition to latitudinal gradient,salinity,oxygenation,sediment grain size affect also the meiofauna latitudinal distribution.As for horizontal distribution,the highest meiofauna abundance was found in low tidal zone at tropical beaches,and in middle tidal zone at temperate beaches.The horizontal distribution of meiofauna was controlled by both physical and biotic factors including feeding and anthropogenic activities.Although meiofauna abundance exhibited a horizontal difference,the composition of meiofaunal main taxa was unanimous horizontally at all beaches at the same sampling latitude. | HUA Er ZHANG Zhinan ZHOU Hong MU Fanghong LI Jia ZHANG Ting CONG Bingqing LIU Xiaoshou | 2016 | Journal of Ocean University of China2016，15，1： | 7 |
| 5 | Biomass of meiobenthic in the Bohai Sea, China显示文摘A grid of 22 stations, giving a broad geographic coverage of the Bohai Sea and the Bohai Strait was selected. Undisturbed sediments were collected from sampling stations during cruises in June 1997, in September/October 1998 and again in April/May 1999. Based on the results of Juario (1975), the average biomass, 0.404 g/(m2a) of meiofauna (including nematode, harpacticoida, bivalve larvae, polycheata and kinorhyncha) in the Bohai Sea is given and accounts for 4.5 percent of the macrofauna in the Bohai Sea. The horizontal distribution of the biomass of meiofauna showed that it was higher at the stations of middle east part of the Bohai Sea and the strait in 1998 and 1999 cruises and it decreased at the stations near to the strait mouth and increased at Station B1 in 1999 cruise. The annual average production in the Bohai Sea is 3.636 g/m2 calculated in term of the formula P = 9B. Compared with the biomass of other sea areas in the world, the biomass of the Bohai Sea is similar but slightly lower. The individual average dry weight of nematodes given by different authors is analyzed. | Guo Yuqing, Zhang Zhinan, Mu Fanghong 1. Department of Life Science, Ocean University of Qingdao, Qingdao 266003, China 2. Agricultural College, jimei University, Xiamen 361021, China | 2001 | Acta Oceanologica Sinica2001，20，3： | 6 |
| 6 | Friction and Wear Performance of Boron Doped, Undoped Microcrystalline and Fine Grained Composite Diamond Films显示文摘Chemical vapor deposition(CVD) diamond films have attracted more attentions due to their excellent mechanical properties. Whereas as-fabricated traditional diamond films in the previous studies don't have enough adhesion or surface smoothness, which seriously impact their friction and wear performance, and thus limit their applications under extremely harsh conditions. A boron doped, undoped microcrystalline and fine grained composite diamond(BD-UM-FGCD) film is fabricated by a three-step method adopting hot filament CVD(HFCVD) method in the present study, presenting outstanding comprehensive performance, including the good adhesion between the substrate and the underlying boron doped diamond(BDD) layer, the extremely high hardness of the middle undoped microcrystalline diamond(UMCD) layer, as well as the low surface roughness and favorable polished convenience of the surface fine grained diamond(FGD) layer. The friction and wear behavior of this composite film sliding against low-carbon steel and silicon nitride balls are studied on a ball-on-plate rotational friction tester. Besides, its wear rate is further evaluated under a severer condition using an inner-hole polishing apparatus, with low-carbon steel wire as the counterpart. The test results show that the BD-UM-FGCD film performs very small friction coefficient and great friction behavior owing to its high surface smoothness, and meanwhile it also has excellent wear resistance because of the relatively high hardness of the surface FGD film and the extremely high hardness of the middle UMCD film. Moreover, under the industrial conditions for producing low-carbon steel wires, this composite film can sufficiently prolong the working lifetime of the drawing dies and improve their application effects. This research develops a novel composite diamond films owning great comprehensive properties, which have great potentials as protecting coatings on working surfaces of the wear-resistant and anti-frictional components. | WANG Xinchang WANG Liang SHEN Bin SUN Fanghong | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 5 |
| 7 | Influence of Range Gate Width on Detection Probability and Ranging Accuracy of Single Photon Laser Altimetry Satellite显示文摘The influence of the single photon laser altimeter range-gate width on the detection probability and ranging accuracy is discussed and analyzed,according to the LiDAR equation,single photon detection equation and the Monte Carlo method to simulate the experiment.The simulated results show that the probability of detection is not affected by the range gate,while the probability of false alarm is relative to the gate width.When the gate width is 100 ns,the ranging accuracy can accord with the requirements of satellite laser altimeter.But when the range gate width exceeds 400 ns,ranging accuracy will decline sharply.The noise ratio will be more as long as the range gate to get larger,so the refined filtering algorithm during the data processing is important to extract the useful photons effectively.In order to ensure repeated observation of the same point for 25 times,we deduce the quantitative relation between the footprint size,footprint,and frequency repetition according to the parameters of ICESat-2.The related conclusions can provide some references for the design and the development of the domestic single photon laser altimetry satellite. | Guoyuan LI Fanghong YE Xinming TANG Dongping XIE Jiapeng HUANG Genhua HUANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 4 |
| 8 | Combination of Human Fas (CD95/Apo-1) Ligand with Adriamycin Significantly Enhances the Efficacy of Antitumor Response显示文摘hepatocellular 癌(HCC ) 的预后是差的,甚至与药品切除术和辅助 chemoradiotherapy 的联合治疗。解决这个问题,许多生物学的治疗被调查了。船边交货 ligand (FasL, CD95L ) 主要在激活的 T 淋巴细胞和生来的杀手(NK ) 房间被表示,并且在调停房间的免疫和有免疫力的 downregulation 起一个中央作用。几研究证明了 FasL 在 HCC 被表示。在现在的报告,我们准备了 recombinant 人 pET-22b (+)/FasL 蛋白质并且在一个鼠科的 HCC 肿瘤模型在 vitro 并且在肿瘤生长上在 HCC 房间上调查了 FasL 的效果。著名细胞毒素的化学疗法的试剂 adriamycin (ADM ) 用作控制。我们发现 FasL 有效地压制了 H22 肿瘤房间的生存能力并且显著地导致了 H22 房间的 apoptosis。与 FasL-ADM 对待的细胞的 apoptotic 层次比独自与 FasL 或 ADM 对待的那些显著地高,并且 FasL-ADM 联合导致了一非常在这个模型的肿瘤生长延期上的添加剂效果。结果建议 FasL 和另外的化学疗法的代理人的那个联合处理可以是一条新途径为 HCC 改进化疗的功效。 | Zhongchen Liu Ruizhen Liu Jinhua Qiu Ping Yin Fanghong Luo Jinhua Su Wenzhu Li Caixia Chen Xin Fan Jiakai Zhang Guohong Zhuang | 2009 | Cellular & Molecular Immunology2009，6，3： | 4 |
| 9 | Transference kinetics of ^(60)Co in an aquatic-terrestrial ecosystem显示文摘The dynamics of transportation,accumulation,disappearance and distribution of 60Co in a simulated aquatic-terrestrial ecosystem was studied by isotope-tracer technique. In the aquatic system,60Co was transported and transformed via depositing,coupling with ions and adsorption. The absorption resulted in the redistribution and accumulation of 60Co in each compartment of the system. Specific activities of 60Co in water started sharply and gently decreased. The sediment accumulated a large amount of 60Co by adsorption and ion exchange. The hornwort (Ceralophyllum demersum) could also adsorb a large amount of 60Co in a short time,because of its large specific surface area. Fish (Carassius auratus) and snail (Bellamya purificata) had a poor capacity of adsorbing 60Co. The distribution of 60Co in the fish was mainly in the viscera,and the amount of 60Co in the snail flesh was greater than that in the shell. The amount of 60Co in individual compartment in the system was changed with time. The highest specific activity of 60Co in the bean of the terrestrial system remained in the root nodule. | ZHAO Xiyue CAI Zhiqing GONG Fanghong SHI Jianjun WANG Shouxiang | 2008 | Nuclear Science and Techniques2008，19，4： | 3 |
| 10 | The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension:Findings from the Prospective Urban Rural Epidemiology China Study显示文摘Background:Both hypertension and grip strength(GS)are predictors of mortality and cardiovascular disease(CVD),but whether these risk factors interact to affect CVD and all-cause mortality is unknown.This study sought to investigate the associations of GS with the risk of major CVD incidence,CVD mortality,and all-cause mortality in patients with hypertension.Methods:GS was measured using a Jamar dynamometer(Sammons Preston,Bolingbrook,IL,USA)in participants aged 3570 years from 12 provinces included in the Prospective Urban Rural Epidemiology China Study.Cox frailty proportional hazards models were used to examine the associations of GS and hypertension and the outcomes of all-cause mortality and CVD incidence/mortality.Results:Among 39,862 participants included in this study,15,964 reported having hypertension,and 9095 had high GS at baseline.After a median follow-up of 8.9 years(interquartile range,6.79.9 years),1822 participants developed major CVD,and 1250 deaths occurred(388 as a result of CVD).Compared with normotensive participants with high GS,hypertensive patients with high GS had a higher risk of major CVD incidence(hazard ratio(HR)=2.39;95%confidence interval(95%CI):1.863.06;p<0.001)or CVD mortality(HR=3.11;95%CI:1.596.06;p<0.001)but did not have a significantly increased risk of all-cause mortality(HR=1.24;95%CI:0.921.68;p=0.159).These risks were further increased if hypertensive participants whose GS level was low(major CVD incidence,HR=3.31,95%CI:2.604.22,p<0.001;CVD mortality,HR=4.99,95%CI:2.649.43,p<0.001;and all-cause mortality,HR=1.93,95%CI:1.472.53,p<0.001).Conclusion:The present study demonstrates that low GS is associated with the highest risk of major CVD incidence,CVD mortality,and all-cause mortality among hypertensive patients.High levels of GS appear to mitigate long-term mortality risk among hypertensive patients. | Weida Liu Darryl P Leong Bo Hu Lap AhTse Sumathy Rangarajan Yang Wang Chuangshi Wang Fanghong Lu Yindong Li Salim Yusuf Lisheng Liu Wei Li | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 11 | Laser-assisted Grinding Wheel Dressing (Ⅱ)-Experimental Researches显示文摘Most of the mechanical dressing technologies for resin bonded superabrasive grinding wheels are time consumingand costly. Based on the outcomes of the simulations in the previous study, this paper demonstrates the comprehensive researches on the laser-assisted dressing process control, grinding wheel topography reconfiguration by 3Dlaser scanning technology and analyses of grinding temperature. The synthesized parameter incorporates the laserdressing process parameters and can be used to the process control. In order to evaluate the laser-assisted dressingeffectiveness, the newly developed non-contact laser measuring system based on the principle of the triangulationwas used. Grain protrusion height and intergrain spacing can characterize the grinding wheel surface. A series ofgrinding tests with the laser-assisted dressed grinding wheel and mechanically dressed grinding wheel were conductedfor comparison. The results proved the feasibility of laser-assisted dressing for resin bonded superabrasive grindingwheels and revealed the importance of choosing appropriate laser dressing parameters. | Ming CHEN Fanghong SUN Youngmoon LEE Seunghan YANG Jongchan LEE | 2003 | Journal of Materials Science & Technology2003，19，z1： | 2 |
| 12 | Correlation of peripheral Th17 cells and Th17-associated cytokines to the severity of carotid artery plaque and its clinical implication显示文摘 | Zhendong Liu Fanghong Lu Hui Pan Yingxin Zhao Shujian Wang Shangwen Sun Jun Li Xiaoliang Hu Lin Wang | 2011 | Atherosclerosis2011，，1： | 2 |
| 13 | Nematode Community Structure and Diversity Pattern in Sandy Beaches of Qingdao,China显示文摘We investigated the diversity and structure of free-living marine nematode communities at three sandy beaches representing typical intertidal environments of a temperate zone in Qingdao,Shandong Province,China.Average nematode abundance ranged from 1006 to 2170 ind.10 cm-2,and a total of 34 nematode genera were recorded,of which only 8 were common in all the studied beaches.Pielou's evenness and Shannon-Wiener diversity index were the lowest at the second beach where nematode abundance was the highest.The highest species diversity index coincided with the lowest nematode abundance at Shilaoren beach.Sediment median grain size,sorting coefficient,and chlorophyll-a content were essential for differentiation in nematode abundance and species diversity,whereas taxonomic diversity of nematode was homogeneous across the three beaches.In 0–20 cm sediment profile,nematode abundance declined abruptly with depth,whereas nematode diversity changed gently with obvious difference in 16–20 cm layer.Sediment granulometry and chlorophyll-a content were the two foremost factors which influenced the vertical distribution pattern of nematode generic diversity.Non-selective deposit feeders constituted the most dominant trophic group,followed by epistratum feeders.Bathylaimus(family:Tripyloididae) dominated at the second and Yangkou beach,while Theristus(family:Xyalidae) prevailed at Shilaoren beach.Omnivores and predators became important at Shilaoren beach because of the high proportion of Enoplolaimus.Even though,nematode community of the studied beaches did not differ significantly from each other. | HUA Er MU Fanghong ZHANG Zhinan YANG Shichao ZHANG Ting LI Jia | 2016 | Journal of Ocean University of China2016，15，1： | 2 |
| 14 | The prevalence of hyperuricemia and its correlates in an inland Chinese adult population, urban and rural of Jinan显示文摘 | Jianmin Yang Zhendong Liu Cheng Zhang Yingxin Zhao Shangwen Sun Shujian Wang Yuxia Zhao Yun Zhang Jifu Li Fanghong Lu | 2013 | Rheumatology International2013，，6： | 2 |
| 15 | Adverse associations of sedentary behavior with cancer incidence and all-cause mortality:A prospective cohort study显示文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death. | Yuan Lin Qiong Liu Fangchao Liu Keyong Huang Jianxin Li Xueli Yang Xinyan Wang Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Xiangfeng Lu Jianfeng Huang Dongfeng Gu | 2021 | Journal of Sport and Health Science2021，10，5： | 2 |
| 16 | Friction Behaviors of the Hot Filament Chemical Vapor Deposition Diamond Film under Ambient Air and Water Lubricating Conditions显示文摘The friction behavior of the hot filament chemical vapor deposition(HFCVD) diamond film plays a critical role on its applications in mechanical fields and largely depends on the environment.Studies on the tribological properties of HFCVD diamond films coated on Co-cemented tungsten carbide(WC-Co) substrates are rarely reported in available literatures,especially in the water lubricating conditions.In this paper,conventional microcrystalline diamond(MCD) and fine-grained diamond(FGD) films are deposited on WC-Co substrates and their friction properties are evaluated on a reciprocating ball-on-plate tribometer,where they are brought to slide against ball-bearing steel and copper balls in dry and water lubricating conditions.Scanning electron microscopy(SEM),atomic force microscopy(AFM),surface profilometer and Raman spectroscopy are adopted to characterize as-deposited diamond films;SEM and energy dispersive X-ray(EDX) are used to investigate the worn region on the surfaces of both counterface balls and diamond films.The research results show that the friction coefficient of HFCVD diamond films always starts with a high initial value,and then gradually transits to a relative stable state.For a given counterface and a sliding condition,the FGD film presents lower stable friction coefficients by 0.02-0.03 than MCD film.The transferred materials adhered on sliding interface are supposed to have predominate effect on the friction behaviors of HFCVD diamond films.Furthermore,the effect of water lubricating on reducing friction coefficient is significant.For a given counterpart,the stable friction coefficients of MCD or FGD films reduce by about 0.07-0.08 while sliding in the water lubricating condition,relative to in dry sliding condition.This study is beneficial for widespread applications of HFCVD diamond coated mechanical components and adopting water lubricating system,replacing of oil lubricating,in a variety of mechanical processing fields to implement the green production process. | SHEN Bin SUN Fanghong | 2009 | Chinese Journal of Mechanical Engineering2009，22，5： | 2 |
| 17 | ,Experimental research on the dynamic characteristics of the cutting temperature in the process of high-speed milling显示文摘 | Chen Ming Sun Fanghong Wang Haili Yuan Renwei | 2003 | Journal of Materials Processing Technology2003，138，： | 1 |
| 18 | Synthesis of branched polystyrene by ATRP exploiting divinybenzene as branching comonomer显示文摘 | Ran Qiang Gong Fanghong Liu Chunlin | 2006 | European Polymer Journal2006，42，10： | 1 |
| 19 | Comparison of chemical vapor deposition diamond-,diamond-like carbon- and TiA1N-coated microdrills in graphite machining显示文摘 | Lei Xuelin Wang Liang Shen Bin Sun Fanghong | 2013 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2013，227，： | 1 |
| 20 | Study on tribological behavior and cutting performance of CVD diamond and DLC films on Co-cemented tungsten carbide substrates显示文摘 | Zhang Dongcan Shen Bin Sun Fanghong | 2010 | Appl Surf Sci2010，256，： | 1 |
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