|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 3 | 卫生政策分析:概念和方法的思考与挑战显示文摘许多专家学者就卫生政策分析开展了大量研究,但很少关注如何进行政策分析以及需要什么样的研究设计、理论和方法。本文着眼于卫生政策分析的环境以及面临的挑战,借鉴中低收入国家中一些卫生政策分析的框架、理论、方法和设计,列举了最近的研究案例,并探讨了案例研究的意义以及研究设计的必要性,发现卫生政策研究者的角色、反思和定位在研究过程中非常重要。最后从理论、方法学和研究人员的反思等角度提出了促进卫生政策分析的建议。 | Gill Walt Jeremy Shiffman Helen Schneider Susan F Murray Ruairi Brugha Lucy Gilson | 2012 | 中国卫生政策研究2012，5，12： | 3 |
| 4 | Rescue of a human mRNA splicing defect by the plant cytokinin kinetin显示文摘 | Slaugenhaupt S A Mull J Leyne M Cuajungco M P Gill S P Hims M M Quintero F Axelrod | | 0，，04： | 1 |
| 5 | Overproduction and assay of Pseudomonas aeruginosa phosphomannose isomerase显示文摘 | Gill J F Deretic V Chakrabarty A M | 1986 | Journal of Bacteriology1986，167，2： | 1 |
| 6 | Thermo - mechanical consequences of phase transformations in the heat - affected zone using a cyclic uniaxial test 显示文摘 | Yannick Vincent Jullien J F Philippe Gilles | 2005 | International Journal of Solids and Structures2005，42，14： | 1 |
| 7 | Emotional and behavioral problems of Chinese left-behind children:A preliminary study显示文摘 | Fan F Su L Gill M K | 2010 | Soc Psychiatry Psychiatr Epidemiol2010，45，6： | 1 |
| 8 | Enzymatic production of acetaldehyde from ethanol in rat brain tissue显示文摘 | GILL K MENEZ J F LUCAS D | 1992 | Alcohol Clin Exp Res1992，16，： | 1 |
| 9 | Coenzyme QlO reduces the toxicity of rotenone in neuronal cultures by preserving the mitochondrial membrane potential 显示文摘 | Menke T Gille G Reber F | 2003 | Biofactnrs2003，18，14： | 1 |
| 10 | Comparative analysis of laparoscopic versus open partial nephrectomy for renal tumors in 200 patients显示文摘 | Gill IS Matin S F Desai M M | 2003 | J Urol2003，170，： | 1 |
| 11 | Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C显示文摘 | Venkatachalam K Zheng F Gill DL | 2003 | J Biol Chem2003，278，29： | 1 |
| 12 | Evaluation of thehygienic performances of the processes for cleaning,dressing and coolingpig carcasses at eight packing plants显示文摘 | GILL C O DUSSAULT F HOLLEY R A A et a1 | 2000 | International Journal of FoodMicrobiology2000，58，： | 1 |
| 13 | Developmental Neuropathology of the Second Half of Gestation 显示文摘 | GILLES F H GOMEZ I G | 2005 | Early Hum Dev2005，81，3： | 1 |
| 14 | Predictive factors of hospitalization for acute exacerbation in a series of 64 patients with chronic obstructive pulmonary disease 显示文摘 | Romain K Michele F Gilles F | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 15 | Vegetated ditches as a management practice in irrigated alfalfa 显示文摘 | Gill S L Spurlock F C Goh K S | 2008 | Environmental Monitoring and Assessment2008，144，： | 1 |
| 16 | Ventriculomegaly, delayed myelination, white matter hypoplasia, and 'periventricular' leukomalacia how are they related? 显示文摘 | Levition A Gills F | 1996 | Pediatr Neurol1996，15，2： | 1 |
| 17 | Structure and function of buffer strips from a water quality perspective in agriculture landscapes显示文摘 | Lena B-M Gilles P Ann F | 1995 | Landscape Urban Plan1995，31，： | 1 |
| 18 | Development of sex-linked PCR markers for gender identification in Actinidia显示文摘 | Gill G P Harvey C F Garern R C | | 0，，03： | 1 |
| 19 | Giant vertebral notochordal rest: a new entity distinct from ehordoma 显示文摘 | Chauvel A Taillat F Gille O | 2005 | Histopathology2005，47，6： | 1 |
| 20 | A decade of dargescale experience in dissolved air flotation显示文摘 | Kempeneers S Van Menxel F Gille L | 2001 | Water Scienceand Technology2001，，43： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员