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| 1 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 2 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 3 | Impairment of CD8^+ T suppressor cell function in patients with active systemic lupus erythematosus显示文摘 | Gilberto F Sabrina B | 2001 | J Immunol2001，166，： | 1 |
| 4 | Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models 显示文摘 | ANA F GILBERTO A PATRICIO S | 2013 | Epilepsy Res2013，107，12： | 1 |
| 5 | CD8+T suppressor cells are back to the game:are they players in autoimmunity显示文摘 | Gilberto F Nicole SF | 2002 | Autoimmun Rev2002，1，5： | 1 |
| 6 | Organic contanminants in sediments from San Quintin Bay, Baja California, Mexico显示文摘 | EFRAIN A G G JULIO A V C GILBERTO F M | 1996 | Marine Pollution Bulletin1996，32，4： | 1 |
| 7 | Eect of drying method and length ofstorage on tannin and total phenol concentrations in Pigeon pea seeds 显示文摘 | EDILENE C F ANA RITA A N GILBERTO B S | 2004 | Food Chemistry2004，86，： | 1 |
| 8 | Radiation effects on optical properties of pure and doped BaF2 crystal显示文摘 | Gilberto M F Matsuoka M Sunta C M | 1998 | Radiat Phys Chem1998，51，46： | 1 |
| 9 | A novel fluorinated Eu(Ⅲ)β-diketone complex as thin film for optical device applications显示文摘 | Gilberto F de Sa | | 0，，： | 1 |
| 10 | Clinical and Genetic Heterogeneity in Mexican Patients With Ulcerative Colitis显示文摘 | JesfJs K Y Luis F U Gilberto Vargas AlarcOn | 2003 | Human hninunology2003，64，1： | 1 |
| 11 | CD8^+T suppressor are back to the game:are they players in autoimmunity显示文摘 | Gilberto F Nicole SF | 2002 | Autoimmun Rev2002，1，5： | 1 |
| 12 | Osmotin purified from the latex of Calotropis procera : Biochemical characterization, biological activity and role in plant defense显示文摘 | Cleverson Diniz Teixeira de Freitas Fábio César Sousa Nogueira Ilka Maria Vasconcelos José Tadeu Abreu Oliveira Gilberto Barbosa Domont Márcio Viana Ramos | 2011 | Plant Physiology and Biochemistry2011，，7： | 1 |
| 13 | o Metal accumulation by Halodlde wrightii populations 显示文摘 | Gilberto M A F Joel C Co Leonardo R Ao | 2004 | Aquatic Botany2004，80，： | 1 |
| 14 | CDs+ T Suppressor cells are back to the game:are they players in autoimmunity? 显示文摘 | Gilberto F Nicole SF | 2002 | Autoimmunity Reviews2002，1，5： | 1 |
| 15 | Spirulina as nutrient source in diets for growing sturgeon (Acipenser baeri) 显示文摘 | Giovanni B P Elisabetta A Gilberto F | 2005 | Aquaculture Nutrition2005，36，： | 1 |
| 16 | A novel fluorinated Eu (III)β-diketone complex as thin film for optical device applications 显示文摘 | Gilberto F de Sa Severino Alves Jr | 1998 | Optical Materials1998，11，1： | 1 |
| 17 | A phaseⅡstudy of second-Line neoadjuvant chemotherapy with capecitabineand radiation therapy for anthracycline-resistant locally advancedbreast cancer显示文摘 | Mariade F Gilberto Amorim Roberto Arcuri | 2007 | Am J Clin Oncol2007，30，1： | 1 |
| 18 | CD+8 T suppressor cells are back to the game: are they players in autoimmunity 显示文摘 | Gilberto F Nicole SF | 2002 | Autoimmunity Reviews2002，1，5： | 1 |
| 19 | Protectiveeffects of Mangifera indica L extract(Vimang),and its major component mangiferin,on iron-induced oxidative damage to rat serum and liver显示文摘 | Gilberto L P A Mariela F B Carlos C | 2008 | Pharmacol Res2008，57，1： | 1 |
| 20 | Polymorphisms in the promoter region of tumor necrosis factor alpha (TNF- α)and the HLA-DRB1 locus in Mexican Mestizo patients with ulcerative colitis 显示文摘 | Jesus K Luis F Gilberto VA | 2004 | Immunology Letters2004，95，： | 1 |
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