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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The genetics of fibrodysplasia ossificans progressiva 显示文摘 | Shore E Feldman G Xu M | 2005 | Clin Rev Bone Miner Metab2005，3，： | 1 |
| 3 | Self-generated Validity and Other Effects of Measurement on Belief, Attitude, Intention and Behavior 显示文摘 | Feldman Jack M Lynch John G | 1988 | Journal of Applied Psychology1988，73，8： | 1 |
| 4 | A specific genomic location within the icm/dot pathogenesis region of different Legionella species enr codes fnnctionally similar but nonhomologous virulence proteins 显示文摘 | Feldman M Sengal G | 2004 | Infect Immun2004，72，： | 1 |
| 5 | Ca2+-induced Ca2+ release through localized Ca2+ uncaging in smooth muscle 显示文摘 | Ji G Feldman M Doran R | 2006 | J Gen Physiol2006，127，： | 1 |
| 6 | Self- generated Validity and Other Effects of Measurement on Belief, Attitude, Intention, and Behav- ior 显示文摘 | Feldman J M Lynch J G | 1988 | Journal of Applied Psychology1988，73，3： | 1 |
| 7 | Ca^2+ -sensing transgenic mice: postsynap- tic signaling in smooth muscle显示文摘 | Ji G Feldman M E Deng K Y Greene K S Wilson J Lee J C | 2004 | J Biol Chem2004，279，21： | 1 |
| 8 | Nurrl mRNA expression in neonatal and adult rat brain following kainic acid-induced seizure activity显示文摘 | Crispino M Tocco G Feldman JD | 1998 | Mol Brain Res1998，59，2： | 1 |
| 9 | Self-generated Validity and other Effects of Measurement on Belief, Attitude, Intention, and Behavior显示文摘 | Feldman J M Lynch J G | 1988 | Journal of Applied Psychology1988，，3： | 1 |
| 10 | PECAM-1 regulates a hydrogen peroxide-activated nonselective cation channel in endothelial cells 显示文摘 | Ji G O' Brien CD Feldman M | 2002 | JCell Biol2002，157，： | 1 |
| 11 | cDNA cloning of FRIL, a leetin from Dolichos lablab, that preserves hemato- poietic progenitors in suspension culture 显示文摘 | Colucci G Moore JG Feldman M | 1999 | PNAS USA1999，96，2： | 1 |
| 12 | Information in organizations as signal and symbol 显示文摘 | Feldman M S March J G | 1981 | Administrative Science Quarterly1981，26，2： | 1 |
| 13 | Influence of penetrating solar radiation on the heat budget of the equatorial Pacific Ocean显示文摘 | LEWIS M R CARR M E FELDMAN G C | 1990 | Nature1990，347，： | 1 |
| 14 | A simplified approach to the treatment of uncomplicated hypertension a cluster randomized,controlled trial显示文摘 | Feldman R D Zou G Y Vandervoort M K | 2009 | Hypertension2009，53，4： | 1 |
| 15 | Air sacs in the turkey显示文摘 | Rigdon R H Ferguson T M Feldman G L | 1958 | Pouh Sci1958，37，： | 1 |
| 16 | Coronary stents: A materials perspective显示文摘 | Mani G Feldman M D Patel D | 2007 | Biomaterials2007，28，9： | 1 |
| 17 | Studies on mechanism of development of physical and mechanical properties of high-volume fly ash-cement pastes 显示文摘 | R F Feldman G G Carette V M Malhotra | 1990 | Cement and Concrete Composites1990，12，： | 1 |
| 18 | Rapid elimination of low-copy DNA sequences in polyploidy wheat: A possible mechanism for differentiation of homoeologous chromosomes 显示文摘 | Feldman M Liu B Segal G | 1997 | Genetics1997，147，： | 1 |
| 19 | Fundamentals of lap- aroscopic surgery simulator training to proficiency improves laparo- scopic performance in the operating room-a randomized controlled trial显示文摘 | Sroka G Feldman L S Vassiliou M C | 2010 | The American journal of surgery2010，199，1： | 1 |
| 20 | Self-generated validity and oth- er effects of measurement on belief, attitude, intention, and be- havior 显示文摘 | FELDMAN J M LYNCH J G | 1988 | Journal of applied Psychology1988，73，3： | 1 |
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