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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Update on Cardiovascular Implantable Electronic Device Infections and Their Management: A Scientific Statement From the American Heart Association显示文摘 | Larry M. Baddour Andrew E. Epstein Christopher C. Erickson Bradley P. Knight Matthew E. Levison Peter B. Lockhart Frederick A. Masoudi Eric J. Okum Walter R. Wilson Lee B. Beerman Ann F. Bolger N A. Mark Estes Michael Gewitz Jane W. Newburger Eleanor B. S | 2010 | Circulation2010，，3： | 4 |
| 3 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 4 | Differentiation of in situ oxidized and fresh coal using FTIR techniques显示文摘 | FREDERICKS P M MOXON N T | 1986 | Fuel1986，65，11： | 2 |
| 5 | Ex- ome sequencing of head and neck squamous cell carcino- ma reveals inactivating mutations in NOTCH1 显示文摘 | Agrawal N Frederick M J Picketing C R | 2011 | Sci- ence2011，333，6046： | 1 |
| 6 | Matrix metal loproteinases显示文摘 | Hideaki N Frederick W | 1999 | J Biol Chem1999，274，21： | 1 |
| 7 | The effects of global climate change on seagrasses 显示文摘 | Frederick T S Hilary A N | 1999 | Aquatic Botany1999，63，： | 1 |
| 8 | Lifestyle Factors, Obesity and the Risk of Chronic Kidney Disease显示文摘 | Bénédicte Stengel Michelle E. Tarver–Carr Neil R. Powe Mark S. Eberhardt Frederick L. Brancati | 2003 | Epidemiology2003，，4： | 1 |
| 9 | Effect of hemagglutinin glycoprotein on influenza virus susceptibility to neuraminidase inhibitors 显示文摘 | Vasiliy P M Dmitri N Frederick G | 2005 | J Virol2005，79，12： | 1 |
| 10 | Research brief plasmodium falciparum, rapid detection of dihydrofclolate reductase mutations that confer resistance to cycloguanil and pyrimethamine显示文摘 | Frederick N Gyang David S | 1992 | Experimental parasitology1992，74，： | 1 |
| 11 | Efficacy of ultravio- let radiation as an alternative technology to inactivate microor- ganisms in grape juices and wines 显示文摘 | FREDERICKS I N DU T M KRUGEL M | 2011 | Food Microbial2011，28，： | 1 |
| 12 | Socio‐Cognitive Functions of L1 Collaborative Interaction in the L2 Classroom显示文摘 | MartaAntón Frederick J.Dicamilla | 2002 | The Modern Language Journal2002，，2： | 1 |
| 13 | 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults显示文摘 | Philip Greenland Joseph S. Alpert George A. Beller Emelia J. Benjamin Matthew J. Budoff Zahi A. Fayad Elyse Foster Mark A. Hlatky John McB. Hodgson Frederick G. Kushner Michael S. Lauer Leslee J. Shaw Sidney C. Smith Allen J. Taylor William S. Weintraub N | 2010 | Journal of the American College of Cardiology2010，，25： | 1 |
| 14 | Matrix metalloproteinase 显示文摘 | Hideaki N Frederick Woesmer J | 1999 | J Biol Chem1999，274，21： | 1 |
| 15 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 1 |
| 16 | Low-profile high-efficiency microchannel-plate detector system for scanning electron microscopy applications 显示文摘 | POSTEK M T KEERY W J FREDERICK N V | 1990 | Review Science Instru- ment1990，61，6： | 1 |
| 17 | Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1显示文摘 | Agrawal N Frederick MJ Pickering CR | 2011 | Science2011，333，6046： | 1 |
| 18 | Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)显示文摘 | Jessica R. Chang Euna Koo Elvira Agrón Joelle Hallak Traci Clemons Dimitri Azar Robert D. Sperduto Frederick L. Ferris Emily Y. Chew | 2011 | Ophthalmology2011，，11： | 1 |
| 19 | The Endings of The French Lieutenant' s Woman: Another Speculation on the Manuscript 显示文摘 | Smith Frederick N | 1987 | Journal of Modem Literature1987，，14： | 1 |
| 20 | Chemical addi- tives migration in rubber显示文摘 | Frederick I H Byron H T Datta R N | 2003 | Rubber Chemistry and Technolo- gy2003，76，3： | 1 |
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