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| 1 | More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells显示文摘在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习发现 Yamanaka 因素在维持胚胎的茎(ES ) 房间 pluripotency 调整一个发展发信号网络。这里,我们完全证实 reprogrammed 导致了 pluripotent 茎(iPS ) 细胞并且由薄片薄片试金在这些细胞分析了 Yamanaka 因素的全球倡导者占有。我们发现 565 基因的倡导者是由在 iPS 房间的四个 Yamanaka 因素的合作界限, 10 褶层增加什么时候与他们在 ES 房间的绑定相比。,在 ES 房间 Oct4, Sox2,或 Klf4 在 iPS 房间在激活并且镇压的基因同等地散布的一个单个 Yamanaka 因素占据的倡导者在激活的主要在镇压基因和 c-Myc 散布了。薄片薄片数据的小径分析表明 Yamanaka 因素在 iPS 房间, 12 在之中是普通的调整了 16 条发展发信号小径, 4 与在 ES 房间调整的小径相比是唯一的。我们进一步在 iPS 房间分析了另一最近出版的薄片薄片数据集并且观察了类似的结果,显示出为揭示 pluripotency 维护和新生的性质的薄片薄片正小径分析的力量。下次,我们试验性地测试了压抑的发信号小径之一并且发现它的抑制确实改进了房间 reprogramming 的效率。一起拿,我们建议有一个核心为 pluripotency 必要的发展发信号网络与 TGF- ,刺猬, Wnt,是的 p53 压抑(殷) 管理者和 Jak-STAT,房间周期,焦点的粘附, adherens 连接作为活跃(杨) ;并且 Yamanaka 因素 synergistically 在 Yin-Yang 调整他们导致 pluripotency 的平衡方法。 | Jinyan Huang Taotao Chen Xiaosong Liu Jing Jian Jinsong Li Dangsheng Li X Shirley Liu Wei Li Jiuhong Kang Gang Pei | 2009 | Cell Research2009，19，10： | 4 |
| 2 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 3 | Limiting current of oxygen reduction on gas-diffusion electrodes for phosphoric-acid fuel-cells显示文摘 | Li Q Gang X Hjuler H A | 1994 | J Electrochem Soc1994，141，11： | 1 |
| 4 | Reconstructive techniques study after anterior decompression of multilevel cervical spondy- lotic myelopathy 显示文摘 | Wei-bing X Wun-Jer S Gang L | 2009 | J Spinal Disord Tech2009，22，7： | 1 |
| 5 | The Lycopodium alkaloids显示文摘 | MA X Q GANG D R | 2004 | Nat Prod Rep2004，21，： | 1 |
| 6 | Nonpara~ial multi-Gaussian beam models and measurement models for phased array transducers显示文摘 | ZHAO X GANG T | 2009 | Ultrasonics2009，49，1： | 1 |
| 7 | Colossal magnetoresistance of 1000000-fold magnitude achieved in the antiferromagnetic phase of La1-x CaxMnO3显示文摘 | GUO G Q CHADWICK C GANG X | 1995 | Appl Phys Lett1995，67，： | 1 |
| 8 | The Lycopodium alkaloids显示文摘 | Ma X Q Gang D R | 2004 | Nat Prod Rep2004，21，： | 1 |
| 9 | Colossal magnetoelectric resistance of 1000000-fold magnitude achieved in the antiferromagnetic phase of La1-xCaxMnO3显示文摘 | Guo G Q Chadwick C Gang X | 1995 | Appl Phys Lett1995，67，： | 1 |
| 10 | Up-regulation of gastric cancer cell invasion by twist is accompanied by N-cadherin and fibronectin expression显示文摘 | Yang Z Zhang X Gang H | 2007 | Biochemical & Biophysical Research Communications2007，358，3： | 1 |
| 11 | Gene expression and function study of fusion immunotoxin anti - Her -2 - scFv - SEC 2 in Escherichia coli 显示文摘 | Ming -Kai X Cheng- Gang Z | 2006 | Appl Microbiol Biotechnol2006，70，1： | 1 |
| 12 | Solid phase modifiers of the Fe( Ⅵ )cathode :effects on the super-iron battery 显示文摘 | Licht S Wang B H Gang X | 1999 | Electrochemistry Communications1999，1，11： | 1 |
| 13 | Pravastatin inhibits plaque rupture and subsequent thrombus formation in atherosclerotic rabbits with hyperlipidemia显示文摘 | Gang W Qiang X Lin X | 2013 | Chem Pharm Bull2013，61，2： | 1 |
| 14 | Soil organic carbon stocks in China and changes from 1980s to 2000s显示文摘 | Zu B X Jiang G Z Gang L | 2007 | Global Change Biology2007，13，： | 1 |
| 15 | Reduced urinary excretion of intact osteopontin in patients with IgA nephropathy显示文摘 | Gang X Ueki K Kon S | 2001 | Am J Kidney Dis2001，37，： | 1 |
| 16 | Control of p-and n-type conductivity in sputter deposition of undoped ZnO显示文摘 | Gang X Willkinson J Mischuck B | 2002 | Appl Phys Lett2002，80，： | 1 |
| 17 | Effects of chromium pieolinate on growth performance, carcass charcteristies, serum metabolites and metabolism of lipid in pigs 显示文摘 | Gang X Zirong X Si H W | 2001 | Asia - Austr J Anim Sci2001，14，2： | 1 |
| 18 | In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease 显示文摘 | Ma X Gang DR | 2008 | Phytochemistry2008，69，10： | 1 |
| 19 | An adaptive parameter tuning of particle swarm optimization algorithm显示文摘 | Gang X | 2013 | Applied Mathematics and Computation2013，219，： | 1 |
| 20 | Mycobacterium tubercu- losis Rv3586(DacA)is a diadenylate cyclase that con- verts ATP or ADP into c-all-AMP 显示文摘 | Bai Y gang J Zhou X | 2012 | PLoS One2012，7，4： | 1 |
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