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| 1 | Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries显示文摘Heterogeneity in clinical presentation, histological severity, prognosis and therapeutic outcomes characteristic of non-alcoholic fatty liver disease(NAFLD) necessitates the development of scientifically sound classification schemes to assist clinicians in stratifying patients into meaningful prognostic subgroups. The need for replacement of invasive liver biopsies as the standard method whereby NAFLD is diagnosed, graded and staged with biomarkers of histological severity injury led to the development of composite prognostic models as potentially viable surrogate alternatives. In the present article, we review existing scoring systems used to(1) confirm the presence of undiagnosed hepatosteatosis;(2) distinguish between simple steatosis and NASH; and(3) predict advanced hepatic fibrosis, with particular emphasis on the role of NAFLD as an independent cardio-metabolic risk factor. In addition, the incorporation of functional genomic markers and application of emerging imaging technologies are discussed as a means to improve the diagnostic accuracy and predictive performance of promising composite models found to be most appropriate for widespread clinical adoption. | Hilmar K Lückhoff Frederik C Kruger Maritha J Kotze | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 2 | Measurement of the intestinal permeability in chronic kidney disease显示文摘AIM: To evaluate methods measuring the intestinal permeability in chronic kidney disease(CKD) and clarify whether there is an increased intestinal permeability in CKD.METHODS: We reviewed the literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis(PRISMA) protocol and performed a systematic literature search through MEDline and EMBASE. All controlled trials and cohort studies using non-invasive methods to assess intestinal permeability in CKD patients were included. Excluded were: Conference abstracts and studies including patients younger than 18 years or animals. From the included studies we summarized the used methods and their advantages and disadvantages. For the comparison of their results we divided the included studies in two categories based on their included patient population, either assessing the intestinal permeability in mild to moderate CKD patients or in end stage renal disease(ESRD) patients. Results were graphically displayed in two plots, one comparing the intestinal permeability in mild to moderate CKD patients to healthy controls and one comparing the intestinal permeability in ESRD patients to healthy controls. RESULTS: From the 480 identified reports, 15 met our inclusion criteria. Methods that were used to assess the intestinal permeability varied from markers measured in plasma to methods based on calculating the urinary excretion of an orally administered test substance. None of the applied methods has been validated in CKD patients and the influence of decreased renal function on the different methods remains unclear to a certain extent. Methods that seem the least likely to be influenced by decreased renal function are the quantitative PCR(qPCR) for bacterial DNA in blood and D-lactate. Considering the results published by the included studies; the studies including patients with mild to moderate CKD conducted conflicting results. Some studies did report an increase in intestinal permeability whilst other did not find a significant increased permeability. However, despite the variety in used methods among the different studies, all studies measuring the intestinal permeability in ESRD point out a significant increased intestinal permeability. Results should nevertheless be interpreted with caution due to the possible influence of a decreased glomerular filtration rate on test results.CONCLUSION: The intestinal permeability in CKD:(1) could be measured by qPCR for bacterial DNA in blood and D-lactate; and(2) seems to be increased in ESRD. | Matty L Terpstra Ramandeep Singh Suzanne E Geerlings Frederike J Bemelman | 2016 | World Journal of Nephrology2016，5，4： | 2 |
| 3 | Measurement invariance of the pay satisfaction questionnaire across three countries显示文摘 | FiliP L Frederik A Miehael MH | 2007 | Educ Psychol Meas2007，67，6： | 1 |
| 4 | Absorbance changes of carotenoids in different solvents显示文摘 | Zang L Y Sommerburg Olaf Van Kuijk Frederik J G M | 1997 | Free Radical Biology & Medicine1997，23，7： | 1 |
| 5 | 显示文摘 | Greg P S Frederik C K Carl M L | 2008 | Sol Energy Mater Sol Cells2008，92，： | 1 |
| 6 | Identity of the Qingdao algal bloom 显示文摘 | FREDERIK L ZHANG X W YEN H | 2009 | Phycological Research2009，57，2： | 1 |
| 7 | Grain size dependency in the occurrence of sand waves显示文摘 | Hennie Henri?t Veen Suzanne Jacqueline Marie Hélène Hulscher Michiel Adrianus Frederik Knaapen | 2006 | Ocean Dynamics (-)2006，，3： | 1 |
| 8 | Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial显示文摘 | Jayant S Vaidya David J Joseph Jeffrey S Tobias Max Bulsara Frederik Wenz Christobel Saunders Michael Alvarado Henrik L Flyger Samuele Massarut Wolfgang Eiermann Mohammed Keshtgar John Dewar Uta Kraus-Tiefenbacher Marc Sütterlin Laura Esserman Helle MR Ho | 2010 | The Lancet2010，，9735： | 1 |
| 9 | Carvedilol therapy in pediatric patients with congestive heart failure: a study in- vestigating clinical and pharmacokinetic parameters 显示文摘 | Stephanie L Thomas S Frederike B | 2002 | Am Heart J2002，143，： | 1 |
| 10 | The enable right vertricalar circulatory suport systom for bcating heast cornary artery bupase Groft surgery 显示文摘 | Gijs G Andre L Dekker Frederik H Vander-veen Keses B Prenger Audrey A Cramer S Jos G Davidshoshan I | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 11 | Carvedilol therapy in pediatric patients with congestive heart failure: a study investi- gating clinical and pharmacokinetic parameters 显示文摘 | Stephanie L Thorns S Frederike B | 2002 | Am Heart J2002，143，： | 1 |
| 12 | Assessment of dermal exposure and skin condition of workers exposed to nickel at a South African base metal refinery 显示文摘 | Du Plessis Johannes L Eloff Frederik C Badenhorst Casper J | 2010 | Annals of occupa- tional hygiene2010，54，1： | 1 |
| 13 | Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition12345显示文摘 | Martine M Ros H Bas Bueno-de-Mesquita Ellen Kampman Katja KH Aben Frederike L Büchner Eugene HJM Jansen Carla H van Gils Lars Egevad Kim Overvad Anne Tj?nneland Nina Roswall Marie Christine Boutron-Ruault Marina Kvaskoff Florence Perquier Rudolf Kaaks Jen | 2012 | American Journal of Clinical Nutrition2012，，4： | 1 |
| 14 | Target-based discovery of novel herbicide显示文摘 | Wolfgang L Frederik B Andreas R | 2004 | Curr Opin Plant Biol2004，7，： | 1 |
| 15 | Synthesis and photophysical properties of luminescent rhenium( Ⅰ ) and manganese( Ⅰ ) polypyridine complexes containing pendant 1,3,4-oxadiazole/triarylamine assemblies 显示文摘 | Kim Youngjin Frederik W M Stern Charlotte L | 2001 | Inorganica Chimica Acta2001，318，： | 1 |
| 16 | Differentiation of pancreas carcinoma from healthy pancreatic tissue using mutipile b-values显示文摘 | Andreas L Frederik B L Miriam K | 2009 | Invest Radiol2009，44，12： | 1 |
| 17 | Disturbed nitrogen metabolism associated with the hyperhydric status of fully habituated callus of sugarbeet显示文摘 | FREDERIK L D JEAN-PIERRE B THOMAS G CLAUDE H | 1993 | Physiologia Plantarum1993，88，： | 1 |
| 18 | Digitally controlled boost PFC conveMer with improved output voltage controller显示文摘 | Frederik M L L De Belie David M Van de Sype Koen De Gusseme | 2007 | Electrical Engineering2007，89，5： | 1 |
| 19 | Self-assembly of a virus- mimicking nanostructure system for effcient tumor-targeted gene delivery显示文摘 | Xu L Frederik P Pirollo KF | 2002 | Hum Gene Ther2002，13，3： | 1 |
| 20 | Efficient, broadband and compact metal grating couplers for silicon-on- insulator waveguides显示文摘 | Scheerlinck S Schrauwen J Frederik V L | 2007 | Optics Express2007，15，15： | 1 |
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