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| 1 | NS1 antigen: A new beam of light in the early diagnosis of dengue infection显示文摘Objective: To evaluate NS1 antigen detection ELISA for the early laboratory diagnosis of dengue virus infection. Methods: The present study was conducted to evaluate the overall positivity of NS1 antigen detection ELISA and its comparison with viral RNA detection via real time PCR and Ig M antibodies detection by ELISA. Results: A total of 1 270 serum samples were tested 86%(1 097/1 270) were detected positive by one or more than one diagnostic test. Out of 1 270, 64%(807/1 270) were positive by NS1 ELISA and 52%(662/1 270), 51%(646/1 270) were positive by real-time RT-PCR and Ig M ELISA respectively.Conclusions: NS1 antigen detection ELISA is highly suitable diagnostic tools and it also has great value for use in outbreak and epidemic situation. | Muhammad Suleman Rani Faryal Muhammad Masroor Alam Salmaan Sharif Shahzad Shaukat Uzma Bashir Aamir Adnan Khurshid Mehar Angez Massab Umair Mian Muhammad Sufian Yasir Arshad Ghulam Mujtaba Syed Sohail Zahoor Zaidi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 6 |
| 2 | What operation for recurrent rectal prolapse after previous Delorme's procedure? A practical reality显示文摘AIM: To report our experience with perineal repair(Delorme's procedure) of rectal prolapse with particular focus on treatment of the recurrence.METHODS: Clinical records of 40 patients who underwent Delorme's procedure between 2003 and 2014 were reviewed to obtain the following data: Gender; duration of symptoms, length of prolapse, operation time, ASA grade, length of post-operative stay, procedure-related complications, development and treatment of recurrent prolapse. Analysis of post-operative complications, rate and time of recurrence and factors influencing the choice of the procedure for recurrent disease was conducted. Continuous variables were expressed as the median with interquartile range(IQR). Statistical analysis was carried out using the Fisher exact test.RESULTS: Median age at the time of surgery was 76 years(IQR: 71-81.5) and there were 38 females and 2 males. The median duration of symptoms was 6 mo(IQR: 3.5-12) and majority of patients presented electively whereas four patients presented in the emergency department with irreducible rectal prolapse. The median length of prolapse was 5 cm(IQR: 5-7), median operative time was 100 min(IQR: 85-120) and median post-operative stay was 4 d(IQR: 3-6). Approximately16% of the patients suffered minor complications such as- urinary retention, delayed defaecation and infected haematoma. One patient died constituting postoperative mortality of 2.5%. Median follow-up was 6.5 mo(IQR: 2.15-16). Overall recurrence rate was 28%(n = 12). Recurrence rate for patients undergoing an urgent Delorme's procedure who presented as an emergency was higher(75.0%) compared to those treated electively(20.5%), P value 0.034. Median time interval from surgery to the development of recurrence was 16 mo(IQR: 5-30). There were three patients who developed an early recurrence, within two weeks of the initial procedure. The management of the recurrent prolapse was as follows: No further intervention(n = 1), repeat Delorme's procedure(n = 3), Altemeier's procedure(n = 5) and rectopexy with faecal diversion(n = 3). One patient was lost during follow up.CONCLUSION: Delorme's procedure is a suitable treatment for rectal prolapse due to low morbidity and mortality and acceptable rate of recurrence. The management of the recurrent rectal prolapse is often restricted to the pelvic approach by the same patientrelated factors that influenced the choice of the initial operation, i.e., Delorme's procedure. Early recurrence developing within days or weeks often represents a technical failure and may require abdominal rectopexy with faecal diversion. | Muhammad A Javed Faryal G Afridi Dmitri Y Artioukh | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 4 |
| 3 | Breakthrough Technologies for the Biorefining of Organic Solid and Liquid Wastes显示文摘有机固液废弃物包含大量能量、养分和水分,不应仅视其为废物。数十年来,人们一直对城市固体废物进行回收、堆制和燃烧,并从中提取能量和有价值的物质。污水的首要管理策略是治理和排放。随着技术的进步,通过新方法使利用固体废物和废水成为可能。考虑到废物特殊的化学、物理和生物性质,需要整合多种技术以使废物的能量和价值回收最大化。为此,生物炼制是完全利用废物中的能量和价值的一个合适的方法。研究证明,不可回收废弃物和生物固体可通过不同方法转化为可利用的热能、电能、燃料和化学品,并且液体废物或能帮助农作物和藻类的成长,为能量回收和食物生产提供不同的选择。本文针对有机固液废物提出新型生物炼制方案,这些废物来源于城市废料、食品和生物加工厂以及动物生产设施。四大新型突破性科技——真空辅助高温厌氧消化、扩展鱼菜共生系统、含油废物经甘油裂解制取生物柴油和微波辅助热化学转化,均可运用于生物炼制方案中,从而成功将废物转化,用以生产化学品、化肥、能量(沼气、合成气、生物柴油和生物油)、食物、饲料,得到干净的水并显著减少污染物的排放。 | Paul Chen Erik Anderson Min Addy Renchuan Zhang Yanling Cheng Peng Peng Yiwei Ma Liangliang Fan Yaning Zhang Qian Lu Shiyu Liu Nan Zhou Xiangyuan Deng Wenguang Zhou Muhammad Omar Richard Griffith Faryal Kabir Hanwu Lei Yunpu Wang Yuhuan Liu Roger Ruan | 2018 | Engineering2018，4，4： | 3 |
| 4 | Bifunctional catalysts of Co3O4@GCN tubular nanostructured (TNS) hybrids for oxygen and hydrogen evolution reactions显示文摘为氧和氢进化反应(OER/HER ) 的催化剂在精力采购例如切开的水的可更新的绿色的心。尽管不可思议的努力被作了为 OER 和她开发有效催化剂,大挑战在 bifunctional 催化剂的发展尚待。这里,我们报导公司 3 在 graphitic 碳氮化物(GCN ) 的管状的 nanostructures 嵌入并且在低温度通过一个灵巧的、大规模化学方法综合了的 O 4 。在公司 3 O 4 和 GCN 为 OER 和她作为 bifunctional 催化剂导致了优秀性能。混血儿的高表面区域,唯一的管状的 nanostructure,和作文为催化作用使所有氧化还原作用地点容易可得到并且提供了更快的离子、电子的传导。公司 3 O 4@GCN 管状的 nanostructured (TNS ) 混血儿展出了最低过电位(0.12 V ) 和优秀当前的密度(在 OER 的 147 妈 / 厘米 2) ,比基准 IrO 2 和 RuO 2, 并且与在碱的媒介的优异耐久性好。而且,公司 3 O 4@GCN TNS 混血儿在她表明了优秀性能与低得多的发作和过电位,并且稳定的当前的密度。这被期望公司 3 在这研究开发的 O 4@GCN TNS 混血儿将是在大规模水切开和燃料房间的高贵金属催化剂的一种吸引人的选择。 | Muhammad Tahir Nasir Mahmood Xiaoxue Zhang Tariq Mahmood Faheem. K. Butt Imran Aslam M.Tanveer Faryal Idrees Syed Khalid Imran Shakir Yiming Yan Jijun Zou Chuanbao Cao Yanglong Hou | 2015 | Nano Research2015，8，11： | 2 |
| 5 | Nepehinol--a new triterpene from Nepeta hindostana 显示文摘 | Viqar U A Shaheen B Faryal V M | 1985 | Planta Med1985，51，6： | 1 |
| 6 | School Management Councils:A Lever For Mobilizing Social Capital In Rural Punjab,Pakistan 显示文摘 | Faryal Khan | 2007 | Prospects2007，37，1： | 1 |
| 7 | Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women显示文摘 | Faryal S Mirza I Desmond Padhi Lawrence G Raisz | 2010 | Clin Endocrinol Metab2010，95，4： | 1 |
| 8 | Metal-catalyzed synthesis of ultralong tin dioxide nanobelts: Electrical and optical properties with oxygen vacancy-related orange emission显示文摘 | Faheem K. Butt Chuanbao Cao Tariq Mahmood Faryal Idrees Muhammad Tahir Waheed S. Khan Zulfiqar Ali Muhammad Rizwan M. Tanveer Sajad Hussain Imran Aslam Dapeng Yu | 2014 | Materials Science in Semiconductor Processing2014，，： | 1 |
| 9 | Nepehinol - a new triterpene from Nepeta hindostana显示文摘 | Viqar U A Shaheen B Faryal V M | | 0，，06： | 1 |
| 10 | Phosphatidylino- sitol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein显示文摘 | Hussain A Faryal R Nore BF | 2009 | Bio- chem Biophys Res Commun2009，390，3： | 1 |
| 11 | The outbreak of dengue during the COVID-19 pandemic in Pakistan:The emergence of overlapping crises显示文摘COVID-19 pandemic has become a serious public health crisis for developed and developing countries around the world.As of February 17,2022,over 420 million cases including 5.8 million deaths have been reported across the globe[1].The first case of COVID-19 in Pakistan was detected on February 26,2020;since then,the toll of confirmed COVID-19 cases reached 1491423 including 29877 deaths as of February 17,2022[1]. | Muhammad Suleman Rana Muhammad Usman Muhammad Masroor Alam Aamer Ikram Muhammad Salman Rani Faryal Massab Umair | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，2： | 0 |
| 12 | Dengue outbreak in Swat and Mansehra,Pakistan 2013;an epidemiological and diagnostic perspective显示文摘Objective:To High light some epidemiological,clinical and diagnostic features of dengue fever during an outbreak and the role of different diagnostic techniques to achieve the highest level of accuracy in results.Methods:Blood samples(n=323) were collected along with epidemiological and clinical data from suspected dengue patients who visited different hospitals in Swat and Mansehra district of Pakistan between May-November 2013 during a dengue outbreak.Samples were tested for the detection of viral nucleic acid by real-lime PCR.non structural protein-1(NS1antigen and IgM antibodies by ELISA.Results:Out of 323 cases with clinical dengue infection,304 were positive by one or more diagnostic parameter:201 samples were positive by real-time PCR,209 were positive by NS1 ELISA and 190 were positive by IgM antibodies.Sensitivities of real-time PCR and NS1 F.LISA were comparable for early diagnosis of dengue virus infection.IgM antibody detection assay was found useful for the diagnosis in the samples collected later than day 5 of onset.Conclusions:The use of real-lime PCR or detection of non stnictural protein NS 1 by ELISA followed by IgM antibodies detection can be recommended for early diagnosis of dengue virus infection with a high level of accuracy. | Muhammad Suleman Rani Faryal Uzma Bashir Aamir Muhammad Masroor Alam Nadia Nisar Salmaan Sharif Shahzad Shaukat Adnan Khurshid Mehar Angez Massab Umair Ghulam Mujtaba Mian Muhammad Sufian Yasir Arshad Lubna Rehman Syed Sohail Zahoor Zaidi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 0 |
| 13 | Preliminary Seroepidemiological survey of dengue infections in Pakistan,2009-2014显示文摘Background:Dengue virus is the causative agent of dengue fever,a vector borne infection which causes selflimiting to life threatening disease in humans.A sero-epidemiological study was conducted to understand the current epidemiology of dengue virus in Pakistan which is now known as a dengue endemic country after its first reported outbreak in 1994.Methods:To investigate the prevalence of dengue virus in Pakistan during 2009-2014,a total of 9,493 blood samples were screened for the detection of anti-dengue IgM antibodies using ELISA.Clinical and demographic features available with hospital records were reviewed to ascertain mortalities related to dengue hemorrhagic shock syndrome.Results:Out of 9,493 samples tested,37%(3,504)were found positive for anti-dengue IgM antibodies.Of the seropositive cases,73.6%(2,578/3,504)were male and 26.4%(926/3,504)were female.The highest number(382/929;41.1%)of sero-positive cases was observed among the individuals of age group 31-40 years.The highest number of symptomatic cases was reported in October(46%;4,400/9,493),and the highest number of sero-positive cases among symptomatic cases was observed in November(45.7%;806/1,764).Mean annual patient incidence(MAPI)during 2009-2014 in Pakistan remained 0.30 with the highest annual patient incidence(11.03)found in Islamabad.According to the available medical case record,472 dengue related deaths were reported during 2009-2014.Conclusion:The data from earlier reports in Pakistan described the dengue virus incidence from limited areas of the country.Our findings are important considering the testing of clinical samples at a larger scale covering patients of vast geographical regions and warrants timely implementation of dengue vector surveillance and control programs.Trial registration number:It is an epidemiological research study,so trial registration is not required. | Muhammad Suleman Hyeong-Woo Lee Syed Sohail Zahoor Zaidi Muhammad Masroor Alam Nadia Nisar Uzma Bashir Aamir Salmaan Sharif Shahzad Shaukat Adnan Khurshid Mehar Angez Massab Umair Ghulam Mujtaba Rani Faryal | 2017 | Infectious Diseases of Poverty2017，6，1： | 0 |
| 14 | Possible association of a distinct combined Glutathione-S-transferase members with allergic asthma patients in Pakistan显示文摘Allergic asthma is a diverse chronic respiratory disease characterized by the inflammation of the lower airway disease affecting many people around the world with rising morbidity and mortality.Association between asthma and certain demographic features was studied in relation to genotype from 244 allergic individuals of local population.Skin prick test was used to confirm asthma.Genetic polymorphism in Glutathione-S-transferases(GSTs)was studied using multiplex PCR based method and IgE level by ELISA.Pollen and dust were the major causative aeroallergens(26%),which were associated to higher IgE levels(P<0.05).Smoking was found to be significantly associated with asthma in only males(P Z 0.004).A low prevalence of null genotype of both GSTM1 and GSTT1 genes was observed in the patients(4.34%)compared to control group(14%).No association of combined GSTM1 and GSTT1 null genotype was found with the asthma in local population.GSTM1t and GSTTgenotype had higher risk(OR Z 1.3681,P Z 0.001)for development of asthma.There was a significant association of asthma with combined genotype of GSTM1t and GSTTwhen data was analyzed on gender basis in males(P Z 0.006)and highly significant in age range of 26e40 years(P Z 0.001).Combined GSTMt and GSTTgenotype was found to be risk factor for asthma in addition to family history in male patients.However a data with large patient size and different ethnic distribution may reveal the exact etiology. | Aamna Dar Rani Faryal Nosheen Masood | 2017 | Genes & Diseases2017，4，2： | 0 |
| 15 | Recurrent Marburg virus disease outbreaks from 1967 to 2022:A perspective on challenges imposed and future implications显示文摘Ongoing COVID-19 pandemic and rapid increase in monkeypox cases across the globe have led to growing realization among the masses that early containment of infectious diseases may prevent their emergence as global havoc.Recently,four cases of Marburg virus disease have been identified in Ghana,a country in West Africa.Marburg virus is one of the causes of deadly viral hemorrhagic fever in humans with a significantly high mortality rate.The management of affected individuals merely relies on supportive care,as no treatments or vaccines have been globally approved yet.Although most of the cases were reported from African countries,the current era of globalization poses a very high probability of its spread across the world. | Yusra Mashkoor Faryal Rafique Amraha Zubair | 2022 | Asian Pacific Journal of Tropical Medicine2022，15，9： | 0 |
| 16 | Pre-oxidative catalytic treatment of toluidine blue with potassium permanganate in acidic solution显示文摘This article describes the potential of KMnO4 for oxidation of the thiazine dye(Toluidine blue TB)in an acidic medium.The effect of different operational parameters like initial concentration of dye,potassium permanganate,pH,ionic strength,catalyst,acids and temperature were investigated spectrophotometrically at λ_(max)=613 nm.The results showed a complete removal of the TB with mineralization of the dye solution.Smooth and complete decoloration was observed in the presence of monobasic acid(HCl)as compared to the H_(2)SO_(4) where little color removal was observed.Pb was found to be an effective catalyst in oxidation for complete and fast decolorization with mineralization.No significant change at elevated temperatures showed that an intermediate complex degraded with slight change in the temperature.UV/visible spectrophotometry and GC mass analysis showed an intermediate activated complex demethylated sulophooxide of TB which later on degraded into smaller fragments. | Rafia AZMAT Faryal Vali MOHAMMED Tehseen AHMED Qurat-ul-Ain TANWIR | 2011 | Frontiers of Chemistry in China2011，6，2： | 0 |
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