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| 1 | Bevacizumab in the pre-operative treatment of locally advanced rectal cancer: A systematic review显示文摘Despite advances in the management of patients with locally advanced,non-metastatic rectal adenocarcinoma(LARC),prognosis remains largely unsatisfactory due to a high rate of distant relapse.In fact,currently available neoadjuvant protocols,represented by fluoropyrimidine-based chemo-radiotherapy(CT-RT)or short-course RT,together with improved surgical techniques,have largely reduced the risk of local relapse,with limited impact on distant recurrence.Available results of phaseⅢtrials with additional cytotoxic agents combined with standard CT-RT are disappointing,as no significant reduction in the risk of recurrence has been demonstrated.In order to improve the control of micrometastatic disease,integrating targeted agents into neoadjuvant treatment protocols thus offers a rational approach.In particular,the antiangiogenic agent bevacizumab has demonstrated synergistic activity with both CT and RT in pre-clinical and clinical models,and thusmay represent a suitable companion in the neoadjuvant treatment of LARC.Preliminary results of phase?Ⅰ-Ⅱclinical studies are promising and suggest potential clinical parameters and molecular predictive biomarkers useful for patient selection:treatment personalization is indeed the key in order to maximize the benefit while reducing the risk of more complex neoadjuvant treatment schedules. | Lorenzo Fornaro Chiara Caparello Caterina Vivaldi Virginia Rotella Gianna Musettini Alfredo Falcone Editta Baldini Gianluca Masi | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 2 | Functional magnetic resonance imaging of internet addiction in young adults显示文摘AIM: To report the results of functional magnetic resonance imaging(f MRI) studies pertaining internet addiction disorder(IAD) in young adults.METHODS: We conducted a systematic review on Pub Med, focusing our attention on f MRI studies involving adult IAD patients, free from any comorbid psychiatric condition. The following search words were used, both alone and in combination: f MRI, internet addiction, internet dependence, functional neuroimaging. The search was conducted on April 20^(th), 2015 and yielded 58 records. Inclusion criteria were the following: Articles written in English, patients' age ≥ 18 years, patients affected by IAD, studies providing f MRI results during resting state or cognitive/emotional paradigms. Structural MRI studies, functional imaging techniques other than f MRI, studies involving adolescents, patients with comorbid psychiatric, neurological or medical conditions were excluded. By reading titles and abstracts, we excluded 30 records. By reading the full texts of the 28 remaining articles, we identified 18 papers meeting our inclusion criteria and therefore included in the qualitative synthesis.RESULTS: We found 18 studies fulfilling our inclusion criteria, 17 of them conducted in Asia, and including a total number of 666 tested subjects. The included studies reported data acquired during resting state or different paradigms, such as cue-reactivity, guessing or cognitive control tasks. The enrolled patients were usually males(95.4%) and very young(21-25 years). The most represented IAD subtype, reported in more than 85% of patients, was the internet gaming disorder, or videogame addiction. In the resting state studies, the more relevant abnormalities were localized in the superior temporal gyrus, limbic, medial frontal and parietal regions. When analyzing the task related fmri studies, we found that less than half of the papers reported behavioral differences between patients and normal controls, but all of them found significant differences in cortical and subcortical brain regions involved in cognitive control and reward processing: Orbitofrontal cortex, insula, anterior and posterior cingulate cortex, temporal and parietal regions, brain stem and caudate nucleus.CONCLUSION: IAD may seriously affect young adults' brain functions. It needs to be studied more in depth to provide a clear diagnosis and an adequate treatment. | Gianna Sepede Margherita Tavino Rita Santacroce Federica Fiori Rosa Maria Salerno Massimo Di Giannantonio | 2016 | World Journal of Radiology2016，8，2： | 4 |
| 3 | Sustained attention in psychosis:Neuroimaging findings显示文摘To provide a systematic review of scientific literatureon functional magnetic resonance imaging(fMRI) stud-ies on sustained attention in psychosis. We searchedPubMed to identify fMRI studies pertaining sustainedattention in both affective and non-affective psycho-sis. Only studies conducted on adult patients using asustained attention task during fMRI scanning wereincluded in the final review. The search was conductedon September 10 th, 2013. 15 fMRI studies met our in-clusion criteria: 12 studies were focused on Schizophre-nia and 3 on Bipolar Disorder Type Ⅰ(BDI). Only halfof the Schizophrenia studies and two of the BDI stud-ies reported behavioral abnormalities, but all of themevidenced significant functional differences in brain re-gions related to the sustained attention system. Alteredfunctioning of the insula was found in both Schizophre-nia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlight-ing differences and similarities between Schizophrenia and BDI. | Gianna Sepede Maria Chiara Spano Marco Lorusso Domenico De Berardis Rosa Maria Salerno Massimo Di Giannantonio Francesco Gambi | 2014 | World Journal of Radiology2014，6，6： | 2 |
| 4 | Strength Exercise Improves Muscle Mass and Hepatic Insulin Sensitivity in Obese Youth显示文摘 | GERT-JAN VAN DER HEIJDEN ZHIYUE J. WANG ZILI CHU GIANNA TOFFOLO ERICA MANESSO PIETER J. J. SAUER AGNETA L. SUNEHAG | 2010 | Medicine & Science in Sports & Exercise2010，，11： | 2 |
| 5 | Full Robotic Gastrectomy with Extended (D2) Lymphadenectomy for Gastric Cancer: Surgical Technique and Preliminary Results显示文摘 | Annibale D’Annibale Vito Pende Graziano Pernazza Igor Monsellato Paolo Mazzocchi Giorgio Lucandri Emilio Morpurgo Tania Contardo Gianna Sovernigo | 2011 | Journal of Surgical Research2011，，2： | 2 |
| 6 | Understanding ethnic tourists显示文摘 | Gianna Moscardo Philip L Pearce | 1999 | Annals of Tourism Research1999，26，2： | 1 |
| 7 | Concurrent performance of two memory tasks: Evidence for domain-specific working memory systems显示文摘 | Robert H Logie Sergio Della Sala etc | 2002 | Memory & Cognition2002，30，7： | 1 |
| 8 | Between subject variations of transition zone epithelial volume and serum PSA levels in men with benign prostatic hyperplasia显示文摘 | Oreste M Giuseppe PG Gianna P | 2010 | World J Urol2010，28，3： | 1 |
| 9 | Robotic Right Colon Resection: Evaluation of First 50 Consecutive Cases for Malignant Disease显示文摘 | Annibale D’Annibale MD Graziano Pernazza MD Emilio Morpurgo MD Igor Monsellato MD Vito Pende MD Giorgio Lucandri MD Barbara Termini MD Camillo Orsini MD Gianna Sovernigo MD | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
| 10 | Mindful visitors: heritage and tourism 显示文摘 | Gianna M | 1996 | Annals of Tourism Research1996，23，2： | 1 |
| 11 | Inversion of two level circulant matrices over Zp显示文摘 | CARLO J A GIANNA M D C GIOVANNI M | 2003 | Linear Algebra and Its Applications2003，366，： | 1 |
| 12 | Comparison of volatile concentrations in hand-squeezed juices of four differ- ent lemon varieties显示文摘 | Gianna A Flavio B Paolo C | 2006 | Journal of Agricultural and Food Chemistry2006，54，5： | 1 |
| 13 | Comparison of volatile concentrations in hand-squeezed juices of four different lemon varieties显示文摘 | GIANNA A FLAVIO B PAOLO C | | 0，，05： | 1 |
| 14 | Incidence of biopsy-proven primary glomerulonephritis in an Italian Province显示文摘 | Piero Stratta Giuseppe P. Segoloni Caterina Canavese Luisa Sandri Gianna Mazzucco Dario Roccatello Marco Manganaro Antonio Vercellone | 1996 | American Journal of Kidney Diseases1996，，5： | 1 |
| 15 | Mindful Visitors:Heritage and tourism显示文摘 | Gianna Moscardo | 1996 | Annals of Tourism Research1996，23，2： | 1 |
| 16 | Heterotopic nasopharyngeal brain tissue associated with cleft palate显示文摘 | Giannas JE Bayat A Davenport PJ | | 0，，06： | 1 |
| 17 | Small medullary thyroid carcinoma: post-operative ealcitonin rather than tumour size predicts disease persistence and progression 显示文摘 | Katerina Saltiki Gianna Rentziou | 2014 | Eur Arch Otorhinolaryngol2014，171，1： | 1 |
| 18 | Cardiovascular risk reduction: what do recent trims with rosuvastatin tell us 显示文摘 | Gianna F Aldo PM | 2009 | Adv Ther2009，26，5： | 1 |
| 19 | Functional Estrogen Receptor β in Colon Cancer Cells显示文摘 | Gianna Fiorelli Lucia Picariello Valentina Martineti Francesco Tonelli Maria Luisa Brandi | 1999 | Biochemical and Biophysical Research Communications1999，，2： | 1 |
| 20 | Cell proliferation’ differentiation’ and apoptosis are modified by n?3 polyunsaturated fatty acids in normal colonic mucosa显示文摘 | Gabriella Calviello Paola Palozza Nicola Maggiano Elisabetta Piccioni Piergiorgio Franceschelli Andrea Frattucci Fiorella Nicuolo Gianna Maria Bartoh | 1999 | Lipids1999，，6： | 1 |
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