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| 1 | Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake显示文摘Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A. | Fang Li Rongfeng Hu Bin Wang Yun Gui Gang Cheng Song Gao Lei Ye Jihui Tang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 15 |
| 2 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 3 | Review-material degradation assessed by digital image processing:Fundamentals,progresses,and challenges显示文摘Material degradation is accompanied by the changes in surface structure,morphology,and composition.These changes can be recorded by a variety of image acquisition devices that export digital images in grayscale or true color to a detector.Information regarding corrosion type and extent can be extracted with image processing methods.This paper provides a comprehensive review of material degradation assessed by digital image processing.Digital image processing systems used to assess material degradation are briefly reviewed,and the algorithms developed to process metallic materials degradation images are described.Physical and electrochemical methods that can be used to support digital image processing results are summarized,and future work that will augment the present methods of evaluating material degradation are discussed. | Da-Hai Xia Shizhe Song Lei Tao Zhenbo Qin Zhong Wu Zhiming Gao Jihui Wang Wenbin Hu Yashar Behnamian Jing-Li Luo | 2020 | Journal of Materials Science & Technology2020，52，18： | 8 |
| 4 | Integrating a weighted-average method into the random walk framework to generate individual friend recommendations显示文摘Friend recommendation is a fundamental service in both social networks and practical applications,and is influenced by user behaviors such as interactions, interests, and activities. In this study, we first conduct in-depth investigations on factors that affect recommendation results. Next, we design Friend++, a hybrid multi-individual recommendation model that integrates a weighted average method(WAM) into the random walk(RW) framework by seamlessly employing social ties, behavior context, and personal information. In Friend++, the first plus signifies recommending a new friend through network features, while the second plus stands for using node features. To verify our method, we conduct experiments on three social datasets crawled from the Sina microblog system(Weibo). Experimental results show that the proposed method significantly outperforms six baseline methods in terms of recall, precision, F1-measure, and MAP. As a final step, we describe a case study that demonstrates the scalability and universality of our method. Through discussion, we reach a meaningful conclusion: although common interests are more important than user activities in making recommendations, user interactions may be the most important factor in finding the most appropriate potential friends. | Jibing GONG Xiaoxia GAO Hong CHENG Jihui LIU Yanqing SONG Mantang ZHANG Yi ZHAO | 2017 | Science China(Information Sciences)2017，60，11： | 7 |
| 5 | Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode显示文摘Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(Li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective strategy.In this work,we report a new type of hybrid sulfur host which is composed of Al_(2)O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2)O_(3)).The NMC-Al_(2)O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2)O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1,212 mAh·g^(-1)at 0.2 C;755 mAh·g^(-1)at 2 C),cycling charge-discharge reversibility(sustainably 100%efficiencies)and stability(1,000 cycles with only 0.023%capacity decay per cycle at 0.5 C).By contrast,the Al_(2)O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during cycling.Density functional theory(DFH')calculations further reveal that the implanted Al_(2)O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode. | Fei Sun Zhibin Qu Hua Wang Xiaoyan Liu Tong Pei Rui Han Jihui Gao Guangbo Zhao Yunfeng Lu | 2021 | Nano Research2021，14，1： | 3 |
| 6 | Long-period Gratings in-situ Sensing for Flow Monitoring in Liquid Composite Molding显示文摘Liquid composite moulding (LCM) processes are used to manufacture high quality and complex-shaped composite parts in the automotive, marine, aerospace and civil industries. On-line sensing plays an important role in controlling the quality of the final product in the LCM manufacturing environment. The long-period fiber grating (LPG)technology, a new real-time fiber optic sensor system, was developed to monitor the flow front progression. The sensor operation and characterization under various process conditions were discussed in detail. The experimental results showed that LPG sensors were robust and reliable to detect the arrival of resin at pre-selected locations in structures with low-medium fiber volume fraction; however were limited at different depths in structures with high fiber volume fraction. | Yingdan ZHU, Chang WANG, Jihui WANG, Wei HE and Guoqiang GAO State Key Laboratory of Advanced Technology for Materials Synthesis and Proceeding, Wuhan University of Technology, Wuhan 430070, China | 2005 | Journal of Materials Science & Technology2005，21，2： | 3 |
| 7 | Nitrogen-rich carbon spheres made by a continuous spraying process for high-performance supercapacitors显示文摘Supercapacitors 有高力量密度,高效率,和长骑车一生;然而,启用他们的更宽的使用,他们的精力密度必须显著地被改进。有更好的电容,率表演,和骑车的稳定性的改进的碳材料的设计和合成作为 supercapacitor 研究的主要主题出现了。此处,我们报导一个灵巧的合成方法基于一个连续喷洒喷雾器的过程准备充满氮的碳粒子。有高表面区域的方法收益粒子,一致多微孔的结构,并且是高度做 N 的,导致在水、商业的器官的电解质为使用与高精力和力量密度启用 supercapacitors 的构造的协同。而且,我们使用了密度证明改进性能由于提高的 wettability,在碳 / 电解质的离子吸附相互作用连接那的功能的理论计算源于氮做。这些调查结果提供新卓见进在碳材料的电容改进做的 heteroatom 的角色;另外,我们的方法为做的碳的大规模生产提供一条有效线路。 | Fei Sun Haobin Wu Xin Liu Fang Liu Huihui zhou Jihui Gao Yunfeng Lu | 2016 | Nano Research2016，9，11： | 2 |
| 8 | Novel phenomena in a Kundt's tube and its analysis显示文摘 | Duan Jihui Li Xiangcheng Gao Wei | 1983 | Coil Phys1983，，3： | 1 |
| 9 | Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms显示文摘Objective:Accurate preoperative identification of benign or malignant pancreatic cystic neoplasms(PCN)may help clinicians make better intervention choices and will be essential for individualized treatment.Methods:Preoperative ultrasound and laboratory examination findings,and demographic characteristics were collected from patients.Multiple logistic regression was used to identify independent risk factors associated with malignant PCN,which were then included in the nomogram and validated with an external cohort.The Net Reclassification Index(NRI)and Integrated Discrimination Improvement(IDI)were calculated to evaluate the improvement in the predictive power of the new model with respect to that of a combined imaging and tumor marker prediction model.Results:Malignant PCN were found in 83(40.7%)and 33(38.7%)of the model and validation cohorts,respectively.Multivariate analysis identified age,tumor location,imaging of tumor boundary,blood type,mean hemoglobin concentration,neutrophil-tolymphocyte ratio,carbohydrate antigen 19-9,and carcinoembryonic antigen as independent risk factors for malignant PCN.The calibration curve indicated that the predictions based on the nomogram were in excellent agreement with the actual observations.A nomogram score cutoff of 192.5 classified patients as having low vs.high risk of malignant PCN.The model achieved good C-statistics of 0.929(95%CI 0.890–0.968,P<0.05)and 0.951(95%CI 0.903–0.998,P<0.05)in predicting malignancy in the development and validation cohorts,respectively.NRI=0.268;IDI=0.271(P<0.001 for improvement).The DCA curve indicated that our model yielded greater clinical benefits than the comparator model.Conclusions:The nomogram showed excellent performance in predicting malignant PCN and may help surgeons select patients for detailed examination and surgery.The nomogram is freely available at http://gffzz301f03ad8b874f7es96xqxvcoxofk6cpq.ffgz.tsg.suse.edu.cn/DynNomapp/. | Xiuchao Wang Junjin Wang Xi Wei Lihui Zhao Bo Ni Zekun Li Chuntao Gao Song Gao Tiansuo Zhao Jian Wang Weidong Ma Xiao Hu Jihui Hao | 2022 | Cancer Biology & Medicine2022，19，10： | 1 |
| 10 | Modelling and experimen- tal study on agglomeration of particles from coal combustion in mul- tistage spouted fluidized tower显示文摘 | Gao Jihui Liu Jiaxun Gao Jianmin | 2009 | Advanced Powder Technology2009，20，4： | 1 |
| 11 | Attitude estimation method based on extended Kalman filter algorithm with 22 dimensional state vector for low-cost agricultural UAV显示文摘To overcome the shortcomings of traditional artificial spraying pesticides and make more efficient prevention of diseases and pests,a coaxial sixteen-rotor unmanned aerial vehicle(UAV)with pesticide spraying system is designed.The coaxial sixteen-rotor UAV’s basic structure and attitude estimation method are explained.The whole system weights 25 kg,cruising speed can reach 15 m/s,and the flight time is more than 20 min.When the UAV takes large load,the traditional extended Kalman filter(EKF)attitude estimation method can not meet the work requirements under the condition of strong vibration,the attitude measure accuracy is poor and the attitude angle divergence is easily caused.Hence an attitude estimation method based on EKF algorithm with 22 dimensional state vector is proposed which can solve these problems.The UAV system consists of STM32F429 as controller,integrating following measure sensors:accelerometer and gyroscope MPU6000,magnetometer LSM303D,GPS NEO-M8N and barometer.The attitude unit quaternion,velocity,position,earth magnetic field,biases error of gyroscope,accelerometer and magnetometer are introduced as the inertial navigation systems(INS)state vector,while magnetometer,global positioning system(GPS)and barometer are introduced as observation vector,thus making the estimate of the navigation information more accurate.The control strategy of coaxial sixteen-rotor UAV is based on the control method of combining active disturbance rejection control(ADRC)and proportion integral derivative(PID)control.Actual flight data are used to verify the algorithm,and the static experiment shows that the precision of roll angle and pitch angle of the algorithm are±0.1°,the precision of yaw angle is±0.2°.The attitude angle output of MTi sensor is used as reference.The dynamic experiment shows that the accuracy of attitude estimated by EKF algorithm is quite similar to that of MTi’s output,moreover,the algorithm has good real-time performance which meets the need of high maneuverability of agricultural UAV. | 吴和龙 Pei Xinbiao Li Jihui Gao Huibin Bai Yue | 2020 | High Technology Letters2020，26，2： | 1 |
| 12 | Interactions between mercury and dry FGD ash in simulated post combustion conditions 显示文摘 | WU Shaohua WANG Shuai GAO Jihui | 2011 | Journal of Hazardous Materials2011，188，： | 1 |
| 13 | Modelling and experimental study on agglomeration ofparticles from coal combustion in multistage spouted fluidized tower显示文摘 | Gao Jihui Liu Jiaxun Gao Jianmin Du Qian Wang Xiaofeng WuShaohua | 2009 | Advanced Powder Technology2009，20，： | 1 |
| 14 | Low-temperature growth and optical properties of Ce-doped ZnO nanorods显示文摘 | Jinghai Yang Ming Gao Yongjun Zhang Lili Yang Jihui Lang Dandan Wang Huilian Liu Yanqing Liu Yaxin Wang Hougang Fan | 2008 | Applied Surface Science2008，255，： | 1 |
| 15 | Determination of corrosion types from electrochemical noise by phase space reconstruction theory显示文摘 | Dahai Xia Shizhe Song Jihui Wang Jiangbo Shi Huichao Bi Zhiming Gao | 2011 | Electrochemistry Communications2011，，1： | 1 |
| 16 | Study on camouflage effect of targets with different characteristics under typical baekground显示文摘 | Gao S S Jin W Q Jihui Wang J H | 2010 | SHE 5th International Symposium on Ad- vanced Optical Manufacturing and Testing Technologies: Opti cal Test and Measurement Technology and Equipment2010，7656，76： | 1 |
| 17 | Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells显示文摘 | He Ren Tiansuo Zhao Xiuchao Wang Chuntao Gao Jian Wang Ming Yu Jihui Hao | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
| 18 | Simultaneous removal of SO2 and NOx by calcium hydroxide at low temperature: evolution of the absorbent surface structure 显示文摘 | Gao Jihui Chela Guoqing Liu Jiaxun | 2010 | Energy & Fuels2010，24，： | 1 |
| 19 | Interactions between mercury and dry FGD ash in simulated post combustion conditions显示文摘 | Wu Shaohua Wang Shuai Gao Jihui | 2011 | Journal of Hazardous Materials2011，188，： | 1 |
| 20 | Preparation of activated carbons for SO2 adsorption by CO2 and steam activation显示文摘 | ZHU Yuwen GAO Jihui LI Yang | 2012 | Journal of the Taiwan Institute of Chemical Engineers2012，43，1： | 1 |
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