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| 1 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 2 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | Sewage measured by the faecal (2) sterol , coprostanol 显示文摘 | Gary L A Steven C C | 1995 | Wat Res1995，29，6： | 1 |
| 5 | Realizing the hydrogen future: the International energy agency's efforts to advance hydrogen energy technologies显示文摘 | Carolyn C E Gary S Andreas L | 2003 | Int J Hydrogen Energy2003，28，： | 1 |
| 6 | Removal of dissolved organic matter by nanofiltration显示文摘 | Amy Gary L Alleman Bruce C Cluff C Brent | 1990 | Journal of Environmental Engineering1990，116，1： | 1 |
| 7 | Reactive evaporation of low-defect density hafnia显示文摘 | Robert C Steve F Gary E L | 1993 | Applied Optics1993，32，28： | 1 |
| 8 | Cultural compe- tence : a systematic review of health care provider education- al interventions 显示文摘 | Beach M C Price E G Gary T L | 2005 | Med Care2005，43，4： | 1 |
| 9 | Albuminuria:moving beyond traditional microalbuminuria cut-points显示文摘 | ERIC L KNIGHT GARY C | 2003 | Current Opinion in Nephrology and Hypertension2003，12，： | 1 |
| 10 | Endometrial carcinoma: paraaortic dissemination显示文摘 | Andrea Mariani Gary L Keeney Giacomo Aletti Maurice J Webb Michael G Haddock Karl C Podratz | 2004 | Gynecologic Oncology2004，，3： | 1 |
| 11 | Ceramic powder synthesis by spray pyrolysis显示文摘 | Gary L M Zhang S C Jayanthi G V | 1993 | Journal of American Ceramic Society1993，76，11： | 1 |
| 12 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 13 | The definition and classification of Dry Eye Disease:Report of the Definition and classification subcommittee of the international Dry Eye Work shop(2007)显示文摘 | Mechael A L Baudouin C Gary N F | 2007 | Ocular surface2007，5，2： | 1 |
| 14 | Antisense transcripts in the human genome显示文摘 | Ben L Gary Williams R Duncan C | 2002 | TRENDS in Cenetics2002，18，2： | 1 |
| 15 | Evidence Based Medicine : What it is and what it isn't显示文摘 | David L Sackett William M C Rosenberg J Muir Gary | 1996 | British Medical Journal1996，，312： | 1 |
| 16 | Carbon dioxide emulsion assisted loading of polymer mierospheres toward sustained release materials 显示文摘 | GARY A B MARY L C MATTHEW Z Y | 2005 | Langmuir2005，21，9： | 1 |
| 17 | 早期乳腺癌最佳辅助化疗方案与人类表皮生长因子受体2阳性乳腺癌辅助靶向治疗选择:依据 ASCO 对 CCO临床实践指南的改编显示文摘目的研究加拿大安大略癌症治疗中心(CCO)关于早期乳腺癌最佳辅助化疗方案,包括人类表皮生长因子受体2(HER2)阳性乳腺癌辅助靶向治疗方案,并对其进行改编。方法按照美国临床肿瘤协会(ASCO)对其他组织临床实践指南改编的策略和程序,对CCO临床实践指南的严谨性与内容适用性进行回顾。结果基于对CCO临床实践指南内容的回顾,ASCO小组认为,CCO临床实践指南在整体上清晰全面,以最确切的科学证据为基础,为患者提供可接受的治疗选项。推荐关于辅助化疗方案的决定,应考虑到基线复发风险、毒性、利益可能性和宿主因素(如合并症)。对于高风险HER2阴性的身体状况良好的人群,蒽环类和紫杉烷治疗方案是标准治疗方案。4个周期的多西他赛和环磷酰胺治疗方案是可接受的非蒽环类治疗方案。对于高风险HER2阳性患者,推荐蒽环类与紫杉烷序贯疗法联合曲妥单抗或多西他赛、卡铂、曲妥单抗进行6个周期的治疗。对于低风险、非淋巴结转移、HER2阳性人群,推荐每周一次的紫杉醇和曲妥单抗连续进行12个周期的替代治疗。曲妥单抗应持续使用1年。不应采用铂复合盐对三阴性人群进行常规的辅助管理,除非出现有效的生存数据加以支持。 | Neelima Denduluri Mark R Somerfield Andrea Eisen Jamie N Holloway Arti Hurria Tari A King Gary H Lyman Ann H Partridge Melinda L Telli Maureen E Trudeau Antonio C Wolff 本刊编辑部 | 2016 | 中国全科医学2016，19，18： | 1 |
| 18 | A comparison of ketamine and ketamine-xylazine in the baboon显示文摘 | Gary L W John F C | 1979 | Veterinary Medicine: Small Animal Clinician1979，3，39： | 1 |
| 19 | Optical multlplay- er films based on an amorphous fluoropolymer显示文摘 | ROBERT C GARY E L RAYMOD L W | 1996 | Vacuum Science1996，14，1： | 1 |
| 20 | Albuminuria:moving beyond traditional microalbuminuria cut-points显示文摘 | Knight and Gary C Curhan | 2003 | Current Opinion in Nephrology and Hypertension2003，12，： | 1 |
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