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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | The serine/ threonine kinase Pim-2 is a transcriptionally regulated apopotot-ic inhibitor显示文摘 | FOX C J HAMMERMAN P S CINALLI R M | 2003 | Genes Dev2003，17，15： | 1 |
| 3 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 4 | Cerebellum and auditory function:an ALE meta-analysis of functional neuroimaging studies显示文摘 | PETACCHI A LAIRD A R FOX P T | 2005 | Hum Brain Mapp2005，25，： | 1 |
| 5 | Effects of low frequeney ultrasound on Properties of restructured beef rolls显示文摘 | Vimini R J Kem P J D Fox J D | 1983 | Journal of Food Seience1983，48，5： | 1 |
| 6 | Rates of change of eigenvalues and eigenvectors显示文摘 | FOX R L KAPOOR M P | 1969 | AIAA Journal1969，6，： | 1 |
| 7 | Potential clinical rele-vance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines显示文摘 | FOX B P TABONE C KANDPAL R P | | 0，，04： | 1 |
| 8 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 9 | Bone density is compromised in amenorrheic women despite return of menses:a 2-year study显示文摘 | Jonnavithula S Warren M P Fox R P | 1993 | Obstet Gynecol1993，81，： | 1 |
| 10 | Experimental study of titanium/aluminium deposits produced by cold gas dynam- ic spray 显示文摘 | Novoselova T Fox P Morgan R | 2006 | Surface and Coatings Technology2006，201，8： | 1 |
| 11 | Helical (spiral)CT of evaluation of acute abdomen显示文摘 | Zemen R K Fox S H Silverman P M | 1993 | A JR1993，160，： | 1 |
| 12 | Analysis of cold gas dynamically sprayed aluminum deposits 显示文摘 | R Morgan P Fox J Pattison | 2004 | Mater Lett2004，58，78： | 1 |
| 13 | Effect of tea,coffee and cocoa extracts on the colloidal stability of milk and concentrated milk显示文摘 | O' Connell J E Fox P D Tan-Kintia R | 1998 | Int Dairy J1998，，8： | 1 |
| 14 | Preliminary results of the investigation of a 3 500 K black body 显示文摘 | Woolliams E R Harrison N J Fox N P | 2000 | Metrologia2000，37，： | 1 |
| 15 | Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats显示文摘 | Fox P R Oyama M A Reynolds C | | 0，，1： | 1 |
| 16 | Trim5 a accelerates degradation of cytosolic capsid associated with productive HIV-1 Entry 显示文摘 | Chatterji U Bobardt M Gaskill P Sheeter D Fox H Gallay R 2006 | 2006 | J Biol Chem2006，281，37： | 1 |
| 17 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 18 | Use of a chlorophyll meter to predict side-dress nitrogen requirement for maize显示文摘 | Piekielek W P Fox R H | 1992 | Agron J1992，84，： | 1 |
| 19 | Rates of change of eigenvalues and eigenvectors 显示文摘 | R L FOX M P KAPOOR | 1968 | AIAA Journal1968，6，12： | 1 |
| 20 | Correlation of CT findings with clinical evalua- tions in 261 patients with symptomatic bronehieetasis显示文摘 | Lynch DA Newell J Hale V Dver D Corkerv K Fox NL Ger-end P Fick R | 1999 | AJR Am J Roentyenol1999，173，1： | 1 |
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