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| 1 | Micro RNAs in the development of non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease or nonalcoholic fatty liver disease(NAFLD) refers to a group of disorders that arise from the accrual of fat in hepatocytes. Although various factors have been associated with the development of NAFLD, including genetic predisposition and environmental exposures, little is known aboutthe underlying pathogenesis of the disease. Research efforts are ongoing to identify biological targets and signaling pathways that mediate NAFLD. Emerging evidence has implicated a role for micro RNAs(mi RNAs), short single-stranded molecules that regulate gene expression either transcriptionally, through targeting of promoter regions, or post-transcriptionally, by blocking translation or promoting cleavage of specific target m RNAs. Several mi RNAs have been associated with NAFLD, although our understanding of the biology underlying their role is still emerging. The goal of this review is to present an overview of the current state of knowledge of mi RNAs involved in the development of NAFLD across a range of in vitro and in vivo models, including mi RNAs that contribute to pathological mechanisms related to fatty liver in humans. Much less is known about the specific targets of mi RNAs in cells, nor the molecular mechanisms involved in the development and progression NAFLD and related outcomes. More recently, the identification and validation of mi RNA signatures in serum may facilitate the development of improved methods for diagnosis and clinical monitoring of disease progression. | Glenn S Gerhard Johanna K DiStefano | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 2 | Joining Performance and Microstructure of the 2024/7075 Aluminium Alloys Welded Joints by Vaporizing Foil Actuator Welding显示文摘Vaporizing foil actuator welding(VFAW) was used for joining 2024-T3 and 7075-T6 aluminum alloy sheets, and the resulting joint microstructure was analyzed. 2024/7075 aluminum alloy pairs with suitable processing parameters can be prepared by using VFAW. Dynamic preform addresses the poor formability problem of target material and advantage of VFAW on dissimilar materials in some conditions. But with standoff sheet inserting in the flyer and target, 2024/7075 welded pairs gets the better weld strength, compared with flyer preformed method. The microstructure of the circular weld area of the welded joint showed a wave interface, in which a thin melt layer formed at the center and edge parts. The crystal grains near the bonding interface were remarkably elongated and refined. Therefore, the joining of the 2024/7075 pairs was facilitated through plastic forming and melting. | 孟正华 WANG Xu GUO Wei HU Zhili Anupam Vivek HUA Lin Glenn S DAEHN | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，2： | 4 |
| 3 | Morphology‐function relationships and repeatability in the sperm of Passer sparrows显示文摘 | Emily R.A. Cramer Terje Laskemoen Even Stensrud Melissah Rowe Fredrik Haas Jan T. Lifjeld Glenn‐Peter S?tre Arild Johnsen | 2015 | Journal of Morphology2015，，： | 2 |
| 4 | Insular biogeography of mammals in Ca-nadian parks显示文摘 | Glenn S M Nudds T D | 1989 | Journal of Biogeography1989，16，3： | 1 |
| 5 | Molecular biology of the natriuretic peptide system: implications for physiology and hypertension 显示文摘 | Gardner D G Chen S Glenn D J | 2007 | Hypertension2007，49，3： | 1 |
| 6 | A four-parameters equation for predicting enthalpies of adduct formation显示文摘 | Russell S Drago Glenn C Vogel Terence E Needham 1971 | 1971 | J Am Chem Sec1971，17，： | 1 |
| 7 | Perspectives on the theory and practice of belief ftmc- tions显示文摘 | Glenn S | 1990 | Intemational Journal of Approximate Reasoning1990，4，： | 1 |
| 8 | Effect of sample size on ductility in electromagnetic expansion 显示文摘 | Tamhane Amit Altynova Marina M Daehn Glenn S | 1996 | Scripta Materialia1996，34，8： | 1 |
| 9 | Molecular biolo- gy of the natriuretic peptide system : implications for physiology and hypertension 显示文摘 | GARDNER D G CHEN S GLENN D J | 2007 | Hypertension2007，49，： | 1 |
| 10 | SeaSonde is integral to coastal flow model development显示文摘 | KOHUT J GLENN S BARRICK D E | 1999 | Hydro Int1999，3，： | 1 |
| 11 | The human papillomavirus (HPV) vaccine and cervical cancer: uptake and next steps显示文摘 | Sheinfeld Gorin S N Glenn B A Perkins R B | 2011 | Adv Ther2011，28，8： | 1 |
| 12 | The evolution of the major hepatitis C genotypes correlates with clinical response to interferon therapy显示文摘 | Pang P S Planet P J Glenn J S | | 0，，08： | 1 |
| 13 | Invasive fungal infections in pediatric oncology patients: I 1-year experience at a single insti- tution显示文摘 | Rosen GP Nielsen K Glenn S | 2005 | J Pediatr Hematol Oncol2005，27，3： | 1 |
| 14 | Bank Competition and Stability:Cross-Country Heterogeneity显示文摘 | Beck T D.Olivier He Jong S Glenn | 2013 | 2013，，： | 1 |
| 15 | New insecticides with ecdysteroidal and juvenile hormone activity显示文摘 | TARLOCHAN S D GLENN R C DAT P L | | 0，，： | 1 |
| 16 | A principled approach towards symbolic geometric constraint satisfaction显示文摘 | Bhansali S Kramer Glenn A Hoar Tim J | 1996 | Journal of Artificial Intelligence Research1996，4，： | 1 |
| 17 | Dialysis Associated Seizures in Children and Adolescents显示文摘 | Glenn C M Astley S J Watkins S L | 1992 | Int J Pediatr Nephrol1992，6，： | 1 |
| 18 | Aquacultures sludge removal and stabilization within created wetlands 显示文摘 | SUMMERFELT S T ADLER P R GLENN D M | 1999 | Aquacuhural Engineering1999，19，2： | 1 |
| 19 | 显示文摘 | NASH A R GLENN W K MOORE S S | 1988 | Aust J Biol Sci1988，41，： | 1 |
| 20 | β-lactam resistance in Salmonella strains isolated from retail meats in the United States by the National Antimicrobial Resistance Monitoring System between 2002 and 2006 显示文摘 | Zhao S Blickenstaff K Glenn A | 2009 | Appl Environ Microbiol2009，75，24： | 1 |
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