| 5 | Emerging role of protein modification in inflammatory bowel disease显示文摘The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune system.Although research on IBD continues to expand,the specific pathogenesis mechanism is still unclear.Protein modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of proteins.Since proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be different.Transitions between different states of protein or changes in modification sites can regulate protein properties and functions.Such modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial barrier.In this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD. | Gaoying WANG Jintao YUAN Ji LUO Dickson Kofi Wiredu OCANSEY Xu ZHANG Hui QIAN Wenrong XU Fei MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 0 |
| 6 | LIMIT CYCLES FOR A CLASS OF NONPOLYNOMIAL PLANAR VECTOR FIELDS (II)显示文摘In this paper, the problem of limit cycles for a class of nonpolynomial planar vector felds is investigated. First, based on Liapunov method theory, we obtain some sufcient conditions for determining the origin as the critical point of such nonpolynomial planar vector felds to be the focus or center. Then, using Dulac criterion, we establish some sufcient conditions for the nonexistence of limit cycles of this nonpolynomial planar vector felds. And then, according to Hopf bifurcation theory, we analyze some sufcient conditions for bifurcating limit cycles from the origin. Finally, by transforming the nonpolynomial planar vector felds into the generalized Li′enard planar vector felds, we discuss the existence, uniqueness and stability of limit cycles for the former and latter planar vector felds. Some examples are also given to illustrate the efectiveness of our theoretical results. | Gaoying Zhang Jia Du Yu Wang Jiuhong Zhou | 2013 | Annals of Differential Equations2013，29，3： | 0 |
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