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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 3 | Orien- ted silicon carbide nanowires: Synthesis and field emis- sion properties 显示文摘 | PAN Z W LAI H L FREDERICK C K | 2000 | Adv Mater2000，12，16： | 1 |
| 4 | Enhancing school - based prevention and youth development through coordinated social, emotional, and academic learning 显示文摘 | Greenberg M T O'Brien M U Weissberg R P Zins J E Resnik H Fredericks L Elias M J | 2003 | American Psy- chologist2003，58，67： | 1 |
| 5 | Mineral deposition in the extracellular matrices of vertebrate tissues: identification of possible apatite nucleation sites on type I collagen显示文摘 | William J L Frederick H S | 2009 | Cells Tissues Organs2009，189，14： | 1 |
| 6 | Emerging Web Graphics Standards and Technologies 显示文摘 | Rynson W H Lau Frederick Li Tosiyasu L Kunii | 2003 | IEEE Computer Graphics and Applications2003，23，1： | 1 |
| 7 | Low and intermediate temperature oxidation of ethanol and ethanol- PRF blends: an experimental and modeling study 显示文摘 | FRANCIS M H MARCOS C FREDERICK L D | 2009 | Combustion and Flame2009，156，12： | 1 |
| 8 | Assembly of type Ⅰ collagen: Fusion of fibril subunits and the influence of fibril diameter on mechanical properties 显示文摘 | Christiansen David L Huang Eric K Silver Frederick H | 2000 | Matrix Biology2000，19，： | 1 |
| 9 | Passive immunity in transmissible gastroenteritis of swine:Intramuscular injection of pregnant swine with a modified live-virus vaccine显示文摘 | Bohl E H Frederick G T Saif L J | 1975 | Am J Vet Res1975，36，： | 1 |
| 10 | A comprehensive mechanism for methanol oxidation显示文摘 | Timothy J H Frederick L D | | 0，，11： | 1 |
| 11 | Oriented silicon carbide nanowires:synthesis and field emission properties显示文摘 | Pan Z W Lai H L Frederick C K | 2000 | Adv Mater2000，12，16： | 1 |
| 12 | Is the nonradiative decay of 1 Cis-stilbene due to the dihydrophenanthrene isomerization channel-sug-gestive evidence from photophysical measurements on 1,2- diphenylcycloalkenes显示文摘 | Petek H Yoshihara K Fujiwara Y Zhe L Penn J H Frederick J H | 1990 | Journal of Physical Chemistry1990，94，19： | 1 |
| 13 | A new solution path algorithm in support vector regression显示文摘 | Wang G Yeung D Y Frederick H L | 2008 | IEEE Trans on Neural Networks2008，19，10： | 1 |
| 14 | Enhancing school-based prevention and youth development through coordinated social,emotional,and academic learning显示文摘 | Greenberg M.T Weissberg R.P O'Brien M.U Zins J.E Fredericks L Resnik H | | 0，，6： | 1 |
| 15 | Cointegration, error correction, and price discovery on informationally linked security markets显示文摘 | Harris Frederick H deB McInish Thomas H Shoesmith Gary L Wood Robert A | 1995 | Journal of Financial and Quantitative Analysis1995，，30： | 1 |
| 16 | The path forward for biofuels and biomaterials显示文摘 | RAGAUSKAS A J WILLIAMS C K DAVISON B H BRITOVSEK G CAIRNEY J ECKERT C A FREDERICK Jr.J W HALLETI J P LEAK D J LIOTIA C L MIELENZ J R MURPHY R TEMPLER R TSCHAPLINSKI T | | 0，，5760： | 1 |
| 17 | An analysis of the relationship between market orientation and business performance in the hotel industry显示文摘 | Sin L Tse A Vincent C S Frederick H Yim H K | 2005 | International Journal of Hospitality Management2005，24，： | 1 |
| 18 | Serogroups of Rhizobium japonieum in soybean nodules as affected by soil type显示文摘 | Damirgi S H L R Frederick I C Anderson | | Agron J0，1967，： | 1 |
| 19 | Testing of cerium oxide coated cermet anodes in a laboratory cell显示文摘 | Gregg J S Frederick M S King H L | 1993 | Light Metals1993，，： | 1 |
| 20 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
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