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| 1 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 2 | Preparation and characteri- zation of PVDF/TiO2 hybrid membranes with ionic liquid modified nano-TiO: particles 显示文摘 | Fengmei Shi Yuxin Ma Jun Ma | 2013 | Joumal of Membrane Science2013，427，： | 1 |
| 3 | Preparation and cha-racterization of PVDF/TiO2 hybrid membranes with differentdosage of nano-TiO2显示文摘 | SHI Fengmei MA Yuxun MA Jun | 2012 | J Membr Sci2012，389，： | 1 |
| 4 | Effect of PEG additive on the morphology and performance of polysul?fone ultrafiltration membranes显示文摘 | Ma Yuxin Shi Fengmei MaJu | 2011 | Desalination2011，272，： | 1 |
| 5 | Temporal and spatial variation in the environmental impacts of China’s resource extraction at the provincial scale显示文摘Introduction:Over the past two decades,China has experienced rapid economic development,which has not only led to a rapid increase in the use of raw materials but has also created environmental problems.This research analyzes the environmental impacts of resource extraction in China at the provincial level,and fully considers the environmental impact of various resources extraction.In addition,it is the first time to quantitatively study the spatial pattern and evolution characteristics of the environmental impacts of China’s resource extraction from multiple perspectives by means of spatial visualization.Outcomes:The results showed that the center of gravity of abiotic depletion potential(ADP)moved northwest,respiratory inorganics(RI)moved southwest and global warming potential(GWP)moved west.The results of the standard deviation ellipse showed that RI and GWP varied over time and space,while ADP showed a discrete trend.In addition,the distribution of the four in the northeast-southwest direction became more prominent.Conclusion:To mitigate the environmental impacts of resource extraction,we recommend that regional governments implement measures to control environmental impacts in the provinces within the distributed ellipse and design targeted policies based on actual conditions. | He-Ming Wang Yao Wei Shen Zhao Guang-Xin Liu Fengmei Ma Guo-Qiang Wang Yao Wang Xin-Zhe Wang Dong Yang Jing-Ru Liu Hong-Tao Wang Feng Shi Wei-Qiang Chen | 2020 | Ecosystem Health and Sustainability2020，6，1： | 1 |
| 6 | Effect of PEG additive on the morphology and performance of polysulfone ulWafiltmtion membranes 显示文摘 | Yuxin Ma Fengmei Shi Jun Ma | 2011 | Desalination2011，272，： | 1 |
| 7 | Effect of membrane hydrophilization on ultrafiltration performance for biomolecules separation显示文摘 | Ma Yuxin Shi Fengmei Ma Jun | | 0，，： | 1 |
| 8 | Pathogenic analysis of coxsackievirus A10 in rhesus macaques显示文摘Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies. | Suqin Duan Fengmei Yang Yanyan Li Yuan Zhao Li Shi Meng Qin Quan Liu Weihua Jin Junbin Wang Lixiong Chen Wei Zhang Yongjie Li Ying Zhang Jingjing Zhang Shaohui Ma Zhanlong He Qihan Li | 2022 | Virologica Sinica2022，37，4： | 1 |
| 9 | JAG1 enhances angiogenesis in triple-negative breast cancer through promoting the secretion of exosomal lncRNA MALAT1显示文摘Despite significant improvements in five-year survival rates due to early diagnosis and combination therapy, triple-negative breast cancer (TNBC) treatment remains a major challenge. Finding new and effective targets for diagnosis and drug therapy is urgent for TNBC patients. Jagged-1 (JAG1), one of the canonical ligands of the Notch signaling pathway, is involved in vascular budding and is a poor prognostic factor of TNBC. In this study, combined with quantitative real-time PCR, database analysis, animal experiments, and other means, JAG1 was confirmed to be related to the poor prognosis of TNBC patients. JAG1 was highly expressed in MDA-MB-231 Bone (231B) cells, with stronger invasion and metastasis ability than MDA-MB-231 (231) cells. Treatment of human vascular endothelial cells (HUVEC) with TNBC conditioned medium showed that TNBC JAG1 promoted the angiogenesis of HUVEC. Next, we detected the exosomes extracted from TNBC conditioned medium and found that JAG1 promoted the exosome secretion from 231 cells via ALIX-RAB11A/RAB35. In addition, we also found that the exosomes from JAG1 overexpressed TNBC cells contained more long non-coding RNA (lncRNA) MALAT1 , and MALAT1 promoted angiogenesis of HUVEC by targeting miR-140-5p . Finally, the angiogenesis-promoting effect of JAG1 in TNBC was further investigated by matrix gel assay. In conclusion, we reveal that JAG1 has a pro-invasion effect on TNBC and is involved in microenvironment angiogenesis by promoting exosome secretion and the MALAT1-miR-140-5p-JAG1/VEGFA pathway. | Junping Liu Yutong Shi Minmin Wu Fengmei Zhang Mengqi Xu Zhiqiang He Min Tang | 2023 | Genes & Diseases2023，10，5： | 1 |
| 10 | Removal of fluoride from aqueous solution by using Ca-Bentonite and H-Bentonite显示文摘 | Yuxin Ma Fengmei Shi Miaonan Wu | 2011 | Advanced Materials Research2011，391，： | 1 |
| 11 | Photoexcitation and Decay of Higher Order Bands in Neutron Irradiated Silicon显示文摘The optically induced excitation and decay processes of the higher order bands in fast neutron irradiated silicon have been investigated in detail using Fourier transform infrared spectrometer at low temperatures with a variety of illumination intensity.It is found that the excitation process follows an exponential time dependence and the decay follows a logarithmic.The present results suggest that the characteristic of the optically active of the higher order bands is associated with the slow relaxation of photoexcited carriers. | SHI Yi WU Fengmei ZHENG Youdou KOji SUMINO | 1993 | Chinese Physics Letters1993，10，4： | 0 |
| 12 | Influence of the Position of the Fermi Level on an Infrared Active Defect in Irradiated Silicon显示文摘Influence of the position of the Fermi level on the infrared active defect,so-called higher order bands(HOB),has been investigated in neutron irradiated silicon by using infrared absorption and Hall-effect measurements at low temperatures.The optical excitation and the introduction of thermal donors(TD)effectively alter the position of the Fermi level.Similar optically active behaviors between the HOB and TD^(+) have been observed.It is suggested strongly that the mechanism of the Fermi level influencing on the HOB is the same as that of the TD^(+). | SHI Yi WU Fengmei ZHENG Youdou SUEZAWA Masashi SUMINO Koji | 1995 | Chinese Physics Letters1995，12，5： | 0 |
| 13 | Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury显示文摘Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion(I/R)injury.However,a genome-wide map of histone modifications and the underlying epigenetic signatures in myocardial I/R injury have not been established.Here,we integrated transcriptome and epigenome of histone modifications to characterize epigenetic signatures after I/R injury.Disease-specific histone mark alterations were mainly found in H3K27me3-,H3K27ac-,and H3K4me1-marked regions 24 and 48 h after I/R.Genes differentially modified by H3K27ac,H3K4me1 and H3K27me3 were involved in immune response,heart conduction or contraction,cytoskeleton,and angiogenesis.H3K27me3 and its methyltransferase polycomb repressor complex 2(PRC2)were upregulated in myocardial tissues after I/R.Upon selective inhibition of EZH2(the catalytic core of PRC2),the mice manifest improved cardiac function,enhanced angiogenesis,and reduced fibrosis.Further investigations confirmed that EZH2 inhibition regulated H3K27me3 modification of multiple pro-angiogenic genes and ultimately enhanced angiogenic properties in vivo and in vitro.This study delineates a landscape of histone modifications in myocardial I/R injury,and identifies H3K27me3 as a key epigenetic modifier in I/R process.The inhibition of H3K27me3 and its methyltransferase might be a potential strategy for myocardial I/R injury intervention. | Le Ni Bowen Lin Yanping Zhang Lingjie Hu Jianghua Lin Fengmei Fu Meiting Shen Can Li Lei Chen Jian Yang Dan Shi Yi-Han Chen | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
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