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| 1 | PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors. | Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng | 2007 | Chinese Medical Sciences Journal2007，22，2： | 41 |
| 2 | Effect of Nitrogen Management on Yield and Water Use Efficiency of Rainfed Wheat and Maize in Northwest China显示文摘A field experiment with four treatments and four replicates in a randomized complete block design was conducted at the Changwu Experimental Station in Changwu County, Shaanxi Province, of Northwest China from 1998 to 2002. The local cropping sequence of wheat, wheat-beans, maize, and wheat over the 4-year period was adopted. A micro-plot study using 15N-labelled fertilizer was carried out to determine the fate of applied N fertilizer in the first year. When N fertilizer was applied wheat (years 1, 2 and 4) and maize (year 3) grain yield increased significantly (P<0.05) (>30%), with no significant yield differences in normal rainfall years (Years 1, 2 and 3) for N application at the commonly application rate and at 2/3 of this rate. Grain yield of wheat varied greatly between years, mainly due to variation in annual rainfall. Results of 15N studies on wheat showed that plants recovered 36.6%-38.4% of the N applied, the N remained in soil (0-40 cm) ranged from 29.2% to 33.6%, and unaccounted-for N was 29.5%-34.2%. The following crop (wheat) recovered 2.1%-2.8% of the residual N from N applied to the previous wheat crop with recovery generally decreasing in the subsequent three crops (beans, maize and wheat). | DANG Ting-Hui CAI Gui-Xin GUO Sheng-Li HAO Ming-De L. K. HENG | 2006 | Pedosphere2006，16，4： | 25 |
| 3 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 4 | Matrix metalloproteinase 2 promotes cell growth and invasion in colorectal cancer显示文摘Colorectal 癌症(CRC ) 是在西方的世界上的癌症相关的死亡的第三个领先的原因。在这研究,我们计算了矩阵 metalloproteinase 的表达式在 CRC 的 2 基因(MMP2 ) 并且与 clinicopathological 特征分析了它的关联。我们发现 MMP2 的表示比在 colorectal 纸巾在 CRC 纸巾是显著地更高的。另外, MMP2 蛋白质的高水平断然与肿瘤尺寸,淋巴节点转移,远转移,公爵阶段,和肿瘤侵略的地位被相关。而且,有更高的 MMP2 层次的病人与低 MMP2 层次比那些有显著地更短的全面幸存。Multivariate 分析结果建议 MMP2 表示的水平是为有 CRC 的病人的幸存的独立预示的指示物。在有调停 lentiviral 的 shRNA 的 CRC 房间线的 Silencing MMP2 表示显著地压制了房间增长,殖民地形成,和侵略。而且,我们观察到那个脉管的 endothelial 生长因素(VEGF ) 和膜打 1 (MT1 )-MMP 蛋白质层次在 MMP2-down-regulated colorectal 细胞被减少。因此,我们的学习证明 MMP2 是与 CRC 的 carcinogenesis 和转移有关的一个重要因素,并且 MMP2 由起来调整的 VEGF 和 MT1-MMP 表示支持 CRC 房间生长和侵略,它为癌症治疗使这条小径成为一个潜在的目标。 | Wei Dong Hong Li Yan Zhang Heng Yang Min Guo Li Li Tongjun Liu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，11： | 10 |
| 5 | The Relation Between Endogenous Hormones and Late-Germination in Buds of Avrolles Apple显示文摘In order to provide the physiological bases for selecting late-germination cultivars that can avoid late frost damage, the very late-germination variety Avrolles (Malus domestica) was used to study the relation between the dynamic changes and balance of endogenous hormones and germination time. The concentrations of endogenous GA3, ABA, IAA, and ZR were determined in buds of Avrolles and Judeline (Malus domestica) from dormancy releasing to germination by capillary electrophoresis. The dynamic changes of endogenous hormones concentration in buds of Avrolles and Judeline were similar; but the magnitude and time of the change were significantly different between the two varieties, especially for GA3. GA3 concentration increased with dormancy releasing, then decreased, and increased again before germination in the two varieties. GA3 concentration in Avrolles was 1.72 times that in Judeline at the first peak, the gap increased to 2.22 times at germination. ZR concentration exhibited a continuous increase trend, but it decreased sharply before germination. ZR accumulation in Avrolles took 36 days longer than in Judeline, the peak value was 44% higher than in Judeline. Before germination, ZR concentration in Avrolles was 2.12 times that in Judeline. The differences between IAA and ABA concentration were relatively small in the two varieties, while the ratios of GA3/ABA and (GA3 + IAA + ZR)/ABA in Avrolles were 2.08 and 1.58 times those in Judeline, respectively. The germination of apple bud was regulated by the endogenous hormones. For the late-germination apple Avrolles, its germination requires higher concentration of GA3 and ZR, which leads to the high ratios of GA3/ABA and (GA3 + IAA + ZR)/ABA. | QIN Dong WANG Jin-zheng GUO Jian-min ZHAI Heng | 2009 | Agricultural Sciences in China2009，8，5： | 10 |
| 6 | Insulin improves cardiomyocyte contractile function through enhancement of SERCA2a activity in simulated ischemia/reperfusion显示文摘瞄准:胰岛素经由 Akt-endothelial 氮的氧化物 synthase 幸存信号小径在 cardiomyocytes 和冠的 endothelial 列在后面 ischemia/reperfusion (I/R ) 施加 anti-apoptotic 效果。发信号的这重要胰岛素可能进一步在灌注以后贡献心脏的功能的改进。在这研究,我们测试了肌质的蜂窝胃 calcium-ATPase (SERCA2a ) 涉及心脏的可收缩的功能追随者 I/R 的导致胰岛素的改进的假设。方法:室的 myocytes 是从成年 SD 老鼠孤立的酶的联盟者。模仿的 I/R 被酒导致有 15 min 的化学缺氧的答案的房间为 30 min 与 Tyrode 的答案由灌注列在后面与或没有胰岛素。弄短的肌细胞和细胞内部的钙 transients 被估计,内在的机制被调查。结果:有胰岛素的灌注((-7) mol/L ) 10 显著地改进了可收缩的功能的恢复(从 6-8 心的 n=15-20 myocytes , P<0.05 ),并且增加了钙 transients ,由增加的钙证实了Ca2+]荧光比率,山峰Ca2+的弄短的时间和50%心脏舒张的Ca2+的时间,与车辆( P<0.05 )在房间与那些相比重新酒。另外, Akt 磷酸化和 SERCA2a 活动两个都在对待胰岛素的 I/R cardiomyocytes 被增加,它被房间的预告的处理显著地与一个特定的 Akt 禁止者禁止。而且, Akt 活动的抑制废除了导致胰岛素积极可收缩并且在 I/R cardiomyocytes 的钙 transients 回答。结论:这些数据第一次证明胰岛素以一种 Akt 依赖、调停 SERCA2a 的方式在模仿的 I/R cardiomyocytes 改进可收缩的功能的恢复。 | Jie YU Hai-feng ZHANG Feng WU Qiu-xia LI Heng MA Wen-yi GUO Hai-chang WANG Feng GAO | 2006 | Acta Pharmacologica Sinica2006，27，7： | 8 |
| 7 | In Situ Coupling Strategy for Anchoring Monodisperse Co_9S_8 Nanoparticles on S and N Dual?Doped Graphene as a Bifunctional Electrocatalyst for Rechargeable Zn–Air Battery显示文摘An in situ coupling strategy to prepare Co_9S_8/S and N dual?doped graphene composite(Co_9S_8/NSG) has been proposed. The key point of this strategy is the function?oriented design of organic compounds. Herein, cobalt porphyrin derivatives with sulfo groups are employed as not only the coupling agents to form and anchor Co_9S_8 on the graphene in situ, but also the heteroatom?doped agent to generate S and N dual?doped graphene. The tight coupling of multiple active sites endows the composite materials with fast electrochemical kinetics and excellent stability for both oxygen reduction reaction(ORR) and oxygen evolution reaction(OER). The obtained electrocatalyst exhibits better activity parameter(ΔE = 0.82 V) and smaller Tafel slope(47.7 mV dec^(-1) for ORR and 69.2 mV dec^(-1) for OER) than commercially available Pt/C and RuO_2. Most importantly, as electrocatalyst for rechargeable Zn–air battery, Co_9S_8/NSG displays low charge–discharge voltage gap and outstanding long?term cycle stability over 138 h compared to Pt/C–RuO_2. To further broaden its application scope, a homemade all?solid?state Zn–air battery is also prepared, which displays good charge–discharge performance and cycle performance. The function?oriented design of N_4?metallomacrocycle derivatives might open new avenues to strategic construction of high?performance and long?life multifunctional electrocatalysts for wider electro?chemical energy applications. | Qi Shao Jiaqi Liu Qiong Wu Qiang Li Heng?guo Wang Yanhui Li Qian Duan | 2019 | Nano-Micro Letters2019，11，1： | 8 |
| 8 | Cu(OAc)_2 catalyzed Sonogashira cross-coupling reaction in amines显示文摘简单 Cu (OAc ) 联合协议的 2 催化 Sonogashira 被介绍。有终端炔属羟的许多芳基卤的政变石楠顺利被进行负担得起相应需要的产品在,这被发现对优秀收益中等,用 Cu (OAc ) 2 作为催化剂和 Et3N 作为溶剂。 | Sheng Mei Guo Chen Liang Deng Jin Heng Li | 2007 | Chinese Chemical Letters2007，18，1： | 8 |
| 9 | Copper methanesulfonate-acetic acid as a novel catalytic system for tetrahydropyranylation of alcohols and phenols显示文摘A synergistic catalytic effect between copper methanesulfonate and acetic acid in tetrahydropyranylation of alcohols and phenol at room temperature under solvent free condition has been described. Both alcohols (primary, secondary and tertiary) and phenols reacted with 3,4-dihydro-2H-pyran smoothly to afford the corresponding tetrahydropyranyl ethers in good yields. | Min Wang Zhi Guo Song Hong Gong Heng Jiang | 2007 | Chinese Chemical Letters2007，18，7： | 7 |
| 10 | Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients显示文摘Objective The purpose of this study was to screen for frequencies of different CYP450 genotypes in the Chinese population and explore the relationship between sorafenib toxicity and CYP450 polymorphism. Methods A total of 600 peripheral blood samples were obtained from two groups for this study. The first group of 300 samples were from Chinese patients with HBV/HCV-associated HCC, while the remaining 300 samples were from a healthy population of recruited subjects. Allele-specific PCR and long-fragment gene sequencing was used to identify the frequencies of CYP450 polymorphism. Aflatoxin-induced HCC rat models expressing CYP3A4*1, CYP3A5*3, CYP2C19*2, and CYP2D6*10 were established and treated with sorafenib at certain time points. Hepatic and renal function, along with plasma concentration of sorafenib, were monitored regularly. Results The most common forms of CYP mutations in the Chinese population were identified. The levels of sorafenib plasma concentration, as well as damage to hepatic and renal function in aflatoxin-induced HCC rat models varied significantly across the different CYP genotypes. Conclusion The mutational frequencies of CYP3A5, CYP3A4, CYP2C19, and CYP2D6 genotypes varied among different ethnic groups and populations. Individuals with CYP3A5*3 demonstrated minimal sorafenib metabolism, which led to severe hepatic and renal damage. Inter-individual variability in sorafenib-toxicity may be interpreted by CYP450 genetic polymorphisms, suggesting that identification of CYP polymorphism within a certain population should be considered in sorafenib therapy. | GUO Xing Gang WANG Zhi Heng DONG Wei HE Xu Dong LIU Fu Chen LIU Hui | 2018 | Biomedical and Environmental Sciences2018，31，8： | 7 |
| 11 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 12 | Salmonella flagella confer anti-tumor immunological effect via activating Flagellin/TLR5 signalling within tumor microenvironment显示文摘Salmonella:mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models,but the detailed mechanism remains unsolved.In this report,the active involvement of the host immune response in this process was confirmed by comparing the tumor-suppressive effects of Salmonella in immunocompetent and immunodeficient mice bearing melanoma allografts.Since flagella are key inducers of the host immune response during bacterial infection,flagella were genetically disrupted to analyse their involvement in Salmonella-mediated cancer therapy.The results showed that flagellum-deficient strains failed to induce significant anti-tumor effects,even when more bacteria were administered to offset the difference in invasion efficiency.Flagella mainly activate immune cells via Flagellin/Toll-like receptor 5(TLR5)signalling pathway.Indeed,we showed that exogenous activation of TLR5 signalling by recombinant Flagellin and exogenous expression of TLR5 both enhanced the therapeutic efficacy of flagellum-deficient Salmonella against melanoma.Our study highlighted the therapeutic value of the interaction between Salmonella and the host immune response through Flagellin/TLR5 signalling pathway during Salmonella-mediated cancer therapy,thereby suggesting the potential application of TLR5 agonists in the cancer immune therapy. | Jianxiang Chen Yiting Qiao Guo Chen Cunjie Chang Heng Dong Bo Tang Xiawei Cheng Xiufeng Liu Zichun Hua | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 6 |
| 13 | Changes in energy metabolism in the quadriceps femoris after a single bout of acute exhaustive swimming in rats: a 31p-magnetic resonance spectroscopy study显示文摘 | Sun Yingwei Pan Shinong Chen Zhian Zhao Heng Ma Ying Zheng Liqiang Li Qi Deng Chunbo Fu Xihu Lu Zaiming Guo Qiyong | 2014 | Chinese Medical Journal2014，，5： | 5 |
| 14 | Oxaliplatin-based combination chemotherapy is still effective for the treatment of recurrent and platinum-resistant epithelial ovarian cancer: results from a single center显示文摘 | ZHANG Guo LI Xiao-ping LIU Bing-jie WANG Jian-liu WANG Shi-jun CUI Heng WEI Li-hui | 2013 | Chinese Medical Journal2013，，23： | 5 |
| 15 | Ferrous methanesulfonate as an efficient and recyclable catalyst for chemoselective synthesis of 1,1-diacetate from aldehydes显示文摘铁的 methanesulfonate catalysing 变换芳香,异种到在在没有溶剂的状况下面的房间温度的 1,1-diacetates 的芳香、不饱和、脂肪族的醛被开发了。十七金属 methanesulfonates 的催化活动在一样的条件下面被比较,铁的 methanesufonate 证明了是最好。它能容易被恢复并且再使用为若干次没有在催化活动的不同恶化。在在有交流 2 O,专门与醛组一起形成的 1,1-diacetate。 | Min Wang Gui Fu Tian Zhi Guo Song Heng Jiang | 2009 | Chinese Chemical Letters2009，20，9： | 5 |
| 16 | Phthalonitrile Resins Derived from Vanillin: Synthesis, Curing Behavior, and Thermal Properties显示文摘Vanillin was used as sustainable source for phthalonitrile monomer synthesis, and allyl/propargyl ether moieties were introduced to improve the processability at the minimal cost of thermal properties. The synthesis route was optimized to minimize side-reactions and simplify post-processing, and the monomers were obtained in high purity and good yields. The curing behavior, mechanism, and processability of the monomers were studied, and the thermal properties of cured polymers were evaluated. Of the two monomers, the allyl ether-containing one exhibited a wide processing window of 185 °C, and was mainly cured into phthalocyanine and linear aliphatic structures through self-catalytic curing process. Also, the glass transition temperature was higher than 500 °C. In contrast, the propargyl ether-containing monomer could only be partially cured, and heat resistance was found to be compromised. Compared with traditional petroleum-based phthalonitrile resins, the biobased monomers could be cured without the addition of catalysts, and improvement in processability was achieved at no cost of thermal performances. | Yue Han Dong-Hao Tang Guang-Xing Wang Ya-Nan Sun Ying Guo Heng Zhou Wen-Feng Qiu Tong Zhao | 2020 | Chinese Journal of Polymer Science2020，38，1： | 4 |
| 17 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 18 | A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy显示文摘The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes.However,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation.Here,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural transformation.The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron injection.Interestingly,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of tumors.Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems. | Xi Hu Nan Wang Xia Guo Zeyu Liang Heng Sun Hongwei Liao Fan Xia Yunan Guan Jiyoung Lee Daishun Ling Fangyuan Li | 2022 | Nano-Micro Letters2022，14，6： | 4 |
| 19 | Defective mitochondrial function by mutation in THICK ALEURONE 1 encoding a mitochondrion-targeted single-stranded DNA-binding protein leads to increased aleurone cell layers and improved nutrition in rice显示文摘Cereal endosperm comprises an outer aleurone and an inner starchy endosperm.Although these two tissues have the same developmental origin,they differ in morphology,cell fate,and storage product accumulation,with the mechanism largely unknown.Here,we report the identification and characterization of rice thick aleurone 1(ta1)mutant that shows an increased number of aleurone cell layers and increased contents of nutritional factors including proteins,lipids,vitamins,dietary fibers,and micronutrients.We identified that the TA1 gene,which is expressed in embryo,aleurone,and subaleurone in caryopses,encodes a mitochondrion-targeted protein with single-stranded DNA-binding activity named OsmtSSB1.Cytological analyses revealed that the increased aleurone cell layers in ta1 originate from a developmental switch of subaleurone toward aleurone instead of starchy endosperm in the wild type.We found that TA1/OsmtSSB1 interacts with mitochondrial DNA recombinase RECA3 and DNA helicase TWINKLE,and downregulation of REC A3 or TWINKLE also leads to ta1-like phenotypes.We further showed that mutation in TA1/OsmtSSB1 causes elevated illegitimate recombinations in the mitochondrial genome,altered mitochondrial morphology,and compromised energy supply,suggesting that the OsmtSSB1-mediated mitochondrial function plays a critical role in subaleur one cell-fate determination in rice. | Dong-Qi Li Xiao-Ba Wu Hai-Feng Wang Xue Feng Shi-Juan Yan Sheng-Yang Wu Jin-Xin Liu Xue-Feng Yao Ai-Ning Bai Heng Zhao Xiu-Fen Song Lin Guo Shi-Yong Zhang Chun-Ming Liu | 2021 | Molecular Plant2021，14，8： | 4 |
| 20 | First total synthesis of(±)-sepicanin A显示文摘为自然地发生的 geranylated flavanoids sepicanin A 的第一全部的合成的一条灵巧的途径与 16% 在四以后从 2,4,6-trihydroxyacetophenone 开始走的全部的产量被获得了。关键步是催化的 protic 酸(HCl 或 p-TsOH ) 在 protic 的 benzopyrone 形成由在一步的 chalcone 的 deprotection 和环合的极的溶剂。 | Jin Hui Yang Wen Qian Huang Jun Shan Luo Dong Dong Guo Yu Heng Zhang Hong Jun Li | 2012 | Chinese Chemical Letters2012，23，2： | 4 |
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