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| 1 | Synthesis and characterization of an environmentally friendly PHBV/PEG copolymer network as a phase change material显示文摘Novel environmentally friendly poly(hydroxybutyrate-co-hydroxyvalerate) and poly(ethylene glycol) (PHBV/PEG) copolymer networks were synthesized through free-radical solution polymerization with PHBV diacrylate (PHBVDA) and polyethylene glycol diacrylate (PEGDA) as macromers. The molecular structure of PHBV/PEG copolymer network was characterized by Fourier transform infrared (FT-IR) and 1 H nuclear magnetic resonance ( 1 H NMR). The morphology of the PHBV/PEG copolymer network was characterized by polarization optical microscopy. Thermal energy storage properties, thermal reliability and thermal stability were investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis. The results indicated that the PHBV/PEG copolymer network hindered the growth of PEG crystalline segments or PHBV segments. PHBV/PEG copolymer network had a higher latent heat enthalpy, which didn't reduce with the components of PHBV increased. Moreover, PHBV/PEG copolymer network still had good thermal stability even at 300 ℃. These results suggested that such environmentally friendly copolymer network would have wide applications in phase change energy storage materials. | XIANG HengXue WANG ShiChao WANG RenLin ZHOU Zhe PENG Cheng ZHU MeiFang | 2013 | Science China Chemistry2013，56，6： | 18 |
| 2 | Isoliquiritigenin inhibits TGF-β1-induced fibrogenesis through activating autophagy via PI3K/AKT/mTOR pathway in MRC-5 cells显示文摘Isoliquiritigenin(ISL),a natural flavonoid derived from the root of liquorice,has been reported to possess anti-inflammatory and antioxidant activities.Previous studies have found that ISL plays a crucial role in anti-fibrosis of adipose tissue and renal tissue;however,its effect on pulmonary fibrogenesis has not been demonstrated.In this study,we aimed to explore the roles and the underlying mechanisms of ISL in TGF-β1-induced fibrogenesis using human lung fibroblast-derived MRC-5 cells.Cell proliferation and migration were determined by MTT and wound healing assay,respectively.The expression levels of alpha-smooth muscle actin(α-SMA),collagen type I alpha 1(COLIA1)and fibronectin(FN),microtubule-associated protein light chain 3(LC3)and related signaling molecules were detected by quantitative real-time PCR,western blot and immunofluorescence assay,correspondingly.EGFP-LC3 transfection was used for autophagy analysis.The results showed that ISL inhibited the TGF-β1-induced proliferation and migration,and down-regulated the expressions ofα-SMA,COLIA1 and FN.ISL treatment led to up-regulation of LC3 in TGF-β1-treated MRC-5 cells,accompanied by significant decrease in the phosphorylation levels of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT),and mammalian target of rapamycin(mTOR).In addition,the inhibitory effects of ISL on TGF-β1-induced fibrogenic features in MRC-5 cells were enhanced by pretreatment with autophagy activator Rapmycin and PI3K/AKT inhibitor LY294002 and reversed by autophagy inhibitor 3-methyladenine and PI3K/AKT activator IGF-1.Taken together,our results demonstrated that ISL could attenuate the fibrogenesis of TGF-β1-treated MRC-5 cells by activating autophagy via suppressing the PI3K/AKT/mTOR pathway.Therefore,ISL holds a great potential to be developed as a novel therapeutic agent for the treatment of pulmonary fibrosis. | Jinjuan He Hao Peng Meifang Wang Ying Liu Xingrong Guo Bin Wang Longjun Dai Xueqin Cheng Zhongji Meng Leyong Yuan Fenglin Cai Yijun Tang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 16 |
| 3 | Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents,β-ionone and linalool显示文摘Sweet osmanthus(Osmanthus fragrans Lour.)is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.Here,manual sectioning,scanning electron microscopy,and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces.However,no secretory structures were observed.Instead,the petal cells protrude slightly outward,and the surfaces of the cells are adorned with highly regular brush-shaped hairs.The surfaces of the‘Yingui’petals possessed mostly curled and more numerous hairs,whereas the‘Dangui’petals possessed fewer brush-shaped and more sparsely arranged hairs.In addition,many granular substances were attached to the brush-shaped hairs,and the granules were denser on the hairs of the‘Yingui’petals compared to the hairs on the‘Dangui’petals.Furthermore,35 aromatic components in the‘Yingui’petals and 30 aromatic components in the‘Dangui’petals were detected via GC-MS.The main aromatic component of the‘Yingui’petals wasβ-ionone,whereas that of the‘Dangui’petals was linalool and its oxides.Transcriptome sequencing and qRT-PCR indicated that the highβ-ionone content in the‘Yingui’petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the‘Dangui’petals was due to the overexpression of MECS,HDR,IDI1,and LIS1,which function upstream of the linalool synthetic pathway.In particular,the expression levels of CCD4 and LIS1 were upregulated by 5.5-and 5.1-fold in the‘Yingui’and‘Dangui’petals,respectively.One transcription factor(ERF61)was cloned and named,and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4.Tobacco transformation experiments,yeast one-hybrid experiments,and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression,thereby regulating the synthesis ofβ-ionone in sweet osmanthus petals. | Yuanji Han Hongyun Wang Xiaodan Wang Ke Li Meifang Dong Yong Li Qian Zhu Fude Shang | 2019 | Horticulture Research2019，6，1： | 13 |
| 4 | Magnetic resonance study of the structure and function of the hippocampus and amygdala in patients with depression显示文摘 | Li Yuefeng Yan Jinchuan Wang Dongqing Sun Meifang Zhu Yan Zhu Xiaolan Jiang Ping Yin Ruigen Zhao Liang | 2014 | Chinese Medical Journal2014，，20： | 6 |
| 5 | Novel Ag nanocrystals based dental resin composites with enhanced mechanical and antibacterial properties显示文摘The aim of this work was to investigate the effect of trace addition of oleic acid coated Ag nanocrystals(Ag NCs) on mechanical and antibacterial properties of dental resin composites.Composites(70 wt%of silica loading) with 25 ppm,50 ppm,75 ppm and 100 ppm(wt) Ag NCs were prepared and the composite without Ag NCs served as a control.The experimental results showed that the addition of Ag NCs significantly improved the strength and modulus of the resin composite without compromising the shade.For the composite with 50 ppm Ag NCs,fiexural strength(140.3 MPa),modulus(13.2 GPa)and compressive strength(347.2 MPa) were increased by 4.1%,22.2%,13.3%,respectively,compared with the control.The antibacterial test demonstrated that trace Ag NCs provided the resin composites with an antibacterial effect.Such strong and antibacterial dental resin composites might be advantageous to prevent secondary caries and be potential for future clinical applications. | Fengwei Liu Ruili Wang Yuyuan Shi Xiaoze Jiang Bin Sun Meifang Zhu | 2013 | Progress in Natural Science:Materials International2013，23，6： | 5 |
| 6 | Lignin-based carbon fibers: Formation, modification and potential applications显示文摘As an aromatic polymer in nature, lignin has recently attracted gross attention because of its advantages of high carbon content, low cost and bio-renewability. However, most lignin is directly burnt for power generation to satisfy the energy demand of the pulp mills. As a result, only a handful of isolated lignin is used as a raw material. Thus, increasing value addition on lignin to expand its scope of applications is currently a challenge demanding immediate attention. Many efforts have been made in the valorization of lignin, including the preparation of precursors for carbon fibers. However, its complex structure and diversity significantly restrict the spinnability of lignin. In this review, we provide elaborate knowledge on the preparation of lignin-based carbon fibers ranging from the relationships among chemical structures, formation conditions and properties of fibers, to their potential applications. Specifically, control procedures for different spinning methods of lignin, including melt spinning, solution spinning and electrospinning, together with stabilization and carbonization are deeply discussed to provide an overall understanding towards the formation of lignin-based carbon fibers. We also offer perspectives on the challenges and new directions for future development of lignin-based carbon fibers. | Shichao Wang Jixing Bai Mugaanire Tendo Innocent Qianqian Wang Hengxue Xiang Jianguo Tang Meifang Zhu | 2022 | Green Energy & Environment2022，7，4： | 5 |
| 7 | Flight dynamics modeling of a small ducted fan aerial vehicle based on parameter identifcation显示文摘This paper presents a simple and useful modeling method to acquire a dynamics model of an aerial vehicle containing unknown parameters using mechanism modeling,and then to design different identifcation experiments to identify the parameters based on the sources and features of its unknown parameters.Based on the mathematical model of the aerial vehicle acquired by modeling and identifcation,a design for the structural parameters of the attitude control system is carried out,and the results of the attitude control flaps are verifed by simulation experiments and flight tests of the aerial vehicle.Results of the mathematical simulation and flight tests show that the mathematical model acquired using parameter identifcation is comparatively accurate and of clear mechanics,and can be used as the reference and basis for the structural design. | Wang Zhengjie Liu Zhijun Fan Ningjun Guo Meifang | 2013 | Chinese Journal of Aeronautics2013，26，6： | 5 |
| 8 | The role of β18-β19 loop structure in insecticidal activity of Cry1Ac toxin from Bacillus thuringiensis显示文摘The β18-β19 loop in domain III of Cry1Ac toxin is unique among Bacillus thuringiensis Cry proteins. In this study, the role of the loop structure in insecticidal activity of Cry1Ac toxin was investigated. Alanine scanning mutations within the loop were initially generated and most mutants were over-expressed and reduced toxicity at different degrees, except mutant N546A that showed almost 2 times enhanced toxicity against Helicoverpa armigera larvae. Further mutagenic analysis of N546 revealed that a charged amino acid in this position would cause very unfavorable influence on insecticidal activity. In addition, the deletion of N546 led to protein instability because of destruction of the loop integrity. Besides, mutant W544F was much more toxic than W544Y, indicating that hydrophobic nature of the position was important for maintaining the stability and activity of Cry1Ac protein. These findings are the first biological evidence for a structural function of β18-β19 loop in insecticidal activity of the Cry1Ac toxin. | XIA LiQiu WANG FaXiang DING XueZhi ZHAO XinMin FU ZuJiao QUAN MeiFang YU ZiNiu | 2008 | Chinese Science Bulletin2008，53，20： | 4 |
| 9 | PHYSICAL PROPERTIES OF SHORT CARBON FIBRE REINFORCED SILVER COMPOSITES显示文摘The electric contact is always made of silver and graphite,the electric conductivity of con-tact materials decreases as the graphite content increased.The hardness of silver-graphiteis low,for example,the hardness of the 3wt% graphite-silver is HB 24.5-39.8MPa,andthe electric conductivity,is 72% IACS.The present work reports the similarity of electricconductivity for the 3wt% short carbon fibre-Ag composite and 3wt% graphite-silver.However,the hardness of the short carbon fiber-Ag composite is two times harder thanthat of graphite-silver. The specific gravity of graphite is 2.2g/cm^3,and that of carbonfibre is 1.75g/cm^3,so the 3wt% short carbon fibre-Ag composite contact will still save5-7%Ag.The electric life of Ag-carbon fibre is much higher than silver-graphite at thesame Ag contact. | WANG Chengfu, YING Meifang, FENG Yi, ZHANG XiaogunHefei University of Technology. Hefei, China | 1994 | Acta Metallurgica Sinica(English Letters)1994，7，3： | 4 |
| 10 | Recent progress in ICF target fabrication at RCLF显示文摘Target is one of the essential parts in inertial confinement fusion(ICF)experiments.To ensure the symmetry and hydrodynamic stability in the implosion,there are stringent specifications for the target.Driven by the need to fabricate the target required by ICF experiments,a series of target fabrication techniques,including capsule fabrication techniques and the techniques of target characterization and assembly,are developed by the Research Center of Laser Fusion(RCLF),China Academy of Engineering Physics(CAEP).The capsule fabrication techniques for preparing polymer shells,glow discharge polymer(GDP)shells and hollow glass micro-sphere(HGM)are studied,and the techniques of target characterization and assembly are also investigated in this paper.Fundamental research about the target fabrication is also done to improve the quality of the target.Based on the development of target fabrication techniques,some kinds of target have been prepared and applied in the ICF experiments. | Kai Du Meifang Liu Tao Wang Xiaoshan He Zongwei Wang Juan Zhang | 2018 | Matter and Radiation at Extremes2018，3，3： | 4 |
| 11 | High thermal stability Cu_(2)O@OZrP micro-nano hybrids for melt-spun excellent antibacterial activity polyester fibers显示文摘Public safety incidents caused by bacterial infections have attracted widespread attention towards antibacterial textiles(fibers,fabrics,etc.).Nevertheless,it is still challenging to efficiently load inorganic nano-antibacterial materials in polymer fibers.In this work,zirconium phosphate(ZrP,layered micro-nano materials)was utilized as a micro-nano carrier.The octadecyl triphenyl phosphonium bromide(OTP)was intercalated between the ZrP sheets by the ion exchange method to improve the carrier-polymer compatibility and the antibacterial performance.Through in-situ chemical reduction,the ultra-small nano-sized cuprous oxide(Cu_(2)O<5 nm)was loaded on the outer surface of ZrP to realize the uniform and stable dispersion of the Cu_(2)O on the carrier and improve the antibacterial performance.The ZrP nanosheets loaded with Cu_(2)O and OTP(Cu_(2)O@OZrP)had excellent antibacterial properties,and the antibacterial rate against E.coli,S.aureus and C.albicans was more than 99%.The intercalation amount of OTP in Cu_(2)O@OZrP can reach 16%,and the thermal stability was excellent and a significant increase in the Zeta potential.Indeed,the decomposition temperature was greater than 350℃,which was suitable for high-temperature melt processing of polymers.Consequently,we prepared PET/Cu_(2)O@OZrP fibers using polyethylene glycol terephthalate(PET),which accounts for 70%of the total chemical fibers,as the fiber matrix.PET/Cu_(2)O@OZrP fibers exhibited excellent mechanical property and antibacterial performance when the content of Cu_(2)O@OZrP was only 0.2%.The antibacterial rate against five types of bacteria including super bacteria(MRSA,VRE)was more than 99%. | Jialiang Zhou Yaping Wang Weinan Pan Hengxue Xiang Peng Li Zhe Zhou Meifang Zhu | 2021 | Journal of Materials Science & Technology2021，，22： | 4 |
| 12 | Preparation and performance of lipophilic α-zirconium phosphate with high thermal stability and its application in thermal-plastic polymers显示文摘To prepare lipophilic α-zirconium phosphate with high grafting ratio and thermal stability(OZrP-HT) and explore its potential application in thermal-plastic polymers,a novel method was developed by surface lipophilicity enhancement strategy.The commercial a-zirconium phosphate(a-ZrP) was pre-intercalated by n-propylamine(PA) and grafted by silane coupling agents.Then the pre-intercalated PA was removed by heattreatment,and the obtained OZrP-HT was utilized to fabricate the phosphorous-containing polyester(P-co-PET)/OZrP-HT nanocomposites by melt-blending method.The prepared OZrP-HT and P-co-PET/OZrP-HT nanocomposites were characterized by Wide Angle X-ray Diffraction(WAXD),Fourier Transform Infrared Spectroscopy(FTIR),Thermogravimetric Analysis(TGA),Transmission Electron Microscope(TEM),etc.The results show that OZrP-HT with high grafting ratio(13.78 wt%) and thermal stability(T_(onset)= 368℃) was successfully prepared via this novel method and was uniformly intercalated by P-co-PET molecular chains.OZrP-HT had no significant effect on the fiber processability of P-co-PET polymer,and flame retardant properties of(P-co-PET)/OZrP-HT nanocomposites were improved.This method may be suitable for organic modification of general inorganic layered compounds and could extend the potential applications in thermo-plastic polymers. | Ya Du Feng Deng Xiaoze Jiang Huquan Ji Dan Yu Wei Wang Bin Sun Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，5： | 3 |
| 13 | Effects of Nutritional Factors on the Growth and Heterotrophic Eicosapentaenoic Acid Production of Diatom Nitzschia laevis显示文摘The effects of several nutritional factors on the growth and eicosapentaenoic acid(EPA) production of diatom Nitzschia laevis were studied. 4 LDM(quadrupled concentration of the nutrient salt) was the optimal concentration of nutrient salt for the growth and EPA production of N. laevis. The growth of N. laevis was inhibited when the glucose concentration was either lower than 10 gL-1 or higher than 15 gL-1. Both sodium nitrate and urea were good nitrogen sources for the growth and EPA production,while ammonium chloride seriously decreased the dry cell weight(DW) and the EPA content. Silicate seriously influenced the growth of N. laevis. The maximum DW of 2.34 gL-1 was obtained in the presence of 150 mgL-1 Na2SiO3· 9H2O. The EPA content remained almost the same when the silicate concentration was lower than 150 mgL-1;however,higher silicate concentrations resulted in a steady de-crease of EPA content. Low medium salinity(≤29) did not seem to influence the DW of N. laevis,and high salinity resulted in a decrease of DW. The highest EPA content(4.08%) and yield(110 mgL-1) were observed at the salinity of 36 and 29,respectively. | CAO Xiaohong LI Songyao WANG Chunling LU Meifang | 2008 | Journal of Ocean University of China2008，7，3： | 3 |
| 14 | Antibiotics-mediated intestinal microbiome perturbation aggravates tacrolimus-induced glucose disorders in mice显示文摘Both immunosuppressants and antibiotics (ABX) are indispensable for transplant patients. However, the former increases the risk of new-onset diabetes, whereas the latter impacts intestinal microbiota (IM). It is still unclear whether and how the interaction between immunosuppressants and ABX alters the IM and thus leads to glucose metabolism disorders. This study examined the alterations of glucose and lipid metabolism and IM in mice exposed to tacrolimus (TAC) with or without ABX. We found that ABX further aggravated TAC-induced glucose tolerance and increased insulin secretion. Combined treatment resulted in exacerbated lipid accumulation in the liver. TAC-altered microbial community was further amplified by ABX administration, as characterized by reductions in phylum Firmicutes, family Lachnospiraceae, and genus Copyococcus. Analyses based on the metagenomic profiles revealed that ABX augmented the effect of TAC on microbial metabolic function mostly related to lipid metabolism. The altered components of gut microbiome and predicted microbial functional profiles showed significant correlation with hepatic lipid accumulation and glucose disorders. In conclusion, ABX aggravated the effect of TAC on the microbiome and its metabolic capacities, which might contribute to hepatic lipid accumulation and glucose disorders. These findings suggest that the ABX-altered microbiome can amplify the diabetogenic effect of TAC and could be a novel therapeutic target for patients. | Yuqiu Han Xiangyang Jiang Qi Ling Li Wu Pin Wu Ruiqi Tang Xiaowei Xu Meifang Yang Lijiang Zhang Weiwei Zhu Baohong Wang Lanjuan Li | 2019 | Frontiers of Medicine2019，13，4： | 3 |
| 15 | In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures显示文摘 | Chao Ni Yuhui Chen Musheng Zeng Rongjuan Pei Yong Du Linquan Tang Mengyi Wang Yazhuo Hu Hanyu Zhu Meifang He Xiawei Wei Shan Wang Xiangkai Ning Manna Wang Jufang Wang Li Ma Xinwen Chen Qiang Sun Hong Tang Ying Wang Xiaoning Wang | 2015 | Cell Research2015，25，7： | 3 |
| 16 | Synthesis of dental resins using diatomite and nano-sized SiO_2 and TiO_2 | Xiaoli Miao a,Meifang Zhu a,Yaogang Li b,Qinghong Zhang b,Hongzhi Wang a a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University,Shanghai 201620,China b Engineering Research Center of Advanced Glasses Manufacturing Technology,MOE,Donghua University,Shanghai 201620,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 17 | Psychometric properties of the Spence Children’s Anxiety Scale (SCAS) in Mainland Chinese children and adolescents显示文摘 | Jinxia Zhao Xiaopei Xing Meifang Wang | 2012 | Journal of Anxiety Disorders2012，，7： | 2 |
| 18 | Rhizobial infection triggers systemic transport of endogenous RNAs between shoots and roots in soybean显示文摘Legumes have evolved a symbiotic relationship with rhizobial bacteria and their roots form unique nitrogen-fixing organs called nodules.Studies have shown that abiotic and biotic stresses alter the profile of gene expression and transcript mobility in plants.However,little is known about the systemic transport of RNA between roots and shoots in response to rhizobial infection on a genome-wide scale during the formation of legume-rhizobia symbiosis.In our study,we found that two soybean(Glycine max)cultivars,Peking and Williams,show a high frequency of single nucleotide polymorphisms;this allowed us to characterize the origin and mobility of transcripts in hetero-grafts of these two cultivars.We identified 4,552 genes that produce mobile RNAs in soybean,and found that rhizobial infection triggers mass transport of m RNAs between shoots and roots at the early stage of nodulation.The majority of these mRNAs are of relatively low abundance and their transport occurs in a selective manner in soybean plants.Notably,the mRNAs that moved from shoots to roots at the early stage of nodulation were enriched in many nodule-related responsive processes.Moreover,the transcripts of many known symbiosis-related genes that are induced by rhizobial infection can move between shoots and roots.Our findings provide a deeper understanding of endogenous RNA transport in legume-rhizobia symbiotic processes. | Chen Zhang Meifang Qi Xiaxia Zhang Qi Wang Yanjun Yu Yijing Zhang Zhaosheng Kong | 2020 | Science China(Life Sciences)2020，63，8： | 2 |
| 19 | Phylogenetic Analysis of the Dengue Virus Strains Causing the 2019 Dengue Fever Outbreak in Hainan,China显示文摘Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes spp.mosquitos,causing the acute infectious disease,dengue fever(DF).Until 2019,no dengue outbreak had been reported in Hainan Province for over 20 years.However,in early September of 2019,an increasing number of infected cases appeared and the DF outbreak lasted for over one month in Haikou City,Hainan Province.In our study,we collected 97 plasma samples from DF patients at three hospitals,as well as 1585 mosquito larvae samples from puddles in different areas of Haikou.There were 49(50.5%)plasma samples found to be strongly positive and 9(9.3%)plasma samples were weakly positive against the NS1 antigen.We discovered DENV both in the patient's plasma samples and mosquito larvae samples,and isolated the virus from C6/36 cells inoculated with the acute phase serum of patients.Phylogenetic analysis revealed that the new strains were the most closely related to the epidemic strain in the southern regions of China,belonging to lineageⅣ,genotypeⅠ,DENV-1.Compared to the seven closest strains from neighboring countries and provinces,a total of 18 amino acid mutations occurred in the coding sequences(CDS)of the new isolated strain,DENV1 HMU-HKU-2.Our data shows that dengue virus is re-emerged in Hainan,and pose new threats for public health.Thus regular molecular epidemiological surveillance is necessary for control and prevention of DENV transmission. | Jiang Du Liyuan Zhang Xiaoyuan Hu Ruoyan Peng Gaoyu Wang Yi Huang Wenqi Wang Kunliang Wu Qiang Wang Haoxiang Su Fan Yang Yun Zhang Chuanning Tang Xiuji Cui Lina Niu Gang Lu Meifang Xiao Yongguo Du Feifei Yin | 2021 | Virologica Sinica2021，36，4： | 2 |
| 20 | Impacts of human interventions on the seasonal and nodal dynamics of the M_(2)and K_(1)tidal constituents in Lingdingyang Bay of the Zhujiang River Delta,China显示文摘Natural and human-induced changes may exert considerable impacts on the seasonal and nodal dynamics of M2 and K1 tidal constituents.Therefore,quantifying the influences of these factors on tidal regime changes is essential for sustainable water resources management in coastal environments.In this study,the enhanced harmonic analysis was applied to extract the seasonal variability of the M2 and K1 tidal amplitudes and phases at three gauging stations along Lingdingyang Bay of the Zhujiang River Delta.The seasonal dynamics in terms of tidal wave celerity and amplification/damping rate were used to quantify the impacts of human-induced estuarine morphological alterations on M2 and K1 tidal hydrodynamics in inner and outer Lingdingyang Bay.The results show that both tidal amplification/damping rate and wave celerity were considerably increased from the pre-anthropogenic activity period(Pre-AAP)to the post-anthropogenic activity period(Post-AAP)excepting the tidal amplification/damping rate in outer Lingdingyang Bay,and the variations in outer Lingdingyang Bay was larger than those in inner Lingdingyang Bay.The alterations in these two parameters were more significant in flood season than in dry season in both inner and outer Lingdingyang Bay.The seasonal variability of M2 and K1 tidal amplitudes were further quantified using a regression model accounting for the 18.61-year lunar nodal modulation,where this study observes a considerable alteration in M2 constituent owing to human interventions.During the Post-AAP,the M2 amplitudes at the downstream station were larger than those that would have occurred in the absence of strong human interventions,whereas the opposite was true for the upstream station,leading to a substantial decrease in tidal amplification in outer Lingdingyang Bay.However,it is opposite in inner Lingdingyang Bay.The underlying mechanism can be primarily attributed to channel deepening and narrowing caused by human interventions,that resulted in substantial enlargement of the bay volume and reduced the effective bottom friction,leading to faster wave celerity and stronger amplified waves. | Ping Zhang Qingshu Yang Haidong Pan Heng Wang Meifang Xie Huayang Cai Nanyang Chu Liangwen Jia | 2021 | Acta Oceanologica Sinica2021，40，10： | 2 |
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