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| 1 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 2 | Toward a Theory of Behavioral Operations显示文摘 | Francesca Gino Gary Pisano | 2008 | Manufacturing & Service Operations Management2008，，4： | 1 |
| 3 | The impact of information from similar or different advisors on judgment显示文摘 | Francesca Gino Jen Shang Rachel Croson | 2008 | Organizational Behavior and Human Decision Processes2008，，2： | 1 |
| 4 | Toward a theory of behavioral operations显示文摘 | FRANCESCA Gino GARY Pisano | 2008 | Manufacturing Service Operations Management2008，10，4： | 1 |
| 5 | Sweeping dishonesty under the rug: How unethical actions lead to forgetting of moral rules 显示文摘 | Shu Gino Francesca | 2012 | Journal of Personality and Social Psychology2012，102，6： | 1 |
| 6 | Toward a theory of operations显示文摘 | Francesca behavioral Operations Gino Gary Pisano | 2008 | Manufacturing & Service Management2008，10，4： | 1 |
| 7 | Toward a theory of behavioral operations 显示文摘 | Francesca Gino Gary Pisano | 2008 | Manufacturing Service Operations Management2008，10，4： | 1 |
| 8 | Toward a theory of behavioral operations显示文摘 | Francesca Gino Gary Pisano | 2008 | Manufacturing Service Operations Management2008，10，4： | 1 |
| 9 | Learning from My Success and from Others' failure: Evidence from Minimally In- vasive Cardiac Surgery 显示文摘 | Diwas K C Bradley R S Francesca Gino | 2013 | Management Science2013，59，11： | 1 |
| 10 | “成功”学习之殇——为什么领导者不从成功中学习显示文摘形形色色的商业故事中,总是有很多类似某个企业曾经垄断整个行业最后却衰败的故事。之前分析所得出的原因,包括和客户们接触太少、在财务报表上的短视观点、不能选择合理的模型进行创新等等都不能充分解释为何一直想让自己公司变得卓越的公司领导们最后却失去了对公司的控制。这篇文章我们讨论的是,成功可能会阻碍个人和组织的继续学习而导致失败。我们都知道对公司和个人来说从失败中学习是我们至关重要的能力之一。但是,从成功中学习挑战性却更大。学者们的研究将导致这种现象的原因聚焦在影响学习进行的三个因素上。 | Francesca Gino Gary P.Pisano 程广浩 | 2011 | 管理@人2011，，5： | 0 |
| 11 | Memantine: New prospective in bipolar disorder treatment显示文摘We review preclinical and clinical evidences strongly suggesting that memantine, an old drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania and for the prevention of manic/hypomanic and depressive recurrences of manicdepressive illness. Lithium remains the first line for the treatment and prophylaxis of bipolar disorders, but currently available treatment alternatives for lithium resistant patients are of limited and/or questionable efficacy. Thus, research and development of more effective mood stabilizer drugs is a leading challenge for modern psychopharmacology. We have demonstrated that 21 d administration of imipramine causes a behavioural syndrome similar to a cycle of bipolar disorder, i.e., a mania followed by a depression, in rats. Indeed, such treatment causes a behavioural supersensitivity to dopamine D2 receptor agonists associated with an increase sexual activity and aggressivity(mania). The dopamine receptor sensitization is followed, after imipramine discontinuation, by an opposite phenomenon(dopamine receptor desensitization) and an increased immobility time(depression) in the forced swimming test of depression. Memantine blocks the development of the supersensitivity and the ensuing desensitization associated with the depressive like behavior. On the basis of these observations we have suggested the use of memantine in the treatment of mania and in the prophylaxis of bipolar disorders. To test this hypothesis we performed several naturalistic studies that showed an acute antimanic effect and a long-lasting and progressive mood-stabilizing action(at least 3 years), without clinically relevant side effects. To confirm the observations of our naturalistic trials we are now performing a randomized controlled clinical trial. Finally we described the studies reporting the efficacy of memantine in maniclike symptoms occurring in psychiatric disorders other than bipolar. Limitations: A randomized controlled clinical trial is needed to confirm our naturalistic observations.Conclusion: We believe that this review presents enough pharmacological and clinical information to consider the administration of memantine in the treatment of bipolar disorders that no respond to standard mood stabilizers. | Giulia Serra Francesca Demontis Francesca Serra Lavinia De Chiara Andrea Spoto Paolo Girardi Giulio Vidotto Gino Serra | 2014 | World Journal of Psychiatry2014，4，4： | 0 |
| 12 | Failure of memantine to “reverse” quinpirole-induced hypomotility显示文摘AIM: To evaluate antidepressant-like effect of memantine in a rat model.METHODS: Male Wistar rats were treated intraperitoneally with either vehicle, memantine(10 mg/kg) or imipramine(20 mg/kg), for 3 wk. Twenty-four hour after the last treatment animals were challenged with quinpirole(0.3 mg/kg s.c.) and tested for motor activity. After 1 h habituation to the motility cages, the motor response was recorded for the following 45-min and the data were collected in 5-min time bins. RESULTS: As expected, chronic treatment with imipramine potentiated the locomotor stimulant effect of quinpirole. On the contrary, chronic memantine administration failed to induce the behavioral supersensitivity to the dopamine agonist. CONCLUSION: The results show that memantine, at variance with antidepressant treatments, fails to induce dopaminergic behavioral supersensitivity. This observation is consistent with the results of preclinical and clinical studies suggesting that memantine does not have an acute antidepressant action but does have an antimanic and mood-stabilizing effect. | Francesca Demontis Gino Serra | 2016 | World Journal of Psychiatry2016，6，2： | 0 |
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