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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 3 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 4 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 5 | Enhanced glypican 3 expression differentiates the majority of bepatoeellular carcinomas from benign hepatic disorders显示文摘 | Zhu Z W Friess H Wang L Abou Shady M Zimmermann A Lander A D | 2001 | Gut2001，48，： | 1 |
| 6 | Growth inhibition of Staphylococcus aureus induced by low-frequency electric and electromagnetic fields显示文摘 | OBERMEIER A MATL FLORIAN D FRIESS W | 2009 | Bioelectromagnetics2009，30，4： | 1 |
| 7 | Enhanced expression of urokinase plasminogen activator and its receptor in pancreatic carcinoma显示文摘 | Cantero D Friess H Zimmermann A | 1997 | Br J Can1997，75，3： | 1 |
| 8 | Adju- vant therapy in pancreatic cancer: historical and current perspectives显示文摘 | Neoptolemos JP Cunningham D Friess H | 2003 | Ann 0ncol2003，14，5： | 1 |
| 9 | B7 -h3 and its role in antitumor immunity显示文摘 | LOOS M HEDDERICH D M FRIESS H | 2010 | Clin Dev hnmunol2010，2010，68： | 1 |
| 10 | Adj uvant therapy in pancreatic cancer: historical and current perspectives显示文摘 | Neoptolemos JP Cunningham D Friess H | 2003 | Ann Oncol2003，14，5： | 1 |
| 11 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 12 | Enhanced urokinase plasminogen activation in chronic pancreatitis suggests a role in its pathogenesis 显示文摘 | Friess H Cantero D Graber H | 1997 | Gastroenterology1997，113，3： | 1 |
| 13 | Are all intertidal wetlands naturally created equal?Bottlenecks,thresholds and knowledge gaps to mangrove and saltmarsh ecosystems显示文摘 | Friess D A Krauss K W Horstman E M | 2012 | Biological Reviews2012，87，2： | 1 |
| 14 | Survival,quality of life and quality-adjusted survival of patients in the ESPAC-1 trial: a European randomized trial to assess the roles of adjuvant chemotherapy and chemoradiation in resectable pancreatic cancer显示文摘 | Neoptolemos JP Moffitt DD Dunn JA Almond J Beger HG Link KH Pederzoli P Bassi C Dervernis C Fernandez Cruz L Lacaine F Spooner D Kerr DJ Friess H Büchler | | 0，，： | 1 |
| 15 | Long -term follow - up of a randomized clinical trial comparing Beger with pylo- rus- preserving Whipple procedure for chronic pancreatitis 显示文摘 | Muller MW Friess H Martin D J | 2008 | BrJ Surg2008，95，3： | 1 |
| 16 | A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer显示文摘 | STOCKEN D D FRIESS H | 2004 | N Engl J Med2004，350，12： | 1 |
| 17 | Fractalkine/CX3CRl: why a single chemokine-receptor duo bears a major and unique therapeutic potential 显示文摘 | D'haese JG Demir IE Friess H | 2010 | Expert Opin Ther Targets2010，14，2： | 1 |
| 18 | Therapeutic potential of the chemo- kine-receptor duo fractalkine/CX3 CR1 :an update 显示文摘 | D'Haese JG Friess H Ceyhan GO | 2012 | Expert Opin T- her Target2012，16，6： | 1 |
| 19 | Adjuvant therapy in pancreatic cancer: historical and current perspectives 显示文摘 | Neoptolemos J P Cunningham D Friess H | 2003 | Ann Oncol2003，14，5： | 1 |
| 20 | Fractalkine/CXC3CR1: why asingle chemokine-receptor duo bears a major and unique therapeuticpotential显示文摘 | D'haese JG Demir IE Friess H | 2010 | Expert Opin Ther Targets2010，14，2： | 1 |
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