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| 1 | Resolvin-D1 inhibits interleukin-8 and hydrogen peroxide production induced by cigarette smoke extract in 16HBE cells via attenuating NF-κB activation显示文摘 | Dong Jiajia Zhang Mingke Liao Zenglin Wu Wei Wang Tao Chen Lei Yang Ting Guo Lingli Xu Dan Wen Fuqiang | 2014 | Chinese Medical Journal2014，，3： | 6 |
| 2 | Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono-and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers显示文摘Sensory processing is strongly modulated by different brain and behavioral states,and this is based on the top-down modulation.In the olfactory system,local neural circuits in the olfactory bulb(OB)are innervated by centrifugal afferents in order to regulate the processing of olfactory information in the OB under different behavioral states.The purpose of the present study was to explore the organization of neural networks in olfactory-related cortices and modulatory nuclei that give rise to direct and indirect innervations to the glomerular layer(GL)of the OB at the whole-brain scale.Injection of different recombinant attenuated neurotropic viruses into the GL showed that it received direct inputs from each layer in the OB,centrifugal inputs from the ipsilateralanterior olfactory nucleus(AON),anterior piriform cortex(Pir),and horizontal limb of diagonal band of Broca(HDB),and various indirect inputs from bilateral cortical neurons in the AON,Pir,amygdala,entorhinal cortex,hippocampus,HDB,dorsal raphe,median raphe and locus coeruleus.These results provide a circuitry basis that will help further understand the mechanism by which olfactory informationprocessing in the OB is regulated. | Pengjie Wen Xiaoping Rao Liuying Xu Zhijian Zhang Fan Jia Xiaobin He Fuqiang Xu | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 3 | Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics显示文摘Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative treatments.Abnormally elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and prognosis.RNAi interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM cells.This study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R complexes.Ap functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,respectively.Ap-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of GBM.The study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment. | Lijuan Wen Yu Peng Kai Wang Zhihua Huang Shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu | 2022 | Nano Research2022，15，2： | 2 |
| 4 | Additional acoustic attenuation of coastal turbid water—Measurements compared with predictions using particle size distributions techniques显示文摘把方法基于回响,粘滞 0.2-2.0 kg/m3 的吸收沉积和玻璃祷告混浊的海水被测量。测量结果与用粒子尺寸分布技术的预言结果更一致而不是使用平均粒子半径技术,这被显示出。由预言的比较,用粒子的结果用平均粒子半径技术与那缩放分布技术,差异是 2.3-2.6 dB,这被观察为沉积的 1.0 kg/m3 的每 100 米在试验性的频率的范围以内的混浊的海水。粒子尺寸分布应该在预言被考虑,这被建议粘滞沿海的混浊的水里的吸收。 | WEN Hongtao YANG Yanming LIU Zhenwen NIU Fuqiang | 2011 | Chinese Journal of Acoustics2011，30，3： | 2 |
| 5 | Plasmonic coupling-enhanced in situ photothermal nanoreactor with shape selective catalysis for C–C coupling reaction显示文摘Carbon-carbon(C–C)coupling reactions represent one of the most powerful tools for the synthesis of complex natural products,bioactive molecules developed as drugs and agrochemicals.In this work,a multifunctional nanoreactor for C–C coupling reaction was successfully fabricated via encapsulating the core-shell Cu@Ni nanocubes into ZIF-8(Cu@Ni@ZIF-8).In this nanoreactor,Ni shell of the core-shell Cu@Ni nanocubes was the catalytical active center,and Cu core was in situ heating source for the catalyst by absorbing the visible light.Moreover,benefiting from the plasmonic resonance effect between Cu@Ni nanocubes encapsulated in ZIF-8,the absorption range of nanoreactor was widened and the utilization rate of visible light was enhanced.Most importantly,the microporous structure of ZIF-8 provided shape-selective of reactant.This composite was used for the highly shape-selective and stable photocatalysed C–C coupling reaction of boric acid under visible light irradiation.After five cycles,the nanoreactor still remained high catalytical activity.This Cu@Ni@ZIF-8 nanoreactor opens a way for photocatalytic C–C coupling reactions with shape-selectivity. | Zhenxing Li Yixuan Gong Xin Zhang Yangyang Wen Jiasai Yao Mingliang Hu Miao He Jiahao Liu Rui Li Fuqiang Wang Chuanxin Zhang | 2020 | Nano Research2020，13，10： | 2 |
| 6 | Combustion Wave Propagation of a Modular Porous Burner with Annular Heat Recirculation显示文摘A numerical investigation of the different arrangements of porous media in a combustor with annular heat recirculation is conducted.The effect of annular heat recirculation and porous block arrangement on the characteristics of combustion wave propagation is numerically studied.Results show that power input,heat capacity of porous matrix,arrangement of porous blocks,and annular heat recirculation are major factors that influence the propagation of combustion wave.The overall temperature of ceramic porous burner is higher than that of ceramic-metal type burner due to the lower heat storage capacity of the former,especially for the temperature downstream.The flame temperature is higher upstream and lower downstream with metal foams in the annulus than that without metal foams.The flame temperature of uniformity type burner is more uniform than that of gradually-varied and modular type burners.The flame front moves more slowly with metal foams in the annulus than that without metal foams due to the better preheating effect of metal foams.The flame position moves downstream,and the flame temperature gradually decreases and is eventually extinguished due to the low preheating temperature. | SONG Fuqiang WEN Zhi FANG Yuan WANG Enyu LIU Xunliang | 2020 | Journal of Thermal Science2020，29，1： | 2 |
| 7 | Single-crystalline Ni(OH)2and Ni O nanoplatelet arrays as supercapacitor electrodes显示文摘 | LI Jiangtian ZHAO Wen HUANG Fuqiang | 2011 | Nanoscale2011，3，12： | 1 |
| 8 | Automatic visual inspection for leather manufacture 显示文摘 | HE Fuqiang WANG Wen CHEN Zichen | 2006 | Key Eng Mater2006，，12： | 1 |
| 9 | Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues显示文摘 | Lizhang Chen Fuqiang Liu Xuegong Fan Jianming Gao Nengzhi Chen Tom Wong Jun Wu Shi Wu Wen | 2008 | International Journal of Infectious Diseases2008，，1： | 1 |
| 10 | Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C-C/C-N formation,annulation and aromatization with 1,2-dichloroethane显示文摘A novel route for tandem C-C/C-N formation,annulation and aromatization of hydrazones with 1,2-dichloroethane to synthesize 1 H-pyrazoles has been developed.Furthermore,the 1,2-dichloroethane serves as alkylation reagent in good to excellent yields.This methodology features mild reaction conditions and good functional group tolerance,providing a direct approach for the preparation of 1 Hpvrazoles. | Liqiang Hao Hongyan Liu Zheng Zhang Fuqiang Wen Chengcai Xia Zengfen Pang | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 11 | A method for detecting two-dimensional plane stress distribution in basin-type insulator based on critically refracted longitudinal wave显示文摘Basin-type insulator often has small cracks due to stress concentration.The current method cannot accurately reflect the stress condition of the insulator to find the stress concentration areas.To solve these problems,a method for detecting two-dimensional plane stress(δ_(1) andδ_(2))within different depth ranges in a basin-type insulator is proposed based on critically refracted longitudinal(LCR)wave.First,the acoustoelastic equation characterising the relationship between the variation of LCR wave propagation time and the plane stress was derived.Next,the propagation characteristics of LCR wave in epoxy resin samples were investigated.Then,the stress distribution within different depth ranges of the insulator subjected to hydraulic load was measured using the proposed method,including direction(θ),δ_(1) andδ_(2).The results show that the magnitude of the stress alone cannot accurately characterise the stress state.Points with equal distances to the centre have similar stress magnitudes,but their directions are not the same.With increasing depth,θremains essentially unchanged at the same location,whileδ1 andδ2 decrease,and the rate of decrease varies at different locations.Comparing the measured and simulated data,the results showed that they were in good agreement,and the maximum errors of stress value andθwere 0.69 MPa and 2.97°,respectively,which confirmed the feasibility and accuracy of the stress detection in the proposed method. | Zhaoyang Kang Fuqiang Ren Hongru Zhang Jingjing Yang Kaining Hou Qingquan Li Dongxin He Hongshun Liu Yongzhi Zhao Huaxin Wen | 2024 | High Voltage2024，9，1： | 0 |
| 12 | Bridging bronchus complicated with a left pulmonary artery sling a rare entity显示文摘To the editor:The bridging bronchus (BB) is a rarely reported congenital anomaly in which right middle and lower lobes are supplied by an accessory bronchus arising from the left main bronchus.1 A sling left pulmonary artery (SLPA) is also a rare congenital cardiac malformation,in which the left pulmonary artery arises from the right pulmonary artery and passes between the trachea and esophagus,causing tracheal stenosis by the pulsating pulmonary artery.2 Here we present a rare pediatric case of BB complicated with a SLPA. A three-year-old boy was admitted with complaints of recurrent respiratory distress and cough,with no signs of cyanosis and clubbing fingers. | Lin Jing Shen Yongchun Huang Zixing Wen Fuqiang | 2014 | Chinese Medical Journal2014，，19： | 0 |
| 13 | A new three-dimensional terrain-following tidal model of free-surface flows显示文摘一个三维的水动力学模型被介绍它联合一个地面追随者有一个水平地直角的曲线的坐标系统的垂直坐标接近河口,大陆人架,和港口适合复杂底部地形学和海岸线。更高效地解决管理方程,我们改进含蓄的方法,它是广泛地在水平二维的浅水方程的数字建模使用了的轮流出现的方向,并且把它递有相对小的计算努力的一个三维的潮汐的模型。通过几个测试用例和现实主义的应用在纸介绍了模型能够在近岸的区域模仿周期的往来活动的水流,风驱动的流动, Ekman 螺线,和潮汐的水流,这能被表明。 | Fuqiang LU | 2015 | Frontiers of Earth Science2015，9，4： | 0 |
| 14 | Application of wavelet scale correlation filtering and its improved algorithm in signal processing with a spark sound source显示文摘It is seriously interfered by ship noise when analyzing and extracting broadband spark sound source signal.In the energy concentrated domain which is below 5 kHz,the traditional scale correlation filtering algorithm,which is based on adjacent-scale correlation,has limited anti-interference ability due to the low signal-to-noise ratio(SNR) and similar Lipschitz exponent characteristic of each other.However,because different frequency bands of the broadband electric spark signal have different noise interferences,the filtering algorithm based on adjacent-scale correlation is adapted to high SNR and small-scale high-frequency wavelet coefficients filtering;the filtering algorithm based on cross-scale correlation is adapted to low SNR and large-scale low-frequency wavelet coefficients filtering,and the threshold coefficient selection method had been corrected in the algorithm.It is shown that the filtering algorithm has a good filtering effect and extracts the broadband spark sound source signal effectively;it is applicable to broadband underwater acoustic signal processing in the presence of narrow-band strong interference background noise. | WEN Hongtao YANG Yanming LIU Zhenwen NIU Fuqiang | 2013 | Chinese Journal of Acoustics2013，32，4： | 0 |
| 15 | Hydrogen gas:a novel antioxidant for chronic obstructive pulmonary disease?显示文摘Oxidative stress plays critical role in the pathogenesis of chronic obstructive pulmonary disease(COPD),so therapy targeted on oxidative stress is of great importance for COPD.However,since the current used antioxidants are not satisfying,scientists have to find more effective antioxidants for COPD.Hydrogen,the most abundant chemical element in the universe,was recently discovered as a novel therapeutic medical gas,and has shown great antioxidant potential in a series of recent published researches for its feature of selectively reducing toxic reactive oxygen species.Based on these findings,we hypothesize that hydrogen gas therapy might be a novel,effective,safe,and economic treatment for COPD patients in one day. | Shen Yongchun Yang Ting Wang Tao Wen Fuqiang | 2011 | Journal of Medical Colleges of PLA(China)2011，26，2： | 0 |
| 16 | Existing tests vs. novel non-invasive assays for detection of invasive aspergillosis in patients with respiratory diseases显示文摘Background: Although existing mycological tests (bronchoalveolar lavage [BAL] galactomannan [GM], serum GM, serum (1,3)-β-D-glucan [BDG], and fungal culture) are widely used for diagnosing invasive pulmonary aspergillosis (IPA) in non-hematological patients with respiratory diseases, their clinical utility in this large population is actually unclear. We aimed to resolve this clinical uncertainty by evaluating the diagnostic accuracy and utility of existing tests and explore the efficacy of novel sputum-basedAspergillus assays.Methods: Existing tests were assessed in a prospective and consecutive cohort of patients with respiratory diseases in West China Hospital between 2016 and 2019 while novel sputum assays (especially sputum GM andAspergillus-specific lateral-flow device [LFD]) in a case-controlled subcohort. IPA was defined according to the modified European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Sensitivity and specificity were computed for each test and receiver operating characteristic (ROC) curve analysis was performed.Results: The entire cohort included 3530 admissions (proven/probable IPA=66, no IPA=3464) and the subcohort included 127 admissions (proven/probable IPA=38, no IPA=89). Sensitivity of BAL GM (≥1.0 optical density index [ODI]: 86% [24/28]) was substantially higher than that of serum GM (≥0.5 ODI: 38% [39/102]) (χ^(2)=19.83,P<0.001), serum BDG (≥70 pg/mL: 33% [31/95]) (χ^(2)=24.65,P<0.001), and fungal culture (33% [84/253]) (χ^(2)=29.38,P<0.001). Specificity varied between BAL GM (≥1.0 ODI: 94% [377/402]), serum GM (≥0.5 ODI: 95% [2130/2248]), BDG (89% [1878/2106]), and culture (98% [4936/5055]). Sputum GM (≥2.0 ODI) had similar sensitivity (84% [32/38]) (Fisher’s exactP=1.000) to and slightly lower specificity (87% [77/89]) (χ^(2)=5.52,P=0.019) than BAL GM (≥1.0 ODI). Area under the ROC curve values were comparable between sputum GM (0.883 [0.812-0.953]) and BAL GM (0.901 [0.824-0.977]) (P=0.734). Sputum LFD had similar specificity (91% [81/89]) (χ^(2)=0.89,P=0.345) to and lower sensitivity (63% [24/38]) (χ^(2)=4.14,P=0.042) than BAL GM (≥1.0 ODI), but significantly higher sensitivity than serum GM (≥0.5 ODI) (χ^(2)=6.95,P=0.008), BDG (χ^(2)=10.43,P=0.001), and fungal culture (χ^(2)=12.70,P<0.001).Conclusions: Serum GM, serum BDG, and fungal culture lack sufficient sensitivity for diagnosing IPA in respiratory patients. Sputum GM and LFD assays hold promise as rapid, sensitive, and non-invasive alternatives to the BAL GM test. | Wei Xiao Longyi Du Linli Cai Tiwei Miao Bing Mao Fuqiang Wen Peter Gerard Gibso Deying Gong Yan Zeng Mei Kang Xinmiao Du Junyan Qu Yan Wang Xuemei Liu Ruizhi Feng Juanjuan Fu | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 17 | A method to quantitatively estimate rainfall rate above water surface based on different spectra shapes generated by rainfall显示文摘从不同光谱形状在水表面上与非线性的最少平方的回归相结合到份量上估计降雨率的一个方法由雨产生了 -- 在一些频率乐队的秋天被介绍。降雨产生的大约 2000 min 光谱数据被收集了在一在厦门开湖城市。作为结果,在 15-30 kHz 的光谱形状被适合到从没有雨,毛毛雨降雨率 10 mm/h 和大雨降雨评估的光谱斜坡允许雨的分类进三个范畴的木头线性的法律 10 ram/h。然后,降雨察觉被做,降雨率在 2-15 的频率乐队与逻辑模型一起在毛毛雨时间被确定 kHz,和在重降雨的降雨率也与木头线性的回归确定了。最后,所有测量光谱数据被用来与算法计算降雨率。结果证明估计的降雨率与同时地测量的是可比较地重合的。积聚的降雨的平均错误仅仅每 min 是 1%-4% 。 | LIU Zhenwen YANG Yanming WEN Hongtao NIU Fuqiang XU Xiaomei | 2011 | Chinese Journal of Acoustics2011，30，3： | 0 |
| 18 | Incorporation of a Toll-like receptor 2/6 agonist potentiates mRNA vaccines against cancer and infectious diseases显示文摘mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases.Improvements of mRNA vaccines have been underway,among which boosting of efficacy is of great importance.Pam2Cys,a simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor(TLR)2/6 pathway,eliciting both humoral and cellular adaptive immune responses,is an interesting candidate adjuvant.To investigate the enhancement of the efficacies of mRNA vaccines by Pam2Cys,the adjuvant was incorporated into mRNA-lipid nanoparticles(LNPs)to achieve co-delivery with mRNA.Immunization with the resulting mRNA-LNPs(Pam2Cys)shaped up the immune milieu in the draining lymph nodes(dLNs)through the induction of IL-12 and IL-17,among other cytokines.Antigen presentation was carried out mainly by migratory and dLNresident conventional type 2 DCs(cDC2s)and significantly more potent antitumor responses were triggered in both prophylactic and therapeutic tumor models in a CD4^(+) and CD8^(+) T cell-dependent fashion.Accompanying memory antitumor immunity was also established.Moreover,the vaccine also stimulated much more robust humoral and cellular immunity in a surrogate COVID-19 prophylactic model.Last but not the least,the new vaccines exhibited good preliminary safety profiles in murine models.These facts warrant future development of Pam2Cys-incorporated mRNA vaccines or relevant mRNA therapeutics for clinical application. | Yangzhuo Gu Jingyun Yang Cai He Tingmei Zhao Ran Lu Jian Liu Xianming Mo Fuqiang Wen Huashan Shi | 2023 | Signal Transduction and Targeted Therapy2023，8，8： | 0 |
| 19 | 本校近期发表IF≥4.0的SCI论文摘要(英文)--Evaluation of Blastomere Biopsy Using a Mouse Model Indicates the Potential High Risk of Neurodegenerative Disorders in the Offspring显示文摘 | Wu Jindao Guo Xuejiang Zhao Chun Zhou Rong Zhang Zhuo Wang Fuqiang Xiao Min Chen Ling Zhu Hui Chen Wen Lin Min Liu Jiayin Zhou Zuomin Wang Liu Huo Ran Sha Jiahao Yu Yang Fan Yong Lv Zhuo Wang Liu Zhou Qi | 2009 | 南京医科大学学报(自然科学版)2009，29，9： | 0 |
| 20 | A case of miss-diagnosed pulmonary hamartomas with atypical radiology findings显示文摘To the editor:Pulmonary hamartoma is one of the most common benign tumour-like lesions of the lung with the characteristic radiograph appearance of a well-defined,solitary,smooth or slightly lobulated,peripheral pulmonary nodule with the presence of popcorn-like calcification.We report a case of multiple pulmonary hamartomas in a patient with unusual radiology performance. | Li Min Shen Yongchun Wen Fuqiang | 2014 | Chinese Medical Journal2014，，1： | 0 |
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