|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 2 | Prediction and diagnosis of colorectal anastomotic leakage: A systematic review of literature显示文摘Although many studies have focused on the preoperative risk factors of anastomotic leakage after colorectal surgery(CAL), postoperative delay in diagnosis is common and harmful. This review provides a systematic overview of all available literature on diagnostic tools used for CAL. A systematic search of literature was undertaken using Medline, Embase, Cochrane and Webof-Science libraries. Articles were selected when a diagnostic or prediction tool for CAL was described and tested. Two reviewers separately assessed the eligibility and level of evidence of the papers. Sixty-nine articles were selected(clinical methods: 11, laboratory tests: 12, drain fluid analysis: 12, intraoperative techniques:22, radiology: 16). Clinical scoring leads to early awareness of probability of CAL and reduces delay of diagnosis. C-reactive protein measurement at postoperative day 3-4 is helpful. CAL patients are characterized by elevated cytokine levels in drain fluid in the very early postoperative phase in CAL patients. Intraoperative testing using the air leak test allows intraoperative repair of the anastomosis. Routine contrast enema is not recommended. If CAL is clinically suspected, rectal contrast-computer tomography is recommended by a few studies. In many studies a 'no-test' control group was lacking, furthermore no golden standard for CAL is available. These two factors contributed to a relatively low level of evidence in the majority of the papers. This paper provides a systematic overview of literature on the available tools for diagnosing CAL. The study shows that colorectal surgery patients could benefit from some diagnostic interventions that can easily be performed in daily postoperative care. | Freek Daams Zhouqiao Wu Max Jef Lahaye Johannus Jeekel Johan Frederik Lange | 2014 | World Journal of Gastrointestinal Surgery2014，6，2： | 10 |
| 3 | Multifractal Simulation of GeochemicalMap Patterns显示文摘Using a simple multifractal model based on the model De Wijs, various geochemical map patterns for element concentration values are being simulated. Each pattern is self-similar on the average in that a similar pattern can be derived by application of the multiplicative cascade model used to any small subarea on the pattern. In other experiments, the original, self-similar pattern is distorted by superimposing a 2-dimensional trend pattern and by mixing it with a constant concentration value model. It is investigated how such distortions change the multifractal spectrum estimated by means of the 3-step method of moments. Discrete and continuous frequency distribution models are derived for patterns that satisfy the model of De Wijs. These simulated patterns satisfy a discrete frequency distribution model that as upper bound has a continuous frequency distribution to which it approaches in form when the subdivisions of the multiplicative cascade model are repeated indefinitely. This limiting distribution is lognormal in the center and has Pareto tails. Potentially, this approach has important implications in mineral and oil resource evaluation. | Agterberg Frederik P Geological Survey of Canada, 601 Booth Street, Ottawa, K1A 0E8, Canada | 2001 | Journal of China University of Geosciences2001，12，1： | 10 |
| 4 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 5 | 地球化学图纹理的多重分形模拟显示文摘利用一个简单的基于DeWijs模型的多重分形模型 ,可以模拟元素富集值的各种地球化学纹理 .每种纹理在平均值上是自相似的 ,因为将乘积阶次模型 (multiplicativecascademodel)应用到任何子区均能得出类似的纹理样式 .在其他的试验中 ,通过叠加一个二维趋势纹理 (2 dimensionaltrendpattern)以及把它与一个常值富集模型混合 ,原始的自相似纹理就产生畸变 .本文将要研究这些畸变是如何改变用三步矩 (3 stepmethodofmoments)所估测的多重分形谱 (multifractalspectrum) .推导出了满足DeWijs模型纹理的离散和连续频率分布模型 .这些模拟纹理满足离散频率分布模型 ,当乘积阶次模型 (multipicativecascademodel)无限细分时 ,假设离散频率分布模型的上界是一连续频率分布 ,这个离散分布就在形式上逼近该连续频率分布的上边界 .这一极限分布在中心是对数正态的 ,但有两个巴利多 (Pareto)分布的尾 .这种方法在矿产和油气评价中有重要的潜在意义 . | Frederik P.Agterberg | 2001 | 地球科学(中国地质大学学报)2001，26，2： | 6 |
| 6 | Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmacological approach显示文摘瞄准:调查在试管内和在活体内治疗学的效果嘘胆道癌症上的一 deacetylase 禁止者 NVP-LAQ824 和 NVP-LBH589。方法:由 NVP-LAQ824 和 NVP-LBH589 的房间生长抑制是在由 MTT 试金的 7 根人的胆道癌症房间线的学习在试管内。另外, NVP-LBH589 的 anti-tumoral 效果在一个妄想的老鼠模型被学习。Anti-tumoral 药机制被为 MIB-1 为 acH4 和 p21 弄污 WAF-1/CIP-1, PARP 试金,房间周期分析, TUNEL 试金,和 immunhistochemistry 的免疫估计。结果:有两混合物的在试管内治疗显著地压制了所有癌症房间线的生长[吝啬的 IC50 ( 3 d ) 0.11 和 0.05 mumol/L ,分别地],并且与 nucleosomal 的 hyperacetylation 被联系嘘一 H4 , p21 WAF-1/CIP-1 的增加的表示, apoptosis ( PARP 劈开)感应,并且房间周期在 G2/M 逮捕检查点。在 28 d 以后, NVP-LBH589 显著地减少了在 66% 集体的肿瘤(胆汁管癌) 并且 87%( 胆囊癌症) 与安慰剂相比的在活体内,并且加强 gemcitabine 的功效。揭示的肿瘤标本的进一步的分析由 TUNEL 试金增加了 apoptosis 并且减少了房间增长(MIB-1 ) 。结论:我们的调查结果建议 NVP-LBH589 和 NVP-LAQ824 对人的胆道癌症是活跃的在试管内。另外, NVP-LBH589 表明了重要在活体内活动并且加强 gemcitabine 的功效。因此,为胆道癌症的治疗的这新药的进一步临床的评估被推荐。 | Thilo Bluethner Manuel Niederhagen Karel Caca Frederik Serr Helmut Witzigmann Christian Moebius Joachim Mossner Marcus Wiedmann | 2007 | World Journal of Gastroenterology2007，13，35： | 5 |
| 7 | Combined hepatocellular and cholangiocellular carcinoma presenting with radiological characteristics of focal nodular hyperplasia显示文摘Combined hepatocellular and cholangiocellular carcinoma (cHCC-CC) is a rare tumor type containing unequivocal elements of both hepatocellular carcinoma and cholangiocarcinoma that are intimately mixed. Although these tumors are usually considered to be more related to hepatocellular carcinoma than to cholangiocarcinoma, they sometimes, in contrast to hepatocellular carcinoma, contain a significant amount of fibrous stroma. This might in some cases explain atypical radiological features. We report a case of a cHCC-CC in a 47-year-old female that resembled focal nodular hyperplasia on Magnetic Resonance Imaging. Correlation of imaging and serum levels of α-fetoprotein and CA19.9 can help to make the correct diagnosis preoperatively. | Inneke Willekens Anne Hoorens Caroline Geers Bart Op de Beeck Frederik Vandenbroucke Johan de Mey | 2009 | World Journal of Gastroenterology2009，15，31： | 4 |
| 8 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 9 | Fractals and Spatial Statistics of Point Patterns显示文摘The relationship between fractal point pattern modeling and statistical methods of parameter estimation in point-process modeling is reviewed. Statistical estimation of the cluster fractal dimension by using Ripley's K-function has advantages in comparison with the more commonly used methods of box-counting and cluster fractal dimension estimation because it corrects for edge effects, not only for rectangular study areas but also for study areas with curved boundaries determined by regional geology. Application of box-counting to estimate the fractal dimension of point patterns has the disadvantage that, in general, it is subject to relatively strong 'roll-off' effects for smaller boxes. Point patterns used for example in this paper are mainly for gold deposits in the Abitibi volcanic belt on the Canadian Shield. Additionally, it is proposed that, worldwide, the local point patterns of podiform Cr, volcanogenic massive sulphide and porphyry copper deposits, which are spatially distributed within irregularly shaped favorable tracts, satisfy the fractal clustering model with similar fractal dimensions. The problem of deposit size (metal tonnage) is also considered. Several examples are provided of cases in which the Pareto distribution provides good results for the largest deposits in metal size-frequency distribution modeling. | Frederik P Agterberg | 2013 | Journal of Earth Science2013，24，1： | 4 |
| 10 | Visualization of geologic geospatial datasets through X3D in the frame of WebGIS显示文摘3D geo spatial data have become the normal.However,to view the data,usually expert software is required,which have up to now hindered the wide spread use of 3D scenes for the display of geological data.The internet real time 3D rendering framework X3D is assessed regarding its suitability for building a geological GIS on the internet.Especially important for geological data,3D rendering enhances the intuitive grasp of the data and enables the user to interactively explore it.It is often necessary to find a solution to distribute this data to a wide range of interested parties,experts and non-experts alike.According to the nature of 3D data,the best technique to display geo-data,the modeling of objects and unresolved issues have to be taken into consideration.The internet is the apparent tool for the public distribution and visualization of 3D data and it was found that through the open ISO-standardized format X3D it offers a multitude of possibilities.A 3D geological interactive map was created with these prerequisites to identify challenges and possibilities through this process.It was found that the use of lead to satisfactory results,that could probably not have been achieved with another technology. | Frederik von Reumont Jamal Jokar Arsanjani Andreas Riedl | 2013 | International Journal of Digital Earth2013，6，5： | 4 |
| 11 | Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity显示文摘Background:To investigate machine-learning(ML)algorithms to differentiate corneal biomechanical properties between different topographical stages of keratoconus(KC)by dynamic Scheimpflug tonometry(CST,Corvis ST,Oculus,Wetzlar,Germany).In the following,ML models were used to predict the severity in a training and validation dataset.Methods:Three hundred and eighteen keratoconic and one hundred sixteen healthy eyes were included in this monocentric and cross-sectional pilot study.Dynamic corneal response(DCR)and corneal thickness related(pachymetric)parameters from CST were chosen by appropriated selection techniques to develop a ML algorithm.The stage of KC was determined by the topographical keratoconus classification system(TKC,Pentacam,Oculus).Patients who were classified as TKC 1,TKC 2 and TKC 3 were assigned to subgroup mild,moderate,and advanced KC.If patients were classified as TKC 1-2,TKC 2-3 or TKC 3-4,they were assigned to subgroups according to the normative range of further corneal indices(index of surface variance,keratoconus index and minimum radius).Patients classified as TKC 4 were not included in this study due to the limited amount of cases.Linear discriminant analysis(LDA)and random forest(RF)algorithms were used to develop the classification models.Data were divided into training(70%of cases)and validation(30%of cases)datasets.Results:LDA model predicted healthy,mild,moderate,and advanced KC eyes with a sensitivity(S_(n))/specificity(S_(p))of 82%/97%,73%/81%,62%/83%and 68%/95%from a validation dataset,respectively.For the RF model,a S_(n)/S_(p) of 91%/94%,80%/90%,63%/87%,72%/95%could be reached for predicting healthy,mild,moderate,and advanced KC eyes,respectively.The overall accuracy of LDA and RF was 71%and 78%,respectively.The accuracy for KC detection including all subgroups of KC severity was 93%in both models.Conclusion:The RF model showed good accuracy in predicting healthy eyes and various stages of KC.The accuracy was superior with respect to the LDA model.The clinical importance of the models is that the standalone dynamic Scheimpflug tonometry is able to predict the severity of KC without having the keratometric data. | Robert Herber Lutz E.Pillunat Frederik Raiskup | 2021 | Eye and Vision2021，8，1： | 3 |
| 12 | Quality of life after liver transplantation:State of the art显示文摘Quality of life(QoL) after deceased donor liver transplantation is increasingly recognized as a major outcome parameter. We reviewed recent publications in this rapidly evolving field in order to summarize recent achievements in the field and to define opportunities and perspectives for research and improvement of patient care. QoL does improve after liver transplantation according to a typical pattern. During the first year, there is a significant improvement in QoL. After one year, the improvement does stabilise and tends to decline slightly. In addition to the physical condition, different psychological parameters(such as depression, anxiety, sexual function) and sociodemographic elements(professional state, sex, marital state) seem to impact QoL. Opportunities for further research are the use of dedicated questionnaires and identification of influencing factors for QoL. | Louis Onghena Wouter Develtere Carine Poppe Anja Geerts Roberto Troisi Aude Vanlander Frederik Berrevoet Xavier Rogiers Hans Van Vlierberghe Xavier Verhelst | 2016 | World Journal of Hepatology2016，8，18： | 3 |
| 13 | 正常心肌与肥厚心肌跨室壁不应期离散度实验研究显示文摘目的 探讨在体犬正常心室肌以及肥厚心室肌三层之间是否存在跨室壁的不应期离散。方法 采用特制电极直接测量在体三层心肌的不应期。结果 正常心肌三层之间的不应期呈均一性 ,没有显著的不应期离散。同正常心肌相比 ,肥厚心肌三层不应期均有延长 ,而中层心肌延长的幅度最大 ,使得跨室壁的不应期离散度增大。采用突然的循环长度改变可使跨室壁的不应期离散度增大更加明显。结论 正常犬三层心肌之间不存在跨室壁的不应期梯度 ,而肥厚心肌中存在跨室壁的不应期离散。采用长—短间期和短—长间期刺激可使跨室壁的不应期离散度增大。 | 吕家高 陆再英 Voss Frederik Wolfgang Schoels | 2001 | 中华心血管病杂志2001，29，10： | 3 |
| 14 | Implications of fine water mist environment on the post-detonation processes of a PE4 explosive charge in a semi-confined blast chamber显示文摘The effects of a fine water mist environment in a semi-confined blast chamber on the chemical and thermodynamic processes following detonation of a 20 g PE4 explosive charge have been investigated.The effects were quantified by the analysis of pressure profiles recorded where several parameters including arrival time of the shock at the sensors, peak overpressures, specific impulse of the positive phase, period of the negative phase and the specific impulse of the multiple reflections were quantified.The effect of the fine water mist on the arrival time, peak pressures and the specific impulse of the positive phase agrees with previous findings in literature. In this paper, the focus is on the implications of the fine water mist on the negative phase and the impulse of multiple pressure reflections. The period of the negative phase was found to have increased by 40% and with higher negative peak pressure in the mist condition compared to the atmospheric condition. The activities of the multiple pressure reflections were found to have decreased considerably, both in number and in amplitude leading to lower impulses(by about 60%) for the water mist conditions. | Zetu Jiba Tleyane Jonas Sono Frederik Johannes Mostert | 2018 | Defence Technology(防务技术)2018，14，5： | 3 |
| 15 | Relativistic-intensity near-single-cycle light waveforms at kHz repetition rate显示文摘The development of ultra-intense and ultra-short light sources is currently a subject of intense research driven by the discovery of novel phenomena in the realm of relativistic optics,such as the production of ultrafast energetic particle and radiation beams for applications.It has been a long-standing challenge to unite two hitherto distinct classes of light sources:those achieving relativistic intensity and those with pulse durations approaching a single light cycle.While the former class traditionally involves large-scale amplification chains,the latter class places high demand on the spatiotemporal control of the electromagnetic laser field.Here,we present a light source producing waveformcontrolled 1.5-cycle pulses with a 719 nm central wavelength that can be focused to relativistic intensity at a 1 kHz repetition rate based on nonlinear post-compression in a long hollow-core fiber.The unique capabilities of this source allow us to observe the first experimental indications of light waveform effects in laser wakefield acceleration of relativistic energy electrons. | Marie Ouille Aline Vernier Frederik Bohle Maimouna Bocoum Aurelie Jullien Magali Lozano Jean-Philippe Rousseau Zhao Cheng Dominykas Gustas Andreas Blumenstein Peter Simon Stefan Haessler Jerome Faure Tamas Nagy Rodrigo Lopez-Martens | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 16 | Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation显示文摘 | Hans F.A. Vasen Martin Wasser Anneke van Mil Rob A. Tollenaar Marja Konstantinovski Nelleke A. Gruis Wilma Bergman Frederik J. Hes Daniel W. Hommes G. Johan A. Offerhaus Hans Morreau Bert A. Bonsing Wouter H. de Vos tot Nederveen Cappel | 2011 | Gastroenterology2011，，3： | 3 |
| 17 | An on-chip electroosmotic micropump with a light-addressable potentiometric sensor显示文摘An on-chip electroosmotic(EO) micropump(EOP) was integrated in a microfluidic channel combined with a light-addressable potentiometric sensor(LAPS). The movement of EO flow towards right and left directions can be clearly observed in the microfluidic channel. The characteristics of photocurrent-time and photocurrent-bias voltage are obtained when buffer solution passes through the sensing region. The results demonstrate that the combination of an on-chip EOP with an LAPS is feasible. | 李学亮 刘诗斌 樊平平 Carl Frederik Werner Koichiro Miyamoto Tatsuo Yoshinobu | 2017 | Optoelectronics Letters2017，13，2： | 2 |
| 18 | Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication显示文摘Magnesium deficiency can cause a variety of symptoms, including potentially life-threatening complications such as seizures, cardiac arrhythmias and secondary electrolyte disturbances. Hypomagnesemia can be a serious adverse effect to proton pump inhibitor(PPI) therapy, which is worrying due to the widespread use of PPIs. Current evidence suggest that the mechanism of PPI induced hypomagnesemia is impaired intestinal magnesium absorption. In this report, we present the case of a long-term PPI user with persistent hypomagnesemia with severe symptoms at presentation. He was unable to stop PPI treatment because of severe reflux symptoms, and was dependent on weekly intravenous magnesium infusions, until his magnesium levels finally normalized without the need for supplementation after a successful laparoscopic fundoplication. | Synne Semb Frederik Helgstrand Flemming Hjorne Peter Bytzer | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 19 | Modelling the bed characteristics in fluidised-beds for top-spray coating processes显示文摘A particle sub-model describing the bed characteristics of a bubbling fluidised bed is presented.Atomisation air,applied at high pressures via a nozzle positioned above the bed for spray formation,is incorporated in the model since its presence has a profound influence on the bed characteristics,though the spray itself is not yet considered.A particle sub-model is developed using well-known empirical relations for particle drag force,bubble growth and velocity and particle distribution above the fluidised-bed surface.Simple but effective assumptions and abstractions were made concerning bubble distribution,particle ejection at the bed surface and the behaviour of atomisation air flow upon impacting the surface of a bubbling fluidised bed.The model was shown to be capable of predicting the fluidised bed characteristics in terms of bed heights,voidage distributions and solids volume fractions with good accuracy in less than 5 min of calculation time on a regular desktop PC.It is therefore suitable for incorporation into general process control models aimed at dynamic control for process efficiency and product quality in top-spray fluidised bed coating processes. | Mike Vanderroost Frederik Ronsse Koen Dewettinck Jan G.Pieters | 2012 | Particuology2012，10，6： | 2 |
| 20 | Fabrication and processing of polymer solar cells: A review of printing and coating techniques显示文摘 | Frederik C. Krebs | 2008 | Solar Energy Materials and Solar Cells2008，，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员