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| 1 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Factors affecting phosphate adsorption equilibria in lake sediments显示文摘 | Ku W C Digiano F A Feng T H | 1978 | Water Res1978，12，： | 2 |
| 5 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression显示文摘 | Nakashima T Hayashi M Fukunaga T Kurata K Oh-Hora M Feng J Q B onewald L F K odama T W utz A W agner E F Penninger JM Takayanagi H | | 0，，： | 1 |
| 6 | Experimental and theoretical studies of the copper(I) and silver(I) dinuclear N,N'-di-p-tolylformamidinato complexes显示文摘 | Cotton F A Feng X Matusz M | 1988 | J Am Chem Soc1988，110，21： | 1 |
| 7 | A Two-Strain TB Model with Age of Infection显示文摘 | Feng Z Innelli M Milner F A | 2002 | SIAM J Appl Math2002，62，： | 1 |
| 8 | 查看详情显示文摘 | Xu X F Niu X J Fan J Wang Y A Feng M | | 0，，05： | 1 |
| 9 | A two-strain tuberculosis model with age of infection显示文摘 | Feng Z Iannelli M Milnewr F A | 2002 | SIAM J Appl Math2002，62，5： | 1 |
| 10 | Vascular permeability factor/ vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis显示文摘 | DVORAK H F NAGY J A FENG D | 1999 | Curr Top Microbiol Immunol1999，237，1： | 1 |
| 11 | Mercury adsorption and oxidation incoal combustion and gasification processes显示文摘 | WILCOX J E RUPP S C YING D H LIM A S NEGREIRA A KIRCHOFER A FENG F LEE K | 2012 | Int J Coal Geol2012，9091，： | 1 |
| 12 | Estimation of parameters governing the transmission dynamics of schistosomes 显示文摘 | FENG Z EPPERT A MILNER F A | 2004 | Appl Math Lett2004，17，： | 1 |
| 13 | A two-strain TB model with age of infection显示文摘 | Feng Z Innelli M Miller F A | 2002 | SIAM J Appl Math2002，62，： | 1 |
| 14 | Surface modified ployacrylonitrile nanofibers and application for metal ions chelation显示文摘 | Feng Q Wang X Q Wei A F | 2011 | Fibers and Polymers2011，12，8： | 1 |
| 15 | Schistosomiasis models with two migrating human groups 显示文摘 | FENG Z LI C C MILNER F A | 2005 | Math and Comput model2005，41，： | 1 |
| 16 | Crystallization and preliminary crystallographic analysis of recombinant immunoglobulin G-binding protein from Streptococcus suis 显示文摘 | Khan A H Chu F Feng Y | 2008 | Acta Crystallogr Sect F Struet Biol Cryst Commun2008，64，8： | 1 |
| 17 | The MADlib analytics library:or MAD skills,the SQL显示文摘 | Hellerstein JM Ré C Schoppmann F Wang DZ Fratkin E Gorajek A Ng KS Welton C Feng X Li K Kumar A | | 0，，12： | 1 |
| 18 | Enterovirus 2Apro targets MDA5and MAVS in infected cells显示文摘 | Feng Q Langereis M A Lork M Nguyen M Hato S V Lanke K Emdad L Bhoopathi P Fisher P B Lloyd R E van Kuppeveld F J | 2014 | J Virol2014，88，6： | 1 |
| 19 | Atrial natriuretic peptide-dependent modulation of hypoxia-induced pulmonary vascular remodeling显示文摘 | Chen Y F Feng J A Li P | 2006 | Life Sci2006，79，14： | 1 |
| 20 | A comparative study of pyrolyzed and doped cobalt-polypyrrole eletrocatalysts for oxygen reduction reaction显示文摘 | FENG W LI H Y CHENG X JAO T C WENG F B SU A CHIANG Y C | 2012 | Appl Surf Sci2012，258，8： | 1 |
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