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| 1 | Turning rice meiosis into mitosis显示文摘通过在庄稼的种子(单性生殖) 的同种细胞的复制的介绍有潜力由允许任何精英变化的自我繁殖革命化农业,特别地 F1 混血儿。在性模型植物 Arabidopsis thaliana,通过种子的合成同种细胞的复制能被联合三个变化把成熟分裂变成有丝分裂(笑剧) 并且(的(i) 人工地实现 ii ) 穿过获得的同种细胞的配偶子,一根线表示修改了 CENH3 并且其染色体在接合子被消除。这里,我们证明变化的另外的联合能把 Arabidopsis 成熟分裂变成有丝分裂并且在米饭(Oryza sativa ) 的三个变化的联合高效地把成熟分裂变成有丝分裂,导致在这主要庄稼的男、女的同种细胞的双配偶子的生产。在种系发生地远的 eudicot Arabidopsis 和 monocot 米饭的笑剧技术的成功的实现为它的申请打开门到任何 flowering 植物并且为在庄稼种类介绍单性生殖铺平道路。 | Delphine Mieulet Sylvie Jolivet Maud Rivard Laurence Cromer Aurore Vemet Pauline Mayonove Lucie Pereira Gaetan Droc Brigitte Courtois Emmanuel Guiderdoni Raphael Mercier | 2016 | Cell Research2016，26，11： | 14 |
| 2 | L-carnitine protects C2C12 cells against mitochondrial superoxide overproduction and cell death显示文摘AIM To identify and characterize the protective effect that L-carnitine exerted against an oxidative stress in C2C12 cells.METHODS Myoblastic C2C12 cells were treated with menadione, a vitamin K analog that engenders oxidative stress, and the protective effect of L-carnitine(a nutrient involved in fatty acid metabolism and the control of the oxidative process), was assessed by monitoring various parameters related to the oxidative stress, autophagy and cell death. RESULTS Associated with its physiological function, a muscle cell metabolism is highly dependent on oxygen and may produce reactive oxygen species(ROS), especially under pathological conditions. High levels of ROS are known to induce injuries in cell structure as they interact at many levels in cell function. In C2C12 cells, a treatment with menadione induced a loss of transmembrane mitochondrial potential, an increase in mitochondrial production of ROS; it also induces autophagy and was able to provoke cell death. Pre-treatment of the cells with L-carnitine reduced ROS production, diminished autophagy and protected C2C12 cells against menadione-induced deleterious effects. CONCLUSION In conclusion, L-carnitine limits the oxidative stress in these cells and prevents cell death. | Francoise Le Borgne Gaetan Ravaut Arnaud Bernard Jean Demarquoy | 2017 | World Journal of Biological Chemistry2017，8，1： | 3 |
| 3 | Secondary non-resectable liver tumors:A single-center living-donor and deceased-donor liver transplantation case series显示文摘Background: During the last decades, deceased-donor liver transplantation (DDLT) has gained a place in the therapeutic algorithm of well-selected patients harbouring non-resectable secondary liver tumors. Living-donor LT (LDLT) might represent a valuable means to further expand this indication for LT. Methods: Between 1985 and 2016, twenty-two adults were transplanted because of neuroendocrine ( n = 18, 82%) and colorectal metastases ( n = 4, 18%);50% received DDLT and 50% LDLT. In LDLT, 4 (36%) right and 7 (64%) left grafts were used;the median graft-to-recipient-weight ratios (GRWR) were 1.03%(IQR 0.86%- 1.30%) and 0.59%(IQR 0.51%- 0.91%), respectively. Median post-LT follow-up was 64 months (IQR 17–107) in the DDLT group and 40 months (IQR 35–116) in the LDLT group. DDLT and LDLT recipients were compared in terms of overall survival, graft survival, postoperative complications and recurrence. Results: The 1- and 5-year actuarial patient survivals were 82% and 55% after DDLT, 100% and 100% after LDLT, respectively ( P < 0.01). One- and 5-year actuarial graft survivals were 73% and 36% after DDLT, 91% and 91% after LDLT ( P < 0.01). The outcomes of right or left LDLT were comparable. Donor hepatectomy proved safe, and one donor experienced a Clavien IIIb complication. Bilirubin peak was significantly lower after left hepatectomy compared with that after right hepatectomy [1.3 (IQR 1.2–2.2) vs. 3.3 (IQR 2.3–5.2) mg/dL;P = 0.02]. Conclusions: The more recent LDLT series compared favorably to our DDLT series in the treatment of secondary liver malignancies. The absence of portal hypertension and the use of smaller left grafts make recipient and donor surgeries safe. The safety of the procedures and lack of interference with the scarce allograft pool are expected to lead to a more frequent use of LDLT in the field of transplant oncology. | Jan Lerut Samuele Iesari Gaetan Vandeplas Tiziana Fabbrizio Kevin Ackenine Milton Eduardo Inostroza Nunez Mina Komuta Laurent Coubeau Olga Ciccarelli Eliano Bonaccorsi-Riani | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 2 |
| 4 | Treatment of gastrointestinal stromal tmors with Imatinib Mesylate:a maj or breakthrough in the understanding of tumor-specific molecular characteristics显示文摘 | Philippe DM Gaetan DG | 2005 | World J Surg2005，29，： | 1 |
| 5 | Past, present and future of nonlinear systemidentification in structural dynamics 显示文摘 | Gaetan Kerschen Keith Worden Alexander F Vakak-is | 2006 | MechanicalSystems and Signal Processing2006，20，3： | 1 |
| 6 | First report of gray leaf spot caused by Alternaria brassicae on canola in Argentina 显示文摘 | Gaetan S Madia M | 2005 | Plant Disease2005，89，2： | 1 |
| 7 | UV disinfection of Giardia lamblia Cysts in water 显示文摘 | Karl G Linden Shin Gwy-Am Gaetan Faubert | 2002 | Environ Sci Technol2002，36，11： | 1 |
| 8 | Fast Quantum State Control of a Single Trapped Neutral Atom 显示文摘 | JONES M P A BEUGNON J GAETAN A | 2007 | Phys Rev A2007，75，04： | 1 |
| 9 | Removal of iron and manganese from groundwater by oxidation and microfiltration显示文摘 | Donald Ellis Christian Bouchard Gaetan Lantagne | 2000 | Desalination2000，130，： | 1 |
| 10 | Removal of iron and manganese from groundwater by oxidation and microfiltration 显示文摘 | Donald Ellis Christian Bouchard Gaetan Lantagne | 2000 | Desalination2000，130，： | 1 |
| 11 | Past, present and future of nonlinear system identification in strucural dynamics 显示文摘 | Gaetan Kerschen | 2006 | Mechanical Systems and Singal Processing2006，20，： | 1 |
| 12 | Heterogeneous porosity distribution in portland cement exposed to CO2 - rich fluids显示文摘 | Gaetan R Veronique B Olivier P | 2008 | Cement and Concrete Research2008，38，89： | 1 |
| 13 | Renal Dysfunction after cardiac surgery with aormothermic cardiopulmonary bypass: in- cidence, risk factors, and effects on clinical outcome 显示文摘 | Sophie P Gaetan P Gilles H | 2003 | Anesth Analg2003，96，： | 1 |
| 14 | Determination of organotin compounds by headspace solid phase microextraction gas chromatography pulsed flame photometric detection(HS-SPMEGC-PFPD)显示文摘 | MANUEL B GAETANE L de GREGORI I | 2005 | Anal Bioanal Chem2005，383，： | 1 |
| 15 | In vivo Reduction of Hepatitis B Virus Antigenemia and Viremia by Antisense Oligonucleotides显示文摘 | Gaetan Billioud Robert L. Kruse Melissa Carrillo Christina Whitten-Bauer Dacao Gao Aneeza Kim Leon Chen Michael L. McCaleb Jeffrey R. Crosby Robert Hamatake Zhi Hong Urtzi Garaigorta Eric Swayze Karl-Dimiter Bissig Stefan Wieland | 2015 | Journal of Hepatology2015，，： | 1 |
| 16 | Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer显示文摘 | Richard Redon Thomas Hussenet Gaetan Bour | 2002 | Cancer Res2002，62，21： | 1 |
| 17 | NOX1 Deficiency Protects From Aortic Dissection in Response to Angiotensin II显示文摘 | Gaetan Gavazzi Christine Deffert Candice Trocme Michela Sch?ppi Fran?ois R. Herrmann Karl-Heinz Krause | 2007 | Hypertension2007，，1： | 1 |
| 18 | Donkey pericardium as a select sourcing to manufacture percutaneous heart valves:Decellularization has not yet demonstrated any clear cut advantage to glutaraldehyde treatment显示文摘Background:The donkey pericardium is considered a good candidate to manufacture percutaneous heart valves based upon its thinness,low cellularity and undulating collagen bundles and laminates.Decellularization represents an avenue worth exploring,should its superiority to glutaraldehyde-treated pericardium be demonstrated.Materials and methods:Donkey pericardium was divided into two groups:regular glutaraldehyde fixation and mild decellularization.The treated pericardia were observed using scanning electron microscopy,histology and transmission electron microscopy.Tensile tests were performed along the axial and perpendicular directions,with the data fitted into both the Gasser–Ogden–Holzapfel(GOH)material model and the Fung’s anisotropic one.Results:The microstructures of the pericardia processed by the two protocols were similar,showing collagen bundles and laminates free of flaws.The decellularization eliminated most of the cells,however leaving the structure somehow compressed.The collagen filaments in bundles were slightly blurry.The anisotropy rates of the non-decellularized specimens were almost identical to the decellularized ones.The decellularized pericardium appeared stiffer.Conclusion:The decellularization proved to be effective.However,it makes the tissue stiffer,which may lead to higher shear concentration during cardiac cycles and reduce its wavy microstructure.Therefore,it appears premature to select decellularized donkey pericardium to manufacture heart valves. | Aisa Rassoli Yiming Li Xianhao Bao Fabien Kawecki Xinzhe Zhao Daniel Chappard Gaetan Le-Bel Jiaxuan Feng Benedikt Weber Nasser Fatouraee Ze Zhang Zaiping Jing Lucie Germain Lu Wang Robert Guidoin | 2019 | Medicine in Novel Technology and Devices2019，，4： | 1 |
| 19 | Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients显示文摘 | Thomas Aparicio Olivier Schischmanoff Cecile Poupardin Nadem Soufir Celine Angelakov Christophe Barrat Vincent Levy Laurence Choudat Joel Cucherousset Marouane Boubaya Christine Lagorce Gaetan Des Guetz Philippe Wind Robert Benamouzig | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 20 | Removal of iron and manganese from groundwater by oxidetion and microfiltration显示文摘 | Donald E Christian B Gaetan L | 2000 | Desalination2000，130，3： | 1 |
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