|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hepatocellular carcinoma in patients with autoimmune hepatitis显示文摘AIM: To evaluate and confirm the low incidence of hepatocellular carcinoma (HCC) in patients with autoimmune hepatitis (AIH). At present only very few cases of HCC in patients with AIH and definite exclusion of chronic viral hepatitis have been published, suggesting that HCC due to AIH is rare. METHODS: In order to further investigate the incidence of HCC in patients with AIH, we reviewed our large cohort of 278 patients with AIH. RESULTS: Eighty-nine patients (32%) were diagnosed with liver cirrhosis, a preneoplastic condition for HCC. We studied a total of 431 patient years of cirrhosis in these patients, an average 4.8 years per patient. During this period none of the patients of our own study cohort developed HCC. However, three patients with HCC due to AIH associated liver cirrhosis were referred to our department for further treatment of HCC. In all three patients chronic viral hepatitis was excluded. CONCLUSION: We conclude that HCC may under rare circumstances develop due to chronic AIH dependent liver cirrhosis. Compared to other causes of liver cirrhosis such as chronic viral hepatitis, alcohol, or hemochromatosis, the incidence of HCC is significantly lower. Pathophysiological differences between AIH and chronic viral hepatitis responsible for differences in the incidence of HCC are yet to be further characterized and may lead to new therapeutic concepts in prevention and treatment of liver cancer. | Andreas Teufel Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，5： | 5 |
| 2 | Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients显示文摘AIM: To report on our large German collective and updated data of 142 patients with autoimmune hepatitis (AIH) type 1. METHODS: Key investigations performed were liver biopsy, serum autoantibodies as well as serum markers such as IgG and elevated transaminases. Antinuclear antigen (ANA) and smooth muscle antigen (SMA) autoantibodies characterized type 1 AIH. Type 3 (AIH) was solely characterized by the occurrence of soluble liver antigen/liver-pancreas antigen (SLA/LP) autoantibodies either with or without ANA or SMA autoantibodies. RESULTS: Most prevalent HLAs were A2 (68 patients, 48%), B8 (63 patients, 44%), C7 (90 patients, 63%), DR3 (49 patients, 38%), DR4 (49 patients, 38%) and DQ2 (42 patients, 30%). Compared to the Italian and North American patients, we found fewer patients with a DQ2 subtype. Furthermore, the B8-DR3-DQ2 human leucocyte antigen (HLA) was also less prominent compared to the North American patients. However, prevalences of B8, DR3, DR4, DR7, DR11 and DR13 were comparable to the Italian and North American patients. Furthermore, we report on an additional subgroup of patients with SLA/LP positive AIH. Generally, in this subgroup of patients the same HLA subtypes were favoured as the AIH type 1. CONCLUSION: Although HLA subtypes were comparable between these three collectives, the German patients were distinct from the Italian and North American patients with respect to DQ2 and from the North American patients with respect to B8-DR3-DQ2HLA. A clinical correlation, e.g. difference in severity or treatability of AIH type 1, has yet to be determined. | Andreas Teufel Markus Wrns Arndt Weinmann Catherine Centner Anja Piendl Ansgar W Lohse Peter R Galle Stephan Kanzler | 2006 | World Journal of Gastroenterology2006，12，34： | 2 |
| 3 | Increase expression of matrix metalloproteinases and matrix degrading activity invulnerable regions of human atherosclerotic plaques显示文摘 | GALLS Z S SUKHOVA G K LARK M W | 1994 | J Clin Invest1994，94，： | 1 |
| 4 | Mice, melatonin and the circadian system 显示文摘 | KORF H W VON GALL C | 2006 | Mol Cell Endocrinol2006，252，12： | 1 |
| 5 | The auxili-like phosphoprotein Swa2p is required for clathrin function in yeast显示文摘 | GALL W E HIGGINBOTHAM M A CHEN C Y | 2000 | Curr Biol2000，10，： | 1 |
| 6 | Effect of microstructure on the fatigue of hot-rolled and cold-drawn Ni-Ti shape memory alloys 显示文摘 | GALL K TYBER J WILKESANDERS G ROBERTSON S W R1TCHIE R O MAIER H J | 2008 | Materials Science and Engineering A2008，486，12： | 1 |
| 7 | Utilizing Ihe-based Electronic Health Record Sys-terns for Secondary Use 显示文摘 | Holzer K Gall W | 2011 | Methods of Information in Medicine2011，50，4： | 1 |
| 8 | An Investigation of Relationships between Communication Style and Leader Member Exchange 显示文摘 | Yrle A C Hartman S Galle W P | 2002 | Journal of Communication Management2002，6，1： | 1 |
| 9 | Rapid, field-adapted indirect enzymelinked immunosorbent assay for detection of antibodies in bovine whole blood and serum to Brucella abortus 显示文摘 | Gall D Nielsen K Yu W | 2006 | Clin Vaccine Immunol2006，13，4： | 1 |
| 10 | Kinetics of thrombornodulin re- lease and endothelial cell injury by neutrophil-derived proteases and oxygen radical显示文摘 | Boehrne MW Galle P Stremmel W | 2002 | Immunology2002，107，3： | 1 |
| 11 | Thermal N2O deconposition in regenerative heat exchanger reactors显示文摘 | Galle M Agar D W Watzenberger O | 2001 | Chemical Engineering Science2001，56，2001： | 1 |
| 12 | Green Purchasing strategies: Trends and Implications显示文摘 | Min H Galle W P | 1997 | International Journal of Purchasing and Materials Management1997，33，3： | 1 |
| 13 | Flux measurements of NH3, N2O and CO2 using dual beam FTIR spectroscopy and the flux-gradient technique 显示文摘 | Griffith D W T Galle B | 2000 | Atmospheric Environment2000，34，7： | 1 |
| 14 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 15 | Breast cancer survivors give voiee: A qualitative analysis of spiritual factors in long-term adjustment显示文摘 | Gall T L Cornblat M W | 2002 | Psychooncology2002，11，6： | 1 |
| 16 | Antiviral potential of interferonomega on hepatitis B virus replication in human hepatoma cells显示文摘 | Hagelstein J Kist A Stremmel W Galle PR | 1998 | Arzneimittelforschung1998，48，： | 1 |
| 17 | Flux measurements of NH3, N2O and CO2 using dual beam FTIR spectroscopy and the flux-gradient technique显示文摘 | Griffith D W T Galle B | 2000 | Atmospheric Environment2000，34，7： | 1 |
| 18 | The genome sequence of Drosophila melanogaster显示文摘 | Adams M D Celniker S E Holt R A Evans C A Gocayne J D Amanatides P G Scherer S E Li P W Hoskins R A Galle R F | | 0，，： | 1 |
| 19 | Sorption, degradation and mobili- ty of microcystins in Chinese agriculture soils: risk assessment for groundwater protection 显示文摘 | Chen W Song L R Gall N Q | 2006 | Environmental Pollution2006，144，3： | 1 |
| 20 | The impact of patient and tumour baseline characteristics on the overall survival of patients with advanced hepatocellular carcinoma treated with sorafenib显示文摘 | Marcus A. W?rns Sandra Koch Ina M. Niederle Jens U. Marquardt Marc Nguyen-Tat Thomas Gamst?tter Marcus Schuchmann Henning Schulze-Bergkamen Peter R. Galle Arndt Weinmann | 2012 | Digestive and Liver Disease2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员