|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Robotic surgery for rectal cancer: A systematic review of current practice显示文摘AIM: To give a comprehensive review of current litera-ture on robotic rectal cancer surgery.METHODS: A systematic review of current literature via PubMed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: 'robotic surgery', 'surgical robotics', 'laparoscopic computer-assisted surgery', 'colectomy' and 'rectal resection'. RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the review.Out of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost. | Tony Wing Chung Mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu Man Ng | 2014 | World Journal of Gastrointestinal Oncology2014，6，6： | 16 |
| 2 | A Comprehensive UAV Indoor Navigation System Based on Vision Optical Flow and Laser FastSLAM显示文摘这份报纸论述为室内的 quadrotor 的全面控制,航行,本地化和印射的答案无人的天线车辆(UAV ) 系统。三个主要传感器在 quadrotor 站台上被使用,也就是,一个惯性的测量单位,一个向下看起来的照相机和扫描激光变化查找者。与这安装, UAV 能要用体力地估计它的自己的速度和位置,当没有碰撞,沿着一个房间的内部墙飞时。在一个以后完成飞行,与收集了数据历史性的 UAV 路径和室内的环境能很好被估计。系统的自治航行部分不要求任何遥远的感觉信息或离线的计算力量,当印射被做时离线。完全的飞行测试被执行了验证忠实和性能航行答案。 | WANG Fei CUI Jin-Qiang CHEN Ben-Mei LEE Tong H | 2013 | 自动化学报2013，39，11： | 12 |
| 3 | Isolation and identification of stem cells from degenerated human intervertebral discs and their migration characteristics显示文摘间充质的干细胞(MSC ) 从 intervertebral 圆盘的三个部件独立被孤立并且识别,即体环 fibrosus (AF ) ,原子核 pulposus (NP ) ,和软骨终板(CEP ) 。然而,很少研究被执行了比较这些三种干细胞的性质,他们为他们的潜在的临床的应用程序必要的特别移植能力。在这研究,分别地, MSC 人的堕落磁盘从 AF, NP,和 CEP 被孤立并且在经过 3 点由表面标记和 multilineage 区别试金识别了。干细胞的这三种类型作为 AF-MSCs, NP-MSCs,和 CEP-MSCs 被说出。然后,他们的生物特征以增长,经过,殖民地形成,移植,和侵略能力被比较。结果证明房间的所有三种类型作为 MSC 被识别并且在增长,经过,和殖民地形成能力有类似的特征。当 NP-MSCs 显示出最低迁居能力时, CEP-MSCs 显示出最高的迁居和侵略力量,建议那 CEP-MSCs 并且几乎,没有侵略力量有移植和侵略的最强大的性质什么时候与 AF-MSCs 和 NP-MSCs 相比。比的, CXCR4 的表示才在 CEP-MSCs 是更高的在。 | Shuhao Liu Haifeng Liang Soo-min Lee Zheng Li Jian Zhang Qinming Fei | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 10 |
| 4 | Novel endogenous angiogenesis inhibitors and their therapeutic potential显示文摘Angiogenesis,从先存在的 vasculature 的新血容器的形成为胚胎的开发和织物动态平衡是必要的。它也在象癌症和 retinopathy 那样的疾病起关键作用。在 pro-angiogenic 和 anti-angiogenic 因素之间的精细的平衡保证正常生理的动态平衡。内长的 angiogenesis 禁止者是在身体被形成并且有能力限制 angiogenesis 的蛋白质或蛋白质碎片。许多内长的 angiogenesis 禁止者被发现了,并且表继续成长。内长的蛋白质 / 肽禁止者是相对不太有毒,更好容忍了并且有药抵抗的更低的风险,它作为药候选人使他们漂亮。在这评论,我们加亮在最后五年以内发现的十个新奇内长的蛋白质 angiogenesis 禁止者,包括 ISM1, FKBPL,薄片, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 和 JWA。尽管一些这些蛋白质很好为另外的生物功能被描绘了,我们在 angiogenesis 抑制集中于他们的新、特定的角色并且为治疗学的申请讨论他们的潜力。 | Nithya RAO Yu Fei LEE Ruowen GE | 2015 | Acta Pharmacologica Sinica2015，36，10： | 7 |
| 5 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 6 | Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens显示文摘A key challenge when imaging whole biomedical specimens is how to quickly obtain massive cellular information over a large field of view(FOV).We report a subvoxel light-sheet microscopy(SLSM)method enabling high-throughput volumetric imaging of mesoscale specimens at cellular resolution.A nonaxial,continuous scanning strategy is developed to rapidly acquire a stack of large-FOV images with three-dimensional(3-D)nanoscale shifts encoded.Then,by adopting a subvoxel-resolving procedure,the SLSM method models these low-resolution,cross-correlated images in the spatial domain and can iteratively recover a 3-D image with improved resolution throughout the sample.This technique can surpass the optical limit of a conventional light-sheet microscope by more than three times,with high acquisition speeds of gigavoxels per minute.By fast reconstruction of 3-D cultured cells,intact organs,and live embryos,SLSM method presents a convenient way to circumvent the trade-off between mapping large-scale tissue(>100 mm3)and observing single cell(∼1-μm resolution).It also eliminates the need of complicated mechanical stitching or modulated illumination,using a simple light-sheet setup and fast graphics processing unit-based computation to achieve high-throughput,high-resolution 3-D microscopy,which could be tailored for a wide range of biomedical applications in pathology,histology,neuroscience,etc. | Peng Fei Jun Nie Juhyun Lee Yichen Ding Shuoran Li Hao Zhang Masaya Hagiwara Tingting Yu Tatiana Segura Chih-Ming Ho Dan Zhu Tzung KHsiaic | 2019 | Advanced Photonics2019，1，1： | 6 |
| 7 | Downscaling and Disaggregating NAO-conflict Nexus in Pre-industrial Europe显示文摘Recently, the desiccation effect of the North Atlantic Oscillation(NAO) is found to be positively correlated with violent conflict in pre-industrial Europe, with agricultural shrinkage and its subsequent economic shocks to be their causal link. However, it remains unexplored whether the correlation persists if the study period is extended backward in time, a different definition of violent conflict is applied, or the relationship is examined at lower geographic levels. In this study, we based on 835 internal disturbance incidents in Europe during 1049–1800 to conduct long-temporal and multi-scalar examination on the NAO-conflict nexus. ′Time-series′ and ′panel data′ disaggregation approaches, together with Granger Causality, Multiple Regression, and Survival Analyses were applied to verify the nexus quantitatively. Results show that the positive NAO-conflict correlation was significant at the continent and physiographic zone levels. During the positive NAO phases, the annual probability of internal disturbance outbreak increased by 70.0% in the southern Europe and the Mediterranean, a zone most affected by the NAO-induced desiccation effect. Yet, the NAO-conflict correlation was rather inconsistent when it was downscaled to the sub-regional level. Moreover, the NAO-conflict correlation was inflated under the time-series approach, while the panel data approach demonstrated the region-specific nature of the NAO forcing more clearly. The associated implications in examining climate-conflict nexus are discussed. Our findings may be crucial in examining violent conflict in the northwestern Africa, a highly agricultural region affected by the NAO. | Harry Fung LEE ZHANG David Dian PEI Qing FEI Jie | 2016 | Chinese Geographical Science2016，26，5： | 5 |
| 8 | Effect of coronary bifurcation angle on clinical outcomes in Chinese patients treated with crush stenting: a subgroup analysis from DKCRUSH-1 bifurcation study显示文摘背景分叉角度可以影响压碎 stenting 的临床的结果。我们寻求了比较高度(60 ( | CHEN Shao-liang ZHANG Jun-jie YE Fei CHEN Yun-dai FANG Wei-yi WEI Meng HE Ben SUN Xue-wen YANG Song CHEN Jin-guo SHAN Shou-jie TIAN Nai-liang LI Xiao-bo LIU Zhi-zhong KAN Jing Lee Michael Kwan Tak W | 2009 | Chinese Medical Journal2009，，4： | 5 |
| 9 | A hierarchical indexing strategy for optimizing Apache Spark with HDFS to efficiently query big geospatial raster data显示文摘Earth observations and model simulations are generating big multidimensional array-based raster data.However,it is difficult to efficiently query these big raster data due to the inconsistency among the geospatial raster data model,distributed physical data storage model,and the data pipeline in distributed computing frameworks.To efficiently process big geospatial data,this paper proposes a three-layer hierarchical indexing strategy to optimize Apache Spark with Hadoop Distributed File System(HDFS)from the following aspects:(1)improve I/O efficiency by adopting the chunking data structure;(2)keep the workload balance and high data locality by building the global index(k-d tree);(3)enable Spark and HDFS to natively support geospatial raster data formats(e.g.,HDF4,NetCDF4,GeoTiff)by building the local index(hash table);(4)index the in-memory data to further improve geospatial data queries;(5)develop a data repartition strategy to tune the query parallelism while keeping high data locality.The above strategies are implemented by developing the customized RDDs,and evaluated by comparing the performance with that of Spark SQL and SciSpark.The proposed indexing strategy can be applied to other distributed frameworks or cloud-based computing systems to natively support big geospatial data query with high efficiency. | Fei Hu Chaowei Yang Yongyao Jiang Yun Li Weiwei Song Daniel Q.Duffy John L.Schnase Tsengdar Lee | 2020 | International Journal of Digital Earth2020，13，3： | 4 |
| 10 | Polydopamine and collagen coated micro-grated polydimethylsiloxane for human mesenchymal stem cell culture显示文摘Natural tissues contain highly organized cellular architecture.One of the major challenges in tissue engineering is to develop engineered tissue constructs that promote cellular growth in physiological directionality.To address this issue,micro-patterned polydimethylsiloxane(PDMS)substrates have been widely used in cell sheet engineering due to their low microfabrication cost,higher stability,excellent biocompatibility,and most importantly,ability to guide cellular growth and patterning.However,the current methods for PDMS surface modification either require a complicated procedure or generate a non-uniform surface coating,leading to the production of poor-quality cell layers.A simple and efficient surface coating method is critically needed to improve the uniformity and quality of the generated cell layers.Herein,a fast,simple and inexpensive surface coating method was analyzed for its ability to uniformly coat polydopamine(PD)with or without collagen on micro-grated PDMS substrates without altering essential surface topographical features.Topographical feature,stiffness and cytotoxicity of these PD and/or collagen based surface coatings were further analyzed.Results showed that the PD-based coating method facilitated aligned and uniform cell growth,therefore holds great promise for cell sheet engineering as well as completely biological tissue biomanufacturing. | Dhavan Sharma Wenkai Jia Fei Long Shweta Pati Qinghui Chen Yibing Qyang Bruce Lee Chang Kyong Choi Feng Zhao | 2019 | Bioactive Materials2019，4，1： | 4 |
| 11 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 12 | Dye-sensitized solar cells based on functionalized truxene structure显示文摘Three new metal-free organic dyes(TX1, TX2 and TX3) based on truxene core structure, with triphenylamine as the electron donor, thiophene as the p spacers, and cyanoacetic acid or rhodanine-3-acetic acid as the electron acceptor are designed and synthesized. Their UV–vis absorption spectra,electrochemical and photovoltaic properties were investigated. The cyanoacrylic acid is verified to be a better acceptor unit(meanwhile the anchoring group) compared to the rhodanine-3-acetic acid. And also, two anchoring groups in TX2 could provide stronger adsorption ability on the Ti O2 surface. In addition, the EIS results indicate a slower charge recombination processes for TX2. As a result, dye TX2 bearing two cyanoacetic acid outperforms the other two dyes, exhibiting the photo-conversion efficiency of 2.64%, with Jsc= 5.09 m A cm–2, Voc= 729 m V, FF = 71.1. | Fei Wu Jian-Lin Liu Lawrence Tien Lin Lee Tao Chen Min Wang Lin-Na Zhu | 2015 | Chinese Chemical Letters2015，26，8： | 3 |
| 13 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 14 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 15 | Zircon U-Pb ages and Hf isotopic characteristics of the Dehe biotite monzonitic gneiss pluton in the North Qinling orogen and their geological significance显示文摘The Dehe granitic pluton intruded the Xiahe Group which is in the core complex of the North Qinling Orogenic Belt(NQOB).It shows gneissic bedding and possesses typical S-type granite minerals such as muscovite and garnet.LA-ICP-MS U-Pb isotopic dating of the Dehe granite yielded a weighted average age of 925±23 Ma which represents the emplacement age of the pluton.Most of the εHf(t) values are negative,and the two-stage model ages are consistent with the age of the Qinling Group.The isotope data show that the Dehe granite was formed in the following geological setting:in the syn-collision setting of the NQOB in the Neoproterozoic,crustal thickening induced partial melting of materials derived from the Qinling complex,and then the maga upwelled and intruded into the Xiahe Group.The formation of the Dehe S-type granite implied the occurrence of a convergent event in the QOB during the Neoproterozoic. | Wang, Fei Zhu, Laimin Li, Jiming Lee, Ben Gong, Hujun Yang, Tao Wang, Wei Xu, Ao | 2011 | Chinese Journal Of Geochemistry2011，30，2： | 1 |
| 16 | Automatic MR volume registration and its evaluation for the pelvis and prostate 显示文摘 | Fei B Wheaton A Lee Z | 2002 | Physics in Medicine and Biology2002，47，5： | 1 |
| 17 | Synthesis of Pyrrole-Imidazole Polyamide显示文摘One simple and versatile method is established for the synthesis of DNA recognition molecules-polyamides containing alternating N-methylpyrrole and N-methylimidazole without necessitating NH2- group protection. | Jun Hua XIAO Gu YUAN Wei Qiang HUANG Fei Li TANG Albert S.C.CHAN K.L.Daniel LEE | 2000 | Chinese Chemical Letters2000，11，3： | 1 |
| 18 | Desalination with a cascade of cross-flow hollow fiber membrane distillation devices integrated with a heat exchanger 显示文摘 | Lee Hanyong He Fei Song Liming | 2011 | AIChE Journal2011，57，7： | 1 |
| 19 | Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells显示文摘 | Hongxia Wang Andrew Gillis Chunyan Zhao Eugene Lee Josephine Wu Fengchun Zhang Fei Ye David Y. Zhang | 2011 | -Genetic Toxicology and Environmental Mutagenesis2011，，2： | 1 |
| 20 | Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues显示文摘 | Fei H Okano HJ Li C Lee GH | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员