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| 1 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 2 | Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy显示文摘AIM To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota(GM),and how ketogenic diet(KD) alters GM.METHODS A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16 S r DNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR,and intergroup comparison was conducted by R software.RESULTS After being on KD treatment for a week,64% of epileptic infants showed an obvious improvement,with a 50% decrease in seizure frequency. GM structure in epileptic infants(P1 group) differed dramatically from that in healthy infants(Health group). Proteobacteria,which had accumulated significantly in the P1 group,decreased dramatically after KD treatment(P2 group). Cronobacter predominated in the P1 group and remained at a low level both in the Health and P2 groups. Bacteroides increased significantly in the P2 group,in which Prevotella and Bifidobacterium also grew in numbers and kept increasing.CONCLUSION GM pattern in healthy infants differed dramatically from that of the epileptic group. KD could significantly modify symptoms of epilepsy and reshape the GM of epileptic infants. | Gan Xie Qian Zhou Chuang-Zhao Qiu Wen-Kui Dai He-Ping Wang Yin-Hu Li Jian-Xiang Liao Xin-Guo Lu Su-Fang Lin Jing-Hua Ye Zhuo-Ya Ma Wen-Jian Wang | 2017 | World Journal of Gastroenterology2017，23，33： | 25 |
| 3 | Immune Responses to the Attenuated Mycoplasma hyopneumoniae 168 Strain Vaccine by Intrapulmonic Immunization in Piglets显示文摘To investigate the immune responses to the attenuated Mycoplasma hyopneumoniae 168 strain vaccine, 8-15 d old piglets were immunized with M. hyopneumoniae 168 strain vaccine by intrapulmonic route. And the specific IgG antibody in serum, lymphoproliferation, IFNγ, and specific secretory IgA (SIgA) antibody in bronchoalveolar lavage fluid were detected on 30 and 60 d post-immunization (DPI), respectively. On 60 DPI, all the pigs except for those in health control group were challenged with a field M. hyopneumoniae strain JS. Necropsy was performed on 30 d post-challenge (DPC). The results showed that IFNγ and specific SIgA were stimulated on surface of respiratory tract after immunization. And peripheral blood mononuclear cells could also be proliferated about 1.81 and 2.12 fold on 30 and 60 DPI when stimulated by M. hyopneumoniae protein in vitro. However, no serum IgG antibody against M. hyopneumoniae was detected during the whole immune phage. After challenge, vaccinated pigs were observed with only very slight histological lesion in individual lobes. None of vaccinated pigs showed any clinical signs. While the unvaccinated pigs from challenge control group showed varying degrees of clinical sign and severe macroscopical lesion of mycoplasmal pneumonia of swine (MPS). The result suggested that the attenuated M. hyopneumoniae 168 strain vaccine inoculated by intrapulmonic route could activate the systemic cellular immunity, the local mucosal immunity and IFNγ secretion in respiratory tract to against M. hyopneumoniae infection in piglets. | FENG Zhi-xin, SHAO Guo-qing, LIU Mao-jun, WU Xu-su, ZHOU Yong-qi and GAN Yuan Key Laboratory of Animal Diseases Diagnostic and Immunology, Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences/National Center for Engineering Research of Veterinary Bio-Products, Ministry of Agriculture, Nanjing 210014, P.R.China | 2010 | Agricultural Sciences in China2010，9，3： | 22 |
| 4 | Review on supermolecules as chemical drugs显示文摘Supramolecular medicinal chemistry field has been a quite rapidly developing,increasingly active and newly rising interdiscipline which is the new expansion of supramolecular chemistry in pharmaceu-tical sciences,and is gradually becoming a relatively independent scientific area. Supramolecular drugs could be defined as medicinal supermolecules formed by two or more molecules through non-covalent bonds. So far a lot of supermolecules as chemical drugs have been widely used in clinics. Supermolecules as chemical drugs,i.e. supramolecular chemical drugs or supramolecular drugs,which might have the excellences of lower cost,shorter period,higher potential as clinical drugs for their successful research and development,may possess higher bioavailability,better biocompatibility and drug-targeting,fewer multidrug-resistances,lower toxicity,less adverse effect,and better curative effects as well as safety,and therefore exhibit wide potential application. These overwhelming advan-tages have drawn enormous special attention. This paper gives the definition of supramolecular drugs,proposes the concept of supramolecular chemical drugs,and systematically reviews the recent ad-vances in the research and development of supermolecules,including organic and inorganic complex ones as chemical drugs in the area of antitumor,anti-inflammatory,analgesic,antimalarial,antibacterial,antifungal,antivirus,anti-epileptic,cardiovascular agents and magnetic resonance imaging agents and so on. The perspectives of the foreseeable future and potential application of supramolecules as chemical drugs are also presented. | ZHOU ChengHe GAN LinLing ZHANG YiYi ZHANG FeiFei WANG GuangZhou JIN Lei GENG RongXia | 2009 | Science China Chemistry2009，52，4： | 17 |
| 5 | Optimization of Adaptive Transit Signal Priority Using Parallel Genetic Algorithm显示文摘Optimization of adaptive traffic signal timing is one of the most complex problems in traffic control systems. This paper presents an adaptive transit signal priority (TSP) strategy that applies the parallel genetic algorithm (PGA) to optimize adaptive traffic signal control in the presence of TSP. The method can optimize the phase plan, cycle length, and green splits at isolated intersections with consideration for the performance of both the transit and the general vehicles. A VISSIM (VISual SIMulation) simulation testbed was developed to evaluate the performance of the proposed PGA-based adaptive traffic signal control with TSP. The simulation results show that the PGA-based optimizer for adaptive TSP outperformed the fully actuated NEMA control in all test cases. The results also show that the PGA-based optimizer can produce TSP timing plans that benefit the transit vehicles while minimizing the impact of TSP on the general vehicles. | Guangwei Zhou Albert Gan L. David Shen | 2007 | Tsinghua Science and Technology2007，12，2： | 15 |
| 6 | Antigen-specific tolerance induced by IL-10 gene modified immature dendritic cells in experimental autoimmune myocarditis in rats显示文摘Background Experimental autoimmune myocarditis (EAM) in rats is a T-cell-mediated disorder. The initiation and maintenance of autoimmune responses in EAM depend on the maturation state of dendritic cells. IL-10 is a pleiotrophic immunomodulatory cytokine that functions at different levels of the immune response, so it has emerged as a promising therapeutic factor for the treatment of autoimmune/inflammatory diseases. This study was designed to test the hypothesis that IL-10 gene modified bone marrow-derived immature dendritic cells (iDCs) ameliorate EAM and to explore the underlying mechanisms. Methods EAM was induced using the methods of cardiac myosin immunization on day 0 and day 7. Immature and mature bone marrow-derived dendritic cells (BMDCs) were generated without or with the stimulation by lipopolysaccharide (LPS) and the phenotype was analyzed by flow cytometry. Some of the iDCs were transfected by pcDNA3-IL-10 plasmid. 2×106/per rat mature DC (mDC), immature DC (iDC), pcDNA3 transfected iDC, pcDNA3-IL-10 transfected iDC or phosphate buffered saline (PBS) were injected intravenously for treatment 5 days after the first immunization. On day 21, HE staining was performed to detect the myocardial inflammation and T lymphocyte proliferation assay was used to determine the effects of IL-10 gene transfected iDC on autoreactive T cell proliferation. Expression of IκB, the inhibitor of NF-κB pathway, was determined by Western blot. Results BMDCs generated in a medium supplemented with granulocyte-macrophage-colony-stimulating factor (GM-CSF) were relatively immature, as determined by flow cytometry. However, stimulation with LPS induced these cells to become mature (m)DCs with higher levels of surface major histocompatibility complex (MHC)-II and costimulatory molecules. Intravenous administration of iDCs, especially pcDNA3-IL-10 transfected iDC, ameliorated the histopathological severity of the myosin induced-EAM, and the effect was lost after the DCs underwent maturation induced by in vitro exposure to LPS. IL-10 gene modified iDC inhibited the antigen specific T cell responses towards cardiac myosin. IκB protein was up-regulated significantly in the IL-10 gene modified iDC group. Conclusions IL-10 gene modified iDC induced antigen-specific tolerance in EAM. The underlying mechanisms may be related to costimulatory molecules down-regulation and NF-κB pathway inhibition. | LI Wei-min LIU Wei GAO Cheng ZHOU Bao-guo YANG Shu-sen WANG Zheng ZHANG Rui-hong GAN Run-tao KONG Yi-hui LI Yue | 2006 | Chinese Medical Journal2006，，19： | 13 |
| 7 | Nidus vespae protein inhibiting proliferation of HepG2 hepatoma cells through extracellular signal-regulated kinase signaling pathways and inducing G1 cell cycle arrest显示文摘蛋白质说出 NVP (1 ) 从巢 vespae 被孤立。T 他现在的学习的目的是阐明 NVP (1 ) 是否并且怎么调制 HepG2 房间的增长。在 6.6 μg/ml 的集中的 NVP (1 ) 能在阶段 G 1 逮捕房间周期并且禁止 cyclinB, cyclinD1 和 cyclinE 的 mRNA 表示。NVP (1 ) 压制了 cdk2 蛋白质表示,但是增加了 p27 和 p21 蛋白质表示。然而, NVP (1 ) 没改变 p16 蛋白质表示层次。NVP (1 ) 在由原子染色质冷凝作用显示了的 HepG2 房间支持了 apoptosis,并且另外,表明小径的细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 被激活。而且,当 HepG2 房间是有英皇家空军之阶级最低之兵禁止者 PD98059 的 pretreated 时,津贴蛋白质表示水平被稀释。这些结果证明 NVP (1 ) 通过表明小径的英皇家空军之阶级最低之兵禁止 HepG2 的增长。NVP (1 ) 能是为肝癌症的潜在的药。 | Changdong Wang Peng Chen Hongjuan Jin Xu Yan Lu Gan Yi Li Shiyi Zhou Junli Chang Yuesheng Wang Guangxiao Yang Guangyuan He | 2008 | Acta Biochimica et Biophysica Sinica2008，40，11： | 11 |
| 8 | Accuracy of multi-echo Dixon sequence in quantification of hepatic steatosis in Chinese children and adolescents显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) is currently the outstanding cause of chronic liver disease in children and adolescents, especially in overweight and obese groups. Liver biopsy is the reference standard to diagnose NAFLD but invasive, thus it is not the best choice in clinical diagnosis and follow-up.Magnetic resonance(MR) is widely used in clinical trials to noninvasively quantify liver fat content in adults and children in foreign countries. While currently, it is rarely used in Chinese children and adolescents. We postulated that quantifying hepatic steatosis by MR could be extended to children and adolescents in China.AIM To investigate the accuracy of MR imaging(MRI) in quantifying liver fat with MR spectroscopy(MRS) as a reference. A secondary goal was to assess the prevalence of NAFLD in overweight and obese Chinese children and adolescents.METHODSThere were 86 children and adolescents enrolled in this study, including 65 overweight and obese children and 21 healthy children. The participants underwent MRI and MRS. MRI and MRS were performed using multi-echo Dixon and HISTO sequences, respectively, to calculate hepatic proton density fat fraction(PDFF). Hepatic steatosis was diagnosed using MRS-PDFF > 5% as the threshold. Spearman's analysis was used to evaluate the correlation between MRI and MRS. The agreement between these two methods was assessed by BlandAltman analysis.RESULTS The MRI-PDFF in the MRS region of interest and the entire liver was 9.9% ±10.3% with a range of 0.3%-39.9%, and 10.6% ± 9.4% with a range of 1.9%-38.9%,respectively. The MRS-PDFF was 9.1% ± 10.0%, with a range of 0.5%-37.8%. The incidence of hepatic steatosis detected by MRS-PDFF was 46.5%(40/86) of all participants, all of whom belonged to the overweight and obese group.Spearman's analysis indicated an excellent correlation between multi-echo Dixon and MRS(r > 0.9, P < 0.01). Bland-Altman analysis also demonstrated a good agreement between these two methods.CONCLUSION Multi-echo Dixon shows an excellent correlation and agreement with MRS in quantifying liver fat content and could be a potential tool to detect hepatic steatosis in Chinese children and adolescents. | Yu-Zhen Zhao Yun-Gen Gan Jian-Li Zhou Jia-Qi Liu Wei-Guo Cao Shu-Mei Cheng Da-Ming Bai Meng-Zhu Wang Fang-Qin Gao Shao-Ming Zhou | 2019 | World Journal of Gastroenterology2019，25，12： | 11 |
| 9 | Changes in microRNAs expression are involved in age-related atrial structural remodeling and atrial fibrillation显示文摘 | XU Guo-jun GAN Tian-yi TANG Bao-peng CHEN Zu-heng Mahemuti Ailiman ZHOU Xian-hui JIANG Tao SONG Jian-guo GUO Xia LI Yao-dong MIAO Hai-jun ZHANG Yu LI Jin-xin | 2013 | Chinese Medical Journal2013，，8： | 11 |
| 10 | Scalable production of self-supported WSe/CNFs by electrospinning as the anode for high-performance lithium-ion batteries显示文摘 | Shasha Zhou Junnian Chen Lin Gan Qing Zhang Zhi Zheng Huiqiao Li Tianyou Zhai | 2016 | Science Bulletin2016，61，3： | 11 |
| 11 | Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal micro- circulation显示文摘BackgroundMyocardial 梗塞(MI ) 多半贡献了心失败(HF ) 的增加的流行。由于减少的心脏的功能,内脏的血流动减少,引起在到肠的障碍的绒毛和损坏的局部缺血。heme oxygenase-1 (HO-1 ) 的正式就职能阻止,或减少应力和发炎的效果。因此,效果和有 HF 的老鼠的肠上的 HO-1 它的机制是有通过左冠的动脉的结扎的心失败的 investigated.MethodsMale Wistar 老鼠与 < 的左室的喷射部分被识别;45% 通过 echocardiography 然后基于他们收到了的腹注射的类型划分了成各种各样的试验性的组[MI:盐;MI + 钴 protoporphyrin (CoPP ) :CoPP 答案;并且 MI + 听 mesoporphyrin IX 二氯化物(简单网络管理协议) :简单网络管理协议答案] 。没有冠的结扎,控制组由老鼠组成。Echocardiography 在结扎以后为一条基线和八个星期在结扎前被执行以便评估老鼠的心脏的功能。细菌的 translocation (BT ) 发生, mesenteric microcirculation,在静脉浆液的内毒素的数量, HO-1 的回肠层次,碳氧化物(公司) ,氮的氧化物(没有) , interleukin (IL )-10, 瘤坏死 factor-α(TNF-α) ,并且在收到 MI + CoPP 注射的 operation.ResultsThe 老鼠在心脏的功能展出了恢复以后,回肠形态学八个星期被决定,在形态学的 mesenteric microcirculation 和变化的改善,更低的 BT 发生,在浆液的减小并且肠阻塞没有并且 TNF-α与 MI 相比的在肠阻塞的 HO-1,公司,和 interleukin-10 (IL-10 ) 的层次,和举起层次组织(P <0.05 ) 。收到了 MI + 简单网络管理协议注射的老鼠展出了对 MI 反的结果(P <0.05 ) group.ConclusionsHO-1 由通过 CO 小径禁止 microcirculation 的发炎和改善与 HF 在老鼠的肠上施加了保护的效果。这保护的效果能从心脏的功能的恢复是独立的。 | Li ZHANG Zhuo-Kun GAN Li-Na HAN Hao WANG Jie BAI Guo-Juan TAN Xiao-Xia LI Ya-Ping XU Yu ZHOU Mei-Liang GONG Mo-Si LIN Xiao-Yang HAN | 2015 | Journal of Geriatric Cardiology2015，12，4： | 11 |
| 12 | Sirolimus induces apoptosis and reverses multidrug resistance in human osteosarcoma cells in vitro via increasing microRNA-34b expression显示文摘瞄准:多药抵抗在化疗提出一个批评瓶颈。在许多 chemoresistant 癌症给 mTOR 小径的起来规定,我们检验了是否 sirolimus (rapamycin ) ,第一个产生 mTOR 禁止者,可能导致人的 osteosarcoma (OS ) 房间 apoptosis 和增加到在 vitro.Methods 的 anticancer 药的 OS 房间的敏感:人的 OS 房间线 MG63/ADM 与 doxorubicin (ADM ) 独自或在联合与 sirolimus 被对待, gemcitabine (宝石) 或 methotrexate (MTX ) 。房间增长和 apoptosis 被检测分别地使用 CCK-8 试金和流动 cytometry。在房间的 MiRNAs 与 miRNA microarray 被分析。miR-34b 的目标基于 TargetScan 分析和酶记者试金被决定。相关 mRNA 和蛋白质的表示用 qRT-PCR 并且西方的弄污被测量。在 OS 病人的 40 件织物样品的 MiR-34, PAK1 和 ABCB1 层次用 qRT-PCR 并且在 situ 杂交 assays.Results 被分析:Sirolimus (1-100 nmol/L ) dose-dependently 压制了房间增长(IC 50=23.97 nmol/L ) 并且导致了 apoptosis。Sirolimus (10 nmol/L ) 显著地敏化房间到 anticancer 药,导致 ADM,宝石和 MTX 的减少的 IC 50 价值(从 25.48, 621.41 和 21.72 μ mol/L 到 4.93, 73.92 和 6.77 μ mol/L,分别地) 。治疗与 sirolimus,增加的 miR-34b 在房间由 7.5 的一个因素铺平。miR-34b 的 Upregulation 也导致了 apoptosis 并且,增加了房间的敏感到 anticancer 药有 miR-34b-AMO 的 transfection, miR-34b 的一个禁止者,颠倒了 sirolimus 的反增长效果。房间周期, apoptosis 和多重药抵抗, PAK1 和 ABCB1 的二个关键管理者,被表明是 miR-34b 的直接目标。在 OS 病人的 40 件织物样品,显著地更高的 miR-34 ISH 分数和 ABCB1 分数在 chemo 敏感的 group.Conclusion 被检测:Sirolimus 由与 PAK1 和 ABCB1 交往的起来调整的 miR-34b 在 vitro 增加人的 OS 房间的敏感到 anticancer 药。低 miR-34 水平是在 OS 病人的差的预后的指示物。 | Yan ZHOU Rui-hua ZHAO Kuo-Fu TSENG Kun-peng LI Zhi-gang LU Yuan LIU Kun HAN Zhi-hua GAN Shu-chenLIN Hai-yan HU Da-liu MIN | 2016 | Acta Pharmacologica Sinica2016，37，4： | 10 |
| 13 | High-voltage Ride Through Strategy for DFIG Considering Converter Blocking of HVDC System显示文摘This paper presents a P-Q coordination based highvoltage ride through(HVRT) control strategy for doubly fed induction generators(DFIGs) based on a combined Q-V control and P-V de-loading control. The active/reactive power injection effect of DFIG on transient overvoltage is firstly analyzed and the reactive power capacity evaluation of DFIG considering its de-loading operation is then conducted. In the proposed strategy, the reactive power limit of DFIG can be flexibly extended during the transient process in coordination with its active power adjustment. As a result, the transient overvoltage caused by DC bipolar block can be effectively suppressed. Moreover, key outer loop parameters such as Q-V control coefficient and deloading coefficient can be determined based on the voltage level of point of common coupling(PCC) and the available power capacity of DFIG. Finally, case studies based on MATLAB/Simulink simulation are used to verify the effectiveness of the proposed control strategy. | Changping Zhou Zhen Wang Ping Ju Deqiang Gan | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，3： | 10 |
| 14 | Vertical Distribution and Seasonal Dynamics of Fine Root Parameters for Apple Trees of Different Ages on the Loess Plateau of China显示文摘The vertical distribution pattern and seasonal dynamics of fine root parameters for the apple trees of different ages(3,10,15,and 20 years old) on the Loess Plateau of China were studied.Soil coring method was used to determine the vertical distribution and seasonal dynamics of fine roots at different root radial distances(1.0,1.5,and 2.0 m from the main tree trunk).The fine root biomass density(FRD),fine root length density(RLD),and specific root length(SRL),as well as soil water content and soil temperature were also measured.The FRD and RLD for the 10,15,and 20 years old trees reached peak values in the 20-30 cm soil layer.For the 3 years old tree,the highest FRD and RLD were observed in the 10-20 cm soil layer.The FRD and RLD decreased with increased soil depth from the 10-20 or 20-30 cm soil layer for all age apple trees.The SRL declined with the increase of tree age.The FRD at the 1.0 m radial distance from the main tree trunk was higher than that at other radial distances in the 3 and 10 years old orchard.However,in the 15 and 20 years old orchards,especially the 20 years old orchard,the FRD at the 2.0 m radial distance was nearly equal to or higher than that at the 1.0 and 1.5 m radial distances.For all the root radiuses or the tree ages,the FRD,RLD,and SRL were the highest in spring and the lowest in autumn.The age of an apple tree does not affect the vertical distribution pattern but the biomass of fine roots and the SRL.Radial distance affects the root horizontal distribution of 3 and 10 years old trees but the 15 and 20 years old trees.Additionally,effects of soil temperature and soil moisture on fine root distribution or seasonal dynamics are not significant. | GAN Zhuo-ting ZHOU Zheng-chao LIU Wen-zhao | 2010 | Agricultural Sciences in China2010，9，1： | 10 |
| 15 | Chinese Herbal Medicine Combined with Entecavir for HBeAg Positive Chronic Hepatitis B:Study Protocol for a Multi-Center,Double-Blind Randomized-Controlled Trial显示文摘Background: The domestic prevalence of chronic hepatitis B(CHB) in China is 7.18% in 2006, imposing great societal healthcare burdens. Nucleot(s)ide analogues(NUCs) anti-hepatitis B virus(HBV) therapies are widely applied despite the relatively low rate of seroconversion and high risk of drug-resistant mutation. More effective treatments for CHB deserve further explorations. Combined therapy of NUCs plus Chinese herbal medicine(CHM) is widely accepted in China, which is recognized as a prospective alternative approach. The study was primarily designed to confirm the hypothesis that Tiaogan-Yipi Granule(调肝益脾颗粒, TGYP) or Tiaogan-Jianpi-Jiedu Granule(调肝健脾解毒颗粒, TGJPJD) plus entecavir tablet(ETV) was superior over ETV monotherapy in enhancing HBeA g loss rate. Methods: The study was a nationwide, large-scale, multi-center, double-blind, randomized, placebo-control ed trial with a designed duration of 108 weeks. A total of 16 hospitals and 596 eligible Chinese HBeA g positive CHB patients were enrolled from November 2012 to September 2013 and randomly allocated into 2 groups in 1:1 ratio via central randomization system: experimental group(EG) and control group(CG). Subjects in EG received CM formulae(TGYP or TGJPJD, 50 g per dose, twice daily) plus ETV tablet(or ETV placebo) 0.5 mg per day in the first 24 weeks(stage 1), and CHM granule plus ETV tablet(0.5 mg per day) from week 25 to 108(stage 2). Subjects in CG received CHM Granule placebo plus ETV tablet(0.5 mg per day) for 108 weeks throughout the trial. The assessments of primary outcomes(HBV serum markers and HBV-DNA) were conducted by a third-party College of American Pathologists(CAP) qualified laboratory. Adverse effects were observed in the hospitals of recruitment. Discussion: The study was designed to compare the curative effect of CM plus ETV and ETV monotherapy in respect of HBe Ag loss, which is recognized by the European Association for the Study of the Liver as 'a valuable endpoint'. We believe this trial could provide a reliable status for patients' 'journey' towards durable responses after treatment discontinuation. The trial was registered before recruitment on Chinese Clinical trial registry(No. ChiC TR-TRC-12002784, Version 1.0, 2015/12/23). | YE Yong-an LI Xiao-ke ZHOU Da-qiao CHI Xiao-ling LI Qin WANG Li LU Bing-jiu MAO De-wen WU Qi-kai WANG Xian-bo ZHANG Ming-xiang XUE Jing-dong LI Yong LU Wei GUO Jian-chun JIANG Feng ZHANG Xin-wei DU Hong-bo YANG Xian-zhao GUO Hui GAN Da-nan LI Zhi-guo | 2018 | Chinese Journal of Integrative Medicine2018，24，9： | 10 |
| 16 | Changes in soil organic carbon and nitrogen after 26 years of farmland management on the Loess Plateau of China显示文摘Soil carbon(C) and nitrogen(N) play a crucial role in determining the soil and environmental quality. In this study, we investigated the effects of 26 years(from 1984 to 2010) of farmland management on soil organic carbon(SOC) and soil N in abandoned, wheat(Triticum aestivum L.) non-fertilized, wheat fertilized(mineral fertilizer and organic manure) and alfalfa(Medicago Sativa L.) non-fertilized treatments in a semi-arid region of the Loess Plateau, China. Our results showed that SOC and soil total N contents in the 0–20 cm soil layer increased by 4.29(24.4%) and 1.39 Mg/hm2(100%), respectively, after the conversion of farmland to alfalfa land. Compared to the wheat non-fertilized treatment, SOC and soil total N contents in the 0–20 cm soil layer increased by 4.64(26.4%) and 1.18 Mg/hm2(85.5%), respectively, in the wheat fertilized treatment. In addition, we found that the extents of changes in SOC, soil total N and mineral N depended on soil depth were greater in the upper soil layer(0–30 cm) than in the deeper soil layer(30–100 cm) in the alfalfa land or fertilizer-applied wheat land. Fertilizer applied to winter wheat could increase the accumulation rates of SOC and soil total N. SOC concentration had a significant positive correlation with soil total N concentration. Therefore, this study suggested that farmland management, e.g. the conversion of farmland to alfalfa forage land and fertilizer application, could promote the sequestrations of C and N in soils in semi-arid regions. | ZHOU Zhengchao ZHANG Xiaoyan GAN Zhuoting | 2015 | Journal of Arid Land2015，7，6： | 10 |
| 17 | Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage显示文摘Objective To investigate the effect of simulated microgravity and carbon ion irradiation(CIR) on spermatogenic cell apoptosis and sperm DNA damage to the testis of male Swiss Webster mice,and assess the risk associated with space environment.Methods Sperm DNA damage indicated by DNA fragmentation index(DFI) and high DNA stainability(HDS) was measured by sperm chromatin structure assay(SCSA).Apoptosis of spermatogenic cells was detected by annexin V-propidium iodide assay.Bax(the expression levels of p53) and proliferating cell nuclear antigen(PCNA) were measured by immunoblotting;p53 and PCNA were located by immunohistology.Results HDS,DFI,apoptosis index,and the expression levels of p53 and Bax were detected to be significantly higher in the experimental groups(P<0.05) compared with those in the control group;however,the PCNA expression varied to a certain degree.p53-and PCNA-positive expression were detected in each group,mainly in relation to the spermatogonic cells and spermatocytes.Conclusion The findings of the present study demonstrated that simulated microgravity and CIR can induce spermatogenic cell apoptosis and sperm DNA damage.Sperm DNA damage may be one of the underlying mechanisms behind male fertility decline under space environment.These findings may provide a scientific basis for protecting astronauts and space traveler's health and safety. | LI Hong Yan ZHANG Hong MIAO Guo Ying XIE Yi SUN Chao DI Cui Xia LIU Yang LIU Yuan Yuan ZHANG Xin MA Xiao Fei XU Shuai GAN Lu ZHOU Xin | 2013 | Biomedical and Environmental Sciences2013，26，9： | 10 |
| 18 | Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients:A Randomized Controlled 48-Week Trial显示文摘Objective:To evaluate the effects of a 48-week course of adefovir dipivoxil(ADV)plus Chinese medicine(CM)therapy,namely Tiaogan Jianpi Hexue(调肝健脾和血)and Tiaogan Jiedu Huashi(调肝解毒化湿)fomulae,in hepatitis B e antigen(HBeAg)-positive Chinese patients.Methods:A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group(EG,received ADV plus CM)and control group(CG,received ADV plus CM-placebo)for 48 weeks.The major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12,24,36,48,respectively.Secondary endpoints including liver functions(enzymes and bilirubin readings)were evaluated every 4 weeks at the beginning of week 24,36,and 48.Routine blood,urine,and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety evaluations.Adverse events(AEs)were documented.Results:The combination therapy demonstrated superior HBeAg loss at 48 weeks,without additional AEs.The full analysis population was 560 and 280 in each group.In the EG,population achieved HBeAg loss on week 12,24,36,and 48 were 25(8.90%),34(12.14%),52(18.57%),and 83(29.64%),respectively;the equivalent numbers in the CG were 20(7.14%),41(14.64%),54(19.29%),and 50(17.86%),respectively.There was a statistically significant difference between two groups on week 48(P<0.01).No additional AEs were found in EG.Subgroup analysis suggested different outcomes among treatment patterns.Conclusion:Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy.The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile(ChiCTR-TRC-11001263). | LI Xiao-ke ZHANG Ming-xiang SHAO Feng-zhen ZHOU Da-qiao XUE Jing-dong LIU Tie-jun CHI Xiao-ling LU Bing-jiu WANG Xian-bo LI Qin LI Jun MAO De-wen YANG Hua-sheng YANG Hong-zhi ZHAO Wen-xia LI Yong ZHANG Guo-liang ZHAO Yi-ming ZOU Jian-dong LIU Meng-yang ZHANG Ke-ke YANG Xian-zhao GAN Da-nan LI Ying ZHANG Peng LI Zhi-guo LI Shuo YE Yong-an | 2020 | Chinese Journal of Integrative Medicine2020，26，5： | 9 |
| 19 | A novel HfNbTaTiV high-entropy alloy of superior mechanical properties designed on the principle of maximum lattice distortion显示文摘This paper reports a synergistic design of high-performance BCC high-entropy alloy based on the combined consideration of the principles of intrinsic ductility of elements,maximum atomic size difference for solid solution strengthening and the valence electron concentration criterion for ductility.The single-phase BCC HfNbTaTiV alloy thus designed exhibited a high compressive yield strength of 1350 MPa and a high compressive ductility of>45%at the room temperature.This represents a 50%increase in yield strength relative to a HfNbTaTiZr alloy.This is attributed to the maximized solid solution strengthening effect caused by lattice distortion,which is estimated to be 1094 MPa.The alloy was also able to retain 53%of its yield strength and 77%of its ductility at 700℃.These properties are superior to those of most refractory BCC high-entropy alloys reported in the literature. | Zibing An Shengcheng Mao Yinong Liu Li Wang Hao Zhou Bin Gan Ze Zhang Xiaodong Han | 2021 | Journal of Materials Science & Technology2021，，20： | 9 |
| 20 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
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