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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Nonviral gene delivery with indoleam-ine 2 ,3-dioxygenase targeting pulmonary endothelium protects a-gainst ischemia-reperfusion injury 显示文摘 | Liu H Liu L Visner GA | 2007 | American Journal of Transplantation2007，1357，10： | 1 |
| 3 | Mycoplasma genitalium among women with nongonococcal nonchlamydial pelvic inflammatory disease 显示文摘 | Catherine L H Patricia A T 3 Sabina GA | 2006 | Infectious Diseases in Obstetrics and Gynecology2006，30，184： | 1 |
| 4 | Optimal coupling condition oflPT system for achieving maximum power transfer显示文摘 | Li H L Hu A P Covic GA | 2009 | Electronics Letters2009，45，1： | 1 |
| 5 | Platalet expression of tumor necrosis factor-alpha (TNF-alpha), TNF receptor and intercellular adhesion molecule-1 (ICAM-1) in patients with proliferative diabetic retinopathy 显示文摘 | Limb GA Webster L Soomro H | 1999 | Clin Exp Immunool1999，118，2： | 1 |
| 6 | Phtelet expression of tumor necrosis factor alpha(TNF-alpha),TNF receptor and intercellular adhesion molecule-1 (ICAM-1)in patients with proliferative diabetic retinopathy显示文摘 | Limb GA Webster L Soomro H | 1999 | Clin Exp lmmunool1999，118，2： | 1 |
| 7 | Platelet expression of tumour necrosis factor-alpha (TNF-alpha),TNF receptors and intercellular adhesion molecule-1(ICAM-1)in patients with proliferative diabetic retinophathy显示文摘 | Limb GA Webster L Soomro H | 1999 | Clinical and Experimental Immunology1999，118，： | 1 |
| 8 | Tooth transplantation and cryopreservation:state of the art显示文摘 | Temmerman L Pauw GA Beele H | | 0，，05： | 1 |
| 9 | Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘 | Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD | 2005 | Tuberculosis (Edinb)2005，85，12： | 1 |
| 10 | Bevacizumab plus irinotecan/5-Fu/leucovorin for treatment of metastatic colorectal cancer results in survival benefit in all pre-specified patient subgroups显示文摘 | Fyfe GA Hurwitz H Fehrenbacher L | 2004 | J Clin Oncol ASCO Meeting Abstracts2004，22，： | 1 |
| 11 | Effect of estrogen on scavenger receptor BI expression in the rat 显示文摘 | Stangl H Graf GA Yu L | 2002 | J Endo- crinol2002，175，3： | 1 |
| 12 | Immucillin H, a powerful transi- tion-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes 显示文摘 | Kicska GA Long L Hgrig H | 2001 | Proc Natl Acad Sci U S A2001，98，8： | 1 |
| 13 | Vitamin E andenzymatic/oxidative Stress-Driven oxysterols in amnestic mildcognitive impairment subtypes and alzheimer's disease 显示文摘 | Iuliano L Monticolo H Straface GA | 2010 | Journal ofAlzheimers Disease2010，21，4： | 1 |
| 14 | Rigorous design and opti- mization of hrushless PM motor using response surface methodology with quantum-behaved PSO operator显示文摘 | GAING Z L LIN C H TSAI M H | 2014 | IEEE Trans on Magne- tics2014，50，1： | 1 |
| 15 | Nonviral gene delivery with indoleamine 2, 3 - dioxygenase targeting pulmonary endothelium protects against is- chemia - reperfusion inju显示文摘 | Liu H Liu L Visner GA | 2007 | American Journal of Transplantation2007，7，： | 1 |
| 16 | Monozygous twins with a microdeletion syndrome involving BTK, DDP1, and two other genes; evidence of intact dendritic cell development and TLR responses 显示文摘 | Jyonouchi H Geng L Toruner GA | 2008 | Eur J Pediatr2008，167，3： | 1 |
| 17 | Platelet expression of tumour necrosis factor-alpha (TNF-alpha), TNF receptors and in-tercellular adhesion moleeule-i (ICAM-1) in patients with proliferative diabetic retinopathy显示文摘 | Limb GA Webster L Soomro H etal | 1999 | Clin EXp lmmunol1999，118，2： | 1 |
| 18 | Benign in- fantile seizures with mild gastroenteritis : study of 22 patients 显示文摘 | Caraballo R H Ga ez L De los Santos C | 2009 | Seizure2009，18，10： | 1 |
| 19 | Donor-Specific Allograft Tolerance by Administration of Recipient-Derived Immature Dendritic Cells and Suboptimal Immunosuppression显示文摘 | Ga?lle Bériou Hélène Pêche Carole Guillonneau Emmanuel Merieau Maria-Cristina Cuturi | 2005 | Transplantation2005，，8： | 1 |
| 20 | Effect of Lactobacillus strains and Saccharomyces boulardii on persistent diarrhea in children显示文摘 | Gaón D García H Winter L | 2003 | Medicina2003，63，4： | 1 |
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