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| 1 | Circular RNA circStag1 promotes bone regeneration by interacting with HuR显示文摘Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the bone microarchitecture,leading to an increased risk of fractures.Recently,circular RNAs(circ RNAs)have been demonstrated to play pivotal roles in regulating bone metabolism.However,the underlying functions of circ RNAs in bone metabolism in postmenopausal osteoporosis remain obscure.Here,we report that circ Stag1 is a critical osteoporosis-related circ RNA that shows significantly downregulated expression in osteoporotic bone marrow mesenchymal stem cells(BMSCs)and clinical bone tissue samples from patients with osteoporosis.Overexpression of circ Stag1 significantly promoted the osteogenic capability of BMSCs.Mechanistically,we found that circ Stag1 interacts with human antigen R(Hu R),an RNA-binding protein,and promotes the translocation of Hu R into the cytoplasm.A high cytoplasmic level of Hu R led to the activation of the Wnt signaling pathway by stabilizing and enhancing low-density lipoprotein receptor-related protein 5/6(Lrp5/6)andβ-catenin expression,thereby stimulating the osteogenic differentiation of BMSCs.Furthermore,overexpression of circ Stag1 in vivo by circ Stag1-loaded adeno-associated virus(circ Stag1-AAV)promoted new bone formation,thereby preventing bone loss in ovariectomized rats.Collectively,we show that circ Stag1 plays a pivotal role in promoting the regeneration of bone tissue via Hu R/Wnt signaling,which may provide new strategies to prevent bone metabolic disorders such as postmenopausal osteoporosis. | Gaoyang Chen Canling Long Shang Wang Zhenmin Wang Xin Chen Wanze Tang Xiaoqin He Zhiteng Bao Baoyu Tan Jin Zhao Yongheng Xie Zhizhong Li Dazhi Yang Guozhi Xiao Songlin Peng | 2022 | Bone Research2022，10，3： | 7 |
| 2 | Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos显示文摘在在 midblastula 转变(MBT ) 的 zygotic 染色体激活前的动物胚胎的开发是实质上 supportedby 导出鸡蛋的母亲的产品。节的蛋白质在 MBT 以后是为中层和内胚叶正式就职的关键信号。Itremains 不清楚母亲的因素它在 zebrafish 胞胚的 ventrolateral blastodermal 边缘激活节的基因的 zygotic 表示。在这研究,我们显示出母亲的 Eomesodermina (Eomesa ) 的那损失,一个 T 盒子抄写因素,损害节的基因 ndr1 和 ndr2 以及 mesodermal 和 endodermal 标记的 zygotic 表示,在 mesendoderm 显示参与感应。母亲的 Eomesa 是为抄写因素基因 mxtx2 的及时 zygotic 表示的 alsorequired,节的基因表示的一个管理者。Eomesa 直接在激活他们的抄写的 ndr1, ndr2,和 mxtx2 的倡导者或 enhancer 绑在 Eomes 有约束力的地点。而且,节的基因也是的人和老鼠由 Eomes 调整了。进鼠科的胚胎的干细胞的 zebrafish eomesa 的 Transfection 与内长的节的表示的经常的高水平支持 mesendodermal 区别,建议 Eomes 的一个保存函数。一起拿,我们的调查结果在在脊椎动物胚胎调整节的基因表示和 mesendoderm 正式就职揭示母亲的 T-boxtranscription 因素的一个保存角色。 | Pengfei Xu Gaoyang Zhu Yixia Wang Jiawei Sun Xingfeng Liu Ye-Guang Chen Anming Meng | 2014 | Journal of Molecular Cell Biology2014，8，4： | 5 |
| 3 | Replanting of broadleaved trees alters internal nutrient cycles of native and exotic pines in subtropical plantations of China显示文摘Background:The replanting of broadleaved trees in pure coniferous plantations is widely implemented,as mixed plantations are generally more stable and functional.However,the effect of interspecific interactions between broadleaved and coniferous trees on internal nutrient cycles of conifers remains unclear.Methods:We selected pure coniferous plantations of a native(Pinus massoniana)and an exotic(P.elliottii)pine species and their corresponding mixed plantations with broadleaved trees(Schima superba)in subtropical China,and measured the nitrogen(N)and phosphorus(P)contents in the rhizosphere soils,fine roots,twigs,needles and needle litter of pines.We calculated the root capture,needle resorption and translocation of N and P by pines to determine the mobility of nutrients in trees.Results:Although the N and P in the rhizosphere soils increased due to the replanting of broadleaved trees,the N and P contents in the aboveground tissues of the two pine species did not increase in mixed plantations.Mixed planting had a negative effect on the N and P capture of native pine and a positive effect on that of exotic pine.The N and P resorption efficiencies increased in native pine but were unchanged in exotic pine after the replanting of S.superba.Native pine preferentially employed an aboveground nutrient resorption strategy,whereas exotic pine tended to adopt a belowground nutrient capture strategy after replanting.Translocation of N and P in trees was detected,which reflected the trade-offs between root nutrient capture and needle nutrient resorption.Conclusions:The effect of mixed planting varied between the species of native and exotic pines,and the internal nutrient cycles of both pine species might be dominated by interspecific interaction effects on nutrients rather than soil nutrients.Our study highlights the importance of selecting suitable broadleaved species for replanting in coniferous plantations. | Yong Lin Chengkang Xia Gaoyang Wu Fangchao Wang Shengnan Wang Yuanqiu Liu Fusheng Chen | 2022 | Forest Ecosystems2022，9，5： | 2 |
| 4 | Photosensitive PZT Gel Films and Their Preparation for Fine Patterning显示文摘 | Zhang Weihua Zhao Gaoyang Chen Zhiming | 2003 | Materials Science and Engineering B2003，99，： | 1 |
| 5 | BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells显示文摘 | Zhongwei Li Teng Fei Jianping Zhang Gaoyang Zhu Lu Wang Danyu Lu Xiaochun Chi Yan Teng Ning Hou Xiao Yang Hongquan Zhang Jing-Dong J. Han Ye-Guang Chen | 2012 | Cell Stem Cell2012，，2： | 1 |
| 6 | Study on the pipe friction resistance in long-distance rock pipe jacking engineering显示文摘Previous studies on pipe friction resistance are mainly concentrated in the soil layer,whereas the study on that in the rock stratum is limited.To estimate the pipe friction resistance in the rock stratum,the calculation models of pipe friction resistance and their applica-tion conditions were compared first.Then the friction resistance calculation model for pipe jacking in the rock stratum was established and simplified.Lastly,the measured(FM)and the computed(FN)pipe friction resistance was compared to validate the simplified friction resistance calculation model.The following conclusions can be drawn:(1)The existing calculation methods of pipe friction resistance can be well verified in the soil layer but cannot be applied in the rock stratum.(2)Sediment,pipe–rock friction coefficient and mud buoyancy are the main factors affecting the pipe friction resistance in long-distance rock pipe jacking engineering.(3)The simplified calculation model established by Deng et al.can estimate the pipe friction resistance in different rock strata at different jacking stages with satisfac-tory outcomes.Further research on the pipe-rock friction coefficient in different rock strata with different pipe–rock contact conditions merits further investigation to better predict the pipe friction resistance in the rock stratum.The research results have certain practica-bility and can provide a reference for similar projects. | Peng Chen Xinrong Liu Zhiyun Deng Ninghui Liang Libing Du Han Du Yedi Huang Lingyun Deng Gaoyang Yang | 2023 | Underground Space2023，，2： | 1 |
| 7 | Synthesis and characterization of Bi 4 Ti 3 O 12 , (Bi 3.25 La 0.75 )Ti 3 O 12 , and Bi 4 Ti 3 O 12 /(Bi 3.25 La 0.75 )Ti 3 O 12 multilayered films prepared using novel photochemical sol–gel method显示文摘 | Yuanqing Chen Gaoyang Zhao Hongwei Liang Weiming Xia | 2011 | Materials Letters2011，，： | 1 |
| 8 | Photosensitive PZT gel films and their preparation for fine patterning 显示文摘 | Zhang Weihua Zhao Gaoyang Chen Zhiming | 2003 | Materials Science and Engineering2003，99，： | 1 |
| 9 | Structural and ferroelectric characterization of PZT thin films显示文摘 | YANG Ying CHEN Zhiming ZHAO Gaoyang | 2002 | Internation Journal of Modern Physies B2002，16，28： | 1 |
| 10 | Textured YBCO films derived from low-flourine -content solution显示文摘 | Chen Yuanqing Zhao Gaoyang Lei Li | | Materail Science Forum0，，： | 1 |
| 11 | Fabrication of YBCO film patterns and their properties显示文摘 | Zhao Gaoyang Zhang Huangli Chen Yuanqing | | 0，，12： | 1 |
| 12 | Epithelioid Hemangioendothelioma of the Liver:Etiology,Natural History and Treatment显示文摘Introduction Epithelioid hemangioendothelioma(EHE)is an uncommon vascular tumor,which also has been called histiocytoid haemangioma.This low-grade malignant tumor was first described as a distinctive entity in 1982 by Weiss and Enzinger.Histopathologically,EHE is charac- terized by round or spindle-shaped endothelial cells with | Weirong Chen Maogen Chen Gaoyang Cai Ziqun Liao | 2008 | Chinese Journal of Clinical Oncology2008，5，4： | 0 |
| 13 | Circularly Polarized Light-Enabled Chiral Nanomaterials:From Fabrication to Application显示文摘For decades,chiral nanomaterials have been extensively studied because of their extraordinary properties.Chiral nanostructures have attracted a lot of interest because of their potential applications including biosensing,asymmetric catalysis,optical devices,and negative index materials.Circularly polarized light(CPL)is the most attractive source for chirality owing to its high availability,and now it has been used as a chiral source for the preparation of chiral matter.In this review,the recent progress in the field of CPL-enabled chiral nanomaterials is summarized.Firstly,the recent advancements in the fabrication of chiral materials using circularly polarized light are described,focusing on the unique strategies.Secondly,an overview of the potential applications of chiral nanomaterials driven by CPL is provided,with a particular emphasis on biosensing,catalysis,and phototherapy.Finally,a perspective on the challenges in the field of CPL-enabled chiral nanomaterials is given. | Changlong Hao Gaoyang Wang Chen Chen Jun Xu Chuanlai Xu Hua Kuang Liguang Xu | 2023 | Nano-Micro Letters2023，15，3： | 0 |
| 14 | Safeguarding cross-silo federated learning with local differential privacy显示文摘Federated Learning(FL)is a new computing paradigm in privacy-preserving Machine Learning(ML),where the ML model is trained in a decentralized manner by the clients,preventing the server from directly accessing privacy-sensitive data from the clients.Unfortunately,recent advances have shown potential risks for user-level privacy breaches under the cross-silo FL framework.In this paper,we propose addressing the issue by using a three-plane framework to secure the cross-silo FL,taking advantage of the Local Differential Privacy(LDP)mechanism.The key insight here is that LDP can provide strong data privacy protection while still retaining user data statistics to preserve its high utility.Experimental results on three real-world datasets demonstrate the effectiveness of our framework. | Chen Wang Xinkui Wu Gaoyang Liu Tianping Deng Kai Peng Shaohua Wan | 2022 | Digital Communications and Networks2022，8，4： | 0 |
| 15 | The Clinical Study of Multigene Combination Test to Guide Chemotherapy Combined with Targeted Therapy in Patients with Advanced Gastrointestinal Tumors显示文摘Objective:To study the clinical effects of multigene combination test to guide chemotherapy combined with targeted therapy in patients with advanced gastrointestinal tumors.Methods:The samples were selected from 60 patients with advanced gastrointestinal tumors admitted to our hospital from March 2019 to July 2020,and were divided into a study group and a control group using a random number table model;patients in the control group did not undergo genetic testing and FOLLOX4+PD-1 chemotherapy,while patients in the study group underwent TYMS,ERCC1,EGFR,and KRAS and VEGF gene expression levels test,and the sensitive treatment plan was determined based on the test results,and the clinical indexes were compared between the two groups.Results:By comparing the total effective rate,survival time,and time to disease progression of chemotherapy in the two groups,the study group has a significant advantage(P<0.05).Conclusion:The combination of chemotherapy and targeted therapy for advanced gastrointestinal tumor patients can improve the efficiency of chemotherapy and prolong the time of disease progression and survival,which is worthy of comprehensive promotion. | Zhisheng Zhang Gaoyang Chen Qin Dai | 2020 | Proceedings of Anticancer Research2020，4，5： | 0 |
| 16 | Pterostilbene supresses inflammation-induced melanoma metastasis by impeding neutrophil elastase-mediated thrombospondin-1 degradation显示文摘Objective: Chronic inflammation plays a fatal role in tumor metastasis. Pterostilbene(PTE) is a natural dimethylated analogue of resveratrol with anticancer and anti-inflammatory activities. This study aimed to investigate the inhibitory effect of PTE on inflammation-associated metastasis and explore the underlying mechanisms.Methods: Lipopolysaccharide(LPS)-induced lung inflammation and melanoma metastasis models were established in mice. After PTE treatment for four weeks, the organ index, histological changes, proinflammatory cytokines, and the expression and activity of neutrophil elastase(NE), a biomarker of neutrophil influx in the lungs, were analysed. Additionally, direct effects of PTE on NE-induced B16 cell migration were explored in wound healing and Transwell assays, and the expression of thrombospondin-1(TSP-1) and epithelial-mesenchymal transition(EMT) markers were also detected.Results: PTE obviously attenuated the LPS-induced metastasis of circulatory B16 cells to lungs by reducing the number of metastatic nodules on the lung surfaces and the lung weight/body weight ratio. PTE treatment also significantly reduced LPS-activated increase levels of tumor necrosis factor(TNF)-a and interleukin(IL)-6 in the lungs of tumor-bearing mice. In addition, increased expression and enzyme activity of NE and decreased expression of TSP-1 were observed, and these were blocked by PTE. In vitro, PTE at concentrations without cytotoxicity also markedly suppressed NE-triggered B16 cell migration, prevented NE-induced TSP-1 proteolysis and reversed the expression of vimentin, N-cadherin and Ecadherin.Conclusion: PTE could block inflammation-enhanced tumor metastasis, and the underlying mechanism might be associated with the inhibition of NE-mediated TSP-1 degradation. | Dan Su Shan Xu Kailin Ji Hailing Xu Yan Li Zhisheng Zhang Yuqing Shen Gaoyang Chen | 2023 | Chinese Herbal Medicines2023，15，1： | 0 |
| 17 | Significance of extracellular signal-regulated kinase (ERK) in the development of rectal carcinoma显示文摘Objective: To study the ERK expression and its significance in the development of human rectal carcinoma. Methods: Samples were obtained from 62 patients with rectal carcinoma, including tumor tissue and adjacent normal rectal tissue. Western blot was used to measure the expression of ERK-1 and ERK-2. S-P immunohistochemical method was used to count the microvessel density (MVD). Results: ERK-1 and ERK-2 protein levels were increased in rectal carcinoma tissue compared with those in adjacent normal tissues (t = 2.980 and 2.194, P < 0.01 and 0.05 respectively). The MVD was higher in patients with higher ERK-1 and/or ERK-2 protein levels than that in cases with lower ERK-1 and/or ERK-2 levels. Conclu- sion: Overexpression of ERK-1 and/or ERK-2 may play an important role in the development of human rectal carcinoma, the overexpression can enhance the growth of tumor microvessel and promote the development of human rectal carcinoma. | Weirong Chen Ziqun Liao Maogen Chen Gaoyang Cai Tinghan Li | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，1： | 0 |
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