|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 3 | NMR study of the supramoleeular structure of dual drug-loaded poly(butylcyanoaerylate) nanopartieles显示文摘 | Margarita Simeonova Maria Rangel Galya Ivanova | 2013 | PCCP2013，15，16： | 1 |
| 4 | Modelling of residual stress relaxation around cold expanded holes in carbon steel显示文摘 | JORDAN T M GALYA V D IVAN N M | 2009 | Journal of Constructional Steel Research2009，65，： | 1 |
| 5 | Novel anticancer polymeric conjugates of activat- ed nucleoside analogues显示文摘 | Thulani H Senanayake Galya Warren Serguei V Vino- gradov | 2011 | Bioconjugate Chemistry2011，22，10： | 1 |
| 6 | Acid and catalytic properties of nonstoichiometric aluminum borates显示文摘 | PEIL K P GALYA L G MARCELIN G | 1989 | J Catal1989，115，2： | 1 |
| 7 | Germanium isotopicvariationsinigneousrocksandmarinesediments显示文摘 | RouxelO GalyA ElderfieldH | 2006 | GeochimicaetCosmochimicaActa2006，70，13： | 1 |
| 8 | Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds 显示文摘 | Brian AP Martin JS Galya V | 1993 | Development1993，119，1： | 1 |
| 9 | Calorimetric study of quindine interaction with o-phenylphenol and coal-derived asphaltenes显示文摘 | Galya L G Egan K M | 1978 | Fuel1978，57，4： | 1 |
| 10 | Ion Channel Formation from a Calixacene Amide That Binds HCI显示文摘 | Vladimir Sidorov Frank W.Kotch Galya Abdrakhmanova Robert Mizani James C.Fettinger Jeffery T.Davis | | 0，，10： | 1 |
| 11 | Inhibition of inflammatory cy-tokine secretion by plant-derived compounds inuviscolide andtomentosin:the role of NFkB and STAT1 显示文摘 | Galya A Sara D Hanna B | 2010 | The Open Phar-macology Journal2010，4，： | 1 |
| 12 | A new 3D finite element model of the spherical mandrelling process显示文摘 | Jordan T. Maximov Galya V. Duncheva | 2007 | Finite Elements in Analysis & Design2007，，6： | 1 |
| 13 | Biliary Acute Pancreatitis in Mice is Mediated by the G-Protein?Coupled Cell Surface Bile Acid Receptor Gpbar1显示文摘 | George Perides Johanna M. Laukkarinen Galya Vassileva Michael L. Steer | 2010 | Gastroenterology2010，，2： | 1 |
| 14 | Effect of Aronia melanocarpa Fruit Juice on the Activity of Antioxidant Enzymes in a Rat Model of Amiodarone-induced Pneumotoxicity显示文摘 | Stefka V Valcheva-Kuzmanoval Galya Ts Stavreva Violeta Y Dancheva | 2012 | J Biomed Clin Res2012，5，11： | 1 |
| 15 | P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse显示文摘 | Qing Zhang Ping Qiu M. Gladys Arreaza Jason S. Simon Andrei Golovko Maureen Laverty Galya Vassileva Eric L. Gustafson Alberto Rojas-Triana Loretta A. Bober Joseph A. Hedrick Frederick J. Monsma Jonathan R. Greene Marvin L. Bayne Nicholas J. Murgolo | 2007 | Genomics2007，，5： | 1 |
| 16 | Epidemiological and Clinical Studies in Patients with Mumps in Pleven District, Bulgaria, 2000-2008显示文摘 | Milena Karcheva Galya Gancheva | 2012 | Journal of US-China Medical Science2012，9，1： | 0 |
| 17 | Aorto-oesophageal fistula after corrosive ingestion:A case report显示文摘BACKGROUND Aorto-oesophageal fistula(AOF)are uncommon and exceedingly rare after corrosive ingestion.The authors report a case of AOF after corrosive ingestion that survived.A comprehensive literature review was performed to identify all cases of AOF after corrosive ingestion to determine the incidence of this condition,how it is best managed and what the outcomes are.CASE SUMMARY A previously healthy 30-year-old male,presented with a corrosive oesophageal injury after drain cleaner ingestion.He did not require acute surgical resection,but developed long-segment oesophageal stricturing,which was initially managed with cautious dilatation and later stenting.An AOF was suspected at endoscopy performed two months after the ingestion,when the patient represented with massive upper gastrointestinal bleeding.The fistula was confirmed on computerised tomographic angiography.The initial bleeding at endoscopy was temporised by oesophageal stenting;a second stent was placed when bleeding recurred later the same day.The stenting successfully achieved temporary bleeding control,but resulted in sudden respiratory distress,which was found to be due to left main bronchus compression caused by the overlapping oesophageal stents.Definitive bleeding control was achieved by endovascular aortic stent-grafting.A retrosternal gastroplasty was subsequently performed to achieve gastrointestinal diversion to reduce the risk of stent-graft sepsis.He was subsequently successfully discharged and remains well one year post injury.CONCLUSION AOF after corrosive ingestion is exceedingly rare,with a very high mortality.Most occur weeks to months after the initial corrosive ingestion.Conservative management is ill-advised. | Matthias Frank Scriba Urda Kotze Nadraj Naidoo Eduard Jonas Galya Eileen Chinnery | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 0 |
| 18 | Rat neuronal nicotinic acetylcholine receptors containing α7 subunit: pharmacological properties of ligand binding and function显示文摘 | Yingxian XIAO Galya R ABDRAKHMANOVA Maryna BAYDYUK Susan HERNANDEZ Kenneth J KELLAR | 2009 | Acta Pharmacologica Sinica2009，30，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员