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| 1 | Platinum drugs:from Pt(Ⅱ)compounds,Pt(Ⅳ)prodrugs,to Pt nanocrystals/nanoclusters显示文摘Platinum(Pt) based drugs, such as cisplatin, are widely used as anti-cancer agents, but their severe adverse reactions and resistance of cancer patients have limited their board clinical use. For the last few decades, Pt(Ⅱ) compounds, Pt(Ⅳ) prodrugs as well as smart drug delivery systems have been developed to overcome these problems. However, most conventional strategies rely on the similar anti-cancer mechanism with cisplatin and consequently only achieve limited success. Recently, Pt nanocrystals/nanoclusters(Pt NCs), with a brand new anti-cancer mechanism, have shown a promising potential in targeted cancer therapy, especially in Pt resistance circumvention. This review is helpful to understand the research strategies of Pt drugs, particularly, the recent developments and medical applications of Pt NCs. | Xi Hu Fangyuan Li Nabila Noor Daishun Ling | 2017 | Science Bulletin2017，62，8： | 4 |
| 2 | A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy显示文摘The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes.However,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation.Here,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural transformation.The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron injection.Interestingly,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of tumors.Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems. | Xi Hu Nan Wang Xia Guo Zeyu Liang Heng Sun Hongwei Liao Fan Xia Yunan Guan Jiyoung Lee Daishun Ling Fangyuan Li | 2022 | Nano-Micro Letters2022，14，6： | 4 |
| 3 | Ferrimagnetic m PEG-b-PHEP copolymer micelles loaded with iron oxide nanocubes and emodin for enhanced magnetic hyperthermia–chemotherapy显示文摘As a non-invasive therapeutic method without penetration-depth limitation,magnetic hyperthermia therapy(MHT)under alternating magnetic field(AMF)is a clinically promising thermal therapy.However,the poor heating conversion efficiency and lack of stimulus–response obstruct the clinical application of magnetofluid-mediated MHT.Here,we develop a ferrimagnetic polyethylene glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)(m PEG-b-PHEP)copolymer micelle loaded with hydrophobic iron oxide nanocubes and emodin(denoted as EMM).Besides an enhanced magnetic resonance(MR)contrast ability(r2=271 m M^-1 s^-1)due to the high magnetization,the specific absorption rate(2518 W/g at 35 k A/m)and intrinsic loss power(6.5 n Hm2/kg)of EMM are dozens of times higher than the clinically available iron oxide nanoagents(Feridex and Resovist),indicating the high heating conversion efficiency.Furthermore,this composite micelle with a flowable core exhibits a rapid response to magnetic hyperthermia,leading to an AMF-activated supersensitive drug release.With the high magnetic response,thermal sensitivity and magnetic targeting,this supersensitive ferrimagnetic nanocomposite realizes an above 70%tumor cell killing effect at an extremely low dosage(10μg Fe/m L),and the tumors on mice are completely eliminated after the combined MHT–chemotherapy. | Yonghong Song Dongdong Li Yang Lu Kun Jiang Yi Yang Yunjun Xu Liang Dong Xu Yan Daishun Ling Xianzhu Yang Shu-Hong Yu | 2020 | National Science Review2020，7，4： | 4 |
| 4 | A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy显示文摘Ferroptosis, as a new type of cell death caused by lipid peroxidation, has attracted much attention since it was first identified in 2012. A lot of progress has been made in unraveling its mechanisms and therapeutic potential as a target for cancer therapy. Hitherto, there are mainly two strategies widely adopted for designing ferroptosis-inducing agents, which include increasing the intracellular reactive oxygen species(ROS) level by Fenton reaction, and inactivating the glutathione peroxidase 4(GPX4). In this mini-review,we summarize the recent advances in ferroptosis-based anticancer treatments with a highlight on nanomaterials, and discuss the current challenges faced by those agents from the perspective of in vivo applications. Moreover, by generalizing ferroptosis induced by excess iron ions to cell death caused by the polyvalent metal-mediated oxidative burden, we introduce a new paradigm of cancer treatment by exploiting various polyvalent metals to disrupt the vulnerable redox balance in cancer cells, which may greatly diversify our arsenal to combat cancer. | Shuaifei Wang Hongwei Liao Fangyuan Li Daishun Ling | 2019 | Chinese Chemical Letters2019，30，4： | 3 |
| 5 | Dynamic supraparticles for the treatment of age-related diseases显示文摘Age-related diseases(ARDs) are arising as a major threat to public health in our fast-aging society.Current development of nanomedicine has sparked much optimism toward ARDs management by improving drug delivery and controlled drug release. However, effective treatments for ARDs, such as cancer and Alzheimer’s diseases(AD), are still lacking, due to the complicated pathological features of ARDs including multifactorial pathogenesis, intricate disease microenvironment, and dynamic symptom manifestation. Recently, dynamic supraparticles(DS), which are reversibly self-assembled functional nanoparticles, have provided a novel strategy for combating ARDs. Besides the intrinsic advantages of nanomedicine including multifunctional and multitarget, DS are capable of dynamic structural reconfiguration upon certain stimulation, creating another layer of maneuverability that allows programmed response to the spatiotemporal alterations of ARDs during progression and treatment. In this review,we will overview the challenges faced by ARDs management, and discuss the unique opportunities brought by DS. Then, we will summarize the designed synthesis of DS for ARDs treatment. Finally, we will dissect the therapeutic targets in ARDs that can be exploited by DS, and present the encouraging advances in this field. Hopefully, this review will bridge our knowledge of the design principle of DS and ARDs management, which may inspire the future development of potent theranostic agents to improve the healthcare. | Hongwei Liao Zeyu Liang Nan Wang Min Wei Ying Chen Fangyuan Li Daishun Ling | 2019 | Science Bulletin2019，64，24： | 2 |
| 6 | Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism显示文摘 | Lu Wang Zejun Wang Xiaoming Li Yi Zhang Min Yin Jiang Li Haiyun Song Jiye Shi Daishun Ling Lihua Wang Nan Chen Chunhai Fan | 2018 | Nano Research2018，11，5： | 2 |
| 7 | Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy显示文摘Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously preventing tumor metastasis and recurrence by activating the host antitumor immune response.Tumor-responsive dynamic nanoassemblies(TDNs)have evolved from being a mere curiosity to a promising platform for high-performance PIT.However,the dynamic nano-bio interaction between TDNs and tumor microenvironment remains poorly understood,which shall be critical for precise control of TDNs assembling/disassembling behavior and superior PIT efficacy.To deepen the understanding of the structure–function relationship of TDNs,this review introduces the rational design,nano-bio interactions,and controllable functionalities of cutting-edge TDNs for enhanced PIT.Moreover,the synergetic mechanism between TDNs-based PIT and immunomodulatory agents-mediated immunomodulation is particularly emphasized.Finally,the challenges and future perspectives in this emerging field are assessed. | Dao Shi Nan Wang Jie Zhang Xi Hu Qiyue Wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling | 2023 | Nano Research2023，16，8： | 1 |
| 8 | Molecular Design of Conjugated Small Molecule Nanoparticles for Synergistically Enhanced PTT/PDT显示文摘Simultaneous photothermal therapy(PTT)and photodynamic therapy(PDT)is beneficial for enhanced cancer therapy due to the synergistic effect.Conventional materials developed for synergistic PTT/PDT are generally multicomponent agents that need complicated preparation procedures and be activated by multiple laser sources.The emerging monocomponent diketopyrrolopyrrole(DPP)-based conjugated small molecular agents enable dual PTT/PDT under a single laser irradiation,but suffer from low singlet oxygen quantum yield,which severely restricts the therapeutic efficacy.Herein,we report acceptor-oriented molecular design of a donor-acceptor-donor(D-A-D)conjugated small molecule(IID-ThTPA)-based phototheranostic agent,with isoindigo(IID)as selective acceptor and triphenylamine(TPA)as donor.The strong D-A strength and narrow singlet-triplet energy gap endow IID-ThTPA nanoparticles(IID-ThTPA NPs)high mass extinction coefficient(18.2 L g^-1 cm^-1),competitive photothermal conversion efficiency(35.4%),and a dramatically enhanced singlet oxygen quantum yield(84.0%)comparing with previously reported monocomponent PTT/PDT agents.Such a high PTT/PDT performance of IID-ThTPA NPs achieved superior tumor cooperative eradicating capability in vitro and in vivo. | Wei Shao Chuang Yang Fangyuan Li Jiahe Wu Nan Wang Qiang Ding Jianqing Gao Daishun Ling | 2020 | Nano-Micro Letters2020，12，11： | 1 |
| 9 | Acute exacerbation of chronic obstructive pulmonary disease was associated with respiratory syncytial virus infection and the upregulation of TLR3显示文摘Respiratory syncytial virus(RSV)infection is known as a risk factor for chronic obstructive pulmonary disease(COPD).RSV infection induces the upregulation of Toll-like receptor 3(TLR3).This study aimed to investigate the association of TLR3 with RSV induced acute exacerbations of chronic obstructive pulmonary disease(AECOPD).Serum/sputum samples from AECOPD patients,stable chronic obstructive pulmonary disease(SCOPD)patients,and healthy controls were collected.Nested PCR was used to detect RSV.The lung function parameters were assessed by blood gas and lung function analysis.The expression levels of inflammatory factors in sputum and serum samples were determined by enzyme-linked immunosorbent assay.BEAS-2B cell lines were infected with RSV,and the expression of TLR3 mRNA was determined by PCR and the levels of inflammatory factors were also investigated.The presence of RSV was detected in 3 SCOPD and 8 AECOPD patients,but not in healthy patients.The expression levels of TNF-αand IRF-3 in both sputum and serum samples of RSV-positive group were significantly higher than in RSV-negative group.TLR3 mRNA levels in RSV-positive group were significantly higher than those in RSVnegative group.Interestingly,the level of TLR3 mRNA expression was negatively correlated with oxygenation index and lung function parameters.Furthermore,BEAS-2B cells infected with RSV led to significant increase of the expression of TLR3 mRNA and inflammatory factors IFN-β,IL-13,IL-32,and TNF-α.Our observations indicate that AECOPD is associated with RSV infection and the upregulation of TLR3. | LING GONG HUAJUN YANG YING HUANG ZHU LI JIN NIE MENG YE PENG XIE DAISHUN LIU | 2022 | BIOCELL2022，46，4： | 1 |
| 10 | Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting显示文摘 | Daishun Ling Byoung-chan Bae Wooram Park Kun Na | 2012 | Biomaterials2012，，21： | 1 |
| 11 | Porous hollow palladium nanoplafform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy显示文摘 | Menglin Song Nian Liu Le He Gang Liu Daishun Ling Xinhui Su Xiaolian Sun | 2018 | Nano Research2018，11，5： | 1 |
| 12 | Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines显示文摘Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized medicine.The integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical research.Mesoporous silica nanoparticles(MSN)with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic nanomedicines.The rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each nanocomponent.In this review,the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are summarized.We categorize MSN-based nanomedicines by their unique heterostructures,including core-shell,yolk-shell,core-satellite,heterodimer and core-shell-satellite structures,and discuss the controlled assembly approaches as well as the intriguing applications for disease theranostics.Finally,a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted. | Fangyuan Li&Daishun Ling Yang Du Zheng Chen Ji Young Lee Peihua Lin Fan Xia Yunan Guan Fangyuan Li Daishun Ling | 2021 | Science China Chemistry2021，64，2： | 0 |
| 13 | A K^(+)-sensitive AND-gate dual-mode probe for simultaneous tumor imaging and malignancy identification显示文摘Although molecular imaging probes have the potential to non-invasively diagnose a tumor,imaging probes that can detect a tumor and simultaneously identify tumor malignancy remain elusive.Here,we demonstrate a potassium ion(K^(+))sensitive dual-mode nanoprobe(KDMN)for non-invasive tumor imaging and malignancy identification,which operates via a cascaded‘AND’logic gate controlled by inputs of magnetic resonance imaging(MRI)and fluorescence imaging(FI)signals.We encapsulate commercial K^(+)indicators into the hollow cavities of magnetic mesoporous silica nanoparticles,which are subsequently coated with a K^(+)-selective membrane that exclusively permits the passage of K^(+)while excluding other cations.The KDMN can readily accumulate in tumors and enhance the MRI contrast after systemic administration.Spatial information of the tumor lesion is thus accessible via MRI and forms the first layer of the‘AND’gate.Meanwhile,the KDMN selectively captures K^(+)and prevents interference from other cations,triggering a K^(+)-activated FI signal as the second layer of the‘AND’gate in the case of a malignant tumor with a high extracellular K^(+)level.This dual-mode imaging approach effectively eliminates false positive or negative diagnostic results and allows for non-invasive imaging of tumor malignancy with high sensitivity and accuracy. | Qiyue Wang Fangyuan Li Zeyu Liang Hongwei Liao Bo Zhang Peihua Lin Xun Liu Shen Hu Jiyoung Lee Daishun Ling | 2022 | National Science Review2022，9，7： | 0 |
| 14 | Metal nanoparticles for cancer therapy:Precision targeting of DNA damage显示文摘Cancer,a complex and heterogeneous disease,arises from genomic instability.Currently,DNA damage-based cancer treatments,including radiotherapy and chemotherapy,are employed in clinical practice.However,the efficacy and safety of these therapies are constrained by various factors,limiting their ability to meet current clinical demands.Metal nanoparticles present promising avenues for enhancing each critical aspect of DNA damage-based cancer therapy.Their customizable physicochemical properties enable the development of targeted and personalized treatment platforms.In this review,we delve into the design principles and optimization strategies of metal nanoparticles.We shed light on the limitations of DNA damage-based therapy while highlighting the diverse strategies made possible by metal nanoparticles.These encompass targeted drug delivery,inhibition of DNA repair mechanisms,induction of cell death,and the cascading immune response.Moreover,we explore the pivotal role of physicochemical factors such as nanoparticle size,stimuli-responsiveness,and surface modification in shaping metal nanoparticle platforms.Finally,we present insights into the challenges and future directions of metal nanoparticles in advancing DNA damage-based cancer therapy,paving the way for novel treatment paradigms. | Qian Chen Chunyan Fang Fan Xia Qiyue Wang Fangyuan Li Daishun Ling | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 15 | Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy显示文摘To the editor:The precise diagnosis and effective therapy of refractory diseases,such as neurodegenerative diseases,coronary heart diseases and cancers,is critical to increase the survival rate and improve the life quality of patients.Most of the conventional small molecular medicines are heavily associated with the limitations of poor solubility,low targeting efficiency,inducing drug resistance and systemic toxicity,promoting scientists to develop new strategies for overcoming these limitations. | Yamin Liu Qiyue Wang Fangyuan Li Daishun Ling | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 0 |
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