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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells显示文摘 | Li Y Y Mctieman C F Feldman A M | 1999 | Carvasc Res1999，42，1： | 1 |
| 3 | Tympanostomy tubes and developmental outcomes at 9 to 11 years of age显示文摘 | Paradise J L Feldman H M Campbell T F | 2007 | N Engl J Med2007，356，3： | 1 |
| 4 | IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EpkA3 in neonatal rat cardiomyocytes显示文摘 | LI Y Y MCTIERNAN C F FELDMAN A M | | 0，，1： | 1 |
| 5 | Samall bowel exclusion from the pelvis by a polyglycolic acid mesh sling 显示文摘 | Devereux D F Kavanab M T Feldman M I | 1984 | J Surg Oncol1984，26，2： | 1 |
| 6 | Lexieal and conceptual representation in beginning and proficient bilinguals显示文摘 | POTTER M C SO K F ECKARDT B V FELDMAN L B | 1984 | Journal of Verbal Learning & Verbal Behavior1984，23，84： | 1 |
| 7 | Niche construction 显示文摘 | F J Odling - Smee K N Laland M W Feldman | 1996 | The America Naturalist1996，147，4： | 1 |
| 8 | Evolutionary consequences of niche construction:a theoretical investigation using two-locus theory显示文摘 | Laland K N Odling-Smee F J Feldman M W | 1996 | Journal of Evolutionary Biology1996，9，3： | 1 |
| 9 | On the evolutionary consequences of niche construction 显示文摘 | K N Laland F J Odling - Smee M W Feldman | 1996 | Journal of Evolutionary Biology1996，，9： | 1 |
| 10 | The angiogenesis inhibitor,endostatin,does not affect murine cutaneous wound healing显示文摘 | BERGER A C FELDMAN A L GNANT M F | 2000 | J Surg Res2000，91，1： | 1 |
| 11 | Cultural niche construction and human evolution 显示文摘 | K N Laland F J Odling - Smee M W Feldman | 2001 | Journal of Evolutionary Biology2001，，14： | 1 |
| 12 | Coronary artery bypass graft surgery versus pereutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Mohr F W Moriee M C Nappetein A P Feldman T E Stfihle E Colombo A | 2013 | Lancet2013，381，： | 1 |
| 13 | Studies on mechanism of development of physical and mechanical properties of high-volume fly ash-cement pastes 显示文摘 | R F Feldman G G Carette V M Malhotra | 1990 | Cement and Concrete Composites1990，12，： | 1 |
| 14 | Tympanostomy tubes and developmental outcomes at9to11years of age显示文摘 | Paradise J L Feldman H M Campbell T F | 2007 | N Engl J Mad2007，356，3： | 1 |
| 15 | The protein encoded by the Arabidopsis homeotic gene AGAMOUS resembles transcription factors显示文摘 | YANOFSKY M F MA H BOWMAN J L DREWS G N FELDMAN K A MEYEROWITZ E M | 1990 | Nature1990，346，： | 1 |
| 16 | Design synthesis, and pharmacological evaluation of ultrashort to Jong2aeting op ioid analgesics显示文摘 | Feldman P L James M K Grackeen M F | 1991 | J Med Chem1991，34，： | 1 |
| 17 | SycE allows secretion of YopE-DHFR hybrids by the Yersinia enterocolitica type III Ysc system显示文摘 | Feldman M F Muller S Wuest E | 2002 | Mol Microbiol2002，46，： | 1 |
| 18 | Studies on mechanism of development of physical and mechanical properties of high-volume fly ash concrete 显示文摘 | Feldman R F Carette G G Malhotra V M | 1990 | Cement andConcrete Composites1990，，12： | 1 |
| 19 | Evolutionary consequences of niche construction: a theoretical investigation using two-locus theory显示文摘 | LALAND K N ODLING S F J FELDMAN M W | 1996 | Journal of Evolutionary Biology1996，9，3： | 1 |
| 20 | Matrix metalloproteinases in pathophysiology and treatment of heart failure显示文摘 | Li Y Y McTiernan C F | 2001 | Lancet2001，357，9257： | 1 |
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