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| 1 | Exotic origin of the Chinese continental shelf: new insights into the tectonic evolution of the western Pacific and eastern China since the Mesozoic显示文摘The effect of paleo-Pacific subduction on the geological evolution of the western Pacific and continental China is likely complex. Nevertheless, our analysis of the distribution of Mesozoic granitoids in the eastern continental China in space and time has led us to an interesting conclusion: The basement of the continental shelf beneath East and South China Seas may actually be of exotic origin geologically unrelated to the continental lithosphere of eastern China. By accepting the notion that the Jurassic–Cretaceous granitoids in the region are genetically associated with western Pacific subduction and the concept that subduction may cease to continue only if the trench is being jammed, then the termination of the granitoidmagmatism throughout the vast region at *88 ± 2 Ma manifests the likelihood of ‘‘sudden'', or shortly beforehand(*100 Ma), trench jam of the Mesozoic western Pacific subduction. Trench jam happens if the incoming‘‘plate'' or portion of the plate contains a sizeable mass that is too buoyant to subduct. The best candidate for such a buoyant and unsubductable mass is either an oceanic plateau or a micro-continent. We hypothesize that the basement of the Chinese continental shelf represents such an exotic, buoyant and unsubductable mass, rather than seaward extension of the continental lithosphere of eastern China. The locus of the jammed trench(i.e., the suture) is predictably located on the shelf in the vicinity of, and parallel to, the arc-curved coastal line of the southeast continental China. It is not straightforward to locate the locus in the northern section of the East China Sea shelf because of the more recent(\20 Ma) tectonic re-organization associated with the opening of the Sea of Japan. We predict that the trench jam at *100 Ma led to the re-orientation of the Pacific plate motion in the course of NNW direction as inferred from the age-progressive Emperor Seamount Chain of Hawaiian hotspot origin(its oldest unsubdued Meiji and Detroit seamounts are *82 Ma),making the boundary between the Pacific plate and the newly accreted plate of eastern Asia a transform fault at the location east of the continental shelf of exotic origin. This explains the apparent *40 Myr magmatic gap from *88to *50 Ma prior to present-day western Pacific subduction initiation. We propose that basement penetration drilling on well-chosen sites is needed to test the hypothesis in order to reveal the true nature of the Chinese continental shelf basement. This testing becomes critical and cannot longer be neglected in order to genuinely understand the tectonic evolution of the western Pacific and its effect on the geology of eastern China since the Mesozoic, includingthe cratonic lithosphere thinning, related magmatism/mineralization, and the mechanism of the subsequent South China Sea opening, while also offering novel perspectives on aspects of the plate tectonics theory. We also suggest the importance of future plate tectonic reconstruction of the western Pacific to consider the nature and histories of the Chinese continental shelf of exotic origin as well as the probable transform plate boundary from *100 to*50 Ma. Effort is needed to reveal the true nature and origin of the *88 ± 2 Ma granitic gneisses in Taiwan and the 110–88 Ma granitoids on the Hainan Island. | Yaoling Niu Yi Liu Qiqi Xue Fengli Shao Shuo Chen Meng Duan Pengyuan Guo Hongmei Gong Yan Hu Zhenxing Hu Juanjuan Kong Jiyong Li Jinju Liu Pu Sun Wenli Sun Lei Ye Yuanyuan Xiao Yu Zhang | 2015 | Science Bulletin2015，60，18： | 32 |
| 2 | Wide-steering-angle high-resolution optical phased array显示文摘Optical phased array(OPA)technology is considered a promising solution for solid-state beam steering to supersede the traditional mechanical beam steering.As a key component of the LIDAR system for long-range detection,OPAs featuring a wide steering angle and high resolution without beam aliasing are highly desired.However,a wide steering range requires a waveguide pitch less than half of the wavelength,which is easily subjected to cross talk.Besides,high resolution requires a large aperture,and it is normally achieved by a high count number of waveguides,which complicates the control system.To solve the mentioned issues,we design two high-performance 128-channel OPAs fabricated on a multilayered SiN-on-SOI platform.Attributed to the nonuniform antenna pitch,only 128 waveguides are used to achieve a 4 mm wide aperture.Besides,by virtue of innovative dual-level silicon nitride(Si_(3)N_(4))waveguide grating antennas,the fishbone antenna OPA achieves a 100°×19.4°field of view(FOV)with divergence of 0.021°×0.029°,and the chain antenna OPA realizes a 140°×19.23°FOV with divergence of 0.021°×0.1°.To our best knowledge,140°is the widest lateral steering range in two-dimensional OPA,and 0.029°is the smallest longitudinal divergence.Finally,we embed the OPA into a frequency-modulated continuous-wave system to achieve 100 m distance measurement.The reflected signal from 100 m distance is well detected with 26 dBm input transmitter power,which proves that OPA serves as a promising candidate for transceiving optical signal in a LIDAR system. | YINGZHI LI BAISONG CHEN QUANXIN NA QIJIE XIE MIN TAO LANXUAN ZHANG ZIHAO ZHI YUXUAN LI XIAOBIN LIU XIANSHU LUO GUOQIANG LO FENGLI GAO XUEYAN LI JUNFENG SONG | 2021 | Photonics Research2021，9，12： | 7 |
| 3 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6suv9kq0qxw5uu66v9.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 4 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 5 | Synthesis of Visible-Light-Driven g-C3N4/PPy/Ag Ternary Photocatalyst with Improved Photocatalytic Performance显示文摘 | Fengli Zhang Fang Duan Zhigang Ding Mingqing Chen | 2017 | Chinese Journal of Chemistry2017，35，2： | 3 |
| 6 | Artificial intelligence-assisted automatic and index-based microbial single-cell sorting system for One-Cell-One-Tube显示文摘Identification,sorting,and sequencing of individual cells directly from in situ samples have great potential for in-depth analysis of the structure and function of microbiomes.In this work,based on an artificial intelligence(AI)-assisted object detection model for cell phenotype screening and a cross-interface contact method for single-cell exporting,we developed an automatic and index-based system called EasySort AUTO,where individual microbial cells are sorted and then packaged in a microdroplet and automatically exported in a precisely indexed,“One-Cell-One-Tube”manner.The target cell is automatically identified based on an AI-assisted object detection model and then mobilized via an optical tweezer for sorting.Then,a crossinterface contact microfluidic printing method that we developed enables the automated transfer of cells from the chip to the tube,which leads to coupling with subsequent single-cell culture or sequencing.The efficiency of the system for single-cell printing is>93%.The throughput of the system for single-cell printing is~120 cells/h.Moreover,>80%of single cells of both yeast and Escherichia coli are culturable,suggesting the superior preservation of cell viability during sorting.Finally,AI-assisted object detection supports automated sorting of target cells with high accuracy from mixed yeast samples,which was validated by downstream single-cell proliferation assays.The automation,index maintenance,and vitality preservation of EasySort AUTO suggest its excellent application potential for single-cell sorting. | Zhidian Diao Lingyan Kan Yilong Zhao Jingyun Song Chen Wang Yang Liu Fengli Zhang Teng Xu Rongze Chen Xixian Wang Xiaoyan Jing Jian Xu Yuandong Li Bo Ma | 2022 | mLife2022，1，4： | 2 |
| 7 | Design,fabrication and characterization of the X-ray supermirrors显示文摘The design, fabrication and characterization of the X-ray supermirrors are discussed in this paper. Using the local optimization method of simplex algorithm and the global one of simulated annealing algorithm with different initial multilayer structures, we designed the broad angular band supermirrors with different grazing incidence angle intervals at the energy of 8.0 keV (the Kα line of Cu) and the broad energetic band supermirrors with different energy intervals at fixed grazing incidence angles. The fabricating techniques for depositing non-periodic multilayers are also studied. The W/C and W/Si supermirrors are deposited on silicon substrates and characterized by a high resolution X-ray D1 diffractometer from Bede Company, UK. Choosing the interface roughness and the densities of the materials as independent variables, some measured reflectivity curves are fitted using the Debye-Waller factor with interface roughness. The experimental results show that the optical performances of the fabricated supermirrors are in agreement with the designed ones. | WANG Zhanshan WANG Fengli ZHANG Zhong CHENG Xinbin QIN Shuji CHEN Lingyan | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，5： | 2 |
| 8 | Temperature field analysis and its application in hot continuous rolling of Inconel 718 superalloy显示文摘A coupled thermo-mechanical model containing metal flow and temperature field for calculating temperature variation has been developed on fourteen-pass hot continu-ous rolling of round rod for Inconel 718 alloy using 3D elastic-plastic finite element method(FEM).The temperature of characteristic analysis points in the intermedi-ate cross-section of the workpiece has been simulated at initial temperature ranging from 960 to 1000 °C and initial velocity in range of 0.15-0.55 m·s-1.Based on fi-nite element analysis and microstructural observation in cylindrical hot compression experiments,the appropriate hot continuous rolling technologies have been designed for rod products with different diameters.For a real rolling practice,the simulated surface temperature was examined and is in good agreement with the measured one. | Fengli SUI Liqing CHEN Xianghua LIU Lintao WANG Wei LI | 2009 | Acta Metallurgica Sinica(English Letters)2009，22，2： | 2 |
| 9 | Baeyer-Villiger Oxidation of Cyclic Ketones Catalyzed by Amino Acid Ionic Liquids显示文摘A series of amino-acid-based ionic liquids was synthesized via one-step protonation of the corresponding L-amiiio acid by utilizing an array of proton sources.The catalytic activity of the amino-acid-based ionic liquids for the Baeyer-Villiger oxidation of cyclic ketones was investigated using cyclopentanone as a model cycloketone.Theproline-based ionic liquid[ProH]CF3SO3 was shown to exliibit thebest catalytic activity.The reaction condition was optimized to give the following reagent ratio of h(cyclopentanone):n(catalyst):w(H2O2)=1:0.06:4,60℃and 6 h.Under the optimum conditions,the conversion of cyclopentanone was 96.57%and the selectivity forδ-valerolactone was 73.01%.The catalytic activity was shown to be constant after 4 cycles.A simple treatment was allowed for the recover and the reuse of[ProH]CF3S03.The successful utilization of[ProH]CF3SO3 to catalyze a host of cyclic ketones via Baeyer-Villiger oxidation clearly demonstrated the capacity of[ProH]CF3S03 to tolerate variation in the substrate. | YU Fengli CHI Yujie GAO Chong CHEN Ruirui XIE Congxia YU Shitao | 2020 | Chemical Research in Chinese Universities2020，36，5： | 1 |
| 10 | SDF-1α upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines显示文摘 | Feng Pan Shijie Ma Weike Cao Haining Liu Fengli Chen Xiaofei Chen Ruihua Shi | 2013 | Molecular Biology Reports2013，，7： | 1 |
| 11 | Targeting histone deacetylases for cancer therapy: Trends and challenges显示文摘Dysregulation of histone deacetylases(HDACs) is closely related to tumor development and progression. As promising anticancer targets, HDACs have gained a great deal of research interests and two decades of effort has led to the approval of five HDAC inhibitors(HDACis). However, currently traditional HDACis, although effective in approved indications, exhibit severe off-target toxicities and low sensitivities against solid tumors, which have urged the development of next-generation of HDACi. This review investigates the biological functions of HDACs, the roles of HDACs in oncogenesis, the structural features of different HDAC isoforms, isoform-selective inhibitors, combination therapies, multitarget agents and HDAC PROTACs. We hope these data could inspire readers with new ideas to develop novel HDACi with good isoform selectivity, efficient anticancer effect, attenuated adverse effect and reduced drug resistance. | Tao Liang Fengli Wang Reham M.Elhassan Yongmei Cheng Xiaolei Tang Wengang Chen Hao Fang Xuben Hou | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 1 |
| 12 | Design, fabrication and characterization of the X-ray supermirrors显示文摘 | Zhanshan Wang Fengli Wang Zhong Zhang Xinbin Cheng Shuji Qin Lingyan Chen | 2005 | Science in China Series G: Physics and Astronomy2005，，5： | 1 |
| 13 | Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis显示文摘眼的裂缝() 在将近所有网膜的祖先房间区别发生了以前,是关门的发展中的脊椎动物眼睛的腹的方面上的短暂开始。关上 OF 的失败导致 coloboma,是童年盲目的一个主要原因的先天的疾病。尽管人的基因研究和动物模型连接了很多基因到 coloboma,驾驶 OF 的闭合的细胞、分子的机制大部分仍然是不清楚的。在这研究,我们使用了 Cre-LoxP-mediated 成纤维细胞生长的有条件的移动因素(FGF ) 受体, Fgfr1 和 Fgfr2,从发展,眼的杯(OC ) 调整关门 OF 显示出发信号的那 FGF。我们的分子,细胞并且 Fgfr1 和 Fgfr2 的 transcriptome 分析加倍有条件的猛烈 OC 建议发信号的 FGF 通过网膜的祖先房间增长,命运说明和词法变化的调整控制 OF 闭合。而且, Fgfr1 和 Fgfr2 加倍房间没能开始网膜的中心房间(RGC ) 的有条件的变异的网膜的祖先开始。一起拿,我们基因研究揭示的鼠标发信号的那 FGF 是必要的为形态发生和 RGC 开发。 | Shuyi Chen Hua Li Karin Gaudenz Ariel Paulson Fengli Guo Rhonda Trimble Allison Peak Christopher Seidel Chuxia Deng Yasuhide Furuta Ting Xie | 2013 | Cell Research2013，23，2： | 1 |
| 14 | TRANSCUTANEOUS ACUPOINT ELECTRIC STIMULATION IN COMBINATION WITH ENFLURANE ANESTHESIA FOR CRANIOCEREBRAL OPERATIONS显示文摘The reinforcing effect of transcutaneous acupoint electric stimulation(TAES)on enflurane anesthesia during craniotomy was studied.One hundred and ten neurosurgical patientswere randomly divided into three groups.Anesthesia was maintained with enflurane in Group A(n=40).In Group B,enflurane anesthesia was supplemented by TAES with Han’s acupoint nerve stimu-lator(HANS)at Hegu(LI 4),Yuyao(EX-HN 4)and Fengchi(GB 20)points on the operated side(n=40).In Group C,enflurane anesthesia was supplemented by TAES and scalp infiltration with 0.5%procaine solution(n=30).The results showed that the minimum alveolar concentration(MAC)of enflurane in Group B and C decreased by 37.8-47.0%and 42.1-66.1%respectively than thatin Group A.The hemodynamics was more stable during operation,and the patients recovered after operation in group B and C.It was concluded that TAES with HANS significantly the anesthetic effect and decreased the side effects of enflurane during operation,and that the triplecombination of TAES,enflurane and scalp infiltration with procaine appeared to be a better anestheticmethod for craniotomy. | Wang Baoguo Wang Enzhen Chen Xinzhong Sun Fengli Yang Enhua, Beijing Tiantan Hospital, Beijing 100050, China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，3： | 1 |
| 15 | Development of corrector magnet power supply for high energy photon source显示文摘Purpose High Energy Photon Source(HEPS)requires high quality,high energy beam and ultra-low emittance of 0.1 nm·rad,which puts forward high demand for power supply.In this paper,a high-performance corrector magnet power supply is developed to calibrate and adjust beam track within a certain bandwidth range to ensure the stability of beam track.Methods The prototype of power supply adopts the new'One control Two'control mode,which adjusts the performance of two power supplies simultaneously based on digital control.Results The experimental results show that the stability of the power supply is lower than 20 ppm,which is far better than the design index.Voltage ripple is less than 10 mV,and other performance indexes meet the physical design requirements,which can well meet the requirements of HEPS construction.Conclusions After a lot of experiments and tests,all the parameters passed the design indicators.The successful development of this power supply has laid a foundation for the successful application of HEPS. | Han Chao Long Fengli Gao Yao Wei Pengfei Liu Yuting Guo Xiaoling Chen Suying Du Yunze | 2022 | Radiation Detection Technology and Methods2022，6，4： | 1 |
| 16 | Palladium and ceria infiltrated La 0.8 Sr 0.2 Co 0.5 Fe 0.5 O 3? δ cathodes of solid oxide fuel cells显示文摘 | Jing Chen Fengli Liang Bo Chi Jian Pu San Ping Jiang Li Jian | 2009 | Journal of Power Sources2009，，1： | 1 |
| 17 | Processing map for hot working of Inconel 718 alloy显示文摘 | SUI 'Fengli XU Lixia CHEN Liqing | 2011 | Journal of Materials Processing Technology2011，211，： | 1 |
| 18 | Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques显示文摘SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains elusive.In this study,comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed.Compared to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ventricle.Intriguingly,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related genes.Meanwhile,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral cortex.Based on our findings,neuropilin 1(NRP1),a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral encephalitis.Overall,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-19-asso-ciated clinical complications. | Chun-Chun Gao Man Li Wei Deng Chun-Hui Ma Yu-Sheng Chen Yong-Qiao Sun Tingfu Du Qian-Lan Liu Wen-Jie Li Bing Zhang Lihong Sun Si-Meng Liu Fengli Li Feifei Qi Yajin Qu Xinyang Ge Jiangning Liu Peng Wang Yamei Niu Zhiyong Liang Yong-Liang Zhao Bo Huang Xiao-Zhong Peng Ying Yang Chuan Qin Wei-Min Tong Yun-Gui Yang | 2022 | Protein & Cell2022，13，12： | 1 |
| 19 | Activated carbon-hybridized and amine-modified polyacrylonitrile nanofibers toward ultrahigh and recyclable metal ion and dye adsorption from wastewater显示文摘Nanofibers with high specific surface area and chemical stability have broad prospects in the applications of adsorption.However,the adsorption capacity is limited by the scarcity of adsorption groups and storage space.Herein,the activated carbon-hybridized and amine-modified nanofibers are prepared by integrating activated carbon(AC)and polyacrylonitrile(PAN)via electrospinning method and the subsequent amination,which could provide additional storage space and adsorption groups for ultrahigh adsorption capability.Thus,the obtained amine-rich porous PAN nanofibers(APAN/AC)readily realized the ultrahigh adsorption capacity for metal ions and dyes in wastewater.Specifically,the adsorption capacity of APAN/AC nanofibers were 284 mg·g^(-1) for Cr(VI)and 248 mg·g^(-1) for methyl orange,which were almost 2 and 4 times than that of amine-modified nanofibers(APAN)and carbon-hybridized nanofibers(PAN/AC),respectively.Moreover,the AC inhibited the chain mobility of polymer matrix and thereby endowing APAN/AC nanofibers with excellent recyclability.The adsorption capability retained 80%after nine adsorption-desorption cycles.The adsorption kinetics and corresponding mechanism were further explored.This strategy combines the advantages of polymer nanofibers and AC,opening a new avenue for developing next-generation absorbent materials. | Fengli Li Chuang Chen Yuda Wang Wenpeng Li Guoli Zhou Haoqin Zhang Jie Zhang Jingtao Wang | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 1 |
| 20 | Genistein Inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 Expression of HUVECs Through Heme Oxygenase-1显示文摘 | Huaping Zhang Fengli Zheng Jiahui Zhao Dongxing Guo Xiaolong Chen | 2012 | Archives of Medical Research2012，，： | 1 |
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