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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 3 | Electronic measurement and control of spin transport in silicon 显示文摘 | Appelbaum I Huang B Monsma D J | 2007 | Nature Lett2007，447，7142： | 1 |
| 4 | The GP64 envelope fusion protein is an essential baculovirus protein required for cell-tocell transmission of infection显示文摘 | Monsma S A Oomens A G Blissard G W | 1996 | J Virol1996，70，7： | 1 |
| 5 | A GP64-null baculovirus pseudotyped with vesicular stomatitis virus G protein 显示文摘 | Mangor J T Monsma S A Johnson M C | 2001 | J Virol2001，75，6： | 1 |
| 6 | Develop-mental and contextual risks of social physique anxiety a-mong female athletes显示文摘 | Gay JL Monsma EV Torres-McGehee TM | 2011 | Res Q Exerc Sport2011，82，2： | 1 |
| 7 | Expression of functional D2dopamine receptors following differentiation of Y-79human retinoblastoma cells显示文摘 | Monsma F J Jr Barton A C Sibley D R | 1990 | J Neurochem1990，54，4： | 1 |
| 8 | Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family显示文摘 | Lachowicz JE Shen Y Monsma FJ Jr | | 0，，： | 1 |
| 9 | The GP64 envelope fusion protein is an essential baculovirus protein required for cell-to-cell transmission of infection显示文摘 | Monsma S A Oomens A C Blissard G W | | 0，，： | 1 |
| 10 | Molecular cloning of a nov el G protein coulpled receptor related to the opiate receptor family显示文摘 | Shen Y Monsma FJ, | 1995 | J Ne urochem1995，64，： | 1 |
| 11 | The baeulo- virus GP64 envelope fusion protein: synthesis, oligome- rization, and processing显示文摘 | ()omens A G Monsma S A Blissard G W | 1995 | Virology1995，209，2： | 1 |
| 12 | Molecular biology of dopamine receptors显示文摘 | Sibley DR Monsma FJ | 1992 | TIPS1992，13，： | 1 |
| 13 | Cohe- rent spin transport through a 350-micron-thick silicon wafer 显示文摘 | HUANG B Q MONSMA D J APPELBAUM I | 2007 | Physical Review Letters2007，99，17： | 1 |
| 14 | Host cell receptor binding by baculovirus GP64 and kinetics of virion entry 显示文摘 | Hefferon K L Oomens A G P Monsma S A | 1999 | Virology1999，258，： | 1 |
| 15 | Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation显示文摘 | MONSMA F J JR MAHAN L C MCVITTIE L D | 1990 | Proc Natl Acad Sci USA1990，87，17： | 1 |
| 16 | Developmental and contextual risks of social physique anxiety among female athletes显示文摘 | Gay JL Monsma EV Torres-McGehee TM | | 0，，： | 1 |
| 17 | Molecular neurobiology of dopaminergic receptors显示文摘 | SIBLEY D R MONSMA F J JR SHEN Y | 1993 | Int Rev Neurobiol1993，35，： | 1 |
| 18 | Molecular biology of dopamine receptors 显示文摘 | Sibley DR Monsma FJ Jr | 1992 | TrendsPharmaeolSci1992，13，2： | 1 |
| 19 | Establishment ofgenetically diverse patient-derived xenografts of colorectal cancer显示文摘 | Burgenske DM Monsma DJ Dylewski D etal | 2014 | Am J Cancer Res2014，4，6： | 1 |
| 20 | The GP64 envelope fusion protein is an essential baculovirus protein required for cell- to-cell transmission of infection显示文摘 | Oomens A G Blissard G W | 1996 | J Virol1996，70，： | 1 |
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