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| 1 | Effects of environmental factors on sulfamethoxazole photodegradation under simulated sunlight irradiation: Kinetics and mechanism显示文摘To advance the knowledge of the environmental fate of sulfamethoxazole(SMX),we systematically investigated the effects of natural water constituents and synthetic substances(i.e.,TiO2 nanoparticles(nTiO2) and Ti-doped β-Bi2O3(NTB)) on the photodegradation kinetics of SMX under xenon lamp irradiation.The photolysis of SMX in aqueous solution followed first-order kinetics.Our results showed that higher concentrations of SMX,fulvic acid,suspended sediments,NTB and higher pH value decreased the photodegradation rates of SMX,whereas H2O2 improved the SMX photodegradation.TiO2 nanoparticles had a dual effect on photodegradation due to their photocatalytic activity and photoabsorption of photons.No intermediates more toxic toward Vibrio fischeri than SMX were produced after direct photolysis and photocatalytic degradation for 3 hr.The photolysis of SMX involved three pathways:hydroxylation,cleavage of the sulfonamide bond,and fragmentation of the isoxazole ring.This study lays the groundwork for a better understanding of the environmental fate of SMX. | Junfeng Niu Lilan Zhang Yang Li Jinbo Zhao Sidan Lv Keqing Xiao | 2013 | Journal of Environmental Sciences2013，25，6： | 14 |
| 2 | PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation显示文摘A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear. Here we show that the M2 isoform of pyruvate kinase (PKM2), one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis. mTOR increases the PKM2:MFN2 interaction by phosphorylating MFN2 and thereby modulates the effect of PKM2: MFN2 on glycolysis, mitochondrial fusion and OXPHOS. Thus, an mTOR-MFN2-PKM2 signaling axis couples glycolysis and OXPHOS to modulate cancer cell growth. | Tong Li Jinbo Han Liangjie Jia Xiao Hu Liqun Chen Yiguo Wang | 2019 | Protein & Cell2019，10，8： | 10 |
| 3 | Reemergent Cases of COVID-19--Dalian City,Liaoning Province,China,July 22,2020显示文摘From July 22-23,3 local COVID-19 cases were reported in Dalian City,Liaoning Province,China.All 3 patients reported that they did not leave Dalian 14 days before the onset of disease and had no COVID-19 case contact history and no foreign personnel contact history.Epidemiological investigation,medical isolation,and nucleic acid detection was immediately carried out in Dalian,and 12 asymptomatic infections were detected in close contacts of Patient 1.Because asymptomatic infections made up a large proportion of total infections,the outbreak was likely observed in the beginning stages. | Xiang Zhao Lingling Mao Jianqun Zhang Yong Zhang Yang Song Zhijian Bo Hong Wang Ji Wang Cao Chen Jinbo Xiao Tianjiao Ji Qian Yang Wenbo Xu Dayan Wang Wenqing Yao | 2020 | China CDC weekly2020，2，34： | 5 |
| 4 | Integrated energy storage system based on triboelectric nanogenerator in electronic devices显示文摘The emergence of electronic devices has brought earth-shaking changes to people's life.However,an extemal power source may become indispensable to the electronie devices due to the limited capacity of batteries.As one of the possible solutions for the extermal power sources,the triboelectric nanogenerator(TENG)provides a novel idea to the increasing mumber of personal electronic devices.TENG is a new type of energy ollector,which has become a hot spot in the field of nanotechnology.It is widely used at the acquisition and conversion of mechan-ical enegy to electrice energy through the principle of electrostatic induction.On this basis,the TENG could be integrated with the energy stonage system into a self-powered system,W hich can supply power to the electronic devices and make them work continuously.In this review,TENG's basic structure as well as its working process and working mode are firstly discussed.The integration method of TENGs with enegy storage systems and the related research status are then introduced in detail.At the end of this paper,we put forward some problems and discuss the prospect in the future. | Xiao Feng Yang Zhang Le Kang Licheng Wang Chongxiong Duan Kai Yin Jinbo Pang Kai Wang | 2021 | Frontiers of Chemical Science and Engineering2021，15，2： | 5 |
| 5 | Fast-Suppressor Screening for New Components in Protein Trafficking,Organelle Biogenesis and Silencing Pathway in Arabidopsis thaliana Using DEX-Inducible FREE1-RNAi Plants显示文摘Membrane trafficking is essential for plant growth and responses to external signals.The plant unique FYVE domain-containing protein FREE1 is a component of the ESCRT complex(endosomal sorting complex required for transport).FREE1 plays multiple roles in regulating protein trafficking and organelle biogenesis including the formation of intraluminal vesicles of multivesicular body(MVB),vacuolar protein transport and vacuole biogenesis,and autophagic degradation.FREE1 knockout plants show defective MVB formation,abnormal vacuolar transport,fragmented vacuoles,accumulated autophagosomes,and seedling lethality.To further uncover the underlying mechanisms of FREE1 function in plants,we performed a forward genetic screen for mutants that suppressed the seedling lethal phenotype of FREE1-RNAi transgenic plants.The obtained mutants are termed as suppressors of free1(sof).To date,229 putative sof mutants have been identified.Barely detecting of FREE1 protein with M3plants further identified 84 FREE1-related suppressors.Also145 mutants showing no reduction of FREE1 protein were termed as RNAi-related mutants.Through next-generation sequencing(NGS)of bulked DNA from F2mapping population of two RNAi-related sof mutants,FREE1-RNAi T-DNA inserted on chromosome 1 was identified and the causal mutation of putative sof mutant is being identified similarly.These FREE1-and RNAi-related sof mutants will be useful tools and resources for illustrating the underlying mechanisms of FREE1 function in intracellular trafficking and organelle biogenesis,as well as for uncovering the new components involved in the regulation of silencing pathways in plants. | Qiong Zhao Caiji Gao PoShing Lee Lin Liu Shaofang Li Tangjin Hu Jinbo Shen Shuying Pan Hao Ye Yunru Chen Wenhan Cao Yong Cui Peng Zeng Sheng Yu Yangbin Gao Liang Chen Beixin Mo Xin Liu Shi Xiao Yunde Zhao Silin Zhong Xuemei Chen Liwen Jiang | 2015 | Journal of Genetics and Genomics2015，42，6： | 4 |
| 6 | Genomic characterization of SARS-CoV-2 identified in a reemerging COVID-19 outbreak in Beijing's Xinfadi market in 2020显示文摘After 56 days without coronavirus disease 2019(COVID-19)cases,reemergent cases were reported in Beijing,China on June 11,2020.Here,we report the genetic characteristics of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)sequenced from the clinical specimens of 4 human cases and 2 environmental samples.The nucleotide similarity among six SARS-CoV-2 genomes ranged from 99.98%to 99.99%.Compared with the reference strain of SARS-CoV-2(GenBank No.NC_045512),all six genome sequences shared the same substitutions at nt241(C→T),nt3037(C→T),nt14408(C→T),nt23403(A→G),nt28881(G→A),nt28882(G→A),and nt28883(G→C),which are the characteristic nucleotide substitutions of L-lineage European branch I.This was also proved by themaximum likelihood phylogenetic tree based on the full-length genome of SARS-CoV-2.They also have a unique shared nucleotide substitution,nt6026(C→T),which is the characteristic nucleotide substitution of SARS-CoV-2 in Beijing's Xinfadi outbreak.It is noteworthy that there is an amino acid D614Gmutation caused by nt23403 substitution in all six genomes,which may enhance the virus's infectivity in humans and help it become the leading strain of the virus to spread around the world today.It is necessary to continuously monitor the genetic variation of SARS-CoV-2,focusing on the influence of key mutation sites of SARS-CoV-2 on viral transmission,clinical manifestations,severity,and course of disease. | Yong Zhang Yang Pan Xiang Zhao Weifeng Shi Zhixiao Chen Sheng Zhang Peipei Liu Jinbo Xiao Wenjie Tan Dayan Wang William J.Liu Wenbo Xu Quanyi Wang Guizhen Wu | 2020 | Biosafety and Health2020，2，4： | 3 |
| 7 | Identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge, Guyana显示文摘Here,we report the identification of Histoplasma causing an unexplained disease cluster in Matthews Ridge,Guyana.In March 2019,14 employees of Chongqing Bosai Mining Company,China,working in a manganese mining of Guyana,had unexplained fever,and two of them died.We obtained lung and brain tissues as well as the blood samples from the two deceased cases(patient No.1 and 2),and bronchoscopy lavages and cerebrospinal fluid samples from one severe case(patient No.3),respectively.All samples were tested by pathological examination,high-throughput sequencing,and real-time PCR.Pathological detection showed the presence of spore-like structures in the lung tissue of patient No.1,indicating a fungal infection in this patient.Nanopore sequencing identified the existing of H.capsulatum in the lung tissue sample within 13 h.Next-generation sequencing identified specific fragments of H.capsulatum in all of the samples tested(lung,brain and blood serum from the deceased cases,and plasma from the severe case).Real-time PCR assays did not reveal any viral infection related to transmission from bat feces.We conclude that H.capsulatum was the causative pathogen of this disease cluster based on epidemiologic,clinical,pathological and nucleic acid evidence. | Ji Wang Weimin Zhou Hua Ling Xiaoping Dong Yi Zhang Jiandong Li Yong Zhang Jingdong Song William J.Liu Yang Li Ruiqing Zhang Wei Zhen Kun Cai Shuangli Zhu Dongyan Wang Jinbo Xiao Yigang Tong Wenli Liu Lihua Song Wei Wu Yang Liu Xiang Zhao Ruihuan Wang Sheng Ye Jing Wang Roujian Lu Baoying Huang Fei Ye Wenwen Lei Rongbao Gao Qi Shi Cao Chen Jun Han Wenbo Xu George F.Gao Xuejun Ma Guizhen Wu | 2019 | Biosafety and Health2019，1，3： | 3 |
| 8 | Catalytic decomposition of ethyl acetate over La-modified Cu-Mn oxide supported on honeycomb ceramic显示文摘The La-modified Cu-Mn spinel oxide was successfully coated onto honeycomb ceramic by a washcoating method for complete catalytic decomposition of ethyl acetate.The La-modified Cu-Mn oxides were characterized by X-ray diffraction,X-ray fluorescence,H_(2)-temperature programmed reduction,Brunauer-Emmett-Teller method,field-emission scanning electron microscopy and high-resolution transmission electron microscopy.The effects of different precipitants and rare earth doping on the structure and catalytic performance of the catalysts were investigated.The results show that the CuMn_(2)O_(4) spinel with(NH_(4))_(2)CO_(3) as a precipitant can form a larger specific surface area and a suitable pore size,which is beneficial to the absorption of ethyl acetate.Although the rare earth doping does not significantly change the crystal phase structure of the catalyst,it improves its reducibility and lowers the temperature of the catalytic decomposition.With respect to the catalytic decomposition of ethyl acetate,the rare earth-modified Cu-Mn oxide supported on honeycomb ceramic shows excellent catalytic performance with 100% conversion under the conditions of 239℃,space velocity of 12500 h^(-1) and 1000 ppm.And the ethyl acetate removal rate is still 100% after 1440 min of continuous reaction. | Rui Xiao Ruixiang Qin Chunxue Zhang Shan Chen Jinbo Wang | 2021 | Journal of Rare Earths2021，39，7： | 2 |
| 9 | Fano effect of rnetamaterial resonance in terahertz extraordinary transmission 显示文摘 | XIAO Xiao WU Jinbo Fumiaki Miyamaru | 2011 | Applied Physics Letters(S0003-6951)2011，98，01： | 1 |
| 10 | Active pipe-embedded structures in buildings for utilizing low-grade energy sources: A review显示文摘 | Xinhua Xu Shengwei Wang Jinbo Wang Fu Xiao | 2010 | Energy & Buildings2010，，10： | 1 |
| 11 | Active Pipe-embedded Structures in Buildings for Utilizing Low-Grade Energy Sources:A Review显示文摘 | Xu Xinhua Wang Shengwei Wang Jinbo Xiao Fu | | 0，，10： | 1 |
| 12 | Resonant terahertz transmissions through metal hole array on silicon substrate显示文摘 | Xiao X Jinbo W Sasagawa Y | | 0，，18： | 1 |
| 13 | E2F is required for STAT3-mediated upregulation of cyclin B1 and Cdc2 expressions and contributes to G2–M phase transition显示文摘Activation of transcription factor STAT3 is involved in cell proliferation,differentiation,and cell survival.Constitutive activation of STAT3 pathway has been associated with the oncogenesis of various types of cancers.It has been reported that STAT3 plays a key role in the G1 to S phase cell cycle transition induced by the cytokine receptor subunit gp130,through the upregulation of cyclins D1,D2,D3,A,and Cdc25A and the concomitant downregulation of p21 and p27.However,its role in mediating G2–M phase transition has not been studied.The cyclin B1/Cdc2 complex is widely accepted as the trigger of mitosis in all organisms and is believed to be necessary for progression through S phase and keep active during the G2–M transition and progression.In the present study,we found that activation of STAT3 stimulates cyclin B1 and Cdc2 expressions.Deletion and site-directed mutations on cyclin B1 and Cdc2 promoters indicated that E2F element mediates the upregulation of these two promoters in a STAT3-dependent manner.The findings reported here demonstrated that STAT3 participates in modulating G2–M phase checkpoint by regulating gene expressions of cyclin B1 and Cdc2 via E2F. | Jingjie Sun Yuping Du Qiaoling Song Jing Nan Peizhu Guan Jihui Guo Xiao Wang Jinbo Yang Chenyang Zhao | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 1 |
| 14 | Antibody Response to COVID-19 Virus--Heilongjiang Province and Gansu Province,China,2020显示文摘What is already known about this topic?Coronavirus disease 2019(COVID-19)has become a global pandemic,while the profile of antibody response against the COVID-19 virus has not been well clarified.What is added by this report?In this study,210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited.The IgM,IgA,IgG,and neutralizing antibodies(NAb)against COVID-19 virus were determined.Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset,then rapidly increasing and peaking from the 3^(rd) to 5^(th) Weeks.NAb decreased between 5^(th) and 9^(th) Weeks,and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks(p<0.05),while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks(p<0.05).What are the implications for public health practice?Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection.The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects. | Naiying Mao Zhen Zhu Shuangli Zhu Deshan Yu Jun Xu Aili Cui Lei Cao Jinyuan Guo Huiling Wang Dongyan Wang Dongmei Yan Yang Song Qian Yang Zhongyi Jiang Hui Zhang Chang Shu Ming Yang Yanhai Wang Jinbo Xiao Zhenzhi Han Yong Zhang Yan Zhang Wenbo Xu | 2020 | China CDC weekly2020，2，34： | 1 |
| 15 | Applications of MXenes in human-like sensors and actuators显示文摘Human beings perceive the world through the senses of sight,hearing,smell,taste,touch,space,and balance.The first five senses are prerequisites for people to live.The sensing organs upload information to the nervous systems,including the brain,for interpreting the surrounding environment.Then,the brain sends commands to muscles reflexively to react to stimuli,including light,gas,chemicals,sound,and pressure.MXene,as an emerging two-dimensional material,has been intensively adopted in the applications of various sensors and actuators.In this review,we update the sensors to mimic five primary senses and actuators for stimulating muscles,which employ MXene-based film,membrane,and composite with other functional materials.First,a brief introduction is delivered for the structure,properties,and synthesis methods of MXenes.Then,we feed the readers the recent reports on the MXene-derived image sensors as artificial retinas,gas sensors,chemical biosensors,acoustic devices,and tactile sensors for electronic skin.Besides,the actuators of MXene-based composite are introduced.Eventually,future opportunities are given to MXene research based on the requirements of artificial intelligence and humanoid robot,which may induce prospects in accompanying healthcare and biomedical engineering applications. | Jinbo Pang Songang Peng Chongyang Hou Xiao Wang Ting Wang Yu Cao Weijia Zhou Ding Sun Kai Wang Mark H.Rümmeli Gianaurelio Cuniberti Hong Liu | 2023 | Nano Research2023，16，4： | 1 |
| 16 | Applications of 2D-Layered Palladium Diselenide and Its van der Waals Heterostructures in Electronics and Optoelectronics显示文摘The rapid development of two-dimensional(2D)transition-metal dichalcogenides has been possible owing to their special structures and remarkable properties.In particular,palladium diselenide(PdSe_(2))with a novel pentagonal structure and unique physical characteristics have recently attracted extensive research inter-est.Consequently,tremendous research progress has been achieved regarding the physics,chemistry,and electronics of PdSe_(2).Accordingly,in this review,we recapitulate and summarize the most recent research on PdSe_(2),including its structure,properties,synthesis,and appli-cations.First,a mechanical exfoliation method to obtain PdSe_(2) nanosheets is introduced,and large-area synthesis strate-gies are explained with respect to chemical vapor deposition and metal selenization.Next,the electronic and optoelectronic properties of PdSe_(2) and related hetero-structures,such as field-effect transistors,photodetectors,sensors,and thermoelec-tric devices,are discussed.Subsequently,the integration of systems into infrared image sensors on the basis of PdSe_(2) van der Waals heterostructures is explored.Finally,future opportunities are highlighted to serve as a general guide for physicists,chemists,materials scientists,and engineers.Therefore,this com-prehensive review may shed light on the research conducted by the 2D material community. | Yanhao Wang Jinbo Pang Qilin Cheng Lin Han Yufen Li Xue Meng Bergoi Ibarlucea Hongbin Zhao Feng Yang Haiyun Liu Hong Liu Weijia Zhou Xiao Wang Mark HRummeli Yu Zhang Gianaurelio Cuniberti | 2021 | Nano-Micro Letters2021，13，9： | 1 |
| 17 | Iron-doxorubicin prodrug loaded liposome nanogenerator programs multimodal ferroptosis for efficient cancer therapy显示文摘Ferroptosis is a new mode of cell death,which can be induced by Fenton reactionmediated lipid peroxidation.However,the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ferroptosis.Herein,a self-supplying lipid peroxide nanoreactor was developed to co-delivery of doxorubicin(DOX),iron and unsaturated lipid for efficient ferroptosis.By leveraging the coordination effect between DOX and Fe3+,trisulfide bond-bridged DOX dimeric prodrug was actively loaded into the core of the unsaturated lipids-rich liposome via iron ion gradient method.First,Fe3+could react with the overexpressed GSH in tumor cells,inducing the GSH depletion and Fe2+generation.Second,the cleavage of trisulfide bond could also consume GSH,and the released DOX induces the generation of H2O2,which would react with the generated Fe2+in step one to induce efficient Fenton reaction-dependent ferroptosis.Third,the formed Fe3+/Fe2+couple could directly catalyze peroxidation of unsaturated lipids to boost Fenton reaction-independent ferroptosis.This iron-prodrug liposome nanoreactor precisely programs multimodal ferroptosis by integrating GSH depletion,ROS generation and lipid peroxidation,providing new sights for efficient cancer therapy. | Yinxian Yang Shiyi Zuo Linxiao Li Xiao Kuang Jinbo Li Bingjun Sun Shujun Wang Zhonggui He Jin Sun | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 18 | Plastid KEA-type cation/H+ antiporters are required for vacuolar protein trafficking in Arabidopsis显示文摘Arabidopsis plastid antiporters KEA1 and KEA2are critical for plastid development, photosynthetic efficiency, and plant development.Here, we show that KEA1 and KEA2 are involved in vacuolar protein trafficking. Genetic analyses found that the kea1 kea2 mutants had short siliques, small seeds, and short seedlings. Molecular and biochemical assays showed that seed storage proteins were missorted out of the cell and the precursor proteins were accumulated in kea1 kea2. Protein storage vacuoles(PSVs) were smaller in kea1 kea2. Further analyses showed that endosomal trafficking in kea1 kea2 was compromised. Vacuolar sorting receptor 1(VSR1) subcellular localizations, VSR–cargo interactions, and p24 distribution on the endoplasmic reticulum(ER) and Golgi apparatus were affected in kea1 kea2. Moreover, plastid stromule growth was reduced and plastid association with the endomembrane compartments was disrupted in kea1 kea2. Stromule growth was regulated by the cellular pH and K+homeostasis maintained by KEA1 and KEA2. The organellar pH along the trafficking pathway was altered in kea1 kea2. Overall, KEA1 and KEA2 regulate vacuolar trafficking by controlling the function of plastid stromules via adjusting pH and K+homeostasis. | Xiao Zhang Lu Wang Ting Pan Xuexia Wu Jinbo Shen Liwen Jiang Hiromi Tajima Eduardo Blumwald Quan-Sheng Qiu | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 19 | Influence of B_4C Additive on Sintering and Crystallization of Fused Silica Ceramics显示文摘The green bodies were prepared by adding B4C (0.5%,1.5%,2.5%and 3.5%in mass) or B2O3 (6%and 9%in mass) infused silica powders,respectively and then were fired at 1 150℃for 4 h,1 200℃for 4 h,and 1 350℃for 0.5 h,respectively.The bulk density,apparent porosity,cold modulus of rupture and thermal expansion coefficient of the fired specimens were determined,and phase compositions and microstructure were researched.The results show that:(1 ) B4C promotes the sintering of fused silica ceramics,but many closed pores will form easily with B4 C increase; (2) fused silica ceramics with 3.5 mass%B4C have 1.045×10-6 V-1 of the lowest average thermal expansion coefficient between 40℃and 730℃;(3 ) B4C additive is more effective to restrain crystallization of fused silica than B2O3 with the same content of boron. | YAN Wenchao WANG Min XIAO Jianzhong WANG Jinbo XIA Feng | 2013 | China's Refractories2013，22，1： | 0 |
| 20 | Nucleophilic Difluoro(phenylsulfonimidoyl)methylation of Unactivated Alkyl Bromides with PhSO(NTBS)CF_(2)H: Facile Entry into gem-Difluoroalkenes显示文摘An efficient nucleophilic difluoro(phenylsulfonimidoyl)methylation of unactivated primary alkyl bromides with PhSO(NTBS)CF_(2)H has been developed.It is particularly remarkable that,when 1.5 equiv.of alkyl bromides are used,the substitution products are obtained in moderate to excellent yields.The prepared difluoro(phenylsulfonimidoyl)methylated alkanes can be readily transformed to gem-difluoroalkenes via base-mediatedβ-elimination reaction. | Xiao Shen Qinghe Liu Chuanfa Ni Jinbo Hu | 2014 | Chinese Journal of Chemistry2014，32，8： | 0 |
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