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| 1 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites显示文摘 | Cai Yibing Wei Qufu Huang Fenglin | 2008 | Appl Energy2008，85，： | 1 |
| 4 | Semantic Driven Design Reuse for 3D Scene Modeling 显示文摘 | Cao Xue Cai Hongming Bu Fenglin | 2012 | JournaI of ShanghaiJiaotong University (Science)2012，，2： | 1 |
| 5 | Thermal stability,latent heat and flame retardant properties of the thermal energy storage phase change materials based on paraffin/high density polyethylene composites显示文摘 | Yibing Cai Qufu Wei Fenglin Huang | 2009 | Renewable Energy2009，34，10： | 1 |
| 6 | Comparison between structures and properties of ABS nanocomposites derived from two different kinds of OMT 显示文摘 | CAI Yibing HUANG Fenglin XIA Xin | 2010 | J Mater Eng Perform2010，19，2： | 1 |
| 7 | Thermal sta- bility, latent heat and flame retardant properties of the thermal energy storage phase change materials based on paraffin/high density polyethylene composites显示文摘 | CAI Yibing WEI Qufu HUANG Fenglin | 2009 | Renew- able Energy2009，34，10： | 1 |
| 8 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites 显示文摘 | CAI Yibing WEI Qufu HUANG Fenglin | 2008 | Applied Energy2008，85，： | 1 |
| 9 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin / high density polyethylene composites显示文摘 | Cai Yibing Wei Qufu Huang Fenglin | 2008 | Applied Energy2008，85，8： | 1 |
| 10 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites显示文摘 | Yibing Cai Qufu Wei Fenglin Huang | 2008 | Applied Energy2008，85，8： | 1 |
| 11 | Preparation and properties studies of halogen-free flame retardant form-stable phase change materials based on paraffin/high density polyethylene composites 显示文摘 | CAI Yibing WEI Qufu HUANG Fenglin | 2005 | Appl Energ2005，85，5： | 1 |
| 12 | Thermal stability, latent heat and flame retardant properties of the thermal energy storage phase change materials based on paraffin/high density polyethylene composites 显示文摘 | CAI Yibing WEI Qufu HUANG Fenglin | 2009 | Renewable Energ2009，34，9： | 1 |
| 13 | CONFORMATION ANALYSIS OF GUANOSINE-5'-DIPHOSPHO-FUCOSE显示文摘CONFORMATIONANALYSISOFGUANOSINE-5'-DIPHOSPHO-FUCOSEMinBoCHEN;YuLIU;ZhongWuGUO;GeQingCAI(ShanghaiInstituteofCrganicofOrganicCh... | Min Bo CHEN Yu LIU Zhong Wu GUO Ge Qing CAI(Shanghai Institute of Crganic of Organic Chemistry Chinese Academy of Sciences,354 Fenglin Road. Shanghai 200032) | 1996 | Chinese Chemical Letters1996，7，1： | 0 |
| 14 | Urban built heritage protection and realistic dilemmas:the development process,protection system,and critical thinking of historic districts in Dalian显示文摘In China,the northeastern region has preserved many valuable modern built heritage buildings,which are undergoing difficult exploratory protection during the industrial and urbanisation process.Taking Dalian city as a case study,this article retraces the history of Dalian’s opening up and colonial management from the perspective of urban planning and historic district protection and management systems.This article sorts out the influence of national and local institutional policies on Dalian’s urban construction and development to analyse the past evolution,current problems and internal causes of the renovation and protection of Dalian’s typical historic districts.This influence is mainly reflected in the lack of protection and damage done to unofficial heritage,the disconnection between historic districts and the surrounding environments and urban textures,and the Chinese-style transformation and economic decline of exotic areas.This paper calls for attention to and the rapid clarification of the built heritage list,the improvement of planning and protection systems and related supporting policies,and a focus on the protection of the authenticity of colonial heritage.This paper provides strategic guidance for improving the protection of historic districts in Dalian in Northeast China and hopes to serve as a reference for the protection of built heritage in other nonfamous historic and cultural cities. | Hongchi Zhang Fenglin Wang Fei Guo Jun Cai Jing Dong | 2023 | Built Heritage2023，7，4： | 0 |
| 15 | CONFORMATION ANALYSIS OF TUNICAMYCIN V AND ITS NATURAL SUBSTRATE显示文摘CONFORMATIONANALYSISOFTUNICAMYCINVANDITSNATURALSUBSTRATE￥MinBoCHEN;YuLIU;ZhongWuGUO;GeQingCAI(ShanghaiInstituteofOrganicChemi... | Min Bo CHEN Yu LIU Zhong Wu GUO Ge Qing CAI(Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,354 Fenglin Road,Shanghai 200032) | 1996 | Chinese Chemical Letters1996，7，2： | 0 |
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