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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 3 | Support vector machines (SVMs) for monitoring network design显示文摘 | TIRUSEW A MARIUSH K GILBERTO U | 2005 | Ground Water2005，43，3： | 1 |
| 4 | First report of CTX-M producing Escherichia coli , including the new ST2526, isolated from beef cattle and sheep in Portugal显示文摘 | Sónia Ramos Gilberto Igrejas Nuno Silva Daniela Jones-Dias José-Luís Capelo-Martinez Manuela Cani?a Patrícia Poeta | 2013 | Food Control2013，，1： | 1 |
| 5 | A Raman spectroscopy study of alumina-supported vanadium oxide catalyst during propane oxidative dehydrogenation with online activity measurement显示文摘 | Gilberto Garcia Cortez Miguel A Banares | 2002 | J Catal2002，209，1： | 1 |
| 6 | The Application of Reconfigurable Logic to High Speed CNC Milling Machines Controllers显示文摘 | Roque A O Rene de J R Gilberto H | 2008 | Control Engineering Practices2008，16，6： | 1 |
| 7 | Hydrogen distribution network optimization:a refinery case study显示文摘 | Fonseca André Sá Ví tor Bento Hugo Tavares Manuel L C Pinto Gilberto Gomes Luí sa A C N | 2008 | Journal of Cleaner Production2008，16，16： | 1 |
| 8 | Serum levels of chemokines in adolescents with major depression treated with fluoxetine显示文摘BACKGROUND Major depressive disorder(MDD)is a global health issue that affects 350 million people of all ages.Although between 2%and 5.6%of affected individuals are adolescents,research on young patients is limited.The inflammatory response contributes to the onset of depression,and in adult MDD patients,symptom severity has been linked to chemokine levels.AIM To determine the differences in circulatory levels of chemokines in healthy volunteers(HVs)and adolescents with MDD,and assess the changes induced by fluoxetine consume.METHODS The 22 adolescents with MDD were monitored during the first 8 wk of clinical follow-up and clinical psychiatric evaluation was done using the Hamilton depresión rating scale(HDRS).The serum levels of monocyte chemoattractant protein-1(MCP-1),macrophage inflammatory protein(MIP)-1α,MIP-1β,interleukin(IL)-8,interferon gamma-induced protein(IP)-10,and eotaxin were measured in patients and HVs.RESULTS In all cases,significant differences were detected in circulating chemokine levels between patients before treatment and HVs(P<0.0001).All chemokines decreased at 4 wk,but only MCP-1 and IL-8 significantly differed(P<0.05)between 0 wk and 4 wk.In the patients,all chemokines rose to their initial concentrations by 8 wk vs 0 wk,but only IP-10 did so significantly(P<0.05).All patients experienced a significant decrease in HDRS scores at 4 wk(P<0.0001)and 8 wk(P<0.0001)compared with 0 wk.CONCLUSION Despite the consumption of fluoxetine,patients had significantly higher chemokine levels,even after considering the improvement in HDRS score.The high levels of eotaxin,IP-10,and IL-8 partially explain certain aspects that are affected in MDD such as cognition,memory,and learning. | Francisco Rafael de la Peña Carlos Cruz-Fuentes Lino Palacios Manuel Iván Girón-Pérez Emilio Medina-Rivero Maria Dolores Ponce-Regalado Samantha Alvarez-Herrera Gilberto Pérez-Sánchez Enrique Becerril-Villanueva JoséLuis Maldonado-García María C Jiménez-Martínez Lenin Pavón | 2020 | World Journal of Psychiatry2020，10，8： | 1 |
| 9 | Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models 显示文摘 | ANA F GILBERTO A PATRICIO S | 2013 | Epilepsy Res2013，107，12： | 1 |
| 10 | Organic contanminants in sediments from San Quintin Bay, Baja California, Mexico显示文摘 | EFRAIN A G G JULIO A V C GILBERTO F M | 1996 | Marine Pollution Bulletin1996，32，4： | 1 |
| 11 | Eect of drying method and length ofstorage on tannin and total phenol concentrations in Pigeon pea seeds 显示文摘 | EDILENE C F ANA RITA A N GILBERTO B S | 2004 | Food Chemistry2004，86，： | 1 |
| 12 | Using a minimum quantity of lubricant (MQL) and a diamond coated tool in the drilling of alumi- num- silicon alloys 显示文摘 | Durval U B Diniz A E Gilberto W A | 2002 | Journal of Materials Processing Technology2002，122，1： | 1 |
| 13 | Complexation of Cd(Ⅱ ) and Pb( Ⅱ ) with humic acids studied by anodic stripping vohammetry using differential equilibrium functions and discrete site models 显示文摘 | GILBERTO A JORGE C M | 2002 | Organic Geochemistry2002，33，10： | 1 |
| 14 | Com- paring submerged and solid -state fermentation of agro - industrial residues for the production and characterization of lipase by Trichoderma harzianum 显示文摘 | Gilberto V C Viviane L V Evandro A L | 2013 | Annals of Microbiology2013，63，2： | 1 |
| 15 | The effect of oxidation and reduction on themlal expansion of magnetite from 298 to 1 173 K at different vacuum conditions 显示文摘 | Davide L Gilberto A | 2004 | Journal of Solid State Chemislry2004，177，5： | 1 |
| 16 | A differential evolution approach for solving constrained rain-max optimization problems 显示文摘 | Gilberto A S Segundo A Renato A Krohling B Rodrigo C Cosme | 2012 | Expert Systems with Applications2012，39，13： | 1 |
| 17 | o Metal accumulation by Halodlde wrightii populations 显示文摘 | Gilberto M A F Joel C Co Leonardo R Ao | 2004 | Aquatic Botany2004，80，： | 1 |
| 18 | The ( G > A ) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study显示文摘 | Gilberto Vargas-Alarcón Carlos Posadas-Romero Teresa Villarreal-Molina Edith Alvarez-León Javier Angeles-Martinez María Elena Soto Irma Monroy-Mu?oz Juan Gabriel Juárez Carlos Jerges Sánchez-Ramírez Julian Ramirez-Bello Silvestre Ramírez-Fuentes José Manu | 2014 | BioMed Research International2014，，： | 1 |
| 19 | Estimating population and energy consumption in Brazilian Amazonia using DMSP night-time satellite data显示文摘 | Silvana A Gilberto C Antonio M | 2005 | Computers Environment and Urban Systems2005，29，： | 1 |
| 20 | Spirulina as nutrient source in diets for growing sturgeon (Acipenser baeri) 显示文摘 | Giovanni B P Elisabetta A Gilberto F | 2005 | Aquaculture Nutrition2005，36，： | 1 |
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