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| 1 | Helicobacter pylori infection as a cause of iron deficiency anaemia of unknown origin显示文摘AIM: To assess the aetiological role of Helicobacter pylori (H. pylori) infection in adult patients with ironrefractory or iron-dependent anaemia of previously unknown origin. METHODS: Consecutive patients with chronic irondeficient anaemia (IDA) with H. pylori infection and a negative standard work-up were prospectively evaluated. All of them had either iron refractoriness or iron dependency. Response to H. pylori eradication was assessed at 6 and 12 mo from follow-up. H. pylori infection was considered to be the cause of the anaemia when a complete anaemia resolution without iron supplements was observed after eradication. RESULTS: H. pylori was eradicated in 88 of the 89 patients. In the non-eradicated patient the four eradicating regimens failed. There were violations of protocol in 4 patients, for whom it was not possible to ascertain the cause of the anaemia. Thus, 84 H. pylori eradicated patients (10 men; 74 women) were available to assess the effect of eradication on IDA. H. pylori infection was considered to be the aetiology of IDA in 32 patients (38.1%; 95%CI: 28.4%-48.8%). This was more frequent in men/postmenopausal women than in premenopausal women (75% vs 23.3%; P < 0.0001) with an OR of 9.8 (95%CI: 3.3-29.6). In these patients, anaemia resolution occurred in the first follow-up visit at 6 mo, and no anaemia or iron deficiency relapse was observed after a mean follow-up of 21 ± 2 mo. CONCLUSION: Gastric H. pylori infection is a frequent cause of iron-refractory or iron-dependent anaemia of previously unknown origin in adult patients. | Helena Monzón Montserrat Forné Maria Esteve Mercé Rosinach Carme Loras Jorge C Espinós Josep M Viver Antonio Salas Fernando Fernández-Baares | 2013 | World Journal of Gastroenterology2013，19，26： | 13 |
| 2 | A short review of malabsorption and anemia显示文摘Anemia is a frequent finding in most diseases which cause malabsorption. The most frequent etiology is the combination of iron and vitamin B12 deficiency. Celiac disease is frequently diagnosed in patients referred for evaluation of iron deficiency anemia (IDA), being reported in 1.8%-14.6% of patients. Therefore, duodenal biopsies should be taken during endoscopy if no obvious cause of iron defi ciency (ID) can be found. Cobalamin defi ciency occurs frequently among elderly patients, but it is often unrecognized because the clinical manifestations are subtle; it is caused primarily by food-cobalamin malabsorption and pernicious anemia. The classic treatment of cobalamin deficiency has been parenteral administration of the vitamin. Recent data suggest that alternative routes of cobalamin administration (oral and nasal) may be useful in some cases. Anemia is a frequent complication of gastrectomy, and has been often described after bariatric surgery. It has been shown that banding procedures which maintain digestive continuity with the antrum and duodenum are associated with low rates of ID. Helicobacter pylori (H pylori) infection may be considered as a risk factor for IDA, mainly in groups with high demands for iron, such as some children and adolescents. Further controlled trials are needed before making solid recommendations about H pylori eradication in these cases. | Fernando Fernández-Baares Helena Monzón Montserrat Forné | 2009 | World Journal of Gastroenterology2009，15，37： | 6 |
| 3 | Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: A double-blind RCT显示文摘 | Juan Carlos Garc??a-Pagán Rosa Morillas Rafael Ba?ares Agustin Albillos Candido Villanueva Carme Vila Joan Genescà Manuel Jimenez Manuel Rodriguez Jose Luis Calleja Joaquin Balanzó Fernando Garcáa-Durán Ramón Planas Jaume Bosch | 2003 | Hepatology2003，，6： | 1 |
| 4 | Incidence of collagenous and lymphocytic colitis: a 5-year population-based study显示文摘 | Fernando Fernández-Ba?ares Antonio Salas Montserrat Forné Maria Esteve Jorge Espinós Josep Maria Viver | 1999 | The American Journal of Gastroenterology1999，，2： | 1 |
| 5 | Efficacy of azithromycin 1g single dose in the management of uncomplicated gonorrhoea显示文摘 | Habib AR Fernando R | 2004 | Int J STD AIDS2004，15，4： | 1 |
| 6 | Accuracy of GastroPanel for the diagnosis of atrophic gastritis显示文摘 | Adrian G. McNicholl Montserrat Forné Jesus Barrio Cristobal De la Coba Bego?a González Robin Rivera Maria Esteve Fernando Fernandez-Ba?ares Beatriz Madrigal Beatriz Gras-Miralles Angeles Perez-Aisa Jose M. Viver-Pi-Sunyer Felipe Bory Merce Rosinach Carmen | 2014 | European Journal of Gastroenterology & Hepatology2014，，9： | 1 |
| 7 | Findings related to IL-8 and IL-10 gene polymorphisms in a Mexican patient population with irritable bowel syndrome infected with Blastocystis显示文摘 | Angelica Olivo-Diaz Mirza Romero-Valdovinos Areli Gudi?o-Ramirez Jesus Reyes-Gordillo Diego Jimenez-Gonzalez Maria Ramirez-Miranda Williams Martinez-Flores Fernando Martinez-Hernandez Ana Flisser Pablo Maravilla | 2012 | Parasitology Research2012，，1： | 1 |
| 8 | Nutritional care of the patient with constipation显示文摘 | Fernando Femandez-Ba? ares | 2006 | Nutrit & Diet Consequ Gastronintestin Dis2006，20，3： | 1 |
| 9 | Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study显示文摘 | Andrés Díaz-López Mònica Bulló Marti Juanola-Falgarona Miguel A. Martínez-González Ramón Estruch Maria-Isabel Covas Fernando Arós Jordi Salas-Salvadó | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，11： | 1 |
| 10 | Local anaesthesia for fibreptic bronchoscopy显示文摘 | Webb AR Fernando SS Dalton HR | 1990 | Thorax1990，5，： | 1 |
| 11 | A longitudinal study of the growth of the nasopharynx and its contents in normal children显示文摘 | Jeans WD Fernando DC Maw AR | 1981 | Br J Radiol1981，54，： | 1 |
| 12 | Randomized Controlled Trial of Aspiration Needle versus Automated Biopsy Device for Transjugular Liver Biopsy显示文摘 | Rafael Ba?ares Sonia Alonso María-Vega Catalina Marta Casado Diego Rincón Magdalena Salcedo Emilio Alvarez Carmen Guerrero Antonio Echenagusía Fernando Camú?ez Gonzalo Simó | 2001 | Journal of Vascular and Interventional Radiology2001，，5： | 1 |
| 13 | Structuring and coding in health care records: a qualitative analysis using diabetes as a case study 显示文摘 | Robertson AR Fernando B Morrison Z | 2015 | J Innov Health Inform2015，22，2： | 1 |
| 14 | Intravenous inosine for ischaemic renal injury显示文摘 | Wickham JE Fernando AR Hendry WF | 1979 | Br J Urol1979，51，： | 1 |
| 15 | Reducción de la mortalidad precoz y a 6 meses en pacientes con IAM en el periodo 1995-2005. Datos de los registros PRIAMHO I, II y MASCARA显示文摘 | Fernando Arós Magda Heras Joan Vila Héctor Sanz Ignacio Ferreira-González Gaietà Permanyer-Miralda José Cu?at Lorenzo López-Bescós Adolfo Cabadés Angel Loma-Osorio Jaume Marrugat | 2011 | Revista Espa?ola de Cardiología2011，，11： | 1 |
| 16 | Smoking and Age-Related Macular Degeneration: Review and Update显示文摘 | Sara Velilla José Javier García-Medina Alfredo García-Layana Rosa Dolz-Marco Sheila Pons-Vázquez M. Dolores Pinazo-Durán Francisco Gómez-Ulla J. Fernando Arévalo Manuel Díaz-Llopis Roberto Gallego-Pinazo Gabriele Thumann | 2013 | Journal of Ophthalmology2013，，： | 1 |
| 17 | Comparison of transjugular intrahepatic portosystemic shunt dysfunction in PTFE-covered stent-grafts versus bare stents显示文摘 | José Barrio Cristina Ripoll Rafael Ba?ares Antonio Echenagusia María-Vega Catalina Fernando Camú?ez Gonzalo Simó Leandro Santos | 2004 | European Journal of Radiology2004，，1： | 1 |
| 18 | Impact of mass screening for gluten-sensitive enteropathy in working population显示文摘AIM:To assess:(1)frequency and clinical relevanceof gluten sensitive enteropathy(GSE)detected by serology in a mass screening program;(2)sensitivity of antitransglutaminase(tTGA)and antiendomysium antibodies(EmA);and(3)adherence to gluten-free diet(GFD)and follow-up. METHODS:One thousand,eight hundred and sixtyeight subjects recruited from an occupational health department underwent analysis for tTGA and EmA and, if positive,duodenal biopsy,DQ2/DQ8 genotyping, clinical feature recording,blood tests,and densitometry were performed.Since>98%of individuals had tTGA <2 U/mL,this value was established as the cut-off limit of normality and was considered positive when confirmed twice in the same sample.Adherence to a GFD and follow up were registered. RESULTS:Twenty-six(1.39%)subjects had positive tTGA and/or EmA,and 21 underwent biopsy:six Marsh Ⅲ(oneⅢa,fourⅢb,oneⅢc),nine MarshⅠand six Marsh 0(frequency of GSE 1:125).The sensitivity of EmA for GSE was 46.6%(11.1%for MarshⅠ,100% for MarshⅢ),while for tTGA,it was 93.3%(88.8% for MarshⅠ,100%for MarshⅢ).All 15 patients with abnormal histology had clinical features related to GSE.MarshⅠandⅢsubjects had more abdominal pain than Marsh 0(P=0.029),and a similar trend was observed for distension and diarrhea.No differences in the percentage of osteopenia were found between MarshⅠandⅢ(P=0.608).Adherence to follow-up was 69.2%.Of 15 GSE patients,66.7%followed a GFD with 80%responding to it. CONCLUSION:GSE in the general population is frequent and clinically relevant,irrespective of histological severity.tTGA is the marker of choice.Mass screening programs are useful in identifying patients who can benefit from GFD and follow-up. | Meritxell Mariné Fernando Fernández-Baares Montserrat Alsina Carme Farré Montserrat Cortijo Rebeca Santaolalla Antonio Salas Margarita Tomàs Elias Abugattas Carme Loras Ingrid Ordás Josep M Viver Maria Esteve | 2009 | World Journal of Gastroenterology2009，15，11： | 0 |
| 19 | Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test显示文摘BACKGROUND Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)detection.Nevertheless,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIM To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without CRC.METHODS Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion detection.Ambulatory patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete colonoscopy.Patients without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the research.We determined the cumulative risk of GIC,CRC and upper GIC.Hazard rate(HR)was calculated adjusted by age,sex and presence of significant colonic lesion.RESULTS We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/gr.During a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to CRC.FIT-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An upper GIC was detected in 22(0.8%)patients during the first year.Two variables were independently associated:anaemia(OR 5.6,95%CI:2.2-13.9)and age≥70 years(OR 2.7,95%CI:1.1-7.0).CONCLUSION Symptomatic patients without CRC have a moderate risk increase in upper GIC,regardless of the FIT result.Patients with a positive FIT have an increased risk of post-colonoscopy CRC. | Noel Pin-Vieito María J Iglesias David Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-Moranta VictoriaÁlvarez-Sánchez Fernando Fernández-Bañares Jaume Boadas Eva Martínez-Bauer Rafael Campo Luis Bujanda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella | 2020 | World Journal of Gastroenterology2020，26，1： | 0 |
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