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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Operating principles and detection characteristics of the Visible and Near-Infrared Imaging Spectrometer in the Chang'e-3显示文摘The Visible and Near-Infrared Imaging Spectrometer(VNIS), using two acousto-optic tunable filters as dispersive components, consists of a VIS/NIR imaging spectrometer(0.45–0.95 μm), a shortwave IR spectrometer(0.9–2.4 μm) and a calibration unit with dust-proofing functionality. The VNIS was utilized to detect the spectrum of the lunar surface and achieve in-orbit calibration, which satisfied the requirements for scientific detection. Mounted at the front of the Yutu rover, lunar objects that are detected with the VNIS with a 45° visual angle to obtain spectra and geometrical data in order to analyze the mineral composition of the lunar surface. After landing successfully on the Moon, the VNIS performed several explorations and calibrations, and obtained several spectral images and spectral reflectance curves of the lunar soil in the region of Mare Imbrium. This paper describes the working principle and detection characteristics of the VNIS and provides a reference for data processing and scientific applications. | Zhi-Ping He Bin-Yong Wang Gang Lü Chun-Lai Li Li-Yin Yuan Rui Xu Bin Liu Kai Chen Jian-Yu Wang | 2014 | Research in Astronomy and Astrophysics2014，14，12： | 12 |
| 3 | Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats显示文摘AIM:To explore the therapeutic effects of Morinda officinalis capsules(MOP) on osteoporosis in ovariectomized rats.METHOD:Six-month-old female Sprague–Dawley rats were induced for postmenopausal osteoporosis(PMOP) by bilateral ovariectomy and divided into seven groups as follows:sham-operated group,ovariectomized(OVX) control group,OVX treated with xianlinggubao(XLGB)(270 mg·kg-1·d-1),OVX treated with alendronate sodium(ALN)(3 mg·kg-1·d-1),and OVX treated with Morinda officinalis capsule(MOP) of graded doses(90,270 and 810 mg·kg-1·d-1) groups.Oral treatments were administered daily on the 4th week after ovariectomy and lasted for 12 weeks.The bone mineral density was evaluated by dual-energy X-ray absorptiometry.The tartrate-resistant acid phosphatase(TRAP),alkaline phosphatase(AKP),and osteocalcin(OC) levels in the serum and plasma were determined by standard colorimetric and enzyme immunoassays methods.Bone biomechanical properties and morphological parameters were analyzed by three-point bending test and histomorphometry respectively.RESULTS:Morinda officinalis capsules at all doses were able to significantly prevent the OVX-induced loss of bone mass due to diminishing serum AKP and TRAP levels while elevating OC level in the plasma.Morinda officinalis capsules also enhanced the bone strength and prevented the deterioration of trabecular microarchitecture.CONCLUSION:Morinda officinalis capsules possess potent anti-osteoporotic activity in OVX rats which could be an effective treatment for postmenopausal osteoporosis. | LI Ye Lü Shan-Shan TANG Gui-Ying HOU Min TANG Qing ZHANG Xiao-Na CHEN Wei-Hai CHEN Gang XUE Qiang ZHANG Cong-Cong ZHANG Ji-Fen CHEN Yi XU Xiao-Yu | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 10 |
| 4 | Development of genome-wide insertion/deletion markers in rice based on graphic pipeline platform显示文摘DNA markers play important roles in plant breeding and genetics.The Insertion/Deletion(InDel) marker is one kind of co-dominant DNA markers widely used due to its low cost and high precision.However,the canonical way of searching for InDel markers is time-consuming and laborintensive.We developed an end-to-end computational solution(InDel Markers Development Platform,IMDP) to identify genome-wide InDel markers under a graphic pipeline environment.IMDP constitutes assembled genome sequences alignment pipeline(AGA-pipe) and next-generation resequencing data mapping pipeline(NGS-pipe).With AGA-pipe we are able to identify 12,944 markers between the genome of rice cultivars Nipponbare and 93-11.Using NGS-pipe,we reported 34,794 InDels from re-sequencing data of rice cultivars Wu-Yun-Geng7 and Guang-Lu-Ai4.Combining AGApipe and NGS-pipe,we developed 205,659 InDels in eight japonica and nine indica cultivars and 2,681 InDels showed a subgroup-specific pattern.Polymerase chain reaction(PCR)analysis of subgroup-specific markers indicated that the precision reached 90%(86 of 95).Finally,to make them available to the public,we have integrated the InDels/markers information into a website(Rice InDel Marker Database,RIMD,http://gffzz71b3756633b74a6ehp0qopkou59pf6cxb.ffgz.tsg.suse.edu.cn/).The application of IMDP in rice will facilitate efficiency for development of genome-wide InDel markers,in addition it can be used in other species with reference genome sequences and NGS data. | Yang L Xiao Cui Rui Li Piaopiao Huang Jie Zong Danqing Yao Gang Li Dabing Zhang Zheng Yuan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 9 |
| 5 | Dynamic analysis of a flameless combustion model combustor显示文摘Flameless combustion is a new technology with the following advantages:1)Ultra-low emissions of both NOX and CO;2)fuel flexibility,from liquid fuels,natural gas to hydrogen-rich syngas;3)lower possibility of flashback and thermoacoustic oscillations.In this paper,we focus on the dynamic characteristics of a flameless model combustor.Experimental results show that flameless combustion can lower emissions while maintaining combustion stability.However,combining a pilot flame with flameless combustion may excite thermoacoustic instability. | CUI YuFeng 1* ,LüXuan 1,2 ,XU Gang 1 &NIE ChaoQun 1 1 Institute of Engineering Thermophysics,Chinese Academy of Sciences,Beijing 100190,China 2Graduate School of the Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Technological Sciences)2010，53，8： | 5 |
| 6 | Polar interaction of polymer host-solvent enables stable solid electrolyte interphase in composite lithium metal anodes显示文摘The lithium(Li) metal anode is an integral component in an emerging high-energy-density rechargeable battery.A composite Li anode with a three-dimensional(3 D) host exhibits unique advantages in suppressing Li dendrites and maintaining dimensional stability.However,the fundamental understanding and regulation of solid electrolyte interphase(SEI),which directly dictates the behavior of Li plating/stripping,are rarely researched in composite Li metal anodes.Herein,the interaction between a polar polymer host and solvent molecules was proposed as an emerging but effective strategy to enable a stable SEI and a uniform Li deposition in a working battery.Fluoroethylene carbonate molecules in electrolytes are enriched in the vicinity of a polar polyacrylonitrile(PAN) host due to a strong dipole-dipole interaction,resulting in a LiF-rich SEI on Li metal to improve the uniformity of Li deposition.A composite Li anode with a PAN host delivers 145 cycles compared with 90 cycles when a non-polar host is employed.Moreover,60 cycles are demonstrated in a 1:0 Ah pouch cell without external pressure.This work provides a fresh guidance for designing practical composite Li anodes by unraveling the vital role of the synergy between a 3 D host and solvent molecules for regulating a robust SEI. | Peng Shi Ze-Yu Liu Xue-Qiang Zhang Xiang Chen Nan Yao Jin Xie Cheng-Bin Jin Ying-Xin Zhan Gang Ye Jia-Qi Huang Stephens IfanE L Titirici Maria-Magdalena Qiang Zhang | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 7 | Upwelling Process of the Western Himalaya Mountains:Height and Velocity Estimation Evidenced by Formation and Evolution of the Zanda Basin,Tibet,China显示文摘把地质的调查, stratigraphic 节测量和室内的全面调查基于地, Zanda 盆在 Himalaya 板中的构造地点被查明,并且 Zanda 盆的形成和进化作为六个阶段在到早更新世的上新世期间被分类:(a) 主要指责裂缝的舞台,(b) 快指责裂缝的舞台,(c) 集中的指责裂缝的舞台,(d) 壅滞舞台,(e) 第二等的指责裂缝的舞台,和(f) 第二等的快指责裂缝的舞台。基于 Zanda 盆的这个六阶段的形成进化理论,当下列五上演,到早更新世的从上新世的西方的 Himalaya 山的 upwelling 过程被分类:(a) 慢 upwelling 舞台(5.44.4 妈) ,(b) 中间速度的 upwelling 舞台(4.43.5 妈) ,(c) 快 upwelling 舞台(3.53.2 妈) ,(d)停止 upwelling 阶段(3.22.7 妈) ,和(e) 快 upwelling 舞台(2.7 妈) 。研究从早上新世(4.7 妈) 在持续时间显示出那到上新世(2.67 妈) 的目的,它持续了 203 万年, Himalaya 山高举了在 0.74 mm/a 的速度的 1500 m;这属于中间速度的 upwelling。在在早更新世的早阶段的 131 万年期间, Himalaya 山在 1.15 mm/a 的速度在另一 1500 m 上面升起了;这是相当快的 upwelling。所有这些数据证明了西方的 Himalaya 山的 upwelling 沿着有 multi-stages,多速度,和非天律不变论的特征的一个复杂过程。 | ZHU Dagang MENG Xian' gang SHAO Zhaogang YANG Chaobin HAN Jian'en YU Jia MENG Qingwei Lü Rongping | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 8 | Repair of spinal cord injury by neural stem cells transfected with brain-derived neurotrophic factor-green fluorescent protein in rats A double effect of stem cells and growth factors?显示文摘Brain-derived neurotrophic factor (BDNF) can significantly promote nerve regeneration and repair. High expression of the BDNF-green fluorescent protein (GFP) gene persists for a long time after transfection into neural stem cells. Nevertheless, little is known about the biological characteristics of BDNF-GFP modified nerve stem cells in vivo and their ability to induce BDNF expression or repair spinal cord injury. In the present study, we transplanted BDNF-GFP transgenic neural stem cells into a hemisection model of rats. Rats with BDNF-GFP stem cells exhibited significantly increased BDNF expression and better locomotor function compared with stem cells alone. Cellular therapy with BDNF-GFP transgenic stem cells can improve outcomes better than stem cells alone and may have therapeutic potential for spinal cord injury. | Yansong Wang Gang Lü | 2010 | Neural Regeneration Research2010，5，17： | 3 |
| 9 | Effect of oxygen partial pressure and transparent substrates on the structural and optical properties of ZnO thin films and their performance in energy harvesters显示文摘Zinc oxide(ZnO) thin films were deposited onto different substrates — tin-doped indium oxide(ITO)/glass, ITO/polyethylene naphthalate(PEN), ITO/polyethylene terephthalate(PET) — by the radio-frequency(RF) magnetron sputtering method. The effect of various O2/(Ar+O2) gas flow ratios(0, 0.1, 0.2, 0.3, 0.4, 0.5, and 0.6) was studied in detail. ZnO layers deposited onto ITO/PEN and ITO/PET substrates exhibited a stronger c-axis preferred orientation along the(0002) direction compared to ZnO deposited onto ITO/glass. The transmittance spectra of ZnO films showed that the maximum transmittances of ZnO films deposited onto ITO/glass, ITO/PEN, and ITO/PET substrates were 89.2%, 65.0%, and 77.8%, respectively. Scanning electron microscopy(SEM) images of the film surfaces indicated that the grain was uniform. The cross-sectional SEM images showed that the ZnO films were columnar structures whose c-axis was perpendicular to the film surface. The test results for a fabricated ZnO thin film based energy harvester showed that its output voltage increased with increasing acceleration of external vibration. | Yan-ping Xia Pei-hong Wang Shi-wei Shi Gang He Miao Zhang Jian-guo Lü Zhao-qi Sun | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，6： | 3 |
| 10 | Enterprise resource planning implementation decision & optimization models显示文摘To study the uncertain optimization problems on implementation schedule, time-cost trade-off and quality in enterprise resource planning (ERP) implementation, combined with program evaluation and review tech-nique (PERT), some optimization models are proposed, which include the implementation schedule model, the time-cost trade-off model, the quality model, and the implementation time-cost-quality synthetic optimization model. A PERT-embedded genetic algorithm (GA) based on stochastic simulation technique is introduced to the optimiza-tion models solution. Finally, an example is presented to show that the models and algorithm are reasonable and effective, which can offer a reliable quantitative decision method for ERP implementation. | Wang Shaojun Wang Gang Lü Min | 2008 | Journal of Systems Engineering and Electronics2008，19，3： | 3 |
| 11 | Structural characteristics of the KPR-CBR triple-junction inferred from gravity and magnetic interpretations,Philippine Sea Plate显示文摘The intersection of the Kyushu-Palau Ridge(KPR)and the Central Basin Rift(CBR)of the West Philippine Basin(WPB)is a relic of a trench-trench-rift(TTR)type triple-junction,which preserves some pivotal information on the cessation of the seafloor spreading of the WPB,the emplacement and disintegration of the proto-Izu-Bonin-Mariana(IBM)Arc,and the transition from initial rifting to steady-state spreading of the Parece Vela Basin(PVB).However,the structural characteristics of this triple-junction have not been thoroughly understood.In this paper,using the newly acquired multi-beam bathymetric,gravity,and magnetic data obtained by the Qingdao Institute of Marine Geology,China Geological Survey,the authors depict the topographic,gravity,and magnetic characteristics of the triple-junction and adjacent region.Calculations including the upward continuations and total horizontal derivatives of gravity anomaly are also performed to highlight the major structural features and discontinuities.Based on these works,the morphological and structural features and their formation mechanisms are analyzed.The results show that the last episode amagmatic extension along the CBR led to the formation of a deep rift valley,which extends eastward and incised the KPR.The morphological and structural fabrics of the KPR near and to the south of the triple-junction are consistent with those of the western PVB,manifesting as a series of NNE-SSW-and N-S-trending ridges and troughs,which were produced by the extensional faults associated with the initial rifting of the PVB.The superposition of the above two reasons induced the prominent discontinuity of the KPR in deep and shallow crustal structures between 15°N‒15°30′N and 13°30′N‒14°N.Combined with previous authors’results,we propose that the stress produced by the early spreading of the PVB transmitted westward and promoted the final stage amagmatic extension of the CBR.The eastward propagation of the CBR destroyed the KPR,of which the magmatism had decayed or ceased at that time.The destruction mechanism of the KPR associated with the rifting of the PVB varies along strike the KPR.Adjacent to the triple-junction,the KPR was destroyed mainly due to the oblique intersection of the PVB rifting center.Whereas south of the triple-junction,the KPR was destroyed by the E-W-directional extensional faulting on its whole width. | Lu-ning Shang Pan-feng Li Run-lin Du Feng-long Bai Gang Hu Wen-chao Lü Xia Li Xi Mei Tian-yu Zhang Hou-zhen Cao Jing-yi Cong Xian-yao Shi | 2021 | China Geology2021，4，4： | 3 |
| 12 | Sodium guide star laser generation by single-pass frequency doubling in a periodically poled near-stoichiometric LiTaO_3 crystal显示文摘We report in this work a continuous wave(CW) narrowband 589 nm light generation for the purpose of laser guide assisted adaptive optics.A 39 mm long 1 mm thick periodically poled near stoichiometric LiTaO3 crystal with duty cycle near 50% was fabricated using electrical poling at room temperature and pumped by a Raman fiber amplifier.We tested two temperature control ovens,and a maximum conversion efficiency of about 14.3%,corresponding to 4 W of yellow light with 28 W of fundamental power,and bandwidth less than 0.18 GHz was achieved. | YUAN Ye ZHANG Lei LIU YanHua Lü XinJie ZHAO Gang FENG Yan ZHU ShiNing | 2013 | Science China(Technological Sciences)2013，56，1： | 2 |
| 13 | Performance measure for image fusion considering region information显示文摘An objective performance measure for image fusion considering region information is proposed. The measure not only reflects how much the pixel level information that fused image takes from the source image, but also considers the region information between source images and fused image. The measure is meaningful and explicit. Several simulations were conducted to show that it accords well with the subjective evaluations. | LIU Gang Lü Xue-qin | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，4： | 2 |
| 14 | HBV infection increases the risk of pancreatic cancer: a meta-analysis显示文摘 | Gang Luo Ning-Bo Hao Chang-Jiang Hu Xin Yong Mu-Han Lü Bo-Jun Cheng Yao Zhang Shi-Ming Yang | 2013 | Cancer Causes & Control2013，，3： | 2 |
| 15 | New generations of dihydropyridines for treatment of hypertension显示文摘自从钙隧道, blocker ( CCB )在世界上为 antihypertensive monotherapy 成为了大多数规定代理人之一,这简短评论将集中于 dihydropyridine ( DHP )的最近的研究和发展 CCB ,为 DHP CCB 的第三和第四代的临床的功效探讨药理学机制,特别在他们位于阴沉的血压下面的可能的中央机制上。 | Angela L Wang Costantino Iadecola Gang Wang | 2017 | Journal of Geriatric Cardiology2017，14，1： | 2 |
| 16 | Diagnosis and treatment oftracheobronchial foreign bodies in 1 024 children显示文摘 | Gang W Zhengxia P Hongbo L | 2012 | J PediatrSurg2012，47，11： | 1 |
| 17 | A digital imaging based multifunc- tional flame monitoring system 显示文摘 | Gang L Yong Y Mike C | 2004 | IEEE Transactions on Instru- mentation and Measurement2004，53，4： | 1 |
| 18 | Reconstructive techniques study after anterior decompression of multilevel cervical spondy- lotic myelopathy 显示文摘 | Wei-bing X Wun-Jer S Gang L | 2009 | J Spinal Disord Tech2009，22，7： | 1 |
| 19 | Indirect chemiluminescence detection for capillary zone electrophoresis of monoamines and catechol using luminol-K3system显示文摘 | YONG Gang H Xinxin L Zhitao P | 2005 | Journal of Chromatography A2005，，1091： | 1 |
| 20 | Road fugitive dust emission characteristics in Beijing during Olympics Game 2008 in Beijing, China 显示文摘 | Shou-bin F Gang T Gang L | 2009 | Atmospheric Environment2009，43，38： | 1 |
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