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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | High entropy defective fluorite structured rare-earth niobates and tantalates for thermal barrier applications显示文摘Rare-earth tantalates and niobates(REjTaO7 and REjNbO7)have been considered as promising candidate thermal barrier coating(TBC)materials in next generation gas-turbine engines due to their ultra-low thermal conductivity and better thermal stability than yttria-stabilized zirconia(YSZ).However,the low Vickers hardness and toughness are the main shortcomings of RE;TaO-and REjNbOr that limit their applications as TBC materials.To increase the hardness,high entropy(Yu3Ybu3Er/3)sTaOr,(Y13YbnErns)NbO,and(Sm1/6Eu1/6Y 1/6Yb1/6Lu1/6Er1/6)3(Nb1/2Ta1/2)O7 are designed and synthesized in this study.These high entropy ceramics exhibit high Vickers hardness(10.912.0 GPa),close thermal expansion coefficients to that of single-principal-component RE3TaO,and RE;NbO,(7.9×10^-6-10.8×10-6 C-1 at room temperature),good phase stability,and good chemical compatibility with thermally grown Al2O3,which make them promising for applications as candidate TBC materials. | Zifan ZHAO Heng CHEN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Wei XU Kuang SUN Zhjjian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，3： | 27 |
| 3 | High entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12:A novel high temperature stable thermal barrier material显示文摘Ytterbium aluminum garnet(Yb3Al5O12)is considered as a promising thermal barrier material.However,the main limitations of Yb3Al5O12 for thermal barrier applications are relative low thermal expansion coefficient and high thermal conductivity.In order to overcome these obstacles,herein,a new high entropy(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic was designed,and then powders and bulk were prepared through solid-state reaction method and spark plasma sintering(SPS),respectively.The thermal expansion coefficient of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 is(8.54±0.29)×10^-6 K^-1 at 673 K–1273 K,which is about 9%higher than that of Yb3Al5O12.The thermal conductivity of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 ceramic is 3.81 W·m^-1 K^-1 at 300 K,which is about 18%lower than that of Yb3Al5O12.Moreover,there is no reaction between HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 and thermally grown(TG)Al2O3 even at 1600℃.After annealing at 1590℃for 18 h,the average grain size of HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 increases only from 1.56μm to 2.27μm.Close thermal expansion coefficient to TG Al2O3,low thermal conductivity,good phase stability,excellent chemical compatibility with TG Al2O3 and slow grain growth rate make HE(Y0.2Yb0.2Lu0.2Eu0.2Er0.2)3Al5O12 promising for thermal barrier applications. | Heng Chen Zifan Zhao Huimin Xiang Fu-Zhi Dai Wei Xu Kuang Sun Jiachen Liu Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，13： | 14 |
| 4 | Circulating miR-125a but not miR-125b is decreased in active disease status and negatively correlates with disease severity as well as inflammatory cytokines in patients with Crohn's disease显示文摘AIM To determine the association of circulating mi R-125 a/b expression with the risk and disease severity of Crohn's disease(CD), and with inflammatory cytokines.METHODS Plasma samples were collected from patients with active CD(A-CD), or CD in remission(R-CD) and from healthy controls(HCs). The levels of the inflammatory cytokines interleukin-17(IL-17), tumour necrosis factor-α(TNF-α), and interferon-γ(IFN-γ) were measured by enzyme-linked immunosorbent assay. The expression of mi R-125 a/b was assessed by quantitative polymerase chain reaction(q PCR).RESULTS Twenty-nine A-CD patients, 37 R-CD patients, and 37 HCs were included in the study. Plasma mi R-125 a expression was decreased in A-CD patients comparedwith that in R-CD patients(P < 0.001) and HCs(P < 0.001). mi R-125 a expression levels enabled the differentiation of A-CD from R-CD patients [area under curve(AUC) = 0.854] and from HCs(AUC = 0.780), whereas mi R-125 b expression did not. mi R-125 a was negatively correlated with C-reaction protein(CRP)(P = 0.017), erythrocyte sedimentation rate(ESR)(P = 0.026), Crohn's disease activity index(CDAI)(P = 0.003), IL-17(P = 0.015), and TNF-α(P = 0.004) in A-CD patients. Furthermore, mi R-125 a was negatively associated with CRP(P = 0.038) and CDAI(P = 0.021) in R-CD patients. Regarding mi R-125 b, no association with CRP, CDAI, IL-17, TNF-α, or IFN-γ was found in A-CD or in R-CD patients. mi R-125 a levels gradually increased in A-CD patients who achieved clinical remission(P = 0.009) after 3-mo treatment, whereas they remained unchanged among patients who failed to achieve remission. No changes in mi R-125 b expression were detected in remission or non-remission patients after treatment. CONCLUSION Circulating mi R-125 a but not mi R-125 b is decreased in patients with active disease status and negatively correlates with disease severity and inflammatory cytokines in patients with CD. | Chen-Ming Sun Jie Wu Heng Zhang Gan Shi Zhi-Tao Chen | 2017 | World Journal of Gastroenterology2017，23，44： | 12 |
| 5 | Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization显示文摘Macrophage-mediated inflammation compromises bone repair in diabetic patients.Electrical signaling cues are known to regulate macrophage functions.However,the biological effects of electrical microenvironment from charged biomaterials on the immune response for regulating osteogenesis under diabetic conditions remain to be elucidated.Herein the endogeneous electrical microenvironment of native bone tissue was recapitulated by fabricating a ferroelectric BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membrane.In vitro,the polarized BaTiO_(3)/poly(vinylidene fluoridetrifluoroethylene)(BTO/P(VDF-TrFE))nanocomposite membranes inhibited high glucose-induced M1-type inflammation,by effecting changes in cell morphology,M1 marker expression and pro-inflammatory cytokine secretion in macrophages.This led to enhanced osteogenic differentiation of human bone marrow mesenchymal stem cells(BM-MSCs).In vivo,the biomimetic electrical microenvironment recapitulated by the polarized nanocomposite membranes switched macrophage phenotype from the pro-inflammatory(M1)into the pro-healing(M2)phenotype,which in turn enhanced bone regeneration in rats with type 2 diabetes mellitus.Mechanistic studies revealed that the biomimetic electrical microenvironment attenuated pro-inflammatory M1 macrophage polarization under hyperglycemic conditions by suppressing expression of AKT2 and IRF5 within the PI3K-AKT signaling pathway,thereby inducing favorable osteo-immunomodulatory effects.Our study thus provides fundamental insights into the biological effects of restoring the electrical microenvironment conducive for osteogenesis under DM conditions,and offers an effective strategy to design functionalized biomaterials for bone regeneration therapy in diabetic patients. | Xiaohan Dai Boon Chin Heng Yunyang Bai Fuping You Xiaowen Sun Yiping Li Zhangui Tang Mingming Xu Xuehui Zhang Xuliang Deng | 2021 | Bioactive Materials2021，6，7： | 9 |
| 6 | Fulminant type 1 diabetes: report of two cases显示文摘 | WANG Tong XIAO Xin-hua LI Wen-hui YUAN Tao SUN Xiao-fang WANG Heng | 2008 | Chinese Medical Journal2008，，2： | 9 |
| 7 | High-entropy(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3:A promising thermal/environmental barrier material for oxide/oxide composites显示文摘Yttrium aluminum perovskite(YAl O3)is a promising candidate material for environmental barrier coatings(EBCs)to protect Al2 O3 f/Al2 O3 ceramic matrix composites(CMCs)from the corrosion of high-temperature water vapor in combustion environments.Nevertheless,the relatively high thermal conductivity is a notable drawback of YAl O3 for environmental barrier coating application.Herein,in order to make REAl O3 more thermal insulating,a novel high-entropy rare-earth aluminate ceramic(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 was designed and synthesized.The as-prepared(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 ceramic possesses close thermal expansion coefficient(9.02×10-6/oC measured from room temperature to 1200℃)to that of Al2 O3.The thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3 at room temperature is 4.1 W·m-1K-1,which is almost one third of the value of YAl O3.Furthermore,to effectively prevent the penetration of water vapor from possible pores/cracks of coating layer,which are often observed in T/EBCs,a tri-layer EBC system REAl O3/RE3 Al5 O12/(Al2 O3 f/Al2 O3 CMCs)is designed.Close thermal expansion coefficient to Al2 O3 and low thermal conductivity of(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3,as well as the formation of dense garnet layer at(Y0.2Nd0.2Sm0.2Eu0.2Er0.2)AlO3/Al2 O3 interface,indicate that this new type of high-entropy ceramic is suitable as a candidate environmental barrier coating material for Al2 O3 f/Al2 O3 CMCs. | Zifan Zhao Heng Chen Huimin Xiang Fu-Zhi Dai Xiaohui Wang Wei Xu Kuang Sun Zhijian Peng Yanchun Zhou | 2020 | Journal of Materials Science & Technology2020，47，12： | 9 |
| 8 | Self-supported high-entropy alloy electrocatalyst for highly efficient H_(2) evolution in acid condition显示文摘Developing non-precious catalysts as Pt substitutes for electrochemical hydrogen evolution reaction(HER)with superior stability in acidic electrolyte is of critical importance for large-scale,low-cost hydrogen production from water.Herein,we report a CoCrFeNiAl high-entropy alloy(HEA)electrocatalyst with self-supported structure synthesized by mechanical alloying and spark plasma sintering(SPS)consolidation.The HEA after HF treatment and in situ electrochemical activation for 4000 cycles of cyclic voltammetry(HF-HEAa2)presents favourable activity with overpotential of 73 mV to reach a current density of 10 mA cm^(2) and a Tafel slope of 39.7 mV dec1.The alloy effect of Al/Cr with Co/Fe/Ni at atomic level,high-temperature crystallization,as well as consolidation by SPS endow CoCrFeNiAl HEA with high stability in 0.5 M H2SO4 solution.The superior performance of HF-HEAa2 is related with the presence of metal hydroxides/oxides groups on HEA. | Peiyan Ma Mingming Zhao Long Zhang Heng Wang Junfeng Gu Yuchen Sun Wei Ji Zhengyi Fu | 2020 | Journal of Materiomics2020，6，4： | 8 |
| 9 | EFFECTS OF VITAMIN D RECEPTOR GENE POLYMORPHISMS ON SUSCEPTIBILITY TO TYPE 1 DIABETES MELLITUS显示文摘Objective To investigate the influence of vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes mellitus (T1DM) in the Chinese Han population. Method One hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamI. Results The frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects (P = 0.033) while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms. Conclusion The BsmI polymorphism of VDR gene may be associated with the susceptibility to T1DM in the Chinese Han population of Beijing. | Xin-hua Xiao Zhe-long Liu Heng Wang Qi Sun Wen-hui Li Guo-hua Yang Qiu-ying Liu | 2006 | Chinese Medical Sciences Journal2006，21，2： | 8 |
| 10 | Expanded endoscopic therapy criteria should be cautiously used in intramucosal gastric cancer显示文摘Objective: Accurate estimation of lymph node metastasis(LNM) in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM.Methods: A retrospective review of data from 386 intramucosal gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed.Results: LNM was detected in 40(10.4%) of the 386 patients. Histological type and vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection(ESD) indication also revealed that the undifferential type was the only significant factor for LNM.Conclusions: It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients. | Hongshan Wang Heng Zhang Cong Wang Yong Fang Xuefei Wang Weidong Chen Fenglin Liu Kuntang Shen Xinyu Qin Zhenbin Shen Yihong Sun | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 11 | Beneficial effects of a diabetes specific formula on insulin sensitivity and free fatty acid in patients with type 2 diabetes mellitus显示文摘背景这未来的、使随机化的、控制研究被设计调查糖尿病的效果特定的公式(Diason 低 energy:313.8 kJ/100 ml ) 与一个标准公式相比,在在类型 2 糖尿病患者的胰岛素敏感,浆液 C 肽,浆液类脂化合物和免费的丰满的酸(船边交货) 上。2 名糖尿病患者完成了学习的总共 71 类型的方法。Enteral 公式作为营养的唯一的来源口头上地被给这些题目 6 天。静脉的血样品(0.5,1,2,3 个小时) 在 75 g 以后在 day-7 被收集口头的葡萄糖忍耐测试(OGTT ) ,在标准测试饭(1673.6 kJ ) 以后并且在 6 天也以后的白天 1 测试糖尿病特定的公式或一个标准公式。血浆葡萄糖,浆液胰岛素, C 肽和类脂化合物是。测量。在干预时期以后结果,糖尿病特定的公式在 0.5 小时( P0.05 )和 1 个小时( P0.01 )在血葡萄糖集中导致了显著地更低的饭后的上升;血浆葡萄糖( P=0.05 )的显著地更低的山峰高度;在 0.5 小时( P0.01 )的显著地更低的血浆胰岛素集中, 1 个小时( P0.01 )和 2 个小时( P0.01 );并且与控制相比的一座显著地更低的血浆胰岛素山峰;OGTT 和标准测试饭(P0.05 ) 在在糖尿病以后的曲线下面的 .The 葡萄糖和胰岛素区域与标准公式相比的特定的公式显著地更低。C 肽水平在 6 天公式比作 75 g OGTT 的两营养以后是更低的,然而并非与标准混合的饭不同。两个公式是井 toleraled。在摘要的结论糖尿病有相对高的 monounsaturated 的特定的公式丰满的酸和高度多,纤维比例显著地改进了 glycemic 控制。在这上,胰岛素敏感(HOMA ) 显著地被改进并且可以直接因此在长期的复杂并发症上改进影响。疾病特定的公式应该因此是被糖尿病患者和 hyperglycemic 病人需要营养的支持要过去常的比较喜欢的选择。 | LI Yu-xiu ZENG Jing-bo YU Kang SUN Qi LIU Qiu-ying QIN Wei ZHANG Qian YU Jian-chun WANG Heng | 2008 | Chinese Medical Journal2008，，8： | 8 |
| 12 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 13 | Sonic hedgehog protein promotes bone marrow-derived endothelial pro-genitor cell proliferation,migration and VEGF production via PI 3-kinase/Akt signaling pathways显示文摘瞄准:调查声音的刺猬(嘘) 的效果骨髓上的蛋白质 -- 表明小径的导出的内皮祖先房间(BM-EPC ) 增长,迁居和脉管的内皮生长因素(VEGF ) 生产,和潜力在这些包含了效果。方法:骨头导出髓的 Flk-1 (+) 房间从成年 Kunming 鼠标用 MACS 系统被充实然后 BM-EPC 在明胶涂的培养皿是有教养的。BM-EPC 增长上的嘘 N 终端肽的效果用 MTT 比色测定被评估。细胞移行是用一种修改 Boyden 房间技术的 assayed。VEGF 的生产被 ELISA 和免疫萤光分析决定。表明小径的 PKC 和 PI3K 的潜在的参与用选择禁止者或西方的污点被探索。结果:在 BM-EPC 的增长,迁居和 VEGF 生产能被内长的嘘 N 终端肽在 0.1 microg/mL 的集中提升到 10 microg/mL,并且能被反嘘抗体禁止。在 BM-EPC 的调停嘘的增长和移植能被 anti-VEGF 部分稀释。在最新分开的 BM-EPC 的 Phospho-PI3-kinase 表示是低的,并且外长的嘘 N 终端肽什么时候被增加,但是能被 anti-human/mouse 嘘 N 终端肽抗体稀释,显著地增加了。而且, PI3-kinase 的禁止者,然而并非 PKC 的禁止者,显著地禁止了调停嘘的增长,迁居和 VEGF 生产。结论:嘘蛋白质罐头 stimulate 骨头导出髓的 BM-EPC 增长,移植和 VEGF 生产,它可以把 neovascularization 提升到是化学家纸巾。这也结果建议表明小径的 PI3-kinase/Akt 涉及嘘的 angiogenic 效果。 | Jin-rong FU Wen-li LIU Jian-feng ZHOU Han-ying SUN Hui-zhen XU Li LUO Heng ZHANG Yu-feng ZHOU | 2006 | Acta Pharmacologica Sinica2006，27，6： | 7 |
| 14 | CmFTL2 is involved in the photoperiod- and sucrose-mediated control of flowering time in chrysanthemum显示文摘The chrysanthemum genome harbors three FT-like genes:CmFTL1 and CmFTL3 are thought to act as regulators of floral induction under long-day(LD)and short-day(SD)conditions,respectively,whereas the function of CmFTL2 is currently unclear.The objective of the present research was to explore the function of CmFTL2 in the determination of flowering time of the photo-insensitive chrysanthemum cultivar‘Floral Yuuka’,both in response to variation in the photoperiod and to the exogenous provision of sucrose.Spraying leaves of‘Floral Yuuka’plants with 50 mM sucrose accelerated flowering and increased the level of CmFTL2 transcription in the leaf more strongly than either CmFTL1 or FTL3 under both long and SD conditions.Transcription profiling indicated that all three CmFTL genes were upregulated during floral induction.The relationship of the CmFTL2 sequence with that of other members of the PEBP family suggested that its product contributes to the florigen rather than to the anti-florigen complex.The heterologous expression of CmFTL2 in the Arabidopsis thaliana ft-10 mutant rescued the mutant phenotype,showing that CmFTL2 could compensate for the absence of FT.These results suggest that CmFTL2 acts as a regulator of floral transition and responds to both the photoperiod and sucrose. | Jing Sun Heng Wang Liping Ren Sumei Chen Fadi Chen Jiafu Jiang | 2017 | Horticulture Research2017，4，1： | 7 |
| 15 | First 30 endobronchial ultrasound-guided transbronchial needle aspirations: a single institution's early experience显示文摘一种新技术在 2002 开发了的背景,实时 endobronchial 指导超声的 transbronchial 针渴望(EBUS-TBNA ) ,是在淋巴节点(行) 的最重要的工具之一在肺癌症外科前的阶段。EBUS-TBNA 在在 2009 年 6 月之间的 2008 .Methods 被介绍进中国, 2009 年 10 月,有 mediastinal/hilar lymphadenopathy 的 30 个病人和胸的群众以前与 CT 检测了扫描没有,经历了 EBUS-TBNA 快速现场 cytological 检查。从 30 个病人,的结果 33 件样品从 intrapulmonary 损害从行和七件样品被获得。二十通过过程从癌症诊断的 23 肺被澄清,与是的敏感,特性,积极预兆的价值,否定预兆的价值和精确性 87% ,百分之百 100% , 70% 和 90% 分别地。所有三个假否定盒子在开始的五个过程被发现。在检验的 33 行之中,另外,没有淋巴细胞的三个标本也在开始的五个过程以内被发现。没有主要复杂并发症,并且过程是 uneventful.Conclusions EBUS-TBNA 在为 mediastinal/hilar 行和 intrapulmonary 群众做诊断似乎是一种安全、有效的技术。为在 bronchoscopy 经验丰富的 pulmonologists,为诊断肺癌症的过程的敏感应该是不亚于 90% 在以后起始五个过程。 | SUN Jia-yuan ZHAO Heng ZHANG Jie WANG Xiang-dong HAN Bao-hui | 2011 | Chinese Medical Journal2011，，12： | 7 |
| 16 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 17 | RELATIONSHIP BETWEEN HEMOGLOBIN A1C AND BLOOD GLUCOSE THROUGHOUT THE DAY IN WELL-GLYCEMIC-CONTROLLED MEDICAL NUTRITION THERAPY ALONE TYPE 2 DIABETIC PATIENTS显示文摘Objective To investigate the relationship between glycosylated hemoglobin A1c (HbA1c) and blood glucose levels of eight different points throughout the day in well-glycemic-controlled medical nutrition therapy (MNT) alone type 2 diabetic patients. Methods Data were collected as capillary blood glucose value of eight different sample points among sixteen observing days in thirty MNT alone type 2 diabetic patients. The correlation between HbA1c and capillary blood glucose value was evaluated by Pearson’s correlation method. Results The r-values between HbA1c and capillary blood glucose of 3:00, 6:00, and bedtime (22:00-23:00) were 0.81, 0.79, and 0.78, respectively(P<0.001). The best correlation was found between the mean value of 8-point blood glucose value throughout the day and HbA1c (r=0.84, P<0.001). Conclusion Fasting blood glucose and postabsorptive blood glucose have better correlations with HbA1c compared with other points in this group of well-glycemic-controlled MNT alone type 2 diabetic patients. | Wen-hui Li Xin-hua Xiao Qi Sun Guo-hua Yang Heng Wang | 2006 | Chinese Medical Sciences Journal2006，21，2： | 6 |
| 18 | Preparation and Characterization of Novel Ti-doped M-site Deficient Olivine LiFePO_4显示文摘A novel Ti-doped M-site deficient olivine LiFePO4, i.e. Li0.95Fe0.95Ti0.05PO4, was synthesized by a solid-state reaction method. XRD and FTIR were used to characterize the as-prepared samples. As a cathode material for lithium-ion batteries, Li0.95Fe0.95Ti0.05PO4 exhibited improved rate capability. | Yu Heng SUN Xing Quan LIU | 2006 | Chinese Chemical Letters2006，17，8： | 6 |
| 19 | Identification of Serum Exosomal MicroRNA Expression Profiling in Menopausal Females with Osteoporosis by High-throughput Sequencing显示文摘Estrogen deficiency,which mainly occurs in postmenopausal women,is a primary reason for osteoporosis in clinical diagnosis.However,the molecular regulation of osteoporosis in menopausal females is still not adequately explained in the literature,with the diagnosis and treatment for osteoporosis being limited.Herein,exosomal microRNAs(miRNAs)were used to evaluate their diagnosis and prediction effects in menopausal females with osteoporosis.In this study,6 menopausal females without osteoporosis and 12 menopausal females with osteoporosis were enrolled.The serum exosomes were isolated,and the miRNA expression was detected by miRNA high-throughput sequencing.Exosomal miRNA effects were analyzed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses.The miRNA-targeted genes were evaluated by Targetscan 7.2 and the protein-protein interactions(PPI)by STRING.Hub genes were analyzed by the CytoHubba app of Cytoscape.The results showed that 191 aberrant miRNAs were found in the group of menopausal females with osteoporosis,including 72 upregulated miRNAs and 121 downregulated miRNAs.Aberrant miRNAs were involved in many signaling pathways,such as the Wnt,MAPK,and Hippo pathways.Based on PPI network analysis,FBXL3,FBXL13,COPS2,UBE2D3,DCUN1D1,DCUN1D4,CUL3,FBXO22,ASB6,and COMMD2 were the 10 most notable genes in the PPI network.In conclusion,aberrant serum exosomal miRNAs were associated with an altered risk of osteoporosis in menopausal females and may act as potential biomarkers for the prediction of risk of osteoporosis in menopausal females. | Jian-li SHAO Heng LI Xiao-rong ZHANG Xia ZHANG Zhi-zhong LI Gen-long JIAO Guo-dong SUN | 2020 | Current Medical Science2020，40，6： | 6 |
| 20 | Atomic Fe-Zn dual-metal sites for high-efficiency pH-universal oxygen reduction catalysis显示文摘An effective electrocatalyst being highly active in all pH range for oxygen reduction reaction(ORR)is crucial for energy conversion and storage devices.However,most of the high-efficiency ORR catalysis was reported in alkaline conditions.Herein,we demonstrated the preparation of atomically dispersed Fe-Zn pairs anchored on porous N-doped carbon frameworks(Fe-Zn-SA/NC),which works efficiently as ORR catalyst in the whole pH range.It achieves high half-wave potentials of 0.78,0.85 and 0.72 V in 0.1 M HClO4,0.1 M KOH and 0.1 M phosphate buffer saline(PBS)solutions,respectively,as well as respectable stability.The performances are even comparable to Pt/C.Furthermore,when assembled into a Zn-air battery,the high power density of 167.2 mWcm−2 and 120 h durability reveal the feasibility of Fe-Zn-SA/NC in real energy-related devices.Theoretical calculations demonstrate that the superior catalytic activity of Fe-Zn-SA/NC can be contributed to the lower energy barriers of ORR at the Fe-Zn-N6 centers.This work demonstrates the potential of Fe-Zn pairs as alternatives to the Pt catalysts for efficient catalytic ORR and provides new insights of dual-atom catalysts for other energy conversion related catalytic reactions. | Jie Xu Shuhua Lai Defeng Qi Min Hu Xianyun Peng Yifan Liu Wei Liu Guangzhi Hu Heng Xu Fan Li Chao Li Jia He Longchao Zhuo Jiaqiang Sun Yuan Qiu Shusheng Zhang Jun Luo Xijun Liu | 2021 | Nano Research2021，14，5： | 6 |
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