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| 1 | Resistin induces insulin resistance, but does not affect glucose output in rat-derived hepatocytes显示文摘目的: 现在的学习的目的是观察效果抵抗在在在导出老鼠的 hepatocytes.Methods 的胰岛素敏感度和葡萄糖输出上: 老鼠肝细胞瘤房间线 H4IIE 与有教养、刺激抵抗在; supernant 葡萄糖和肝糖内容被检测。胰岛素受体底层(红外)-1 和 IRS-2,蛋白质激酶 B/Akt,肝糖 synthase kinase-3 (3 (GSK-3p ) , suppress 或表明 3 的 cytokine (SOCS-3 ) ,蛋白质内容,以及磷酸化地位被西方的弄污估计。对 SOCS-3 指导的特定的反感觉 oligodeoxynucleotides 习惯于击倒的 SOCS-3.Results :抵抗素导致了抗胰岛素性,但是在老鼠肝细胞瘤房间的affect 葡萄糖输出没衬里 H4IIE.Resistin 胰岛素的稀释多重效果包括刺激胰岛素的肝糖合成和红外的磷酸化,蛋白质激酶 B/Akt ,象 GSK-3beta.Resistin 一样,处理显著地导致了基因和 SOCS-3 的蛋白质表示,胰岛素发信号的一个已知的禁止者。而且,对 SOCS-3 处理指导的特定的反感觉 oligodeoxynucleotide 阻止了抵抗在从反对胰岛素 action.Conclusion : 主要功能抵抗在在肝上是导致胰岛素 resistance.SOCS-3 感应的可以贡献胰岛素在 H4HE hepatocytes 发信号的调停 resistin 的抑制。 | Feng LIU Tao YANG Bin WANG Min ZHANG Nan GU Jie QIU Hong-qi FAN Chun-mei ZHANG Li FEI Xiao- qing PAN Mei GUO Rong-hua CHEN Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，1： | 21 |
| 2 | Incidence and predictors of radial artery spasm during transradial coronary angiography and intervention显示文摘背景光线的动脉痉挛(地岬) 是在 transradial 的最普通的复杂并发症冠的 angiography 和干预。在这研究,我们设计了用汉语在 transradial 过程期间调查地岬的发生,通过多重回归发现独立预言者,并且分析在后续期间的地岬的临床的效果。方法病人安排了收到 transradial 冠的 angiography 和干预连续地被注册。地岬的发生被记录。Univariate 分析被执行发现地岬的影响因素,并且逻辑回归分析被执行发现地岬的独立预言者。病人被要求 1 个月以后为对地岬的发生是的光线的 access.Results 的评价回来(112/1427 )7.8% 在所有病人收到了 transradial 过程。 Univariate 分析显示那幼仔( P=0.038 ),女性( P=0.026 ),光线的动脉的小直径( P < 0.001 ),糖尿病( P=0.026 ),吸烟( P=0.019 ),中等或严重的疼痛在光线的动脉管子期间( P < 0.001 ),失败起初存取尝试( P=0.002 ),大鞘( P=0.004 ),导管的数字(> 3 )( P=0.048 ),快速的基线心率( P=0.032 )和长操作时间( P=0.021 )与地岬被联系。逻辑回归给那女性看了(OR=1.745, 95% CI:1.148-3.846, P=0.024 ) ,小光线的动脉直径(OR=4.028, 95%CI:1.264-12.196, P=0.008 ) ,糖尿病(OR= 2.148, 95%CI:1.579-7.458, P=0.019 ) 并且失败的存取起初尝试(OR=1.468, 95%CI:1.212-2.591, P=0.032 ) 是地岬的独立预言者。后续在(28 慥?? | JIA De-an ZHOU Yu-jie SHI Dong-mei LIU Yu-yang WANG Jian-long LIU Xiao-li WANG Zhi-jian YANG Shi-wei GE Hai-long HU Bin YAN Zhen-xian CHEN Yi GAO Fei | 2010 | Chinese Medical Journal2010，，7： | 21 |
| 3 | Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration显示文摘 | Hu Wang Hongna Zuo Jin Liu Fei Wen Yawei Gao Xudong Zhu Bo Liu Feng Xiao Wengong Wang Gang Huang Bin Shen Zhenyu JU | 2018 | Cell Research2018，28，10： | 16 |
| 4 | Electroacupuncture preconditioning protects against focal cerebral ischemia/reperfusion injury via suppression of dynamin-related protein 1显示文摘Electroacupuncture preconditioning at acupoint Baihui(GV20) can reduce focal cerebral ischemia/reperfusion injury. However, the precise protective mechanism remains unknown. Mitochondrial fission mediated by dynamin-related protein 1(Drp1) can trigger neuronal apoptosis following cerebral ischemia/reperfusion injury. Herein, we examined the hypothesis that electroacupuncture pretreatment can regulate Drp1, and thus inhibit mitochondrial fission to provide cerebral protection. Rat models of focal cerebral ischemia/reperfusion injury were established by middle cerebral artery occlusion at 24 hours after 5 consecutive days of preconditioning with electroacupuncture at GV20(depth 2 mm, intensity 1 m A, frequency 2/15 Hz, for 30 minutes, once a day). Neurological function was assessed using the Longa neurological deficit score. Pathological changes in the ischemic penumbra on the injury side were assessed by hematoxylin-eosin staining. Cellular apoptosis in the ischemic penumbra on the injury side was assessed by terminal deoxyribonucleotidyl transferase-mediated d UTP-digoxigenin nick end labeling staining. Mitochondrial ultrastructure in the ischemic penumbra on the injury side was assessed by transmission electron microscopy. Drp1 and cytochrome c expression in the ischemic penumbra on the injury side were assessed by western blot assay. Results showed that electroacupuncture preconditioning decreased expression of total and mitochondrial Drp1, decreased expression of total and cytosolic cytochrome c, maintained mitochondrial morphology and reduced the proportion of apoptotic cells in the ischemic penumbra on the injury side, with associated improvements in neurological function. These data suggest that electroacupuncture preconditioning-induced neuronal protection involves inhibition of the expression and translocation of Drp1. | Gao-feng Zhang Pei Yang Zeng Yin Huai-long Chen Fu-guo Ma Bin Wang Li-xin Sun Yan-lin Bi Fei Shi Ming-shan Wang | 2018 | Neural Regeneration Research2018，13，1： | 16 |
| 5 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 6 | Multidrug-resistant Tuberculosis Burden among the New Tuberculosis Patients in Zhejiang Province: An Observational Study, 2009-2013显示文摘 | Ying Peng Song-Hua Chen Le Zhang Bin Chen Ming-Wu Zhang Tie-Niu He Fei Wang Cheng-Liang Chai Lin Zhou Yu Zhang Xiao-Meng Wang Zhongwei Jia | 2017 | Chinese Medical Journal2017，，17： | 13 |
| 7 | Plasma neutrophil-gelatinase-associated lipocalin and cystatin C could early diagnose contrast-induced acute kidney injury in patients with renal insufficiency undergoing an elective percutaneous coronary intervention显示文摘 | LIU Xiao-li WANG Zhi-jian YANG Qing YU Miao SHEN Hua NIE Bin HAN Hong-ya GAO Fei ZHOU Yu-jie | 2012 | Chinese Medical Journal2012，，6： | 12 |
| 8 | Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells显示文摘Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluorescent staining and Western blot analysis were employed to detect apoptosis and autophagy, and the role of autophagy was assessed using autophagy inhibitors. Apigenin dose- and time-dependently repressed the proliferation and clonogenic survival of the human breast cancer T47D and MDA-MB-231 cell lines. The death of T47D and MDA-MB-231 cells was due to apoptosis associated with increased levels of Caspase3, PARP cleavage and Bax/Bcl-2 ratios. The results from flow cytometry and fluorescent staining also verified the occurrence of apoptosis. In addition, the apigenin-treated cells exhibited autophagy, as characterized by the appearance of autophagosomes under fluorescence microscopy and the accumulation of acidic vesicular organelles (AVOs) by flow cytometry. Furthermore, the results of the Western blot analysis revealed that the level of LC3-II, the processed form of LC3-I, was increased. Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage. Similar results were also confirmed by flow cytometry and fluorescence microscopy. These results indicate that apigenin has apoptosis-and autophagy-inducing effects in breast cancer cells. Autophagy plays a cyto-protective role in apigenin-induced apoptosis, and the combination of apigenin and an autophagy inhibitor may be a promising strategy for breast cancer control. | Xuchen Cao Bowen Liu Wenfeng Cao Weiran Zhang Fei Zhang Hongmeng Zhao Ran Meng Lin Zhang Ruifang Niu Xishan Hao Bin Zhang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 12 |
| 9 | SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses显示文摘The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression,and participates in cytokine secretion in many diseases.However,the effects of the SOCS1/JAK2/STAT3 axis in experimental subarachnoid hemorrhage remain to be studied.A subarachnoid hemorrhage model was established in rats by infusing autologous blood into the optic chiasm pool.Some rats were first treated with JAK2/STAT3 small interfering RNA(Si-JAK2/Si-STAT3)or overexpression plasmids of JAK2/STAT3.In the brains of subarachnoid hemorrhage model rats,the expression levels of both JAK2 and STAT3 were upregulated and the expression of SOCS1 was downregulated,reaching a peak at 48 hours after injury.Simultaneously,the interactions between JAK2 and SOCS1 were reduced.In contrast,the interactions between JAK2 and STAT3 were markedly enhanced.Si-JAK2 and Si-STAT3 treatment alleviated cortical neuronal cell apoptosis and necrosis,destruction of the blood-brain barrier,brain edema,and cognitive functional impairment after subarachnoid hemorrhage.This was accompanied by decreased phosphorylation of JAK2 and STAT3 protein,decreased total levels of JAK2 and STAT3 protein,and increased SOCS1 protein expression.However,overexpression of JAK2 and STAT3 exerted opposite effects,aggravating subarachnoid hemorrhage-induced early brain injury.Si-JAK2 and Si-STAT3 inhibited M1-type microglial conversion and the release of pro-inflammatory factors(inducible nitric oxide synthase,interleukin-1β,and tumor necrosis factor-α)and increased the release of anti-inflammatory factors(arginase-1,interleukin-10,and interleukin-4).Furthermore,primary neurons stimulated with oxyhemoglobin were used to simulate subarachnoid hemorrhage in vitro,and the JAK2 inhibitor AG490 was used as an intervention.The in vitro results also suggested that neuronal protection is mediated by the inhibition of JAK2 and STAT3 expression.Together,our findings indicate that the SOCS1/JAK2/STAT3 axis contributes to early brain injury after subarachnoid hemorrhage both in vitro and in vivo by inducing inflammatory responses.This study was approved by the Animal Ethics Committee of Anhui Medical University and the First Affiliated Hospital of University of Science and Technology of China(approval No.LLSC-20180202)on March 1,2018. | Yang Wang Xiang-Qian Kong Fei Wu Bin Xu De-Jun Bao Chuan-Dong Cheng Xiang-Ping Wei Yong-Fei Dong Chao-Shi Niu | 2021 | Neural Regeneration Research2021，16，12： | 11 |
| 10 | Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function显示文摘BACKGROUND:Triptolide(TPT)is a diterpenoid triepoxide extracted from the Chinese herb Tripterygium wilfordii Hook.F.It exhibits potent immunosuppressive and anti-inflammatory properties.This study was undertaken to investigate its effects on prolongation of islet allograft survival in rodents.Additionally,we investigated whether TPT would be toxic to islet function in vivo.METHODS:We transplanted BALB/c islets to either chemically induced diabetic C57BL/6 mice or spontaneously diabetic nonobese diabetic(NOD)mice.TPT was injected within 2 weeks or continuously,until rejection,in the two combinations.Then, we evaluated the toxicity of TPT on islet function by daily injection to naive BALB/c or diabetic BALB/c that was cured by syngeneic islet transplantation under the kidney capsule.Mice injected with cyclosporine A(CsA)or vehicle served as controls.Intraperitoneal glucose tolerance tests(IPGTTs)performed at 4 and 8 weeks in the na?ve BALB/c group,and at 2,4,6,and 8 weeks in the syngeneic transplanted group.RESULTS:The medium survival time of islets allograft from TPT treated C57BL/6 and NOD recipients were 28.5 days(range 24-30 days,n=10)and 33.0 days(range 15-47 days,n=6), respectively,and they were significantly different from those of the vehicle treated controls,which were 14.0 days(range 13-16 days,n=6)and 5.0 days(range 4-10 days,n=6),respectively(all P<0.0001).The IPGTT demonstrated that there was no difference between the TPT treated and vehicle treated groups, either in the normal or syngeneic transplanted islet BALB/c mice.However,CsA injection impaired islet function in both normal and syngeneic transplanted mice as early as 4 weeks.CONCLUSION:TPT prolonged islets allograft survival in a chemically induced diabetic or an autoimmune diabetic murine model without impairment of islet function. | Xin, Ming-Jun Cui, Shi-Hua Liu, Shuang Sun, Hai-Chen Li, Fei Sun, Jia-Bang Luo, Bin | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 11 |
| 11 | Evaluation of a New Real-time PCR Assay for Detection of Mycoplasma Pneumoniae in Clinical Specimens显示文摘Objective To establish and evaluate a real-time PCR assay to detect Mycoplasma pneumoniae (M.pneumoniae) in clinical specimens.Methods By analysing the whole p1 gene sequence of 60 M.pneumoniae clinical isolates in Beijing of China,an optimized real-time PCR assay (MpP1) using p1 gene conserved region was designed.The specificity and sensitivity of this assay were evaluated and compared with other two reported assays (RepMp1 and Mp181) using 40 positive and 100 negative clinical specimens.Results The detection limit of the new assay was 8.1 fg (about 1~3CFU) M.pneumoniae DNA.The sensitivity of MpP1,RepMp1,and Mp181 assays appeared to be 100%,100%,and 85%,respectively.Conclusion MpP1 assay is suitable for the detection of M.pneumoniae in Chinese clinical specimens. | ZHAO Fei CAO Bin HE Li Hua YIN Yu Dong TAO Xiao Xia SONG Shu Fan MENG Fan Liang ZHANG Jian Zhong | 2012 | Biomedical and Environmental Sciences2012，25，1： | 11 |
| 12 | Ultrathin Al2O3-coated reduced graphene oxide membrane for stable lithium metal anode显示文摘Lithium(Li) metal has been considered as the most attractive anode materials for Li-ion batteries(LIBs)due to its high theoretic specific capacity. The formation of unstable solid electrolyte interphase(SEI) and dendritic Li on the metal anode, however, hindered its practical application. Herein, to address the issues, a Li-free electrode with ultrathin Al_2O_3 coated on reduced graphene oxide(rGO) membrane that covers a Cu foil current collector was developed. The composite electrode exhibits excellent interfacial protection of lithium metal deposited between Cu foil and rGO electrochemically. Firstly, it affords good Li^+ permeability from the electrolyte. Secondly, the ultrathin Al_2O_3 has sufficient mechanical strength to inhibit the penetration of Li dendrite. Li metal was observed uniformly deposited between rGO membrane and Cu collector, and stable cycle performance of Li plating/stripping with Coulombic efficiency of ~91.75% at the 100 th cycle is achieved in organic carbonate electrolyte without any additives. | Fan Zhang Fei Shen ZhaoYang Fan Xin Ji Bin Zhao ZhouTing Sun YingYing Xuan XiaoGang Han | 2018 | Rare Metals2018，37，6： | 11 |
| 13 | On-orbit sleep problems of astronauts and countermeasures显示文摘Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very common among astronauts and has potential detrimental influences on the health of crewmembers and the safety of flight missions. Sleep in space is becoming a new medical research frontier. In this review we summarized on-orbit sleep problems of astronauts and six kinds of causes, and we presented the effects of lack of sleep on performance as well as mental and physical health, then we proposed seven kinds of countermeasures for sleep disturbance in spaceflight, including pharmacologic interventions, light treatment, crew selection and training, Traditional Chinese Medicine and so on. Furthermore, we discussed and oriented the prospect of researches on sleep in space. | Bin Wu Yue Wang Xiaorui Wu Dong Liu Dong Xu Fei Wang | 2018 | Military Medical Research2018，5，3： | 10 |
| 14 | Evaluation of Latest TMPA and CMORPH Precipitation Products with Independent Rain Gauge Observation Networks over High-latitude and Low-latitude Basins in China显示文摘The Tropical Rainfall Measuring Mission(TRMM) Multi-satellite Precipitation Analysis(TMPA) and National Oceanic and Atmospheric Administration(NOAA) Climate Prediction Center(CPC) morphing technique(CMORPH) are two important multi-satellite precipitation products in TRMM-era and perform important functions in GPM-era. Both TMPA and CMORPH systems simultaneously upgraded their retrieval algorithms and released their latest version of precipitation data in 2013. In this study, the latest TMPA and CMORPH products(i.e., Version-7 real-time TMPA(T-rt) and gauge-adjusted TMPA(T-adj), and Version-1.0 real-time CMORPH(C-rt) and Version-1.0 gauge-adjusted CMORPH(C-adj)) are evaluated and intercompared by using independent rain gauge observations for a 12-year(2000–2011) period over two typical basins in China with different geographical and climate conditions. Results indicate that all TMPA and CMORPH products tend to overestimate precipitation for the high-latitude semiarid Laoha River Basin and underestimate it for the low-latitude humid Mishui Basin. Overall, the satellite precipitation products exhibit superior performance over Mishui Basin than that over Laoha River Basin. The C-adj presents the best performance over the high-latitude Laoha River Basin, whereas T-adj showed the best performance over the low-latitude Mishui Basin. The two gauge-adjusted products demonstrate potential in water resource management. However, the accuracy of two real-time satellite precipitation products demonstrates large variability in the two validation basins. The C-rt reaches a similar accuracy level with the gauge-adjusted satellite precipitation products in the high-latitude Laoha River Basin, and T-rt performs well in the low-latitude Mishui Basin. The study also reveals that all satellite precipitation products obviously overestimate light rain amounts and events over Laoha River Basin, whereas they underestimate the amount and events over Mishui Basin. The findings of the precision characteristics associated with the latest TMPA and CMORPH precipitation products at different basins will offer satellite precipitation users an enhanced understanding of the applicability of the latest TMPA and CMORPH for water resource management, hydrologic process simulation, and hydrometeorological disaster prediction in other similar regions in China. The findings will also be useful for IMERG algorithm development and update in GPM-era. | JIANG Shanhu REN Liliang YONG Bin HONG Yang YANG Xiaoli YUAN Fei | 2016 | Chinese Geographical Science2016，26，4： | 10 |
| 15 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 16 | Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats显示文摘MicroRNAs (miRNAs ) 是否定地 post-transcriptionally 调整基因表示的小、非编码的 RNA (22 核苷酸) 的一个类,通过目标 mRNAs 的翻译抑制或降级的任何一个。我们揭开了在在在在在用 microarray 分析的老鼠的臀部的神经的切除术以后的 1, 4, 7,和 14 天的背面的根 ganglia (DRG ) 的 miRNAs 的表示的以前未知的改变。32 显著地, upregulated 和 18 downregulated miRNAs 在跟随臀部的神经损害的四个次点在 DRG 被识别。四的表示连续地 deregulated miRNAs,由即时 Taqman 聚合酶链反应分析了,与 microarray 数据一致(upregulated:miR-21, miR-221;downregulated:miR-500, miR-551b ) 。为这些 miRNAs 的潜在的目标,在臀部的神经切除术以后改变了,主要涉及细胞的进程的神经系统开发,多细胞的 organismal 开发,和规定。这研究在一只老鼠在臀部的神经的切除术以后在 DRG 表明了 miRNAs 的不同参与模型,和它可以也在说明为神经新生负责的分子的机制作出贡献。 | Bin Yu Songlin Zhou Tianmei Qian Yongjun Wang Fei Ding Xiaosong Gu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 9 |
| 17 | Complete Genomic Sequence of a Chinese Isolate of Duck Hepatitis Virus显示文摘The complete genomic sequence of Duck hepatitis virus 1(DHV-1) ZJ-V isolate was sequenced and determined to be 7 691 nucleotides(nt) in length with a 5'-terminal un-translated region(UTR) of 626 nt and a 3'-terminal UTR of 315 nt(not including the poly(A) tail).One large open reading frame(ORF) was found within the genome(nt 627 to 7 373) coding for a polypeptide of 2 249 amino acids.Our data also showed that the poly(A) tail of DHV-1 has at least 22 A's.Sequence comparison revealed significant homology(from 91.9% to 95.7%) between the protein sequences of the ZJ-V isolate and those of 21 reference isolates.Although DHV-1 has been classified as an unassigned virus in the Picornaviridae family,its genome showed some unique characteristics.DHV-1 contains 3 copies of the 2A gene and only 1 copy of the 3B gene,and its 3'-NCR is longer than those of other picornaviruses.Phylogenetic analysis to do sequence homology based on the VP1 protein sequences showed that the ZJ-V isolate shares high sequence homology with the reported DHV-1 isolates(from 92.9% to 99.2%),indicating that DHV-1 is genetically stable. | Guang-qing LIU Fei WANG Zheng NI Tao YUN Bin YU Jiong-gang HUANG Jian-Ping CHEN | 2007 | 中国病毒学2007，22，5： | 8 |
| 18 | VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis显示文摘尽管 VEGFR-3 缺乏破坏血脉管的开发在早 embryogenesis 期间,内在的机制不是清楚的。在 angiogenesis 和 lymphangiogenesis 描绘它的函数,我们在这研究雇用了二个遗传上修改的鼠标模特儿,与一个 inactivation 点变化(Vegfr3TKmut ) 为 ligand 有约束力的域(Vegfr3 螖 L BD ) 或酷氨酸 kinase 域指向编码区域。我们证明淋巴的生长在 Vegfr3 螖 L BD/螖 L BD 和 Vegfr3TKmut/TKmut 老鼠被破坏,但是血容器在胚胎和蛋黄囊通常发展了。有趣地在 Vegfr3 螖 L BD/螖 L BD 然而并非 Vegfr3TKmut/TKmut 老鼠,淋巴囊是在场的,但是有发芽的 lymphangiogenic 的缺乏。我们进一步证明 VEGFR-3 的野类型、变异的形式能与 VEGFR-2 形成 heterodimers,并且减少在 endothelial 房间的 phospho-VEGFR-2 和下游的 phospho-Erk1/2 的水平当他们与 VEGF 被对待时 -- 一。这些调查结果显示发信号由它的血缘的 ligands (VEGF-C/-D ) 经由 VEGFR-3 激活调停了没为 angiogenesis 被要求,并且那 VEGFR-3 可以由 modulating VEGFR-2-mediated 信号在这个过程起一个作用。 | Luqing Zhang Fei Zhou Wencan Han Bin Shen Jincai LUO Masabumi Shibuya Yulong He | 2010 | Cell Research2010，20，12： | 7 |
| 19 | Mobile crowd sensing task optimal allocation: a mobility pattern matching perspective显示文摘 | Liang WANG Zhiwen YU Bin GUO Fei YI Fei XIONG | 2018 | Frontiers of Computer Science2018，12，2： | 7 |
| 20 | Probabilistic-constrained robust secure transmission for energy harvesting over MISO channels显示文摘In this paper, we consider a system supporting simultaneous wireless information and power transfer(SWIPT), where the transmitter delivers private message to a destination receiver(DR) and powers to multiple energy receivers(ERs) with multiple single-antenna external eavesdroppers(Eves). We study secure robust beamformer and power splitting(PS) design under imperfect channel state information(CSI).The artificial noise(AN) scheme is further utilized at the transmitter to provide strong wireless security. We aim at maximizing the energy harvested by ERs subject to the transmission power constraint, a range of outage constraints concerning the signal-to-interference-plus-noise ratio(SINR) recorded at the DR and the Eves, as well as concerning the energy harvested at the DR. The energy harvesting maximization(EHM)problem is challenging to directly solve, we resort to Bernstein-type inequality restriction technique to reformulate the original problem as a tractable approximated version. Numerical results show that our robust beamforming scheme outperforms the beamforming scheme relying on the worst-case design philosophy. | Bin LI Zesong FEI | 2018 | Science China(Information Sciences)2018，61，2： | 7 |
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