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| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | 互联网群体协作概念、应用与适用理论探讨显示文摘文章以文献数据库收集的31篇互联网群体协作的英文文献为主要样本集,用内容分析法提取描述互联网群体协作概念的关键词,映射于IPO过程模型的9个方面,得到该概念完整的特征描述,总结出较为全面的定义。通过与14个相近概念进行比较,明确概念之间的特征,典型案例被映射于过程模型以突出概念的特性和包容性。基于互联网群体协作的新特点进行了理论展望。 | 范哲 吴克文 朱庆华 徐孝娟 Julita Vassileva | 2013 | 情报理论与实践2013，36，6： | 13 |
| 3 | Does conflict matter in the success of mass collaboration? Investigating antecedents and consequence of conflict in Wikipedia显示文摘Purpose: Web2.0 has facilitated the emergence of mass collaboration. Being a new model of virtual collaboration, mass collaboration has distinct characteristics such as self-organized voluntary participation and many-to-many communications mechanism. Behind the sparking achievements, mass collaboration systems are suffering from high coordination cost, reflecting intense conflict among the participants. This study explains how conflict interacts with its antecedents(participation and task complexity) and decedent(group performance) related to the mass collaboration process.Design/methodology/approach: Theoretical model is built upon literatures. Twenty-six measurable items, including social network indices used to reflect conflicts(e.g., density and degree), are extracted from Wikipedia database. The structural equation modeling is used to validate the proposed model.Findings: Participation increases task complexity, conflict and performance; task complexity and conflict increase group performance, but task complexity decreases conflict.Research limitations: This study is limited to one mass collaboration platform, other contexts can cause variance in the result. More characteristics of conflict network(e.g., self-loop)should be taken into consideration in future studies.Practical implications: Conflict management is critical to mass collaboration, and functions that increase the awareness of conflict may motivate users to participant, resulting better group performance.Originality/value: Few studies have investigated the consequences of conflict in mass collaboration context. Meanwhile, limited number of social network studies build network based on negative link. Moreover, most of extant studies on Wiki are descriptive researches without theoretical model. This study builds a theoretical model and incorporates social network approach to explore the influence of conflict. | Kewen WU Qinghua ZHU Julita VASSILEVA Yuxiang ZHAO | 2012 | Chinese Journal of Library and Information Science2012，，1： | 8 |
| 4 | Rock phosphate solubilization by Aspergillus niger on olive cake- based medium and its further application in a soil- plant system显示文摘 | Vassileva M | 1998 | World J Micro Biotech1998，14，： | 4 |
| 5 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 6 | Auxin-dependent cell cycle reactivation through transcriptional regulation of Ara- bidopsis E2Fa by lateral organ boundary proteins显示文摘 | BERCKMANS B VASSILEVA V SCHMID S P | 2011 | The Plant Cell2011，23，10： | 1 |
| 7 | Behaviour of elements and minerals during preparation and combustion of the Pemik coal显示文摘 | Stanislav V V Greta M E Vassileva C G | 2001 | Fuel Processing Technology2001，，72： | 1 |
| 8 | Rock phosphate solubilization by Aspergillus niger grown on sugar-beet waste medium 显示文摘 | Vassilev N Baca M T Vassileva M | 1995 | Appl Microbiol Biotech1995，44，： | 1 |
| 9 | Immobilized cell technology applied in solubilization of insoluble inorganic (rock) phosphates and P plant acquisition 显示文摘 | Vassilev N Vassileva M Fenlce M | 2001 | Bioresour Technol2001，79，： | 1 |
| 10 | Impact of race on short-term outcomes of patients undergoing combined coronary artery bypass grafting and mitral valve repair显示文摘 | Christina M. Vassileva Steve Markwell Theresa Boley Stephen Hazelrigg | 2011 | The Journal of Thoracic and Cardiovascular Surgery2011，，3： | 1 |
| 11 | Bullous systemic lupus erythematosus 显示文摘 | Vassileva S | 2004 | Clin Dermatol2004，22，2： | 1 |
| 12 | Contents, modes of occurrence and origin of chlorine and bromine in coal显示文摘 | Vassilev S V Eskenazy G M Vassileva C G | 2000 | Fuel2000，79，8： | 1 |
| 13 | Microembolic signals and carotid plaque morphology:a study of 71 patients with moderate or high grade carotid stenosis显示文摘 | Comelli M Vassileva E | 2003 | Aeta Neurol Scand2003，108，： | 1 |
| 14 | Microembolic signals and carotid plaque morphology:a study of 71 patients with moderate or high grade carotid stenosis显示文摘 | Comelli M Vassileva E | 2003 | Acta Neurol Scand2003，108，： | 1 |
| 15 | Glucooligosaccharides synthesized by glucosyltransferases from constitutive mutants of Leuconostocmesenteroides strain Lm28显示文摘 | Iliev I Vassileva T Ignatova C | 2008 | Journal of applied microbiology2008，104，1： | 1 |
| 16 | The KiSS-1 receptor GPR54 is essential for the development of lhe murin reproductive system显示文摘 | FUNES S HEDRICK JA VASSILEVA G | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 17 | Avastin use in high risk corneal transplantation显示文摘 | Vassileva PI Hergeldzhieva TG | 2009 | Graefes Arch Clin Exp Ophthalmol2009，247，12： | 1 |
| 18 | An overview of the behaviour of biomass during combustion: Part I. Phase-mineral transformations of organic and inorganic matter显示文摘 | Stanislav V. Vassilev David Baxter Christina G. Vassileva | 2013 | Fuel2013，，： | 1 |
| 19 | Effect of copy munber on the expression levels of hepatitis B surface antigen in the methylotrophie yeast Pichia pastoris显示文摘 | CHUGH D A S WAMINATHAN S | 2001 | Protein Expr Purif2001，21，： | 1 |
| 20 | Capillary mechanisms in membrane emulsification: oil- in-water emulsions stabilized by Tween 20 and milk proteins显示文摘 | Christov N C Ganchev D N Vassileva N D | 2002 | Colloid Surf B2002，209，： | 1 |
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