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| 1 | Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway显示文摘In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the 'first rapid, then slow' variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed. | LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 14 |
| 2 | Classification and regionalization of the forming environment of windblown sand disasters along the Tarim Desert Highway显示文摘Through the systematic field survey and observations, the factor quantification as well as setting the criteria, the sand disaster-forming environment along the Tarim Desert Highway can be divided into four grades by the classification and regionalization based on fuzzy mathematics. The length of the regions with significant sand disaster accounted for 37.1% of the total highway length. Particularly, the area along the Tarim Desert Highway, based on the sand disaster-forming environment classification as well as the difference in the five basic landform units along the highway, combined with the difference of wind regime, can be divided into five regions, in which the length of the regions suffering severe sand damage occupied 64.3% of the total highway length. In addition, the index of disaster formation grade along the highway decreased from north to south, showing a repeated spatial pattern in small length scales. | LEI JiaQiang LI ShengYu FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo LIU Shang DU WenYi YAN ZengHui WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 3 | How does the motor relearning program improve neurological function of brain ischemia monkeys?显示文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. | Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng | 2013 | Neural Regeneration Research2013，8，16： | 9 |
| 4 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 5 | Expression and signal regulation of the alternative oxidase genes under abiotic stresses显示文摘在他们的自然环境的植物经常面对各种各样的不能生活的压力,例如干旱,高咸度,并且寒心。植物线粒体包含其他的 oxidase (AOX ) ,它被原子基因的一个小家庭编码。AOX 基因被显示了对不能生活的压力高度应答。用有改变 AOX 表示的层次的转基因的植物, AOX 基因为不能生活的应力公差是重要的,这被证实了。尽管在不能生活的压力下面的 AOX 的角色广泛地被学习了,这个话题上有几优秀评论, AOX 基因家庭成员和在不能生活的压力下面的 AOX 基因的信号规定的微分表情模式广泛地没被总结。这里,我们考察并且讨论这二个重要问题的当前的进步。 | Hanqing Feng Dongdong Guan Kun Sun Yifeng Wang Tengguo Zhang Rongfang Wang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 7 |
| 6 | Oncostatin M-induced cardiomyocyte dedifferentiation regulates the progression of diabetic cardiomyopathy through B-Raf/Mek/Erk signaling pathway显示文摘oncostatin M (OSM ) 能在 vivo 并且在 vitro 开始 cardiomyocyte dedifferentiation,这被报导了。导致 OSM 的 cardiomyocyte dedifferentiation 可能是为糖尿病的心肌症(DCM ) 的处理的一个新目标。这研究被设计在 cardiomyocyte dedifferentiation 和 DCM 的前进决定 OSM 的角色。一个老鼠 DCM 模型被建立在 vivo 评估 OSM 的效果。Echocardiography 被使用决定心脏的功能。染色的天狼星红被用来检测纤维变性区域。传播电子显微镜学被用来评估线粒体缺陷。实时聚合酶链反应和西方的污点分析被执行检测相对 mRNA 表情和 cardiomyocyte dedifferentiation 相关的蛋白质表情分别地。OSM 处理导致了类似的损害心脏的功能和心脏的超微结构缺陷到在 DCM 鼠标检测的那些。cardiomyocyte 的 dedifferentiation 标记的表达式(Runx1,和 -SM-actin) 与在控制组的那些相比在对待 OSM 的鼠标是起来调整的。为了推进,表明 OSM 的重要角色, OSM 受体大美人(O ko ) 老鼠被使用。在 O ko 老鼠, c 工具包的 cardiomyocytes dedifferentiation 标记, Runx1,和 atrial natriuretic 肽是下面调整的,与稀释 DCM 损害和废除 OSM/B-Raf/Mek/Erk 发信号小径。在结论,导致 OSM 的 cardiomyocyte dedifferentiation 在 DCM 的前进起一个关键作用。导致 OSM 的 cardiomyocyte dedifferentiation 的机制与通过 OSM 受体 O 表明小径的 B-Raf/Mek/Erk 被联系。 | Xiaotian Zhang Sai Ma Ran Zhang Shuang Li Di Zhu Dong Han Xiuiuan Li Congye Li Wei Yan Dongdong Sun Bin Xu Yabin Wang Feng Cao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 7 |
| 7 | Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg显示文摘Layered double hydroxides(LDHs)are widely studied to enhance corrosion resistance and biocompatibility of Mg alloys,which are promising bone implants.However,the influence of LDH coating on the osteointegration of Mg implants lacks of a systematic study.In this work,Mg-Al LDH coating was prepared on pure Mg via hydrothermal treatment.The as-prepared Mg-Al LDH coated Mg exhibited better in vitro and in vivo corrosion resistance than bare Mg and Mg(OH)2 coated Mg.In vitro culture of mouse osteoblast cell line(MC3T3-E1)suggested that Mg-Al LDH coated Mg was more favorable for its osteogenic differentiation.In vitro culture of HUVECs revealed that cells cultured in the extract of Mg-Al LDH coated Mg showed superior angiogenic behaviors.More importantly,the immune response of Mg-Al LDH coated Mg was studied by in vitro culturing murine-derived macrophage cell line(RAW264.7).The results verified that Mg-Al LDH coated Mg could induce macrophage polarize to M2 phenotype(anti-inflammatory).Furthermore,the secreted factor in the macrophageconditioned culture medium of Mg-Al LDH group was more suitable for the bone differentiation of rat bone marrow stem cells(rBMSCs)and the angiogenic behavior of human umbilical vein endothelial cells(HUVECs).Finally,the result of femoral implantation suggested that Mg-Al LDH coated Mg exhibited better osteointegration than bare Mg and Mg(OH)2 coated Mg.With favorable in vitro and in vivo performances,Mg-Al LDH is promising as protective coating on Mg for orthopedic applications. | Shi Cheng Dongdong Zhang Mei Li Xuanyong Liu Yu Zhang Shi Qian Feng Peng | 2021 | Bioactive Materials2021，6，1： | 7 |
| 8 | A transceptor-channel complex couples nitrate sensing to calcium signaling in Ambidopsis显示文摘Nitrate-induced Ca^(2+) signaling is crucial for the primary nitrate response in plants.However,the molecular mechanism underlying the generation of the nitrate-specific calcium signature remains unknown.We report here that a cyclic nucleotide-gated channel(CNGC)protein,CNGC15,and the nitrate transceptor(NRT1.1)constitute a molecular switch that controls calcium influx depending on nitrate levels.The expression of CNGC15 is induced by nitrate,and its protein is localized at the plasma membrane after establishment of young seedlings.We found that disruption of CNGC15 results in the loss of the nitrate-induced Ca^(2+) signature(primary nitrate response)and retards root growth,reminiscent of the phenotype observed in the nrt1.1 mutant.We further showed that CNGC15 is an active Ca^(2+)-permeable channel that physically interacts with the NRT1.1 protein in the plasma membrane.Importantly,we discovered that CNGC15-NRT1.1 interaction silences the channel activity of the heterocomplex,which dissociates upon a rise in nitrate levels,leading to reactivation of the CNGC15 channel.The dynamic interactions between CNGC15 and NRT1.1 therefore control the channel activity and Ca^(2+) influx in a nitrate-dependent manner.Our study reveals a new nutrient-sensing mechanism that utilizes a nutrient transceptor-channel complex assembly to couple nutrient status to a specific Ca^(2+) signature. | Xiaohan Wang Changxin Feng LiLi Tian Congcong Hou Wang Tian Bin Hu Qian Zhang Zhijie Ren Qi Niu Jiali Song Dongdong Kong Liangyu Liu Yikun He Ligeng Ma Chengcai Chu Sheng Luan Legong Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 9 | Effect of Different Dietary Protein and Lipid Levels on the Growth,Body Composition,and Intestinal Digestive Enzyme Activities of Juvenile Yellow Drum Nibea albiflora(Richardson)显示文摘An 8-week feeding trial was conducted to determine the optimal dietary protein-to-lipid ratio for juvenile Nibea albiflora with an initial weight of(11.76 ± 0.20) g.Nine experimental diets containing different concentrations of protein(40%,47%,or 54%) and lipids(5%,9%,or 13%) in a 3 × 3 factorial experimental design were tested in triplicate groups of fish,while the protein-to-energy(P/E) ratios of the diets varied in the range of 19.74–28.32 mg k J^(-1).Results showed that fish fed diets containing 9% or 13% lipids with 54% protein exhibited significantly higher weight gains and specific growth rates than those fed other diets.The feed conversion rate of fish fed the diet with 40% protein and 5% lipids was significantly poorer than that of fish fed other diets.The protein efficiency rate of fish fed diets with 5% lipids was significantly lower than that of fish fed 9% or 13% lipid diets.Carcass lipid and energy contents were positively correlated with dietary lipid level regardless of protein level.Fish fed a 54% protein diet showed the highest trypsin activity.The intestinal lipase activity of fish fed the diet containing 13% lipids was significantly higher than that of fish fed 5% or 9% lipid diets.These results demonstrate the high protein dietary requirements of N.albiflora.A diet containing 54% protein and 9%–13% lipids with a P/E ratio of 26.2–27.81 mg protein k J^(-1) can be considered optimal for juvenile N.albiflora. | WANG Ligai HU Shenyu LOU Bao CHEN Dongxing ZHAN Wei CHEN Ruiyi LIU Feng XU Dongdong | 2018 | Journal of Ocean University of China2018，17，5： | 4 |
| 10 | Joints of continuous carbon fiber reinforced lithium aluminosilicate glass ceramics matrix composites to Ti60 alloy brazed using Ti-Zr-Ni-Cu active alloy显示文摘Continuous carbon fiber reinforced lithium aluminosilicate glass ceramics matrix composites(C_f/LAS composites) are joined to Ti60 alloy vacuum brazed using Ti-Zr-Ni-Cu brazing alloy. The effects of the brazing temperature on the interfacial microstructure and mechanical properties of brazed joints are investigated in details. The interfacial microstructure varies apparently with an increase of the brazing temperature. The thicknesses of the banded Ti solid solution(Ti(s, s)) and the reactive layer between Cf/LAS composites and the interlayer grow gradually. The mechanical properties of brazed joints increase firstly and then decrease with an increasing temperature. In addition, a joint that is brazed at 980 °C for 10 min shows the highest shear strength of$38.13 MPa. At the same time, the fracture paths of brazed joints also change as the temperature increases. When the brazing temperature is 950 °C, the fracture position is in the TiC + ZrC +Ti_2O + ZrSi_2+ Ti_5Si_3 layer on the composite side. When the brazing temperature is 980 °C, the fracture position is on the side of the braze seam(Ti, Zr)2(Ni, Cu), Ti_2O + ZrSi_2+ Ti_5Si_3 layer,and carbon fiber in the composite material. When the brazing temperature is 990 °C, the fracture position is in the Ti_2O + ZrSi_2+ Ti_5Si_3 layer on the composite side and the carbon fiber in the composite material. | Shengpeng HU Dongdong FENG Long XIA Ke WANG Renwei LIU Zhentao XIA Hongwei NIU Xiaoguo SONG | 2019 | Chinese Journal of Aeronautics2019，32，3： | 4 |
| 11 | Low-temperature Sintering of FeCuCo based Pre-alloyed Powder for Diamond Bits显示文摘We studied the effects of sintering temperature on FeCuCo based pre-alloyed powder for diamond bits.The FeCuCo composite was fabricated by co-precipitation method.With the addition of tungsten carbide(WC),sintering under different temperatures was investigated.Mechanical properties of the FeCuCo based matrix were systematically studied.The structure of the composite was evaluated by X-ray diffraction(XRD) and scanning electron microscope(SEM) was used to analyze the surface of the powder and matrix.The suitable sintering temperature was determined through differential scanning calorimeter(DSC).Micro drilling experiments were performed,and 820 ℃ was identified to be the ideal sintering temperature,at which the matrix shows the best mechanical properties and drilling performance. | 谢德龙 万隆 SONG Dongdong QIN Haiqing PAN Xiaoyi LIN Feng FANG Xiaohu | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，4： | 4 |
| 12 | Mg-Fe LDH sealed PEO coating on magnesium for biodegradation control,antibacteria and osteogenesis显示文摘Attempt of developing bio-safety and functional layered double hydroxides(LDHs)modifed plasma electrolytic oxidation(PEO)coatings,has become a hotspot in the protection of magnesium(Mg)based biomedical implants.In the present work,Mg-Fe LDH flms with different Fe contents were fabricated on PEO coating via a novel two-step method:frstly,the Fe OOH flms were prepared by immersing PEO sample in Fe^(2+)-containing solution,and then Mg-Fe LDH flms were formed by transforming the Fe OOH flms via a hydrothermal treatment in water.The highly-oriented LDH nano-sheets could enhance the anti-corrosion performance of PEO coating,which was proved by the results of electrochemical test,hydrogen evolution and corroded morphology.PEO/Mg-Fe LDH coatings showed a low hemolysis rate(less5%)than PEO coating.In addition,PEO/Mg-Fe LDH coatings were more favorable for cell adhesion and proliferation than PEO coating.Moreover,PEO/Mg-Fe LDH coatings showed good photothermal conversion property,which demonstrated the excellent rapid antibacterial effect under NIR light.In vitro culture of rat bone marrow stem cell(r BMSC)suggested that cells cultured in the extract of PEO/Mg-Fe LDH coatings had a better osteogenic activity.In vivo subcutaneous implantation test revealed that PEO/Mg-Fe LDH coatings exhibited good anti-corrosion and histocompatibility. | Dongdong Zhang Jielong Zhou Feng Peng Ji Tan Xianming Zhang Shi Qian Yuqin Qiao Yu Zhang Xuanyong Liu | 2022 | Journal of Materials Science & Technology2022，，10： | 3 |
| 13 | Recent progress in superhydrophobic coating on Mg alloys:A general review显示文摘Magnesium(Mg)is a vital engineering material owing to its light weight and excellent mechanical properties.However,poor corrosion resistance limits its widely applications as well as its economic value.Hence,surface modification is essential for Mg and its alloys.Among the various coatings,superhydrophobic coating,which is inspired by nature,has received increasing attentions in the past decade.With a water contact angle larger than 150°,superhydrophobic coating can provide sufficient protection for Mg-based substrates.The model of superhydrophobic states and the protection mechanism of superhydrophobic coating are discussed in this review.Especially,the methods for fabricating superhydrophobic coatings on Mg alloys are reviewed.Meanwhile,some functional superhydrophobic coatings on Mg alloys are summarized.Finally,the challenges and future directions are proposed.We hope that this paper will provide a serviceable review for future research on superhydrophobic coatings on Mg alloys. | Feng Peng Dongdong Zhang Xuanyong Liu Yu Zhang | 2021 | Journal of Magnesium and Alloys2021，9，5： | 3 |
| 14 | Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling显示文摘Dear Editor,Colorectal cancer(CRC)is one of the most frequent diseases with high mortality around the world.Conventional treatments of CRC remain unsatisfactory due to the increasing recurrence rate and adverse reactions including neutropenia,drug resistance,etc.Recently,autophagy has been shown to be involved in regulating cancer development and progression by regulating apoptosis through pro-apoptosis proteins including caspases,in addition to being a potential target for cancer therapeutic intervention.1 Trifolirhizin(Supplementary Fig.S1a)is a natural flavonoid glycosides isolated from Sophora flavescens as well as a bioactive constituent of Xian-Lian-Ke-Li,a commercial traditional Chinese medicine for the cancer prevention.Numerous evidence manifested that trifolirhizin inhibited proliferative activity in melanoma B16 cell,lung cancer H23 cell,human ovarian A2780 cell,and human gastric cancer cell MKN45.2 However,its pharmacological effect and mechanism on CRC remain elusive.Herein,we evaluated the effect of trifolirhizin on autophagy and apoptosis on CRC as well as its related mechanisms,in order to provide evidence to develop a potential agent with less adverse effect in treating CRC. | Dongdong Sun Weiwei Tao Feng Zhang Weixing Shen Jiani Tan Liu Li Qinghai Meng Yugen Chen Ye Yang Haibo Cheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 15 | Effects of hepatocyte growth factor overexpressed bone marrow‐derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts显示文摘 | Shenxu Wang Xing Qin Dongdong Sun Yunfang Wang Xiaoyan Xie Weiwei Fan Yabin Wang Dong Liang Xuetao Pei Feng Cao | 2012 | Cell Biochem Funct2012，，7： | 2 |
| 16 | Time Sequence Change-Point Model of Electrostatic State Parameters of Aircraft Engine显示文摘Electrostatic monitoring technology of particle charging information can facilitate online monitoring of aero-engine,which effectively enhances engine fault diagnosis and health managements.Unlike traditional engine state monitoring technologies,aircraft engine monitoring by gas path electrostatic monitoring not only covers the predicted information source itself,but also detects the information that can provide an early warnings for initial fault states through gas path charging levels.This paper establishes a non-stationary time sequence change-point model for anomaly recognition of electrostatic signals based on change-point theory combined with difference method of non-stationary time series.Finally,electrostatic induction data were utilized by the engine life test for a particular aircraft to validate the proposed algorithm.The results indicate that the activity level and the event rate were0.5—0.8(nc)and 50%,respectively,which were far greater than 4—12(pc)and 0—4% under normal working conditions of the engine. | Fu Yu Wei Dongdong Zuo Hongfu Feng Zhengxing | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 2 |
| 17 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 18 | Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation显示文摘As a potential cancer immunotherapeutic agent,chlorogenic acid(CHA)has entered phase II clinical trials in China as a lyophilized powder formulation for treating glioma.However,the in vivo instability of CHA necessitates daily intramuscular injections,resulting in patient noncompliance.In this study,CHA-phospholipid complex(PC)-containing PEGylated liposomes(CHA-PC PEG-Lipo,named as CPPL),with CHA-PC as the drug intermediate,were prepared to lower the administration frequency.CPPL demonstrated excellent physicochemical properties,enhanced tumor accumulation,and inhibited tumor growth even when the administration interval was prolonged to 4 days when compared to a CHA solution and CHA-PC loaded liposomes(CHA-PC Lipo,labeled as CPL),both of which only demonstrated antitumor efficacy with once-daily administration.Further evaluation of the in vivo antitumor immune mechanism suggested that the extended antitumor immune efficacy of CPPL could be attributed to its distinct immune-stimulating mechanism when compared with CHA solution and CPL,such as stimulating both CD4+and CD8+T cell infiltration,inhibiting myeloid-derived suppressor cell expression,reducing the expression of Th2 related factors,and notably,increasing the memory T cells in tumor tissues.This CHA-containing formulation could reduce the frequency of in vivo CHA administration during cancer treatment via T cells,especially memory T cell regulation. | Yun Zhang Yanfang Yang Jun Ye Yue Gao Hengfeng Liao Junzhuo Zhou Yu Feng Dongdong Liu Yingying Meng Xiaoguang Chen Lili Gao Yuling Liu | 2021 | Science China(Life Sciences)2021，64，7： | 2 |
| 19 | Expression pattern of dmrt4 from olive flounder (Paralichthys olivaceus) in adult gonads and during embryogenesis显示文摘 | Aiyun Wen Feng You Xungang Tan Peng Sun Jing Ni Yuqing Zhang Dongdong Xu Zhihao Wu Yongli Xu Peijun Zhang | 2009 | Fish Physiology and Biochemistry2009，，3： | 1 |
| 20 | Green Electrospun Silk Fibroin Nanofibers Loaded with Cationic Ethosomes for Transdermal Drug Delivery显示文摘Transdermal drug delivery system(TDDS)facilitates the controlled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific surface area,making them excellent candidates for drug delivery.In current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green electrospinning.The data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF nanofibers.The morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)images.The CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and SEM.Using doxorubicin hydrochloride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse skin.The results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without CEs.The as-spun CEs-SFnP in this study could find promising applications in TDDS. | HONG Huoyan ZHANG Dongdong UN Si HAN Feng WANG Kaili JIANG Di WU Jinglei MO Xiumei WANG Hongsheng | 2021 | Chemical Research in Chinese Universities2021，37，3： | 1 |
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