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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 慢性肾脏病中的炎症和动脉硬化:慢性肾功能不全队列研究中的发现显示文摘慢性肾脏病(chronic kidney disease,CKD)和动脉硬化程度与心血管病发病率和死亡率增加相关。目前认为炎症在动脉硬化发展中发挥作用,而CKD被认为是一种促炎症反应的状态。CKD患者的动脉僵硬度增加,横断面数据提示CKD中增多的炎症标志物与较高动脉僵硬度值相关。 | Peyster E Chen J Feldman HI Go AS Gupta J Mitra N Pan Q Porter A Rahman M Raj D Reilly M Wing MR Yang W Townsend RR 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，11： | 12 |
| 3 | Age,disease,and changing sex hormone levels in middle-aged men:Results of the Massachusetts Male Aging Study显示文摘 | Gray A Feldman A Mekinlay JB | 1991 | J Clin Endocrinol Metab1991，73，： | 2 |
| 4 | Developments in on-line,electron-beam emittence measurements using optical-transition radiation techniques显示文摘 | Feldman R B Lumpkin A H | 1990 | Nuclear Instruments and Methods in Physics Research1990，296，： | 2 |
| 5 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 6 | New reactor for production of tungsten disulfide hollow onion-like (inorganic fullerene-like) nanoparticles显示文摘 | Zak A Popovita-Biro R | 2000 | Solid State Sci2000，2，： | 1 |
| 7 | Impotence and its medical and psychosocial correlations: results of the Massachusetts male aging study 显示文摘 | Tenover J Feldman H A Goldstein I | 1994 | J Urol1994，151，1： | 1 |
| 8 | Diabetic neuropathies显示文摘 | LITTLE A A EDWARDS J L FELDMAN E L | 2007 | Pract Neurol2007，，7： | 1 |
| 9 | Myocarditis显示文摘 | Feldman A M Mcnamar A | 2000 | N Engl J Med2000，343，： | 1 |
| 10 | Growth mechanism of MoS2 fullerene-like nanoparticles by gas-phase synthesis显示文摘 | Feldman Y Alperovich V | 2000 | J Am Chem Soc2000，122，11： | 1 |
| 11 | Differential expression of matrix metalloproteinase after stent implatation and balloon angioplasty in the hyper-eholesterolemic rabbit显示文摘 | Mazighi M Scheuble A | 2001 | Cireulation2001，103，25： | 1 |
| 12 | A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies显示文摘 | Rizzieri D A Feldman E DiPersio J F | 2008 | Clin Cancer Res2008，14，9： | 1 |
| 13 | Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells显示文摘 | Li Y Y Mctieman C F Feldman A M | 1999 | Carvasc Res1999，42，1： | 1 |
| 14 | Population structure,fitness surfaces,and linkage in the shifting balance process显示文摘 | BERGMAN A GOLDSTEIN D B FELDMAN M W | 1995 | Genetical Research1995，66，： | 1 |
| 15 | Surface properties and emulsification behavior of denatured soy proteins显示文摘 | Nir I Y Feldman Y Aserin A | 1994 | Journal of Food Science1994，59，： | 1 |
| 16 | Effect of fluticasone ropionate/salmeterol (250/50) on COPD exacerbations and impact on patient outcomes 显示文摘 | Anzueto A Ferguson GT Feldman G | 2009 | COPD2009，6，5： | 1 |
| 17 | Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents:a randomized,controlled pilot study显示文摘 | EBBELING C B FELDMAN H A OSGANIAN S K | | 0，，03： | 1 |
| 18 | Non-debye dielectric relaxation in complex materials显示文摘 | Feldman Y Puzenko A Ryabov Y | 2002 | Chemical Physics2002，284，12： | 1 |
| 19 | Age, disease, and changing sex hormone levers in middle-aged men: results of the massachusetts male aging study显示文摘 | GRAY A FELDMAN A MEKINLAY J B | 1991 | Clin Endocrinol Metah1991，73，： | 1 |
| 20 | Structure-properties relations of thermally cured epoxy resin polyblends显示文摘 | Feldman D Banu D Natansohn A | 1992 | Journal of Apllied Polymer Science1992，42，： | 1 |
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